Enhanced responses of the chorda tympani nerve to sugars in the ventromedial hypothalamic obese rat

Journal of Neurophysiology

Volumn 90, Issue 1, 2003, Pages 128-133

  Shimizu, Yasutake ^a   Yamazaki, Mifumi ^a   Nakanishi, Keiji ^a   Sakurai, Maki ^a   Sanada, Atsushi ^a   Takewaki, Tadashi ^a   Tonosaki, Keiichi ^b  

^a GIFU UNIVERSITY   (Japan)

^b MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; INSULIN; LEPTIN; SUGAR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; CHORDA TYMPANI; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; FEMALE; GENE REPRESSION; GENETICS; GLUCOSE BLOOD LEVEL; GUSTATORY NERVOUS SYSTEM; HORMONE ACTION; INSULIN DEFICIENCY; LIPID DIET; NERVE POTENTIAL; NONHUMAN; OBESITY; OBSERVATION; PRIORITY JOURNAL; PUBLICATION; RAT; STIMULUS RESPONSE; STREPTOZOCIN DIABETES; SWEETNESS; TASTE ACUITY; TASTE BUD; ZONA INCERTA;

EID: 0038500998     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.01170.2002     Document Type: Article

References (43)

1. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, and Zuker CS. A novel family of mammalian taste receptors. Cell 100: 693-702, 2000.
2. Beidler LM and Tonosaki K. Multiple sweet receptor sites and taste theory. In: Taste, Olfaction, and the Central Nervous System, edited by Pfaff DW. New York: The Rockefeller University Press, 1985, p. 47-64.
3. Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, Lynn RB, Zhang PL, Sinha MK, and Considine RV. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 348: 159-161, 1996.
4. Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, and Ryba NJ. T2Rs function as bitter taste receptors. Cell 100: 703-711, 2000.
5. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, and Morgenstern JP. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84: 491-495, 1996.
6. Chua SC Jr, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, and Leibel RL. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271: 994-996, 1996.
7. Corbit JD and Stellar E. Palatability, food intake, and obesity in normal and hyperphagic rats. J Comp Physiol Psychol 58: 63-67, 1964.
8. Elliott SS, Keim NL, Stern JS, Teff K, and Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76: 911-922, 2002.
9. El-Haschimi K, Pierroz DD, Hileman SM, Bjorbaek C, and Flier JS. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 105: 1827-1832, 2000.
10. Gjedde A and Crone C. Blood-brain glucose transfer: repression in chronic hyperglycemia. Science 214: 456-457, 1981.
11. Graff H and Stellar E. Hyperphagia, obesity, and finickiness. J Comp Physiol Psychol 55: 418-424, 1962.
12. Harik SI and LaManna JC. Vascular perfusion and blood-brain glucose transport in acute and chronic hyperglycemia. J Neurochem 51: 1924-1929, 1988.
13. Havel PJ, Uriu-Hare JY, Liu T, Stanhope KL, Stern JS, Keen CL, and Ahren B. Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin. Am J Physiol Regulatory Integrative Comp Physiol 274: R1482-R1491, 1998.
14. Jakinovich W Jr. Stimulation of the gerbil's gustatory receptors by disaccharides. Brain Res 110: 481-490, 1976.
15. Jakinovich W Jr and Goldstein IJ. Stimulation of the gerbil's gustatory receptors by monosaccharides. Brain Res 110: 491-504, 1976.
16. Kawai K, Sugimoto K, Nakashima K, Miura H, and Ninomiya Y. Leptin as a modulator of sweet taste sensitivities in mice. Proc Natl Acad Sci USA 97: 11044-11049, 2000.
17. Kusakabe Y, Yamaguchi E, Tanemura K, Kameyama K, Chiba N, Arai S, Emori Y, and Abe K. Identification of two alpha-subunit species of GTP-binding proteins, Galpha15 and Galphaq, expressed in rat taste buds. Biochim Biophys Acta 1403: 265-272, 1998.
18. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, and Friedman JM. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379: 632-635, 1996.
19. Li X, Staszewski L, Xu H, Durick K, Zoller M, and Adler E. Human receptors for sweet and umami taste. Proc Natl Acad Sci USA 99: 4692-4696, 2002.
20. McLaughlin SK, McKinnon PJ, and Margolskee RF. Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature 357: 563-569, 1992.
21. Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction. J Biol Chem 277: 1-4, 2002.
22. Matsunami H, Montmayeur JP, and Buck LB. A family of candidate taste receptors in human and mouse. Nature 404: 601-604, 2000.
23. Matthaei S, Horuk R, and Olefsky JM. Blood-brain glucose transfer in diabetes mellitus. Decreased number of glucose transporters at blood-brain barrier. Diabetes 35: 1181-1184, 1986.
24. Mei N. Vagal glucoreceptors in the small intestine of the cat. J Physiol 282: 485-506, 1978.
25. Mei N. Intestinal chemosensitivity. Physiol Rev 65: 211-237, 1985.
26. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, and Zuker CS. Mammalian sweet taste receptors. Cell 106: 381-390, 2001.
27. Ninomiya Y, Sako N, and Imai Y. Enhanced gustatory neural responses to sugars in the diabetic db/db mouse. Am J Physiol Regulatory Integrative Comp Physiol 269: R930-R937, 1995.
28. Ninomiya Y, Shigemura N, Yasumatsu K, Ohta R, Sugimoto K, Nakashima K, and Lindemann B. Leptin and sweet taste. Vitam Horm 64: 221-248, 2002.
29. Ogiso K, Shimizu Y, Watanabe K, and Tonosaki K. Possible involvement of undissociated acid molecules in the acid response of the chorda tympani nerve of the rat. J Neurophysiol 83: 2776-2779, 2000.
30. Pardridge WM, Triguero D, and Farrell CR. Downregulation of blood-brain barrier glucose transporter in experimental diabetes. Diabetes 39: 1040-1044, 1990.
31. Ruiz-Avila L, McLaughlin SK, Wildman D, McKinnon PJ, Robichon A, Spickofsky N, and Margolskee RF. Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells. Nature 376: 80-85, 1995.
32. Salto M, Minokoshi Y, and Shimazu T. Brown adipose tissue after ventromedial hypothalamic lesions in rats. Am J Physiol Endocrinol Metab 248: E20-E25, 1985.
33. Satoh N, Ogawa Y, Katsuura G, Tsuji T, Masuzaki H, Hiraoka J, Okazaki T, Tamaki M, Hayase M, Yoshimasa Y, Nishi S, Hosoda K, and Nakao K. Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: evidence for loss of its satiety effect in VMH-lesioned rats. Endocrinology 138: 947-954, 1997.
34. Schwartz MW, Peskind E, Raskind M, Boyko EJ, and Porte D Jr. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 2: 589-593, 1996.
35. Shimizu Y and Tonosaki K. Low environmental temperature modulates gustatory nerve activity and behavioral responses to NaCl in rats. Am J Physiol Regulatory Integrative Comp Physiol 277: R368-R373, 1999.
36. Steinberg GR and Dyck DJ. Development of leptin resistance in rat soleus muscle in response to high-fat diets. Am J Physiol Endocrinol Metab 279: E1374-E1382, 2000.
37. Steinberg GR, Parolin ML, Heigenhauser GJ, and Dyck DJ. Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance. Am J Physiol Endocrinol Metab 283: E187-E192, 2002.
38. Suga A, Hirano T, Inoue S, Tsuji M, Osaka T, Namba Y, Miura M, and Adachi M. Plasma leptin levels and triglyceride secretion rates in VMH-lesioned obese rats: a role of adiposity. Am J Physiol Endocrinol Metab E650-E657, 1999.
39. Suga A, Hirano T, Kageyama H, Osaka T, Namba Y, Tsuji M, Miura M, Adachi M, and Inoue S. Effects of fructose and glucose on plasma leptin, insulin, and insulin resistance in lean and VMH-lesioned obese rats. Am J Physiol Endocrinol Metab 278: E677-E683, 2000.
40. Tonosaki K and Funakoshi M. The mouse taste cell response to five sugar stimuli. Comp Biochem Physiol 79A: 625-630, 1984.
41. Tonosaki K and Funakoshi M. Cross-adapted sugar responses in the mouse taste cell. Comp Biochem Physiol 92A: 181-183, 1989.
42. Van Heek M, Compton DS, France CF, Tedesco RP, Fawzi AB, Graziano MP, Sybertz EJ, Strader CD, and Davis HR Jr. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest 99: 385-390, 1997.
43. Weingarten HP. Diet palatability modulates sham feeding in VMH-lesion and normal rats: inplications for finickiness and evaluation of sham-feeding data. J Comp Physiol Psychol 96: 223-233, 1982.