Caloric restriction shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of ALS

PLoS ONE

Volumn 5, Issue 2, 2010, Pages

  Patel, Barkha P ^a,b   Safdar, Adeel ^c   Raha, Sandeep ^c   Tarnopolsky, Mark A ^c   Hamadeh, Mazen J ^a,b,c  

^a YORK UNIVERSITY   (Canada)

^b YORK UNIVERSITY   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; CATALASE; CITRATE SYNTHASE; CYCLOOXYGENASE 1; CYTOCHROME C OXIDASE; FREE RADICAL; MALONALDEHYDE; PROSTAGLANDIN SYNTHASE; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA; SOD1 G93A PROTEIN; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOENERGY; CALORIC RESTRICTION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GASTROCNEMIUS MUSCLE; INFLAMMATION; LIFESPAN; LIPID PEROXIDATION; MALE; MOTOR PERFORMANCE; MOUSE; NONHUMAN; OXIDATIVE STRESS; SKELETAL MUSCLE; ANIMAL; BODY WEIGHT; DISEASE MODEL; EATING; GENETICS; HUMAN; LONGEVITY; METABOLISM; MITOCHONDRION; MOTOR ACTIVITY; MOUSE STRAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; SEX DIFFERENCE; SURVIVAL; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALIA; MUS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BODY WEIGHT; CALORIC RESTRICTION; CATALASE; DISEASE MODELS, ANIMAL; EATING; ELECTRON TRANSPORT COMPLEX IV; FEMALE; HUMANS; INFLAMMATION; LIPID PEROXIDATION; LONGEVITY; MALE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MITOCHONDRIA; MOTOR ACTIVITY; SEX FACTORS; SUPEROXIDE DISMUTASE; SURVIVAL ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77949752957     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009386     Document Type: Article

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