Nutritional status alters saccharin intake and sweet receptor mRNA expression in rat taste buds

Brain Research

Volumn 1325, Issue , 2010, Pages 53-62

  Chen, Ke ^a   Yan, Jianqun ^a   Suo, Yi ^a   Li, Jinrong ^a   Wang, Qian ^a   Lv, Bo ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Dietary induced obesity; OB Rb; Saccharin; Sweet preference; Sweet taste receptors

Indexed keywords

LEPTIN; MESSENGER RNA; SACCHARIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET RESTRICTION; GENE EXPRESSION; LIPID DIET; MALE; NONHUMAN; NUTRITIONAL STATUS; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; TASTE BUD; TASTE PREFERENCE;

ANIMALS; BODY WEIGHT; DIET; DIETARY FATS; FEEDING BEHAVIOR; FOOD DEPRIVATION; FOOD PREFERENCES; GENE EXPRESSION; LEPTIN; MALE; OBESITY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; SACCHARIN; TASTE BUDS;

RATTUS;

EID: 77949914989     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.02.026     Document Type: Article

References (93)

1. Ackroff K., and Sclafani A. Flavor preferences conditioned by intragastric infusions of dilute polycose solutions. Physiol. Behav. 55 (1994) 957-962
2. Agmo A., and Marroquin E. Role of gustatory and postingestive actions of sweeteners in the generation of positive affect as evaluated by place preference conditioning. Appetite 29 (1997) 269-289
3. Ahima R.S., Prabakaran D., Mantzoros C., Qu D., Lowell B., Maratos-Flier E., and Flier J.S. Role of leptin in the neuroendocrine response to fasting. Nature 382 (1996) 250-252
4. Ahren B., Mansson S., Gingerich R.L., and Havel P.J. Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting. Am. J. Physiol. 273 (1997) R113-R120
5. Anderson G.H. Sugars, sweetness, and food intake. Am. J. Clin. Nutr. 62 (1995) 195S-201S discussion 201S-202S
6. Bachmanov A.A., Li X., Reed D.R., Ohmen J.D., Li S., Chen Z., Tordoff M.G., de Jong P.J., Wu C., West D.B., Chatterjee A., Ross D.A., and Beauchamp G.K. Positional cloning of the mouse saccharin preference (Sac) locus. Chem. Senses 26 (2001) 925-933
7. Bachmanov A.A., Tordoff M.G., and Beauchamp G.K. Sweetener preference of C57BL/6ByJ and 129P3/J mice. Chem. Senses 26 (2001) 905-913
8. Baskin D.G., Seeley R.J., Kuijper J.L., Lok S., Weigle D.S., Erickson J.C., Palmiter R.D., and Schwartz M.W. Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting. Diabetes 47 (1998) 538-543
9. Bennett P.A., Lindell K., Karlsson C., Robinson I.C., Carlsson L.M., and Carlsson B. Differential expression and regulation of leptin receptor isoforms in the rat brain: effects of fasting and oestrogen. Neuroendocrinology 67 (1998) 29-36
10. 2+ in response to sugars and non-sugar sweeteners in transduction of sweet taste in the rat. J. Physiol. 490 Pt 2 (1996) 325-336
11. Berridge K.C. Modulation of taste affect by hunger, caloric satiety, and sensory-specific satiety in the rat. Appetite 16 (1991) 103-120
12. Bezencon C., le Coutre J., and Damak S. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem. Senses 32 (2007) 41-49
13. Cabanac M. Physiological role of pleasure. Science 173 (1971) 1103-1107
14. Cabanac M. Sensory pleasure. Q. Rev. Biol. 54 (1979) 1-29
15. Campbell B.A. Absolute and relative sucrose preference thresholds for hungry and satiated rats. J. Comp. Physiol. Psychol. 51 (1958) 795-800
16. Collier G., and Novell K. Saccharin as a sugar surrogate. J. Comp. Physiol. Psychol. 64 (1967) 401-408
17. Couce M.E., Burguera B., Parisi J.E., Jensen M.D., and Lloyd R.V. Localization of leptin receptor in the human brain. Neuroendocrinology 66 (1997) 145-150
18. Damak S., Rong M., Yasumatsu K., Kokrashvili Z., Varadarajan V., Zou S., Jiang P., Ninomiya Y., and Margolskee R.F. Detection of sweet and umami taste in the absence of taste receptor T1r3. Science 301 (2003) 850-853
19. Damak S., Rong M., Yasumatsu K., Kokrashvili Z., Perez C.A., Shigemura N., Yoshida R., Mosinger Jr. B., Glendinning J.I., Ninomiya Y., and Margolskee R.F. Trpm5 null mice respond to bitter, sweet, and umami compounds. Chem. Senses 31 (2006) 253-264
20. Delay E.R., Eddy M.C., and Eschle B.K. Behavioral studies of umami: tales told by mice and rats. Ann. N. Y. Acad. Sci. 1170 (2009) 41-45
21. Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
22. Giza B.K., and Scott T.R. Blood glucose level affects perceived sweetness intensity in rats. Physiol. Behav. 41 (1987) 459-464
23. Glendinning J.I., Bloom L.D., Onishi M., Zheng K.H., Damak S., Margolskee R.F., and Spector A.C. Contribution of alpha-gustducin to taste-guided licking responses of mice. Chem. Senses 30 (2005) 299-316
24. Glockner L., Fikentscher R., and Ulrich F.E. Taste perception in fasting overweight patients. Z. Gesamte Inn. Med. 41 (1986) 244-246
25. Grill H.J., Roitman M.F., and Kaplan J.M. A new taste reactivity analysis of the integration of taste and physiological state information. Am. J. Physiol. 271 (1996) R677-R687
26. Guerre-Millo M. Regulation of ob gene and overexpression in obesity. Biomed. Pharmacother. 51 (1997) 318-323
27. Hajnal A., Covasa M., and Bello N.T. Altered taste sensitivity in obese, prediabetic OLETF rats lacking CCK-1 receptors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289 (2005) R1675-R1686
28. Hakansson M.L., Brown H., Ghilardi N., Skoda R.C., and Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J. Neurosci. 18 (1998) 559-572
29. Harriman A.E. Intakes of NaCl by rats in extended two-bottle drinking preference tests. J. Psychol. 66 (1967) 93-98
30. Herness S., Zhao F.L., Kaya N., Shen T., Lu S.G., and Cao Y. Communication routes within the taste bud by neurotransmitters and neuropeptides. Chem. Senses 30 Suppl 1 (2005) i37-i38
31. Hofer D., Puschel B., and Drenckhahn D. Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 6631-6634
32. Huang T., and Staehler F. Effects of dietary Na+ deprivation on epithelial Na+ channel (ENaC), BDNF, and trkB mRNA expression in the rat tongue. BMC Neurosci. 10 (2009) 19
33. Huang T., and Yan J. Dietary sodium deprivation reduces gustatory neural responses of the parabrachial nucleus in rats. Neurosci. Lett. 432 (2008) 170-173
34. Huang L., Shanker Y.G., Dubauskaite J., Zheng J.Z., Yan W., Rosenzweig S., Spielman A.I., Max M., and Margolskee R.F. Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Nat. Neurosci. 2 (1999) 1055-1062
35. Inoue M., and Tordoff M.G. Calcium deficiency alters chorda tympani nerve responses to oral calcium chloride. Physiol. Behav. 63 (1998) 297-303
36. Inoue M., Reed D.R., Li X., Tordoff M.G., Beauchamp G.K., and Bachmanov A.A. Allelic variation of the Tas1r3 taste receptor gene selectively affects behavioral and neural taste responses to sweeteners in the F2 hybrids between C57BL/6ByJ and 129P3/J mice. J. Neurosci. 24 (2004) 2296-2303
37. Jacobs K.M., Mark G.P., and Scott T.R. Taste responses in the nucleus tractus solitarius of sodium-deprived rats. J. Physiol. 406 (1988) 393-410
38. Kaplan J.M., Roitman M., and Grill H.J. Food deprivation does not potentiate glucose taste reactivity responses of chronic decerebrate rats. Brain Res. 870 (2000) 102-108
39. Kawai K., Sugimoto K., Nakashima K., Miura H., and Ninomiya Y. Leptin as a modulator of sweet taste sensitivities in mice. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 11044-11049
40. Kitagawa M., Kusakabe Y., Miura H., Ninomiya Y., and Hino A. Molecular genetic identification of a candidate receptor gene for sweet taste. Biochem. Biophys. Res. Commun. 283 (2001) 236-242
41. Kovacs P., and Hajnal A. Altered pontine taste processing in a rat model of obesity. J. Neurophysiol. 100 (2008) 2145-2157
42. Kushner L.R., and Mook D.G. Behavioral correlates of oral and postingestive satiety in the rat. Physiol. Behav. 33 (1984) 713-718
43. Laeng B., Berridge K.C., and Butter C.M. Pleasantness of a sweet taste during hunger and satiety: effects of gender and "sweet tooth". Appetite 21 (1993) 247-254
44. Li X., Staszewski L., Xu H., Durick K., Zoller M., and Adler E. Human receptors for sweet and umami taste. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 4692-4696
45. Liman E.R. TRPM5 and taste transduction. Handb. Exp. Pharmacol. (2007) 287-298
46. Lin S., and Huang X.F. Fasting increases leptin receptor mRNA expression in lean but not obese (ob/ob) mouse brain. NeuroReport 8 (1997) 3625-3629
47. Lin X., Chavez M.R., Bruch R.C., Kilroy G.E., Simmons L.A., Lin L., Braymer H.D., Bray G.A., and York D.A. The effects of a high fat diet on leptin mRNA, serum leptin and the response to leptin are not altered in a rat strain susceptible to high fat diet-induced obesity. J. Nutr. 128 (1998) 1606-1613
48. Lindemann B. Receptors and transduction in taste. Nature 413 (2001) 219-225
49. Liu Z.J., Bian J., Liu J., and Endoh A. Obesity reduced the gene expressions of leptin receptors in hypothalamus and liver. Horm. Metab. Res. 39 (2007) 489-494
50. Mace O.J., Affleck J., Patel N., and Kellett G.L. Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J. Physiol. 582 (2007) 379-392
51. Madiehe A.M., Schaffhauser A.O., Braymer D.H., Bray G.A., and York D.A. Differential expression of leptin receptor in high- and low-fat-fed Osborne-Mendel and S5B/Pl rats. Obes. Res. 8 (2000) 467-474
52. Margolskee R.F., Dyer J., Kokrashvili Z., Salmon K.S., Ilegems E., Daly K., Maillet E.L., Ninomiya Y., Mosinger B., and Shirazi-Beechey S.P. T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 15075-15080
53. Maruyama Y., Pereira E., Margolskee R.F., Chaudhari N., and Roper S.D. Umami responses in mouse taste cells indicate more than one receptor. J. Neurosci. 26 (2006) 2227-2234
54. Max M., Shanker Y.G., Huang L., Rong M., Liu Z., Campagne F., Weinstein H., Damak S., and Margolskee R.F. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat. Genet. 28 (2001) 58-63
55. McCaughey S.A., and Scott T.R. Rapid induction of sodium appetite modifies taste-evoked activity in the rat nucleus of the solitary tract. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 (2000) R1121-R1131
56. McLaughlin S.K., McKinnon P.J., and Margolskee R.F. Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature 357 (1992) 563-569
57. Montmayeur J.P., Liberles S.D., Matsunami H., and Buck L.B. A candidate taste receptor gene near a sweet taste locus. Nat. Neurosci. 4 (2001) 492-498
58. Nakamura K., and Norgren R. Sodium-deficient diet reduces gustatory activity in the nucleus of the solitary tract of behaving rats. Am. J. Physiol. 269 (1995) R647-R661
59. Nakamura Y., Sanematsu K., Ohta R., Shirosaki S., Koyano K., Nonaka K., Shigemura N., and Ninomiya Y. Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels. Diabetes 57 (2008) 2661-2665
60. Nelson G., Hoon M.A., Chandrashekar J., Zhang Y., Ryba N.J., and Zuker C.S. Mammalian sweet taste receptors. Cell 106 (2001) 381-390
61. Nelson G., Chandrashekar J., Hoon M.A., Feng L.X., Zhao G., Ryba N.J.P., and Zuker C.S. An amino-acid taste receptor. Nature 416 (2002) 199-202
62. Nie Y., Vigues S., Hobbs J.R., Conn G.L., and Munger S.D. Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli. Curr. Biol. 15 (2005) 1948-1952
63. Ninomiya Y., Sako N., and Imai Y. Enhanced gustatory neural responses to sugars in the diabetic db/db mouse. Am. J. Physiol. 269 (1995) R930-R937
64. Ninomiya Y., Imoto T., Yatabe A., Kawamura S., Nakashima K., and Katsukawa H. Enhanced responses of the chorda tympani nerve to nonsugar sweeteners in the diabetic db/db mouse. Am. J. Physiol. 274 (1998) R1324-R1330
65. Ninomiya Y., Shigemura N., Yasumatsu K., Ohta R., Sugimoto K., Nakashima K., and Lindemann B. Leptin and sweet taste. Vitam. Horm. 64 (2002) 221-248
66. Perez C.A., Huang L., Rong M., Kozak J.A., Preuss A.K., Zhang H., Max M., and Margolskee R.F. A transient receptor potential channel expressed in taste receptor cells. Nat. Neurosci. 5 (2002) 1169-1176
67. Plata-Salaman C.R. Regulation of hunger and satiety in man. Dig. Dis. 9 (1991) 253-268
68. Priego T., Sanchez J., Palou A., and Pico C. Effect of high-fat diet feeding on leptin receptor expression in white adipose tissue in rats: depot- and sex-related differential response. Genes Nutr. 4 (2009) 151-156
69. Reed D.R., Li S., Li X., Huang L., Tordoff M.G., Starling-Roney R., Taniguchi K., West D.B., Ohmen J.D., Beauchamp G.K., and Bachmanov A.A. Polymorphisms in the taste receptor gene (Tas1r3) region are associated with saccharin preference in 30 mouse strains. J. Neurosci. 24 (2004) 938-946
70. Ren X., Zhou L., Terwilliger R., Newton S.S., and de Araujo I.E. Sweet taste signaling functions as a hypothalamic glucose sensor. Front. Integr. Neurosci. 3 (2009) 12
71. Ruiz-Avila L., Wong G.T., Damak S., and Margolskee R.F. Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in alpha-gustducin. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 8868-8873
72. Scalera G. Taste preferences, body weight gain, food and fluid intake in singly or group-housed rats. Physiol. Behav. 52 (1992) 935-943
73. Schwartz M.W., Woods S.C., Porte Jr. D., Seeley R.J., and Baskin D.G. Central nervous system control of food intake. Nature 404 (2000) 661-671
74. Sclafani A., and Nissenbaum J.W. Oral versus postingestive origin of polysaccharide appetite in the rat. Neurosci. Biobehav. Rev. 11 (1987) 169-172
75. Shen T., Kaya N., Zhao F.L., Lu S.G., Cao Y., and Herness S. Co-expression patterns of the neuropeptides vasoactive intestinal peptide and cholecystokinin with the transduction molecules alpha-gustducin and T1R2 in rat taste receptor cells. Neuroscience 130 (2005) 229-238
76. Shigemura N., Ohta R., Kusakabe Y., Miura H., Hino A., Koyano K., Nakashima K., and Ninomiya Y. Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures. Endocrinology 145 (2004) 839-847
77. Shimizu Y., Yamazaki M., Nakanishi K., Sakurai M., Sanada A., Takewaki T., and Tonosaki K. Enhanced responses of the chorda tympani nerve to sugars in the ventromedial hypothalamic obese rat. J. Neurophysiol. 90 (2003) 128-133
78. Shimura T., Komori M., and Yamamoto T. Acute sodium deficiency reduces gustatory responsiveness to NaCl in the parabrachial nucleus of rats. Neurosci. Lett. 236 (1997) 33-36
79. Shin Y.K., Martin B., Golden E., Dotson C.D., Maudsley S., Kim W., Jang H.J., Mattson M.P., Drucker D.J., Egan J.M., and Munger S.D. Modulation of taste sensitivity by GLP-1 signaling. J. Neurochem. 106 (2008) 455-463
80. Smith M., and Duffy M. Consumption of sucrose and saccharine by hungry and satiated rats. J. Comp. Physiol. Psychol. 50 (1957) 65-69
81. Spector A.C. Linking gustatory neurobiology to behavior in vertebrates. Neurosci. Biobehav. Rev. 24 (2000) 391-416
82. Sudakov K.V. Brain neuronal mechanisms of motivation and reinforcement: systemic organization of behavior. Integr. Physiol. Behav. Sci. 28 (1993) 396-407
83. Tartaglia L.A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J., Muir C., Sanker S., Moriarty A., Moore K.J., Smutko J.S., Mays G.G., Wool E.A., Monroe C.A., and Tepper R.I. Identification and expression cloning of a leptin receptor, OB-R. Cell 83 (1995) 1263-1271
84. Tepper B.J., and Seldner A.C. Sweet taste and intake of sweet foods in normal pregnancy and pregnancy complicated by gestational diabetes mellitus. Am. J. Clin. Nutr. 70 (1999) 277-284
85. Tordoff M.G. Taste solution preferences of C57BL/6J and 129X1/SvJ mice: influence of age, sex, and diet. Chem. Senses 32 (2007) 655-671
86. Wong G.T., Gannon K.S., and Margolskee R.F. Transduction of bitter and sweet taste by gustducin. Nature 381 (1996) 796-800
87. Wrann C.D., Ehmer U., Lautenbach A., Kuhlmann S., and Nave H. Obesity and NK cells affect the expression of the long form of the leptin receptor Ob-Rb in liver of F344 rats. Exp. Toxicol. Pathol. 62 (2010) 1-8
88. Xu H., Staszewski L., Tang H., Adler E., Zoller M., and Li X. Different functional roles of T1R subunits in the heteromeric taste receptors. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 14258-14263
89. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432
90. Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., and Ryba N.J. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell 112 (2003) 293-301
91. Zhao G.Q., Zhang Y., Hoon M.A., Chandrashekar J., Erlenbach I., Ryba N.J., and Zuker C.S. The receptors for mammalian sweet and umami taste. Cell 115 (2003) 255-266
92. Zhou L.H., Liu X.M., Feng X.H., Han L.O., and Liu G.D. Expression of alpha-gustducin in the circumvallate papillae of taste buds of diabetic rats. Acta Histochem. 111 (2008) 145-149
93. Zverev Y.P. Effects of caloric deprivation and satiety on sensitivity of the gustatory system. BMC Neurosci. 5 (2004) 5