The effect of dilution on the rate of hydrogen peroxide production in honey and its implications for wound healing

Journal of Alternative and Complementary Medicine

Volumn 9, Issue 2, 2003, Pages 267-273

  Bang, Lynne M ^a   Buntting, Catherine ^a   Molan, Peter ^a  

^a UNIVERSITY OF WAIKATO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CALLUNA VULGARIS EXTRACT; HYDROGEN PEROXIDE; KNIGHTIA EXCELSA EXTRACT; PLANT EXTRACT; TRIFOLIUM REPENS EXTRACT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CALLUNA; CONCENTRATION (PARAMETERS); CYTOTOXICITY; DILUTION; DRUG SYNTHESIS; EXUDATE; FLOWER; HONEY; NEW ZEALAND; PRIORITY JOURNAL; WHITE CLOVER; WOUND DRESSING; WOUND HEALING;

EID: 0037398639     PISSN: 10755535     EISSN: None     Source Type: Journal    
DOI: 10.1089/10755530360623383     Document Type: Article

References (32)

1. Adcock D. The effect of catalase on the inhibine and peroxide values of various honeys. J Apic Res 1962;1:38-40.
2. Bogdanov S. Characterisation of antibacterial substances in honey. Lebensmittel-Wissenschaft und -Technologie 1984;17:74-76.
3. Burdon RH. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Rad Biol Med 1995;18:775-794.
4. Chung LY, Schmidt RJ, Andrews AM, Turner TD. A study of hydrogen peroxide generation by, and antioxidant activity of, Granufle™ (DuoDERM™) Hydrocolloid Granules and some other hydrogel/hydrocolloid wound management materials. Br J Dermatol 1993;129:145-153.
5. Cochrane CG. Cellular injury by oxidants. Am J Med 1991;91(suppl 3c):23S-30S.
6. Cooper RA, Molan PC. The use of honey as an antiseptic in managing Pseudomonas infection. J Wound Care 1999a;8:161-164.
7. Cooper RA, Molan PC. Honey in wound care. J Wound Care 1999b;8:340.
8. Cooper RA, Molan PC, Harding KG. The effectiveness of the antibacterial activity of honey against strains of Staphylococcus aureus isolated from infected wounds. J R Soc Med 1999;92:283-285.
9. Dustmann JH. Uber die Katalaseaktivitat in Bienenhonig aus der Tracht der Heidekrautgewachse (Ericaceae). Zeitschrift fur Lebensmittel-Untersuchung und Forschung 1971;145:294-295.
10. Greenwood D. Sixty years on: Antimicrobial drug resistance comes of age. Lancet 1995;346(Suppl 1):S1.
11. Lineweaver W, McMorris Soucy S, Howard R. Cellular and bacterial toxicities of topical antimicrobials. Plast Reconstr Surg 1985;75:394-396.
12. Majno G. The Healing Hand. Man and Wound in the Ancient World. Cambridge, MA: Harvard University Press, 1975.
13. Molan PC. The antibacterial activity of honey: 1. The nature of the antibacterial activity. Bee World 1992;73:5-28.
14. Molan PC. A brief review of honey as a clinical dressing. Primary Intention 1998;6:148-158.
15. Molan PC. Potential of honey in the treatment of wounds and burns. Am J Clin Dermatol 2001;1:13-19.
16. Molan PC, Allen KL. The effect of gamma-irradiation on the antibacterial activity of honey. J Pharm Pharmacol 1996;48:1206-1209.
17. Molan PC, Brett M. Honey has potential as a dressing for wounds infected with MRSA. The Second Australian Wound Management Association Conference. Melbourne, Victoria, Australia, March 1994.
18. Postmes T, van den Bogaard AE, Hazen M. Honey for wounds, ulcers, and skin graft preservation. Lancet 1993;341:756-757.
19. Radwan, SS, El-Essawy A, Sarhan M. Experimental evidence for the occurrence in honey of specific substances active against microorganisms. Zentralblatt für Mikrobiologie. 1984;139:249-255.
20. Ransome HM. The Sacred Bee in Ancient Times and Folklore. London: George Allen and Unwin, 1937.
21. Roth, LA, Kwan S, Sporns P. Use of a disc-assay system to detect oxytetracycline residues in honey. J Food Prot. 1986;49:436-441.
22. Schepartz AI, Subers MH. The glucose-oxidase of honey: I. Purification and some general properties of the enzyme. Biochim Biophys Acta 1964;85:228-237.
23. Schepartz AI, Subers MH. Catalase in honey. J Apic Res 1966;5:37-43.
24. Simon RH, Scoggin CH, Patterson D. Hydrogen peroxide causes the fatal injury to human fibroblasts exposed to oxygen radicals. J Biol Chem 1981;256:7181-7186.
25. Thomas S. Wound Management and Dressings. London: The Pharmaceutical Press, 1990.
26. Tur E, Bolton L, Constantine BE. Topical hydrogen peroxide treatment of ischemic ulcers in the guinea pig: Blood recruitment in multiple skin sites. J Am Acad Dermatol 1995;33(2[pt. 1]):217-221.
27. White JW, Subers MH. Studies on honey Inhibine. 2. A chemical assay. J Apic Res 1963;2:93-100.
28. White JW, Subers MH. Studies on honey Inhibine: 4. Destruction of the peroxide accumulation system by light. J Food Sci 1964a;29:819-828.
29. White JW, Subers MH. Studies on honey inhibine: 3. Effect of heat. J Apic Res 1964b;3:45-50.
30. White JW, Subers MH, Schepartz AI. The identification of inhibine. Am Bee J 1962;102:430-431.
31. White JW, Subers MH, Schepartz AI. The identification of inhibine, the antibacterial factor in honey, as hydrogen peroxide and its origin in a honey glucose-oxidase system. Biochim Biophys Acta 1963;73:57-70.
32. Willix DJ, Molan PC, Harfoot CJ. A comparison of the sensitivity of wound-infecting species of bacteria to the antibacterial activity of manuka honey and other honey. J Appl Bacteriol 1992;73:388-394.