Histidine → carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity

Biochemistry

Volumn 36, Issue 50, 1997, Pages 15780-15791

  Lesburg, Charles A ^a,c   Huang, Chih Chin ^b   Christianson, David W ^a   Fierke, Carol A ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; ASPARAGINE; ASPARTIC ACID; CARBON DIOXIDE; CARBONATE DEHYDRATASE II; COORDINATION COMPOUND; GLUTAMIC ACID; GLUTAMINE; HISTIDINE; LIGAND; METAL; SULFONAMIDE; WATER; ZINC; 4 NITROPHENYL ACETATE; 4-NITROPHENYL ACETATE; CARBONATE DEHYDRATASE; ENZYME INHIBITOR; ESTERASE; NITROPHENOL;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; GEOMETRY; HUMAN; LIGAND BINDING; PRIORITY JOURNAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HYDROGEN BOND; KINETICS; METABOLISM; PH; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CARBON DIOXIDE; CARBONIC ANHYDRASES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ESTERASES; HISTIDINE; HUMANS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; KINETICS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NITROPHENOLS; SULFONAMIDES; ZINC;

EID: 0031283056     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971296x     Document Type: Article

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