Identification of 3,4-dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: Synthesis, biological evaluation, and enzyme-ligand X-ray studies

Journal of Medicinal Chemistry

Volumn 53, Issue 6, 2010, Pages 2401-2408

  Gitto, Rosaria ^a   Agnello, Stefano ^a   Ferro, Stefania ^a   De Luca, Laura ^a   Vullo, Daniela ^b   Brynda, Jiri ^c,d   Mader, Pavel ^c,d   Supuran, Claudiu T ^b   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^d INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

1 BUTYL 6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLINE 2(1H) SULFONAMIDE; 1 CYCLOHEXYL 6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLINE 2(1H) SULFONAMIDE; 1 CYCLOPENTYL 6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLINE 2(1H) SULFONAMIDE; 1 CYCLOPROPYL 6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLINE 2(1H) SULFONAMIDE; 3,4 DIHYDROISOQUINOLINE 2(1H) SULFONAMIDE; 6,7 DIMETHOXY 1 ETHYL 3,4 DIHYDROISOQUINOLINE 2(1H) SULFONAMIDE; 6,7 DIMETHOXY 1 ISOPROPYL 3,4 DIHYDROISOQUINOLINE 2(1H) SULFONAMIDE; 6,7 DIMETHOXY 1 METHYL 3,4 DIHYDROISOQUINOLINE 2(1H) SULFONAMIDE; 6,7 DIMETHOXY 1 PROPYL 3,4 DIHYDROISOQUINOLINE 2(1H) SULFONAMIDE; 6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLINE 2(1H) SULFONAMIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XIV; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; X RAY;

ANTIGENS, NEOPLASM; BINDING, COMPETITIVE; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOQUINOLINES; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 77949869987     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm9014026     Document Type: Article

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