Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis

Journal of Neuroscience

Volumn 27, Issue 48, 2007, Pages 13173-13180

  Gifondorwa, David J ^a   Robinson, Mac B ^a   Hayes, Crystal D ^a   Taylor, Anna R ^b   Prevette, David M ^a   Oppenheim, Ronald W ^a   Caress, James ^a   Milligan, Carolanne E ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Axonopathy; Denervation; Motoneuron; Neurodegeneration; NMJ; SOD1

Indexed keywords

HEAT SHOCK PROTEIN 70; RILUZOLE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GLIA CELL; LIFESPAN; LOCOMOTION; MALE; MOTONEURON; MOUSE; NERVE DEGENERATION; NEUROPATHY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD; UPREGULATION;

AGE FACTORS; AMYOTROPHIC LATERAL SCLEROSIS; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; HINDLIMB; HSP70 HEAT-SHOCK PROTEINS; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; MOTOR NEURONS; NEUROMUSCULAR JUNCTION; NEUROPROTECTIVE AGENTS; RILUZOLE; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 36849005504     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4057-07.2007     Document Type: Article

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