Synthesis, resolution, stereochemistry, and molecular modeling of (R)- and (S)-2-acetyl-1-(4′-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline AMPAR antagonists

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 16, 2007, Pages 5417-5423

  Gitto, Rosaria ^a   Ficarra, Rita ^a   Stancanelli, Rosanna ^a   Guardo, Marta ^a   De Luca, Laura ^a   Barreca, Maria Letizia ^a   Pagano, Benedetta ^a   Rotondo, Archimede ^a   Bruno, Giuseppe ^a   Russo, Emilio ^b   De Sarro, Giovanbattista ^b   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

AMPA antagonist; Anticonvulsant; Enantiomeric resolution; Microwave assisted synthesis; Molecular modeling; Tetrahydroisoquinoline; X ray crystal structure

Indexed keywords

2 ACETYL 1 (4' CHLOROPHENYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; AMPA RECEPTOR ANTAGONIST; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CHIRALITY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MOLECULAR MODEL; MOUSE; NONHUMAN; RAT; SEIZURE; STEREOCHEMISTRY; X RAY DIFFRACTION;

ANIMALS; CONVULSANTS; CRYSTALLOGRAPHY, X-RAY; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; RECEPTORS, GLUTAMATE; SEIZURES; STEREOISOMERISM; TETRAHYDROISOQUINOLINES;

EID: 34250753457     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.059     Document Type: Article

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