Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 10, 2009, Pages 3659-3664

  Gitto, Rosaria ^a   Ferro, Stefania ^a   Agnello, Stefano ^a   De Luca, Laura ^a   De Sarro, Giovanbattista ^b   Russo, Emilio ^b   Vullo, Daniela ^c   Supuran, Claudiu T ^c   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Anticonvulsants; Carbonic anhydrase inhibitors; DBA 2 mice; Isoquinolines

Indexed keywords

1 (4' AMINOPHENYL) 6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLINE 2(1H) SULFONAMIDE; 1 (4' CHLOROPHENYL) 6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLINE 2(1H) SULFONAMIDE; 6,7 DIMETHOXY 1 (4' NITROPHENYL) 3,4 DIHYDROISOQUINOLINE 2(1H) SULFONAMIDE; 6,7 DIMETHOXY 1,2,3,4 DIHYDROISOQUINOLINE DERIVATIVE; 6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLINE 2(1H) SULFONAMIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; ISOQUINOLINE DERIVATIVE; TOPIRAMATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDIOGENIC SEIZURE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYMATIC ASSAY; ENZYME INHIBITION; MOUSE; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; ANTICONVULSANTS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; ISOQUINOLINES; MICE; MICE, INBRED DBA; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; MUS;

EID: 65349164659     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.066     Document Type: Article

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