Contribution of honey in nutrition and human health: A review

Mediterranean Journal of Nutrition and Metabolism

Volumn 3, Issue 1, 2010, Pages 15-23

  Alvarez Suarez, Jose Miguel ^a   Tulipani, Sara ^a   Romandini, Stefania ^a   Bertoli, Enrico ^a   Battino, Maurizio ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Antibacterial activity; Gastric ulcer; Gastroenteritis; Honey; Natural products; Wound healing

Indexed keywords

AMINO ACID DERIVATIVE; ANTIBIOTIC AGENT; AROMATIC COMPOUND; CARBOHYDRATE DERIVATIVE; ENZYME; MINERAL; NATURAL PRODUCT; PLANT MEDICINAL PRODUCT; POLYPHENOL DERIVATIVE; PROTEIN DERIVATIVE; TRACE ELEMENT; VITAMIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; BLADDER CANCER; CALORIC INTAKE; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; DIET SUPPLEMENTATION; DIET THERAPY; DIETARY INTAKE; ENTERITIS; FOOD COMPOSITION; FOOD QUALITY; FOOD STORAGE; GASTROINTESTINAL DISEASE; HONEY; HUMAN; NONHUMAN; NUTRITIONAL HEALTH; NUTRITIONAL REQUIREMENT; NUTRITIONAL VALUE; PHYSICAL CHEMISTRY; PHYTOCHEMISTRY; PRIORITY JOURNAL; REVIEW; TUMOR;

EID: 77949918289     PISSN: 1973798X     EISSN: 19737998     Source Type: Journal    
DOI: 10.1007/s12349-009-0051-6     Document Type: Review

References (99)

1. Crane E (1983) The archaeology of beekeeping. Gerald Duckworth & Co, London
2. Crane E (1975) History of honey. In: Crane E (ed) Honey, a comprehensive survey. William Heinemann, London
3. Jones R (2001) Honey and healing through the ages. In: Munn P, Jones R (eds) Honey and healing. International Bee Research Association IBRA, Cardiff
4. Crane E (1999) The world history of beekeeping and honey hunting. Gerald Duckworth & Co, London
5. K.A. Allsop J.B. Miller 1996 Honey revisited: a reappraisal of honey in pre-industrial diets Br J Nutr 75 513 520 10.1079/BJN19960155 1:CAS:528:DyaK28XivVylsLw%3D (Pubitemid 26142017)
6. A.M. Coulston 2000 Honey...how sweet it is! Nutr Today 35 96 100 10.1097/00017285-200005000-00004
7. S. Bogdanov T. Jurendic R. Sieber 2008 Honey for nutrition and health: a review Am J Coll Nutr 27 677 689 1:CAS:528:DC%2BD1MXislOisL0%3D
8. J. Chow 2002 Probiotics and prebiotics: a brief overview J Ren Nutr 12 76 86 10.1053/jren.2002.31759
9. R.A. Pérez 2002 Analysis of volatiles from Spanish honeys by solid-phase microextraction and gas chromatography-mass spectrometry J Agric Food Chem 50 2633 2637 10.1021/jf011551r (Pubitemid 34437380)
10. A. Terrab M.M.L. Gonzále A.G. González 2003 Characterisation of Moroccan unifloral honeys using multivariate analysis Eur Food Res Technol 218 88 95 10.1007/s00217-003-0797-x 1:CAS:528: DC%2BD3sXpslChsbw%3D (Pubitemid 40877211)
11. I. Martos F. Ferreres L. Yao 2000 Flavonoids in monospecific Eucalyptus honeys from Australia J Agric Food Chem 48 4744 4748 10.1021/jf000277i 1:CAS:528:DC%2BD3cXmsVCntLo%3D
12. F.A. Tomas-Barberán I. Martos F. Ferreres 2001 HPLC flavonoid profiles as markers for the botanical origin of European unifloral honeys J Sci Food Agric 81 485 496 10.1002/jsfa.836 (Pubitemid 32285730)
13. B. Dimitrova R. Gevrenova E. Anklam 2007 Analysis of phenolic acids in honeys of different floral origin by solid-phase extraction and high-performance liquid chromatography Phytochem Anal 18 24 32 10.1002/pca.948 1:CAS:528:DC%2BD2sXhtFSlsrk%3D (Pubitemid 46138674)
14. P.C. Molan J.A. Betts 2004 Clinical usage of honey as a wound dressing: an update J Wound Care 13 353 356 1:STN:280:DC%2BD2crks1Srtg%3D%3D
15. R. Patzold H. Bruckner 2006 Gas chromatographic detection of D-amino acids in natural and thermally treated bee honeys and studies on the mechanism of their formation as result of the Maillard reaction Eur Food Res Technol 223 347 354 10.1007/s00217-005-0211-y (Pubitemid 43883112)
16. A.R. Pérez M.T. Iglesias E. Pueyo 2007 Amino acid composition and antioxidant capacity of Spanish honeys J Agric Food Chem 55 360 365 10.1021/jf062055b (Pubitemid 46586319)
17. A.M. González-Paramás J.A. Gómez-Bárez C. Cordón Marcos 2006 HPLC-fluorimetric method for analysis of amino acids in products of the hive (honey and bee-pollen) Food Chem 95 148 156 10.1016/j.foodchem.2005.02.008 (Pubitemid 43181202)
18. K. Heitkamp M. Busch-Stockfisch 1986 Pro und Kontra Honig-Sind Aussagen zur Wirkung des Honigs "wissenschaftlich hinreichend gesichert"? Z Lebensm Unters Forsch 182 279 286 10.1007/BF01027625 1:CAS:528: DyaL28XktVGntbw%3D
19. L. Persano-Oddo R. Piro 2004 Main European unifloral honeys: descriptive sheets Apidologie 35 38 81 10.1051/apido:2004049
20. A.E. Jeffrey C.M. Echazarreta 1996 Medical uses of honey Rev Biomed 7 43 49
21. R.F.A. Moreira C.A.B. De Maria 2001 Glícidos no mel Quim Nova 24 516 525 1:CAS:528:DC%2BD3MXls1yrsLY%3D
22. L.C. Azeredo M.A.A. Azeredo S.R. Souza V.M.L. Dutra 2003 Protein contents and physicochemical properties in honey samples of Apis mellifera of different floral origins Food Chem 80 249 254 10.1016/S0308-8146(02)00261-3 1:CAS:528:DC%2BD38Xpt12mtbo%3D (Pubitemid 35463100)
23. M.T. Iglesias C. de Lorenzo M.C. Polo 2004 Usefulness of amino acids composition to discriminate between honeydew and floral honeys. Application to honeys from a small geographic area J Food Agric Chem 52 84 89 10.1021/jf030454q 1:CAS:528:DC%2BD3sXpsFygtb0%3D
24. I. Hermosín R.M. Chicón M.D. Cabezudo 2003 Free amino acid composition and botanical origin of honey Food Chem 83 263 268 10.1016/S0308-8146(03)00089-X (Pubitemid 36962892)
25. E. Bengsch 1992 Connaissance du miel. Des oligo-éléments pour la santé Rev franc apicult 569 383 386
26. M.E. Conti 2000 Lazio region (central Italy) honeys: a survey of mineral content and typical quality parameters Food Control 11 459 463 10.1016/S0956-7135(00)00011-6 1:CAS:528:DC%2BD3MXmtFaku7w%3D
27. A. Stocker P. Schramel A. Kettrup E. Bengsch 2005 Trace and mineral elements in royal jelly and homeostatic effects J Trace Elem Med Biol 19 183 189 10.1016/j.jtemb.2005.08.004 1:CAS:528:DC%2BD28Xhslagt7o%3D (Pubitemid 41606714)
28. M. Careri A. Mangia G. Barbieri 1994 Sensory property relationship to chemical data italian-type dry-cured ham J Food Sci 27 491 495
29. E. Anklam B.S. Radovic 2001 Suitable analytical methods for determining the origin of European honey Am Lab 7 60 64
30. S. Bogdanov K. Ruoff O. L. Persano 2007 Physico-chemical methods for the characterisation of unifloral honeys: a review Apidologie 35 4 17 10.1051/apido:2004047
31. L.F. Cuevas-Glory J.A. Pino L.S. Santiago E. Sauri-Duch 2007 A review of volatile analytical methods for determining the botanical origin of honey Food Chem 103 1032 1043 10.1016/j.foodchem.2006.07.068 1:CAS:528:DC%2BD2sXitFSlt7o%3D (Pubitemid 46306223)
32. E. Alissandrakis P.A. Tarantilis P.C. Harizanis M. Polissiou 2005 Evaluation of four isolation techniques for honey aroma compounds J Sci Food Agric 85 91 97 10.1002/jsfa.1934 1:CAS:528:DC%2BD2MXhvFKrsg%3D%3D (Pubitemid 40059616)
33. E. Alissandrakis P.A. Tarantalis P.C. Harizanis M. Polissiou 2007 Aroma investigation of unifloral Greek citrus honey using solidphase microextraction coupled to gas chromatographic-mass spectrometric analysis Food Chem 100 396 404 10.1016/j.foodchem.2005.09.015 1:CAS:528:DC%2BD28Xmt1agtL8%3D (Pubitemid 43914169)
34. L. Piasenzotto L. Gracco L. Conte 2003 Solid phase microextraction (SPME) applied to honey quality control J Sci Food Agric 83 1037 1044 10.1002/jsfa.1502 1:CAS:528:DC%2BD3sXmt1Sjsbo%3D (Pubitemid 36941035)
35. I. Martos F. Ferreres F.A. Tomás-Barberán 2000 Identification of flavonoid markers for the botanical origin of Eucalyptus honey J Food Agric Chem 48 1498 1502 10.1021/jf991166q 1:CAS:528:DC%2BD3cXis1Wgsrw%3D (Pubitemid 30331479)
36. F.A. Tomas-Barberán I. Martos F. Ferreres 2001 HPLC flavonoid profiles as markers for the botanical origin of European unifloral honeys J Sci Food Agric 81 485 496 10.1002/jsfa.836 (Pubitemid 32285730)
37. M.J. Amiot S. Aubert M. Gonnet M. Tacchini 1989 Les composés phénoliques des miels: étude préliminaire sur l'identification et la quantification par familles Apidologie 20 115 125 10.1051/apido:19890202 1:CAS:528:DyaL1MXkvFGrtbs%3D
38. F. Ferreres F.A. Tomas-Barberan M.I. Gil F. Tomas-Lorente 1991 An HPLC technique for flavonoid analysis in honey J Sci Food Agric 56 49 56 10.1002/jsfa.2740560106 1:CAS:528:DyaK3MXmsFCntr4%3D
39. M.I. Gil F. Ferreres A. Ortiz E. Subra F.A. Tomas-Barberan 1995 Plant phenolic metabolites and floral origin of rosemary honey J Agric Food Chem 43 2833 2838 10.1021/jf00059a012 1:CAS:528:DyaK2MXovFSksb8%3D
40. L. Vela C. Lorenzo R.A. Pérez 2007 Antioxidant capacity of Spanish honeys and its correlation with polyphenol content and other physicochemical properties J Sci Food Agric 87 1069 1075 10.1002/jsfa.2813 1:CAS:528: DC%2BD2sXkslGgtrY%3D (Pubitemid 46657851)
41. P. Truchado F. Ferreres L. Bortolotti 2008 Nectar flavonol rhamnosides are markers of acacia (Robinia pseudacacia) honey J Food Agric Chem 56 8815 8824 10.1021/jf801625t 1:CAS:528:DC%2BD1cXhtVGgurbN
42. A. Michalkiewicz M. Biesaga K. Pyrzynska 2008 Solid-phase extraction procedure for determination of phenolic acids and some flavonols in honey J Chrom A 1187 18 24 10.1016/j.chroma.2008.02.001 1:CAS:528:DC%2BD1cXktV2lsLk%3D
43. L. Estevinho A.P. Pereira L. Moreira 2008 Antioxidant and antimicrobial effects of phenolic compounds extracts of Northeast Portugal honey Food Chem Toxicol 46 3774 3779 10.1016/j.fct.2008.09.062 1:CAS:528:DC%2BD1cXhsVajtLjI
44. F. Ferreres F.A. Tomas-Barberan M.I. Gil F. Tomas-Lorente 1991 An HPLC technique for flavonoid analysis in honey J Sci Food Agric 56 49 56 10.1002/jsfa.2740560106 1:CAS:528:DyaK3MXmsFCntr4%3D
45. M.I. Gil F. Ferreres A. Ortiz 1995 Plant phenolic metabolites and floral origin of rosemary honey J Agric Food Chem 43 2833 2838 10.1021/jf00059a012 1:CAS:528:DyaK2MXovFSksb8%3D
46. F.A. Tomás-Barberán I. Martos F. Ferreres 2001 HPLC flavonoid profiles as markers for the botanical origin of European unifloral honeys J Sci Food Agric 81 485 496 10.1002/jsfa.836 (Pubitemid 32285730)
47. S. Bogdanov 1997 Nature and origin of the antibacterial substances in honey Lebensm-Wiss Technol 30 748 753 10.1006/fstl.1997.0259 1:CAS:528:DyaK2sXntlertr4%3D
48. R.J. Weston K.R. Mitchell K.L. Allen 1999 Antibacterial phenolic components of New Zealand manuka honey Food Chem 64 295 301 10.1016/S0308- 8146(98)00100-9 1:CAS:528:DyaK1MXms1Wmuw%3D%3D (Pubitemid 29060717)
49. P.J. Taormina B.A. Niemira L.R. Beuchat 2001 Inhibitory activity of honey against food-borne pathogens as influenced by the presence of hydrogen peroxide and level of antioxidant power Int J Food Microbiol 69 217 225 10.1016/S0168-1605(01)00505-0 1:CAS:528:DC%2BD3MXms12ntbk%3D (Pubitemid 32826260)
50. K.L. Allen P.C. Molan G.M. Reid 1991 A survey of the antibacterial activity of some New Zealand honeys J Pharm Pharmacol 43 817 822 1:STN:280:DyaK383mtVeltA%3D%3D
51. H.A.L. Wahdan 1998 Causes of the antimicrobial activity of honey Infection 26 26 10.1007/BF02768748 1:STN:280:DyaK1c7ms1Sktg%3D%3D
52. R.J. Weston L.K. Brocklebank Y. Lu 2000 Identification and quantitative levels of antibacterial components of some New Zealand honeys Food Chem 70 427 435 10.1016/S0308-8146(00)00127-8 1:CAS:528:DC%2BD3cXkslShtrs%3D (Pubitemid 30421080)
53. J.W. Fahey K.K. Stephenson 2002 Pinostrobin from honey and Thai ginger (Boesenbergia pandurata): A potent flavonoid inducer of mammalian phase 2 chemoprotective and antioxidant enzymes J Agric Food Chem 50 7472 7476 10.1021/jf025692k 1:CAS:528:DC%2BD38XosFSnsbw%3D (Pubitemid 35424920)
54. B. Zeina B.I. Zohra S. al Assad 1997 The effects of honey on Leishmania parasites: an in vitro study Trop Doct 27 [Suppl1] 36 38
55. B. Kilicoglu K. Kismet O. Koru 2006 The scolicidal effects of honey Adv Ther 23 1077 1083 10.1007/BF02850228
56. K.M. Russell P.C. Molan A.L. Wilkins P.T. Holland 1990 Identification of some antibacterial constituents of New Zealand manuka honey J Agric Food Chem 38 10 13 10.1021/jf00091a002 1:CAS:528:DyaK3cXlsVSntA%3D%3D
57. N. Gheldof N.J. Engeseth 2002 Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples J Agric Food Chem 50 3050 3055 10.1021/jf0114637 1:CAS:528:DC%2BD38XisFKrtbc%3D (Pubitemid 34493623)
58. N. Gheldof X.H. Wang N.J. Engeseth 2003 Buckwheat honey increases serum antioxidant capacity in humans J Agric Food Chem 51 1500 1505 10.1021/jf025897t 1:CAS:528:DC%2BD3sXmt1ygsw%3D%3D
59. G. Beretta P. Granata M. Ferrero M. Orioli R.M. Facino 2005 Standardization of antioxidant properties of honey by a combination of spectrophotometric/fluorimetric assays and chemometrics Anal Chim Acta 533 185 191 10.1016/j.aca.2004.11.010 1:CAS:528:DC%2BD2MXis1Cjs70%3D (Pubitemid 41373335)
60. D'Arcy BR (2005) Antioxidants in Australian floral honeys - Identification of health enhancing nutrient components. RIRDC Publication No 05/040
61. N. Gheldof X.H. Wang N.J. Engeseth 2002 Identification and quantification of antioxidant components of honeys from various floral sources J Agric Food Chem 50 5870 5877 10.1021/jf0256135 1:CAS:528:DC%2BD38Xmsl2qtbc%3D (Pubitemid 35155307)
62. S. Frankel G.E. Robinson M.R. Berenbaum 1998 Antioxidant capacity and correlated characteristics of 14 unifloral honeys J Apic Res 37 27 31 1:CAS:528:DyaK1cXmtlOmtrs%3D
63. A.M. Aljadi M.Y. Kamaruddin 2004 Evaluation of the phenolic contents and antioxidant capacities of two Malaysian floral honeys Food Chem 85 513 518 10.1016/S0308-8146(02)00596-4 1:CAS:528:DC%2BD2cXmtFCnsg%3D%3D (Pubitemid 38142496)
64. K. Inoue S. Murayarna F. Seshimo 2005 Identification of phenolic compound in manuka honey as specific superoxide anion radical scavenger using electron spin resonance (ESR) and liquid chromatography with coulometric array detection J Sci Food Agric 85 872 878 10.1002/jsfa.1952 1:CAS:528:DC%2BD2MXis12itL8%3D (Pubitemid 40398829)
65. M. Blasa M. Candiracci A. Accorsi 2006 Raw Millefiori honey is packed full of antioxidants Food Chem 97 217 222 10.1016/j.foodchem.2005.03.039 1:CAS:528:DC%2BD2MXhtleru77O (Pubitemid 41828308)
66. T. Nagai R. Inoue N. Kanamori 2006 Characterization of honey from different floral sources. Its functional properties and effects of honey species on storage of meat Food Chem 97 256 262 10.1016/j.foodchem.2005.03.045 1:CAS:528:DC%2BD2MXhtleru77L (Pubitemid 41828313)
67. N.S. Al-Waili 2003 Effects of daily consumption of honey solution on hematological indices and blood levels of minerals and enzymes in normal individuals J Med Food 6 135 140 10.1089/109662003322233549 1:CAS:528: DC%2BD3sXmtFKqtrk%3D
68. A. Meda C.E. Lamien M. Romito 2005 Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity Food Chem 91 571 577 10.1016/j.foodchem.2004.10.006 1:CAS:528:DC%2BD2cXhtFejsrfE (Pubitemid 40023291)
69. J. McKibben N.J. Engeseth 2002 Honey as a protective agent against lipid oxidation in ground turkey J. Agric Food Chem 50 592 595 10.1021/jf010820a 1:CAS:528:DC%2BD3MXptFanu7Y%3D (Pubitemid 34106683)
70. A.M. Aljadi M.Y. Kamaruddin 2004 Evaluation of the phenolic contents and antioxidant capacities of two Malaysian floral honeys Food Chem 85 513 518 10.1016/S0308-8146(02)00596-4 1:CAS:528:DC%2BD2cXmtFCnsg%3D%3D (Pubitemid 38142496)
71. J. Bertoncelj U. Dobersěk M. Jamnik T. Golob 2007 Evaluation of the phenolic content, antioxidant activity and colour of Slovenian honey Food Chem 105 822 828 10.1016/j.foodchem.2007.01.060 1:CAS:528:DC%2BD2sXns1Krtbc%3D (Pubitemid 47048525)
72. V. Baltrušaitė P. Rimantas V. Čksterytė 2007 Radical scavenging activity of different floral origin honey and beebread phenolic extracts Food Chem 101 502 514 10.1016/j.foodchem.2006.02.007 (Pubitemid 44362981)
73. D.D. Schramm M. Karim H.R. Schrader 2003 Honey with high levels of antioxidants can provide protection to healthy human subjects J Agric Food Chem 51 1732 1735 10.1021/jf025928k 1:CAS:528:DC%2BD3sXhtVaku7o%3D
74. G. Beretta M. Orioli R.M. Facino 2007 Antioxidant and radical scavenging activity of honey in endothelial cell culture (EA.hy926) Planta Med 73 1182 1189 10.1055/s-2007-981598 1:CAS:528:DC%2BD2sXht1eisLvM (Pubitemid 47572353)
75. P.C. Molan 2001 Potential of honey in the treatment of wounds and burns Am J Clin Dermatol 2 9 13 10.2165/00128071-200102010-00003
76. Hamzaoglu I, Saribeyoglu K, Durak H et al (2000) Protective covering of surgical wounds with honey impedes tumor implantation. Arch Surg 135-142
77. A.T.M. Mobarok Ali A.O. Al-Swayeh 1997 Natural honey prevents ethanol.induced increased vascular permeability changes in the rat stomach J Ethnopharmacol 55 231 239 10.1016/S0378-8741(96)01504-8 1:CAS:528: DyaK2sXhtlygtLk%3D (Pubitemid 27122311)
78. L.M. Bang C. Buntting P. Molan 2003 The effect of dilution on the rate of hydrogen peroxide production in honey and its implications for wound healing J Altern Compl Med 9 267 273 10.1089/10755530360623383
79. M. Lopez-Lazaro 2006 Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy Cancer Lett 252 1 8 10.1016/j.canlet.2006.10.029
80. R.M. Facino 2001 Honey in tumor surgery Arch Surg 136 600 10.1001/archsurg.136.5.600
81. P. Michaluart J.L. Masferrer A.M. Carothers 1999 Inhibitory effects of caffeic acid phenethyl esther on the activity and expression of cyclooxygenase-2 in human oral epithelial cell and in rat model of inflammation Cancer Res 59 2347 2352 1:CAS:528:DyaK1MXjsVygtLg%3D
82. F.R. Greten L. Eckmann T.F. Greten 2004 IKK links inflammation and tumorigenesis in mouse model of colitis associated cancer Cell 118 285 296 10.1016/j.cell.2004.07.013 1:CAS:528:DC%2BD2cXmslKrs7o%3D (Pubitemid 39061110)
83. X.H. Wang L. Andrae N.J. Engeseth 2002 Antimutagenic effect of various honeys and sugars against Trp-p-1 J Agric Food Chem 50 6923 6928 10.1021/jf025641n 1:CAS:528:DC%2BD38Xns1Cqsrk%3D (Pubitemid 35253194)
84. N. Orsolic I. Basic 2004 Honey as a cancer-preventive agent Periodicum Biolog 106 397 401
85. T. Swellam N. Miyanaga M. Onozawa 2003 Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies Int J Urol 10 213 219 10.1046/j.0919-8172.2003.00602.x 1:CAS:528:DC%2BD3sXktlGks7s%3D (Pubitemid 36606371)
86. N.S. Al-Waili N.S. Boni 2003 Natural honey lowers plasma prostaglandin concentrations in normal individuals J Med Food 6 129 133 10.1089/ 109662003322233530 1:CAS:528:DC%2BD3sXmtFKqt70%3D
87. Y. Bilsel D. Bugra S. Yamaner 2002 Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation Dig Surg 19 306 311 10.1159/000064580 1:CAS:528:DC%2BD38Xms1ert7w%3D
88. A. Jeddar A. Kharsany U.G. Ramsaroop 1985 The antibacterial action of honey: an in vitro study S Afr Med J 67 257 258 1:STN:280:DyaL2M7mvVKntQ%3D%3D
89. M.S. Osato S.G. Reddy D.Y. Graham 1999 Osmotic effect of honey on growth and viability of Helicobacter pylori Dig Dis Sci 44 462 464 10.1023/A: 1026676517213 1:STN:280:DyaK1M7nvVahsg%3D%3D
90. A.T. Ali M.N. Chowdhury M.S. Al-Humayyd 1999 Inhibitory effect of natural honey on Helicobacter pylori Tropical Gastroenterol 12 139 143
91. S.N. Salem 1981 Treatment of gastroenteritis by the use of honey Islam Med 1 358 362
92. I.E. Haffejee A. Moosa 1985 Honey in the treatment of infantile gastroenteritis Br Med J 290 1866 1867 10.1136/bmj.290.6485.1866 1:STN:280:DyaL2M3islagtA%3D%3D
93. World Health Organisation (1976) Treatment and prevention of dehydration in diarrhoeal diseases. A guide for use at the primary level. WHO, Geneva, pp 1-13
94. A. Chatterjee D. Mahalanabis K.N. Jalan 1978 Oral rehydration in infantile diarrhea. Controlled trial of a low sodium glucose electrolyte solution Arch Dis Child 53 284 289 10.1136/adc.53.4.284 1:STN:280: DyaE1c7msVynuw%3D%3D
95. M.L. Sanz N. Polemis V. Morales 2005 In vitro investigation into the potential prebiotic activity of honey oligosaccharides J Agric Food Chem 53 2914 2921 10.1021/jf0500684 1:CAS:528:DC%2BD2MXitlKgtbo%3D
96. Y.W. Yun 1996 Fructooligosaccharides: occurrence, preparation and application Enzyme Microb Technol 19 107 117 10.1016/0141-0229(95)00188-3 1:CAS:528:DyaK28XjvFCrs7o%3D (Pubitemid 26246253)
97. S. Kajiwara H. Gandhi Z. Ustunol 2002 Effect of honey on the growth of and acid production by human intestinal Bifidobacterium spp: an in vitro comparison with commercial oligosaccharides and inulin J Food Prot 65 214 218 1:STN:280:DC%2BD38%2FotFyisA%3D%3D
98. N. Yaghoobi N. Al-Waili M. Ghayour-Mobarhan 2008 Natural honey and cardiovascular risk factors; effects on blood glucose, cholesterol, triacylglycerole, CRP, and body weight compared with sucrose Sci World J 20 463 9
99. N.S. Al-Waili 2004 Natural honey lowers plasma glucose, Creactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: comparison with dextrose and sucrose J Med Food 7 100 107 10.1089/109662004322984789 1:CAS:528:DC%2BD2cXjtV2mu7c%3D (Pubitemid 38445930)