Altered pontine taste processing in a rat model of obesity

Journal of Neurophysiology

Volumn 100, Issue 4, 2008, Pages 2145-2157

  Kovacs, Peter ^a   Hajnal, Andras ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SUCROSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; ELECTROPHYSIOLOGY; GUSTATORY NERVOUS SYSTEM; HISTOPATHOLOGY; MALE; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PONS ANGLE; PRIORITY JOURNAL; RAT; SENSORY STIMULATION; TASTE; TONGUE;

ADIPOSITY; AGING; ANIMALS; BODY COMPOSITION; BODY WEIGHT; CLUSTER ANALYSIS; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GLUCOSE TOLERANCE TEST; MALE; MOTIVATION; NEURONS; OBESITY; PONS; RATS; RATS, INBRED OLETF; SUCROSE; TASTE;

EID: 57349178428     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.01359.2007     Document Type: Article

References (64)

1. Bacon AW, Miles JS, Schiffman SS. Effect of race on perception of fat alone and in combination with sugar. Physiol Behav 55: 603-606, 1994.
2. Baird JP, Travers SP, Travers JB. Integration of gastric distension and gustatory responses in the parabrachial nucleus. Am J Physiol Regulatory Integrative Comp Physiol 281: R1581-1593, 2001.
3. Bartoshuk LM, Duffy VB, Hayes JE, Moskowitz HR, Snyder DJ. Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives. Philos Trans R Soc Lond B Biol Sci 361: 1137-1148, 2006.
4. Bi S, Moran TH. Actions of CCK in the controls of food intake and body weight: lessons from the CCK-A receptor deficient OLETF rat. Neuropeptides 36: 171-181, 2002.
5. Cabanac M. Physiological role of pleasure. Science 173: 1103-1107, 1971.
6. Cabanac M, Lafrance L. Ingestive/aversive response of rats to sweet stimuli. Influence of glucose, oil, and casein hydrolyzate gastric loads. Physiol Behav 51: 139-143, 1992.
7. Covasa M, Ritter RC. Attenuated satiation response to intestinal nutrients in rats that do not express CCK-A receptors. Peptides 22: 1339-1348, 2001.
8. Covasa M, Ritter RC. Reduced CCK-induced Fos expression in the hindbrain, nodose ganglia, and enteric neurons of rats lacking CCK-1 receptors. Brain Res 1051: 155-163, 2005.
9. De Jonghe BC, Hajnal A, Covasa M. Increased oral and decreased intestinal sensitivity to sucrose in obese, prediabetic CCK-A receptor-deficient OLETF rats. Am J Physiol Regulatory Integrative Comp Physiol 288: R292-300, 2005.
10. De Jonghe BC, Hajnal A, Covasa M. Conditioned preference for sweet stimuli in OLETF rat: effects of food deprivation. Am J Physiol Regulatory Integrative Comp Physiol 292: R1819-1827, 2007.
11. Desor JA, Greene LS, Maller O. Preferences for sweet and salty in 9- to 15-year-old and adult humans. Science 190: 686-687, 1975.
12. Drewnowski A, Kurth CL, Rahaim JE. Taste preferences in human obesity: environmental and familial factors. Am J Clin Nutr 54: 635-641, 1991.
13. Foster LA, Nakamura K, Greenberg D, Norgren R. Intestinal fat differentially suppresses sham feeding of different gustatory stimuli. Am J Physiol Regulatory Integrative Comp Physiol 270: R1122-1125, 1996.
14. Frijters JE, Rasmussen-Conrad EL. Sensory discrimination, intensity perception, and affective judgment of sucrose-sweetness in the overweight. J Gen Psychol 107: 233-247, 1982.
15. Giza BK, Scott TR, Vanderweele DA. Administration of satiety factors and gustatory responsiveness in the nucleus tractus solitarius of the rat. Brain Res Bull 28: 637-639, 1992.
16. Grinker J, Hirsch J, Smith DV. Taste sensitivity and susceptibility to external influence in obese and normal weight subjects. J Pers Soc Psychol 22: 320-325, 1972.
17. Gyetvai B, Bardos G. Modulation of taste reactivity by intestinal distension in rats. Physiol Behav 66: 529-535, 1999.
18. Hajnal A, Acharya NK, Grigson PS, Covasa M, Twining RC. Obese OLETF rats exhibit increased operant performance for palatable sucrose solutions and differential sensitivity to D2 receptor antagonism. Am J Physiol Regulatory Integrative Comp Physiol 293: R1846-1854, 2007.
19. Hajnal A, Covasa M, Bello NT. Altered taste sensitivity in obese, prediabetic OLETF rats lacking CCK-1 receptors. Am J Physiol Regulatory Integrative Comp Physiol 289: R1675-1686, 2005.
20. Hajnal A, Norgren R. Taste pathways that mediate accumbens dopamine release by sapid sucrose. Physiol Behav 84: 363-369, 2005.
21. Hajnal A, Takenouchi K, Norgren R. Effect of intraduodenal lipid on parabrachial gustatory coding in awake rats. J Neurosci 19: 7182-7190, 1999.
22. Herness MS, Gilbertson TA. Cellular mechanisms of taste transduction. Annu Rev Physiol 61: 873-900, 1999.
23. Herness S, Zhao FL, Lu SG, Kaya N, Shen T. Expression and physiological actions of cholecystokinin in rat taste receptor cells. J Neurosci 22: 10018-10029, 2002.
24. Hill DL. Neural plasticity in the gustatory system. Nutr Rev 62: S208-217, discussion S224-241, 2004.
25. Hill JO, Melanson EL, Wyatt HT. Dietary fat intake and regulation of energy balance: implications for obesity. J Nutr 130: 284S-288S, 2000.
26. Jia HG, Zhang GY, Wan Q. A GABAergic projection from the central nucleus of the amygdala to the parabrachial nucleus: an ultrastructural study of anterograde tracing in combination with post-embedding immunocytochemistry in the rat. Neurosci Lett 382: 153-157, 2005.
27. Kant AK. Consumption of energy-dense, nutrient-poor foods by adult Americans: nutritional and health implications. The third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 72: 929-936, 2000.
28. Kawai K, Sugimoto K, Nakashima K, Miura H, Ninomiya Y. Leptin as a modulator of sweet taste sensitivities in mice. Proc Natl Acad Sci USA 97: 11044-11049, 2000.
29. Kawano K, Hirashima T, Mori S, Saitoh Y, Kurosumi M, Natori T. Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41: 1422-1428, 1992.
30. Kobashi M, Bradley RM. Effects of GABA on neurons of the gustatory and visceral zones of the parabrachial nucleus in rats. Brain Res 799: 323-328, 1998.
31. Kumanyika SK. Special issues regarding obesity in minority populations. Ann Intern Med 119: 650-654, 1993.
32. Li CS, Cho YK. Efferent projection from the bed nucleus of the stria terminalis suppresses activity of taste-responsive neurons in the hamster parabrachial nuclei. Am J Physiol Regulatory Integrative Comp Physiol 291: R914-926, 2006.
33. Li CS, Cho YK, Smith DV. Modulation of parabrachial taste neurons by electrical and chemical stimulation of the lateral hypothalamus and amygdala. J Neurophysiol 93: 1183-1196, 2005.
34. Lucas F, Sclafani A. Hyperphagia in rats produced by a mixture of fat and sugar. Physiol Behav 47: 51-55, 1990.
35. Lundy RF Jr, Hajnal A. Altered parabrachial taste processing in obese OLETF rats. Chem Senses 31: A114-A114, 2006.
36. Lundy RF Jr, Norgren R. Pontine gustatory activity is altered by electrical stimulation in the central nucleus of the amygdala. J Neurophysiol 85: 770-783, 2001.
37. Lundy RF Jr, Norgren R. Activity in the hypothalamus, amygdala, and cortex generates bilateral and convergent modulation of pontine gustatory neurons. J Neurophysiol 91: 1143-1157, 2004a.
38. Lundy RF, Norgren R. Gustatory system. In: The Rat Nervous System (3rd ed.), edited by Paxinos G. San Diego, CA: Elsevier Academic, 2004b, p. 891-921.
39. Malcolm R, O'Neil PM, Hirsch AA, Currey HS, Moskowitz G. Taste hedonics and thresholds in obesity. Int J Obes 4: 203-212, 1980.
40. Moran TH. Cholecystokinin and satiety: current perspectives. Nutrition 16: 858-865, 2000.
41. Moran TH, Bi S. Hyperphagia and obesity of OLETF rats lacking CCK1 receptors: developmental aspects. Dev Psychobiol 48: 360-367, 2006.
42. Nakamura K, Norgren R. Sodium-deficient diet reduces gustatory activity in the nucleus of the solitary tract of behaving rats. Am J Physiol Regulatory Integrative Comp Physiol 269: R647-661, 1995.
43. Ninomiya Y, Sako N, Imai Y. Enhanced gustatory neural responses to sugars in the diabetic db/db mouse. Am J Physiol Regulatory Integrative Comp Physiol 269: R930-937, 1995.
44. Nishijo H, Ono T, Norgren R. Parabrachial gustatory neural responses to monosodium glutamate ingested by awake rats. Physiol Behav 49: 965-971, 1991.
45. Norgren R. Gustatory afferents to ventral forebrain. Brain Res 81: 285-295, 1974.
46. Norgren R. Taste pathways to hypothalamus and amygdala. J Comp Neurol 166: 17-30, 1976.
47. Norgren R, Grigson PS, Hajnal A, and Lundy RF Jr. Motivational modulation of taste. In: Cognition and Emotion in the Brain, edited by T. Ono GM, R. Llinas, A. Berthoz, R. Norgren, H. Nishijo, R. Tamura. New York: Elsevier, 2003, p. 319-334.
48. Norgren R, Hajnal A, Mungarndee SS. Gustatory reward and the nucleus accumbens. Physiol Behav 89: 531-535, 2006.
49. Norgren R, Pfaffmann C. The pontine taste area in the rat. Brain Res 91: 99-117, 1975.
50. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. J Am Med Assoc 295: 1549-1555, 2006.
51. Rolls ET. Taste, olfactory, and food texture processing in the brain, and the control of food intake. Physiol Behav 85: 45-56, 2005.
52. Salbe AD, DelParigi A, Pratley RE, Drewnowski A, Tataranni PA. Taste preferences and body weight changes in an obesity-prone population. Am J Clin Nutr 79: 372-378, 2004.
53. Scalera G, Spector AC, Norgren R. Excitotoxic lesions of the parabrachial nuclei prevent conditioned taste aversions and sodium appetite in rats. Behav Neurosci 109: 997-1008, 1995.
54. Schiffman SS, Graham BG, Sattely-Miller EA, Peterson-Dancy M. Elevated and sustained desire for sweet taste in african-americans: a potential factor in the development of obesity. Nutrition 16: 886-893, 2000.
55. Sclafani A. Oral and postoral determinants of food reward. Physiol Behav 81: 773-779, 2004.
56. Shigemura N, Ohta R, Kusakabe Y, Miura H, Hino A, Koyano K, Nakashima K, Ninomiya Y. Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures. Endocrinology 145: 839-847, 2004.
57. Simon SA, Liu L, Erickson RP. Neuropeptides modulate rat chorda tympani responses. Am J Physiol Regulatory Integrative Comp Physiol 284: R1494-1505, 2003.
58. Smith DV, Travers JB. A metric for the breadth of tuning of gustatory neurons. Chem Senses 4: 215-229, 1979.
59. Sorensen LB, Moller P, Flint A, Martens M, Raben A. Effect of sensory perception of foods on appetite and food intake: a review of studies on humans. Int J Obes Relat Metab Disord 27: 1152-1166, 2003.
60. Takiguchi S, Takata Y, Funakoshi A, Miyasaka K, Kataoka K, Fujimura Y, Goto T, Kono A. Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats. Gene 197: 169-175, 1997.
61. Tamura R, Norgren R. Repeated sodium depletion affects gustatory neural responses in the nucleus of the solitary tract of rats. Am J Physiol Regulatory Integrative Comp Physiol 273: R1381-1391, 1997.
62. Tsunoda K, Osada K, Komai M, Zhang H, Morimoto K, Suzuki H, Furukawa Y. Effects of dietary biotin on enhanced sucrose intake and enhanced gustatory nerve responses to sucrose seen in diabetic OLETF rat. J Nutr Sci Vitaminol 44: 207-216, 1998.
63. Yagi K, Kim S, Wanibuchi H, Yamashita T, Yamamura Y, Iwao H. Characteristics of diabetes, blood pressure, and cardiac and renal complications in Otsuka Long-Evans Tokushima Fatty rats. Hypertension 29: 728-735, 1997.
64. Yeomans MR, Blundell JE, Leshem M. Palatability: response to nutritional need or need-free stimulation of appetite? Br J Nutr 92 Suppl 1: S3-14, 2004.