메뉴 건너뛰기




Volumn 16, Issue 3, 2010, Pages 255-267

Overcoming the hurdles of tumor immunity by targeting regulatory pathways in innate and adaptive immune cells

Author keywords

Dendritic cells; Immunotherapy; NK cells; T lymphocytes; Tumor immune escape

Indexed keywords

ADAPTIVE IMMUNITY; ARTICLE; CANCER IMMUNOLOGY; CANCER IMMUNOTHERAPY; CELL MATURATION; CHRONIC INFLAMMATION; DENDRITIC CELL; HUMAN; IMMUNOMODULATION; INNATE IMMUNITY; LYMPHOCYTE DIFFERENTIATION; MACROPHAGE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; T LYMPHOCYTE SUBPOPULATION; TUMOR ESCAPE;

EID: 77949477553     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161210790170175     Document Type: Article
Times cited : (24)

References (227)
  • 1
    • 0035320526 scopus 로고    scopus 로고
    • A fresh look at tumor immunosurveillance and immunotherapy
    • Smyth MJ, Godfrey DI, Trapani JA. A fresh look at tumor immunosurveillance and immunotherapy. Nat Immunol 2001; 2: 293-9.
    • (2001) Nat Immunol , vol.2 , pp. 293-299
    • Smyth, M.J.1    Godfrey, D.I.2    Trapani, J.A.3
  • 2
  • 4
  • 5
    • 4644293572 scopus 로고    scopus 로고
    • Cancer immunotherapy: Breaking the barriers to harvest the crop
    • Pardoll D, Allison J. Cancer immunotherapy: breaking the barriers to harvest the crop. Nat Med 2004; 10: 887-92.
    • (2004) Nat Med , vol.10 , pp. 887-892
    • Pardoll, D.1    Allison, J.2
  • 6
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: moving beyond current vaccines. Nat Med 2004; 10: 909-15.
    • (2004) Nat Med , vol.10 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 9
    • 9144274980 scopus 로고    scopus 로고
    • Extralymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: Dominant role of cross-tolerance to tumor antigens
    • Cuenca A, Cheng F, Wang H, Brayer J, Horna P, Gu L, et al. Extralymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to tumor antigens. Cancer Res 2003; 63: 9007-15.
    • (2003) Cancer Res , vol.63 , pp. 9007-9015
    • Cuenca, A.1    Cheng, F.2    Wang, H.3    Brayer, J.4    Horna, P.5    Gu, L.6
  • 10
    • 0031963994 scopus 로고    scopus 로고
    • Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity
    • Morgan DJ, Kreuwel HT, Fleck S, Levitsky HI, Pardoll DM, Sherman LA. Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity. J Immunol 1998; 160: 643-51.
    • (1998) J Immunol , vol.160 , pp. 643-651
    • Morgan, D.J.1    Kreuwel, H.T.2    Fleck, S.3    Levitsky, H.I.4    Pardoll, D.M.5    Sherman, L.A.6
  • 12
    • 24344436369 scopus 로고    scopus 로고
    • Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance
    • Willimsky G, Blankenstein T. Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance. Nature 2005; 437: 141-6.
    • (2005) Nature , vol.437 , pp. 141-146
    • Willimsky, G.1    Blankenstein, T.2
  • 13
    • 0033056073 scopus 로고    scopus 로고
    • Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
    • Lee PP, Yee C, Savage PA, Fong L, Brockstedt D, Weber JS, et al. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat Med 1999; 5: 677-85.
    • (1999) Nat Med , vol.5 , pp. 677-685
    • Lee, P.P.1    Yee, C.2    Savage, P.A.3    Fong, L.4    Brockstedt, D.5    Weber, J.S.6
  • 14
    • 33645500590 scopus 로고    scopus 로고
    • In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity
    • Horna P, Cuenca A, Cheng F, Brayer J, Wang HW, Borrello I, et al. In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity. Blood 2006; 107: 2871-8.
    • (2006) Blood , vol.107 , pp. 2871-2878
    • Horna, P.1    Cuenca, A.2    Cheng, F.3    Brayer, J.4    Wang, H.W.5    Borrello, I.6
  • 15
    • 0034671810 scopus 로고    scopus 로고
    • + T cell ignorance and induction of anti-tumor immunity by peptide-pulsed APC
    • + T cell ignorance and induction of anti-tumor immunity by peptide-pulsed APC. J Immunol 2000; 165: 6731-7.
    • (2000) J Immunol , vol.165 , pp. 6731-6737
    • Dalyot-Herman, N.1    Bathe, O.F.2    Malek, T.R.3
  • 19
    • 18544364477 scopus 로고    scopus 로고
    • Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase
    • Munn DH, Sharma MD, Lee JR, Jhaver KG, Johnson TS, Keskin DB, et al. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 2002; 297: 1867-70.
    • (2002) Science , vol.297 , pp. 1867-1870
    • Munn, D.H.1    Sharma, M.D.2    Lee, J.R.3    Jhaver, K.G.4    Johnson, T.S.5    Keskin, D.B.6
  • 21
    • 0036278521 scopus 로고    scopus 로고
    • Alterations in the frequency of dendritic cell subsets in the peripheral circulation of patients with squamous cell carcinomas of the head and neck
    • Hoffmann TK, Muller-Berghaus J, Ferris RL, Johnson JT, Storkus WJ, Whiteside TL, et al. Alterations in the frequency of dendritic cell subsets in the peripheral circulation of patients with squamous cell carcinomas of the head and neck. Clin Cancer Res 2002; 8: 1787-93.
    • (2002) Clin Cancer Res , vol.8 , pp. 1787-1793
    • Hoffmann, T.K.1    Muller-Berghaus, J.2    Ferris, R.L.3    Johnson, J.T.4    Storkus, W.J.5    Whiteside, T.L.6
  • 23
    • 0030786569 scopus 로고    scopus 로고
    • Tumor-infiltrating dendritic cells are defective in their antigen-presenting function and inducible B7 expression in rats
    • Chaux P, Favre N, Martin M, Martin F. Tumor-infiltrating dendritic cells are defective in their antigen-presenting function and inducible B7 expression in rats. Int J Cancer 1997; 72: 619-24.
    • (1997) Int J Cancer , vol.72 , pp. 619-624
    • Chaux, P.1    Favre, N.2    Martin, M.3    Martin, F.4
  • 26
    • 0030724702 scopus 로고    scopus 로고
    • Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma
    • Enk AH, Jonuleit H, Saloga J, Knop J. Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma. Int J Cancer 1997; 73: 309-16.
    • (1997) Int J Cancer , vol.73 , pp. 309-316
    • Enk, A.H.1    Jonuleit, H.2    Saloga, J.3    Knop, J.4
  • 27
    • 9644260767 scopus 로고    scopus 로고
    • Metastatic melanoma secreted IL-10 down-regulates CD1 molecules on dendritic cells in metastatic tumor lesions
    • Gerlini G, Tun-Kyi A, Dudli C, Burg G, Pimpinelli N, Nestle FO. Metastatic melanoma secreted IL-10 down-regulates CD1 molecules on dendritic cells in metastatic tumor lesions. Am J Pathol 2004; 165: 1853-63.
    • (2004) Am J Pathol , vol.165 , pp. 1853-1863
    • Gerlini, G.1    Tun-Kyi, A.2    Dudli, C.3    Burg, G.4    Pimpinelli, N.5    Nestle, F.O.6
  • 28
    • 33745258657 scopus 로고    scopus 로고
    • Tumor-driven evolution of immunosuppressive networks during malignant progression
    • Kim R, Emi M, Tanabe K, Arihiro K. Tumor-driven evolution of immunosuppressive networks during malignant progression. Cancer Res 2006; 66: 5527-36.
    • (2006) Cancer Res , vol.66 , pp. 5527-5536
    • Kim, R.1    Emi, M.2    Tanabe, K.3    Arihiro, K.4
  • 29
    • 0029842830 scopus 로고    scopus 로고
    • Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
    • Gabrilovich DI, Chen HL, Girgis KR, Cunningham HT, Meny GM, Nadaf S, et al. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med 1996; 2: 1096-103.
    • (1996) Nat Med , vol.2 , pp. 1096-1103
    • Gabrilovich, D.I.1    Chen, H.L.2    Girgis, K.R.3    Cunningham, H.T.4    Meny, G.M.5    Nadaf, S.6
  • 30
    • 11144357779 scopus 로고    scopus 로고
    • Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
    • Wang T, Niu G, Kortylewski M, Burdelya L, Shain K, Zhang S, et al. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med 2004; 10: 48-54.
    • (2004) Nat Med , vol.10 , pp. 48-54
    • Wang, T.1    Niu, G.2    Kortylewski, M.3    Burdelya, L.4    Shain, K.5    Zhang, S.6
  • 32
    • 31044453678 scopus 로고    scopus 로고
    • SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling
    • Evel-Kabler K, Song XT, Aldrich M, Huang XF, Chen SY. SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling. J Clin Invest 2006; 116: 90-100.
    • (2006) J Clin Invest , vol.116 , pp. 90-100
    • Evel-Kabler, K.1    Song, X.T.2    Aldrich, M.3    Huang, X.F.4    Chen, S.Y.5
  • 33
    • 0141953994 scopus 로고    scopus 로고
    • Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer
    • Hartmann E, Wollenberg B, Rothenfusser S, Wagner M, Wellisch D, Mack B, et al. Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer. Cancer Res 2003; 63: 6478-87.
    • (2003) Cancer Res , vol.63 , pp. 6478-6487
    • Hartmann, E.1    Wollenberg, B.2    Rothenfusser, S.3    Wagner, M.4    Wellisch, D.5    Mack, B.6
  • 34
    • 0035658072 scopus 로고    scopus 로고
    • Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells
    • Zou W, Machelon V, Coulomb-L'Hermin A, Borvak J, Nome F, Isaeva T, et al. Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells. Nat Med 2001; 7: 1339-46.
    • (2001) Nat Med , vol.7 , pp. 1339-1346
    • Zou, W.1    Machelon, V.2    Coulomb-L'Hermin, A.3    Borvak, J.4    Nome, F.5    Isaeva, T.6
  • 35
    • 4043092238 scopus 로고    scopus 로고
    • Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes
    • Munn DH, Sharma MD, Hou D, Baban B, Lee JR, Antonia SJ, et al. Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J Clin Invest 2004; 114: 280-90.
    • (2004) J Clin Invest , vol.114 , pp. 280-290
    • Munn, D.H.1    Sharma, M.D.2    Hou, D.3    Baban, B.4    Lee, J.R.5    Antonia, S.J.6
  • 37
    • 9244241059 scopus 로고    scopus 로고
    • Zhang M, Tang H, Guo Z, An H, Zhu X, Song W, et al. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat Immunol 2004; 5: 1124-33. [38] Kusmartsev S, Gabrilovich DI. Immature myeloid cells and cancer-associated immune suppression. Cancer Immunol Immunother 2002; 51: 293-8.
    • Zhang M, Tang H, Guo Z, An H, Zhu X, Song W, et al. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat Immunol 2004; 5: 1124-33. [38] Kusmartsev S, Gabrilovich DI. Immature myeloid cells and cancer-associated immune suppression. Cancer Immunol Immunother 2002; 51: 293-8.
  • 41
    • 10744220561 scopus 로고    scopus 로고
    • Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: Abrogation prevents tumor recurrence
    • Terabe M, Matsui S, Park JM, Mamura M, Noben-Trauth N, Donaldson DD, et al. Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence. J Exp Med 2003; 198: 1741-52.
    • (2003) J Exp Med , vol.198 , pp. 1741-1752
    • Terabe, M.1    Matsui, S.2    Park, J.M.3    Mamura, M.4    Noben-Trauth, N.5    Donaldson, D.D.6
  • 42
    • 17044366637 scopus 로고    scopus 로고
    • STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion
    • Kusmartsev S, Gabrilovich DI. STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion. J Immunol 2005; 174: 4880-91.
    • (2005) J Immunol , vol.174 , pp. 4880-4891
    • Kusmartsev, S.1    Gabrilovich, D.I.2
  • 43
    • 0035164478 scopus 로고    scopus 로고
    • Increased production of immature myeloid cells in cancer patients: A mechanism of immunosuppression in cancer
    • Almand B, Clark JI, Nikitina E, van Beynen J, English NR, Knight SC, et al. Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J Immunol 2001; 166: 678-89.
    • (2001) J Immunol , vol.166 , pp. 678-689
    • Almand, B.1    Clark, J.I.2    Nikitina, E.3    van Beynen, J.4    English, N.R.5    Knight, S.C.6
  • 44
    • 1542720380 scopus 로고    scopus 로고
    • Surgical removal of primary tumor reverses tumor-induced immunosuppression despite the presence of metastatic disease
    • Danna EA, Sinha P, Gilbert M, Clements VK, Pulaski BA, Ostrand-Rosenberg S. Surgical removal of primary tumor reverses tumor-induced immunosuppression despite the presence of metastatic disease. Cancer Res 2004; 64: 2205-11.
    • (2004) Cancer Res , vol.64 , pp. 2205-2211
    • Danna, E.A.1    Sinha, P.2    Gilbert, M.3    Clements, V.K.4    Pulaski, B.A.5    Ostrand-Rosenberg, S.6
  • 45
    • 0035874990 scopus 로고    scopus 로고
    • Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients
    • Schmielau J, Finn OJ. Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res 2001; 61: 4756-60.
    • (2001) Cancer Res , vol.61 , pp. 4756-4760
    • Schmielau, J.1    Finn, O.J.2
  • 46
    • 33749488765 scopus 로고    scopus 로고
    • Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes
    • Valenti R, Huber V, Filipazzi P, Pilla L, Sovena G, Villa A, et al. Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes. Cancer Res 2006; 66: 9290-8.
    • (2006) Cancer Res , vol.66 , pp. 9290-9298
    • Valenti, R.1    Huber, V.2    Filipazzi, P.3    Pilla, L.4    Sovena, G.5    Villa, A.6
  • 47
    • 3042822267 scopus 로고    scopus 로고
    • Cancer and the chemokine network
    • Balkwill F. Cancer and the chemokine network. Nat Rev Cancer 2004; 4: 540-50.
    • (2004) Nat Rev Cancer , vol.4 , pp. 540-550
    • Balkwill, F.1
  • 48
    • 47749155653 scopus 로고    scopus 로고
    • Cancer related inflammation: The macrophage connection
    • Sica A, Allavena P, Mantovani A. Cancer related inflammation: the macrophage connection. Cancer Lett 2008; 267: 204-15.
    • (2008) Cancer Lett , vol.267 , pp. 204-215
    • Sica, A.1    Allavena, P.2    Mantovani, A.3
  • 49
    • 33845752914 scopus 로고    scopus 로고
    • p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance
    • Saccani A, Schioppa T, Porta C, Biswas SK, Nebuloni M, Vago L, et al. p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Res 2006; 66: 11432-40.
    • (2006) Cancer Res , vol.66 , pp. 11432-11440
    • Saccani, A.1    Schioppa, T.2    Porta, C.3    Biswas, S.K.4    Nebuloni, M.5    Vago, L.6
  • 50
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, et al. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000; 157: 411-21.
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6
  • 52
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003; 3: 23-35.
    • (2003) Nat Rev Immunol , vol.3 , pp. 23-35
    • Gordon, S.1
  • 53
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004; 10: 942-9.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 54
    • 25844459154 scopus 로고    scopus 로고
    • NF-κB: Linking inflammation and immunity to cancer development and progression
    • Karin M, Greten FR. NF-κB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005; 5: 749-59.
    • (2005) Nat Rev Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 56
    • 58149269348 scopus 로고    scopus 로고
    • Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
    • Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, et al. Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 2009; 457: 102-6.
    • (2009) Nature , vol.457 , pp. 102-106
    • Kim, S.1    Takahashi, H.2    Lin, W.W.3    Descargues, P.4    Grivennikov, S.5    Kim, Y.6
  • 57
    • 55949117914 scopus 로고    scopus 로고
    • Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase
    • Muller AJ, Sharma MD, Chandler PR, Duhadaway JB, Everhart ME, Johnson BA 3rd, et al. Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase. Proc Natl Acad Sci USA 2008; 105: 17073-8.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 17073-17078
    • Muller, A.J.1    Sharma, M.D.2    Chandler, P.R.3    Duhadaway, J.B.4    Everhart, M.E.5    Johnson 3rd, B.A.6
  • 58
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4: 499-511.
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 59
    • 0742272509 scopus 로고    scopus 로고
    • Reis e Sousa C. Toll-like receptors and dendritic cells: for whom the bug tolls. Semin Immunol 2004; 16: 27-34.
    • Reis e Sousa C. Toll-like receptors and dendritic cells: for whom the bug tolls. Semin Immunol 2004; 16: 27-34.
  • 60
    • 35748976563 scopus 로고    scopus 로고
    • Engagement of TLR3, TLR7, and NKG2D regulate IFN-γ secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12
    • Girart MV, Fuertes MB, Domaica CI, Rossi LE, Zwirner NW. Engagement of TLR3, TLR7, and NKG2D regulate IFN-γ secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12. J Immunol 2007; 179: 3472-9.
    • (2007) J Immunol , vol.179 , pp. 3472-3479
    • Girart, M.V.1    Fuertes, M.B.2    Domaica, C.I.3    Rossi, L.E.4    Zwirner, N.W.5
  • 61
    • 38649087921 scopus 로고    scopus 로고
    • Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis
    • Swann JB, Vesely MD, Silva A, Sharkey J, Akira S, Schreiber RD, et al. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci USA 2008; 105: 652-6.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 652-656
    • Swann, J.B.1    Vesely, M.D.2    Silva, A.3    Sharkey, J.4    Akira, S.5    Schreiber, R.D.6
  • 62
    • 0037438340 scopus 로고    scopus 로고
    • Endotoxin/lipopolysaccharide activates NF-κB and enhances tumor cell adhesion and invasion through a β1 integrindependent mechanism
    • Wang JH, Manning BJ, Wu QD, Blankson S, Bouchier-Hayes D, Redmond HP. Endotoxin/lipopolysaccharide activates NF-κB and enhances tumor cell adhesion and invasion through a β1 integrindependent mechanism. J Immunol 2003; 170: 795-804.
    • (2003) J Immunol , vol.170 , pp. 795-804
    • Wang, J.H.1    Manning, B.J.2    Wu, Q.D.3    Blankson, S.4    Bouchier-Hayes, D.5    Redmond, H.P.6
  • 63
    • 35948972112 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 4 on tumor cells in vitro inhibits subsequent tumor growth in vivo
    • Andreani V, Gatti G, Simonella L, Rivero V, Maccioni M. Activation of Toll-like receptor 4 on tumor cells in vitro inhibits subsequent tumor growth in vivo. Cancer Res 2007; 67: 10519-27.
    • (2007) Cancer Res , vol.67 , pp. 10519-10527
    • Andreani, V.1    Gatti, G.2    Simonella, L.3    Rivero, V.4    Maccioni, M.5
  • 64
    • 41149118513 scopus 로고    scopus 로고
    • How dying cells alert the immune system to danger
    • Kono H, Rock KL. How dying cells alert the immune system to danger. Nat Rev Immunol 2008; 8: 279-89.
    • (2008) Nat Rev Immunol , vol.8 , pp. 279-289
    • Kono, H.1    Rock, K.L.2
  • 65
    • 34447116244 scopus 로고    scopus 로고
    • Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
    • Chen CJ, Kono H, Golenbock D, Reed G, Akira S, Rock KL. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med 2007; 13: 851-6.
    • (2007) Nat Med , vol.13 , pp. 851-856
    • Chen, C.J.1    Kono, H.2    Golenbock, D.3    Reed, G.4    Akira, S.5    Rock, K.L.6
  • 66
    • 39049104004 scopus 로고    scopus 로고
    • Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis
    • Yusuf N, Nasti TH, Long JA, Naseemuddin M, Lucas AP, Xu H, et al. Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis. Cancer Res 2008; 68: 615-22.
    • (2008) Cancer Res , vol.68 , pp. 615-622
    • Yusuf, N.1    Nasti, T.H.2    Long, J.A.3    Naseemuddin, M.4    Lucas, A.P.5    Xu, H.6
  • 67
    • 58149149839 scopus 로고    scopus 로고
    • TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events
    • Cavassani KA, Ishii M, Wen H, Schaller MA, Lincoln PM, Lukacs NW, et al. TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events. J Exp Med 2008; 205: 2609-21.
    • (2008) J Exp Med , vol.205 , pp. 2609-2621
    • Cavassani, K.A.1    Ishii, M.2    Wen, H.3    Schaller, M.A.4    Lincoln, P.M.5    Lukacs, N.W.6
  • 68
    • 53049088890 scopus 로고    scopus 로고
    • Tumors sound the alarmin(s)
    • Coffelt SB, Scandurro AB. Tumors sound the alarmin(s). Cancer Res 2008; 68: 6482-5.
    • (2008) Cancer Res , vol.68 , pp. 6482-6485
    • Coffelt, S.B.1    Scandurro, A.B.2
  • 69
    • 33749036894 scopus 로고    scopus 로고
    • Human β-defensin-1, a potential chromosome 8p tumor suppressor: Control of transcription and induction of apoptosis in renal cell carcinoma
    • Sun CQ, Arnold R, Fernandez-Golarz C, Parrish AB, Almekinder T, He J, et al. Human β-defensin-1, a potential chromosome 8p tumor suppressor: control of transcription and induction of apoptosis in renal cell carcinoma. Cancer Res 2006; 66: 8542-9.
    • (2006) Cancer Res , vol.66 , pp. 8542-8549
    • Sun, C.Q.1    Arnold, R.2    Fernandez-Golarz, C.3    Parrish, A.B.4    Almekinder, T.5    He, J.6
  • 70
    • 34848838572 scopus 로고    scopus 로고
    • Functional analysis of the host defense peptide Human β Defensin-1: New insight into its potential role in cancer
    • Bullard RS, Gibson W, Bose SK, Belgrave JK, Eaddy AC, Wright CJ, et al. Functional analysis of the host defense peptide Human β Defensin-1: new insight into its potential role in cancer. Mol Immunol 2008; 45: 839-48.
    • (2008) Mol Immunol , vol.45 , pp. 839-848
    • Bullard, R.S.1    Gibson, W.2    Bose, S.K.3    Belgrave, J.K.4    Eaddy, A.C.5    Wright, C.J.6
  • 71
    • 4644345036 scopus 로고    scopus 로고
    • Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of VEGF-A
    • Conejo-Garcia JR, Benencia F, Courreges MC, Kang E, Mohamed-Hadley A, Buckanovich RJ, et al. Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of VEGF-A. Nat Med 2004; 10: 950-8.
    • (2004) Nat Med , vol.10 , pp. 950-958
    • Conejo-Garcia, J.R.1    Benencia, F.2    Courreges, M.C.3    Kang, E.4    Mohamed-Hadley, A.5    Buckanovich, R.J.6
  • 72
    • 28444480677 scopus 로고    scopus 로고
    • Inhibition of pathologic retinal neovascularization by alpha-defensins
    • Economopoulou M, Bdeir K, Cines DB, Fogt F, Bdeir Y, Lubkowski J, et al. Inhibition of pathologic retinal neovascularization by alpha-defensins. Blood 2005; 106(12): 3831-8.
    • (2005) Blood , vol.106 , Issue.12 , pp. 3831-3838
    • Economopoulou, M.1    Bdeir, K.2    Cines, D.B.3    Fogt, F.4    Bdeir, Y.5    Lubkowski, J.6
  • 73
    • 0034596945 scopus 로고    scopus 로고
    • LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells
    • De Y, Chen Q, Schmidt AP, Anderson GM, Wang JM, Wooters J, et al. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med 2000; 192(7): 1069-74.
    • (2000) J Exp Med , vol.192 , Issue.7 , pp. 1069-1074
    • De, Y.1    Chen, Q.2    Schmidt, A.P.3    Anderson, G.M.4    Wang, J.M.5    Wooters, J.6
  • 74
    • 38749148077 scopus 로고    scopus 로고
    • Ovarian cancers overexpress the antimicrobial protein hCAP-18 and its derivative LL-37 increases ovarian cancer cell proliferation and invasion
    • Coffelt SB, Waterman RS, Florez L, Honer zu Bentrup K, Zwezdaryk KJ, Tomchuck SL, et al. Ovarian cancers overexpress the antimicrobial protein hCAP-18 and its derivative LL-37 increases ovarian cancer cell proliferation and invasion. Int J Cancer 2008; 122(5): 1030-9.
    • (2008) Int J Cancer , vol.122 , Issue.5 , pp. 1030-1039
    • Coffelt, S.B.1    Waterman, R.S.2    Florez, L.3    Honer zu Bentrup, K.4    Zwezdaryk, K.J.5    Tomchuck, S.L.6
  • 75
    • 14844311295 scopus 로고    scopus 로고
    • Antimicrobial protein hCAP18/LL-37 is highly expressed in breast cancer and is a putative growth factor for epithelial cells
    • Heilborn JD, Nilsson MF, Jimenez CI, Sandstedt B, Borregaard N, Tham E, et al. Antimicrobial protein hCAP18/LL-37 is highly expressed in breast cancer and is a putative growth factor for epithelial cells. Int J Cancer 2005; 114(5): 713-9.
    • (2005) Int J Cancer , vol.114 , Issue.5 , pp. 713-719
    • Heilborn, J.D.1    Nilsson, M.F.2    Jimenez, C.I.3    Sandstedt, B.4    Borregaard, N.5    Tham, E.6
  • 77
    • 34948862264 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    • Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 2007; 449(7162): 564-9.
    • (2007) Nature , vol.449 , Issue.7162 , pp. 564-569
    • Lande, R.1    Gregorio, J.2    Facchinetti, V.3    Chatterjee, B.4    Wang, Y.H.5    Homey, B.6
  • 78
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002; 418(6894): 191-5.
    • (2002) Nature , vol.418 , Issue.6894 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 79
    • 29644441337 scopus 로고    scopus 로고
    • Cutting edge: Extracellular high mobility group box-1 protein is a proangiogenic cytokine
    • Mitola S, Belleri M, Urbinati C, Coltrini D, Sparatore B, Pedrazzi M, et al. Cutting edge: extracellular high mobility group box-1 protein is a proangiogenic cytokine. J Immunol 2006; 176: 12-5.
    • (2006) J Immunol , vol.176 , pp. 12-15
    • Mitola, S.1    Belleri, M.2    Urbinati, C.3    Coltrini, D.4    Sparatore, B.5    Pedrazzi, M.6
  • 80
    • 17144400438 scopus 로고    scopus 로고
    • Angiogenetic signaling through hypoxia: HMGB1: an angiogenetic switch molecule
    • Schlueter C, Weber H, Meyer B, Rogalla P, Roser K, Hauke S, et al. Angiogenetic signaling through hypoxia: HMGB1: an angiogenetic switch molecule. Am J Pathol 2005; 166: 1259-63.
    • (2005) Am J Pathol , vol.166 , pp. 1259-1263
    • Schlueter, C.1    Weber, H.2    Meyer, B.3    Rogalla, P.4    Roser, K.5    Hauke, S.6
  • 81
    • 33749332105 scopus 로고    scopus 로고
    • Gene expression of tumor angiogenesis dissected: Specific targeting of colon cancer angiogenic vasculature
    • van Beijnum JR, Dings RP, van der Linden E, Zwaans BM, Ramaekers FC, Mayo KH, et al. Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature. Blood 2006; 108: 2339-48.
    • (2006) Blood , vol.108 , pp. 2339-2348
    • van Beijnum, J.R.1    Dings, R.P.2    van der Linden, E.3    Zwaans, B.M.4    Ramaekers, F.C.5    Mayo, K.H.6
  • 83
    • 34948820602 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
    • Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 2007; 13: 1050-9.
    • (2007) Nat Med , vol.13 , pp. 1050-1059
    • Apetoh, L.1    Ghiringhelli, F.2    Tesniere, A.3    Obeid, M.4    Ortiz, C.5    Criollo, A.6
  • 85
    • 10644274525 scopus 로고    scopus 로고
    • Monocytes promote natural killer cell interferon-γ production in response to the endogenous danger signal HMGB1
    • DeMarco RA, Fink MP, Lotze MT. Monocytes promote natural killer cell interferon-γ production in response to the endogenous danger signal HMGB1. Mol Immunol 2005; 42: 433-44.
    • (2005) Mol Immunol , vol.42 , pp. 433-444
    • DeMarco, R.A.1    Fink, M.P.2    Lotze, M.T.3
  • 86
    • 11144299492 scopus 로고    scopus 로고
    • NK cell recognition
    • Lanier LL. NK cell recognition. Annu Rev Immunol 2005; 23: 225-74.
    • (2005) Annu Rev Immunol , vol.23 , pp. 225-274
    • Lanier, L.L.1
  • 87
    • 30144443832 scopus 로고    scopus 로고
    • Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion
    • Bryceson YT, March ME, Ljunggren H-G, Long EO. Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion. Blood 2006; 107: 159-66.
    • (2006) Blood , vol.107 , pp. 159-166
    • Bryceson, Y.T.1    March, M.E.2    Ljunggren, H.-G.3    Long, E.O.4
  • 88
    • 0035059950 scopus 로고    scopus 로고
    • Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis
    • Moretta A, Bottino C, Vitale M, Pende D, Cantoni C, Mingari MC, et al. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol 2001; 19: 197-223.
    • (2001) Annu Rev Immunol , vol.19 , pp. 197-223
    • Moretta, A.1    Bottino, C.2    Vitale, M.3    Pende, D.4    Cantoni, C.5    Mingari, M.C.6
  • 89
    • 5444243220 scopus 로고    scopus 로고
    • Interplay of natural killer cells and their receptors with the adaptive immune response
    • Raulet DH. Interplay of natural killer cells and their receptors with the adaptive immune response. Nat Immunol 2004; 5: 996-1002.
    • (2004) Nat Immunol , vol.5 , pp. 996-1002
    • Raulet, D.H.1
  • 90
    • 0033618504 scopus 로고    scopus 로고
    • Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
    • Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999; 285: 727-9.
    • (1999) Science , vol.285 , pp. 727-729
    • Bauer, S.1    Groh, V.2    Wu, J.3    Steinle, A.4    Phillips, J.H.5    Lanier, L.L.6
  • 91
    • 0036604988 scopus 로고    scopus 로고
    • Lymphocyte activation via NKG2D: Towards a new paradigm in immune recognition?
    • Vivier E, Tomasello E, Paul P. Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition? Curr Opin Immunol 2002; 14: 306-11.
    • (2002) Curr Opin Immunol , vol.14 , pp. 306-311
    • Vivier, E.1    Tomasello, E.2    Paul, P.3
  • 92
    • 24144443517 scopus 로고    scopus 로고
    • The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    • Gasser S, Orsulic S, Brown EJ, Raulet DH. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 2005; 436: 1186-90.
    • (2005) Nature , vol.436 , pp. 1186-1190
    • Gasser, S.1    Orsulic, S.2    Brown, E.J.3    Raulet, D.H.4
  • 93
    • 0033536068 scopus 로고    scopus 로고
    • Broad tumor-associated expression and recognition by tumorderived gamma delta T cells of MICA and MICB
    • Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH, Spies T. Broad tumor-associated expression and recognition by tumorderived gamma delta T cells of MICA and MICB. Proc Natl Acad Sci USA 1999; 96: 6879-84.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6879-6884
    • Groh, V.1    Rhinehart, R.2    Secrist, H.3    Bauer, S.4    Grabstein, K.H.5    Spies, T.6
  • 94
    • 0036829733 scopus 로고    scopus 로고
    • Major histocompatibility complex class i-related chain a and UL16-binding protein expression on tumor cell lines of different histotypes: Analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity
    • Pende D, Rivera P, Marcenaro S, Chang C-C, Biassoni R, Conte R, et al. Major histocompatibility complex class i-related chain a and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. Cancer Res 2002; 62: 6178-86.
    • (2002) Cancer Res , vol.62 , pp. 6178-6186
    • Pende, D.1    Rivera, P.2    Marcenaro, S.3    Chang, C.-C.4    Biassoni, R.5    Conte, R.6
  • 95
    • 0041737499 scopus 로고    scopus 로고
    • Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia
    • Salih HR, Antropius H, Gieseke F, Lutz SZ, Kanz L, Rammensee HG, et al. Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia. Blood 2003; 102: 1389-96.
    • (2003) Blood , vol.102 , pp. 1389-1396
    • Salih, H.R.1    Antropius, H.2    Gieseke, F.3    Lutz, S.Z.4    Kanz, L.5    Rammensee, H.G.6
  • 97
    • 32944472253 scopus 로고    scopus 로고
    • Natural killer cell-mediated rejection of experimental human lung cancer by genetic overexpression of major histocompatibility complex class I chain-related gene A
    • Busche A, Goldmann T, Naumann U, Steinle A, Brandau S. Natural killer cell-mediated rejection of experimental human lung cancer by genetic overexpression of major histocompatibility complex class I chain-related gene A. Hum Gene Ther 2006, 17: 135-46.
    • (2006) Hum Gene Ther , vol.17 , pp. 135-146
    • Busche, A.1    Goldmann, T.2    Naumann, U.3    Steinle, A.4    Brandau, S.5
  • 98
    • 0035855872 scopus 로고    scopus 로고
    • Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
    • Diefenbach A, Jensen ER, Jamieson AM, Raulet DH. Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 2001; 413: 165-71.
    • (2001) Nature , vol.413 , pp. 165-171
    • Diefenbach, A.1    Jensen, E.R.2    Jamieson, A.M.3    Raulet, D.H.4
  • 100
    • 13444257757 scopus 로고    scopus 로고
    • Interleukin-2, interleukin-15, and their roles in human natural killer cells
    • Becknell B, Caligiuri MA. Interleukin-2, interleukin-15, and their roles in human natural killer cells. Adv Immunol 2005; 86: 209-39.
    • (2005) Adv Immunol , vol.86 , pp. 209-239
    • Becknell, B.1    Caligiuri, M.A.2
  • 101
    • 0036005890 scopus 로고    scopus 로고
    • Interleukin-12 in anti-tumor immunity and immunotherapy
    • Colombo MP, Trinchieri G. Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev 2002; 13: 155-68.
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 155-168
    • Colombo, M.P.1    Trinchieri, G.2
  • 102
    • 9344263448 scopus 로고    scopus 로고
    • Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs
    • Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, et al. Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. Proc Natl Acad Sci USA 2004; 101: 16606-11.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16606-16611
    • Ferlazzo, G.1    Pack, M.2    Thomas, D.3    Paludan, C.4    Schmid, D.5    Strowig, T.6
  • 103
    • 0032903599 scopus 로고    scopus 로고
    • Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo
    • Fernandez NC, Lozier A, Flament C, Ricciardi-Castagnoli P, Bellet D, Suter M, et al. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 1999; 5: 405-11.
    • (1999) Nat Med , vol.5 , pp. 405-411
    • Fernandez, N.C.1    Lozier, A.2    Flament, C.3    Ricciardi-Castagnoli, P.4    Bellet, D.5    Suter, M.6
  • 105
    • 34247100277 scopus 로고    scopus 로고
    • Dendritic cells prime natural killer cells by trans-presenting interleukin 15
    • Lucas M, Schachterle W, Oberle K, Aichele P, Diefenbach A. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 2007; 26: 503-17.
    • (2007) Immunity , vol.26 , pp. 503-517
    • Lucas, M.1    Schachterle, W.2    Oberle, K.3    Aichele, P.4    Diefenbach, A.5
  • 106
    • 11244255868 scopus 로고    scopus 로고
    • Kobayashi H, Dubois S, Sato N, Sabzevari H, Sakai Y, Waldmann TA, et al. Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance. Blood 2005; 105: 721-7.
    • Kobayashi H, Dubois S, Sato N, Sabzevari H, Sakai Y, Waldmann TA, et al. Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance. Blood 2005; 105: 721-7.
  • 109
    • 0042931206 scopus 로고    scopus 로고
    • Dendritic cells mediate NK cell help for Th1 and CTL responses: Two-signal requirement for the induction of NK cell helper function
    • Mailliard RB, Son YI, Redlinger R, Coates PT, Giermasz A, Morel PA, et al. Dendritic cells mediate NK cell help for Th1 and CTL responses: two-signal requirement for the induction of NK cell helper function. J Immunol 2003; 171: 2366-73.
    • (2003) J Immunol , vol.171 , pp. 2366-2373
    • Mailliard, R.B.1    Son, Y.I.2    Redlinger, R.3    Coates, P.T.4    Giermasz, A.5    Morel, P.A.6
  • 111
    • 42449123606 scopus 로고    scopus 로고
    • Natural killer cell-directed therapies: Moving from unexpected results to successful strategies
    • Terme M, Ullrich E, Delahaye NF, Chaput N, Zitvogel L. Natural killer cell-directed therapies: moving from unexpected results to successful strategies. Nat Immunol 2008; 9: 486-94.
    • (2008) Nat Immunol , vol.9 , pp. 486-494
    • Terme, M.1    Ullrich, E.2    Delahaye, N.F.3    Chaput, N.4    Zitvogel, L.5
  • 112
    • 59049094662 scopus 로고    scopus 로고
    • Adaptive immune features of natural killer cells
    • Sun JC, Beilke JN, Lanier LL. Adaptive immune features of natural killer cells. Nature 2009; 457: 557-61.
    • (2009) Nature , vol.457 , pp. 557-561
    • Sun, J.C.1    Beilke, J.N.2    Lanier, L.L.3
  • 115
    • 0036852191 scopus 로고    scopus 로고
    • Natural selection of tumor variants in the generation of "tumor escape" phenotypes
    • Khong HT, Restifo NP. Natural selection of tumor variants in the generation of "tumor escape" phenotypes. Nat Immunol 2002; 3: 999-1005.
    • (2002) Nat Immunol , vol.3 , pp. 999-1005
    • Khong, H.T.1    Restifo, N.P.2
  • 116
    • 0037141153 scopus 로고    scopus 로고
    • Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles
    • Andreola G, Rivoltini L, Castelli C, Huber V, Perego P, Deho P, et al. Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J Exp Med 2002; 195: 1303-16.
    • (2002) J Exp Med , vol.195 , pp. 1303-1316
    • Andreola, G.1    Rivoltini, L.2    Castelli, C.3    Huber, V.4    Perego, P.5    Deho, P.6
  • 117
    • 33947259319 scopus 로고    scopus 로고
    • Immunosuppressive strategies that are mediated by tumor cells
    • Rabinovich GA, Sotomayor E, Gabrilovich D. Immunosuppressive strategies that are mediated by tumor cells. Ann Rev Immunol 2007; 25: 267-96.
    • (2007) Ann Rev Immunol , vol.25 , pp. 267-296
    • Rabinovich, G.A.1    Sotomayor, E.2    Gabrilovich, D.3
  • 118
    • 12144285871 scopus 로고    scopus 로고
    • Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege
    • Rubinstein N, Alvarez M, Zwirner NW, Toscano MA, Ilarregui JM, Bravo A, et al. Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege. Cancer Cell 2004; 5: 241-51.
    • (2004) Cancer Cell , vol.5 , pp. 241-251
    • Rubinstein, N.1    Alvarez, M.2    Zwirner, N.W.3    Toscano, M.A.4    Ilarregui, J.M.5    Bravo, A.6
  • 121
    • 0347302952 scopus 로고    scopus 로고
    • Cytokines in cancer pathogenesis and cancer therapy
    • Dranoff G. Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer 2004; 4: 11-22.
    • (2004) Nat Rev Cancer , vol.4 , pp. 11-22
    • Dranoff, G.1
  • 123
    • 46849090674 scopus 로고    scopus 로고
    • Strowig T, Brilot F, Munz C. Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity. J Immunol 2008; 180: 7785-91. [125] Zwirner NW, Fuertes MB, Girart MV, Domaica CI, Rossi LE. Cytokine-driven regulation of NK cell functions in tumor immunity: role of the MICA-NKG2D system. Cytokine Growth Factor Rev 2007; 18: 159-70.
    • Strowig T, Brilot F, Munz C. Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity. J Immunol 2008; 180: 7785-91. [125] Zwirner NW, Fuertes MB, Girart MV, Domaica CI, Rossi LE. Cytokine-driven regulation of NK cell functions in tumor immunity: role of the MICA-NKG2D system. Cytokine Growth Factor Rev 2007; 18: 159-70.
  • 124
    • 33644512391 scopus 로고    scopus 로고
    • Expression of the stress-related MHC class I chain-related protein MICA is an indicator of good prognosis in colorectal cancer patients
    • Watson NF, Spendlove I, Madjd Z, McGilvray R, Green AR, Ellis IO, et al. Expression of the stress-related MHC class I chain-related protein MICA is an indicator of good prognosis in colorectal cancer patients. Int J Cancer 2006; 118: 1445-52.
    • (2006) Int J Cancer , vol.118 , pp. 1445-1452
    • Watson, N.F.1    Spendlove, I.2    Madjd, Z.3    McGilvray, R.4    Green, A.R.5    Ellis, I.O.6
  • 125
    • 24944500112 scopus 로고    scopus 로고
    • Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
    • Oppenheim DE, Roberts SJ, Clarke SL, Filler R, Lewis JM, Tigelaar RE, et al. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nat Immunol 2005; 6: 928-37.
    • (2005) Nat Immunol , vol.6 , pp. 928-937
    • Oppenheim, D.E.1    Roberts, S.J.2    Clarke, S.L.3    Filler, R.4    Lewis, J.M.5    Tigelaar, R.E.6
  • 126
    • 0037126310 scopus 로고    scopus 로고
    • Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    • Groh V, Wu J, Yee C, Spies T. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 2002; 419: 734-8.
    • (2002) Nature , vol.419 , pp. 734-738
    • Groh, V.1    Wu, J.2    Yee, C.3    Spies, T.4
  • 127
    • 0037108517 scopus 로고    scopus 로고
    • Down-regulation of MICA on human tumors by proteolytic shedding
    • Salih HR, Rammensee HG, Steinle A. Down-regulation of MICA on human tumors by proteolytic shedding. J Immunol 2002; 169: 4098-102.
    • (2002) J Immunol , vol.169 , pp. 4098-4102
    • Salih, H.R.1    Rammensee, H.G.2    Steinle, A.3
  • 128
    • 23944519927 scopus 로고    scopus 로고
    • Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells
    • Coudert JD, Zimmer J, Tomasello E, Cebecauer M, Colonna M, Vivier E, et al. Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells. Blood 2005; 106: 1711-7.
    • (2005) Blood , vol.106 , pp. 1711-1717
    • Coudert, J.D.1    Zimmer, J.2    Tomasello, E.3    Cebecauer, M.4    Colonna, M.5    Vivier, E.6
  • 129
    • 0037388134 scopus 로고    scopus 로고
    • Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NKmediated killing of dendritic cells
    • Castriconi R, Cantoni C, Della Chiesa M, Vitale M, Marcenaro E, Conte R, et al. Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NKmediated killing of dendritic cells. Proc Natl Acad Sci USA 2003; 100: 4120-5.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4120-4125
    • Castriconi, R.1    Cantoni, C.2    Della Chiesa, M.3    Vitale, M.4    Marcenaro, E.5    Conte, R.6
  • 130
    • 5644248080 scopus 로고    scopus 로고
    • RNA interference targeting transforming growth factor-β enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo
    • Friese MA, Wischhusen J, Wick W, Weiler M, Eisele G, Steinle A, et al. RNA interference targeting transforming growth factor-β enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo. Cancer Res 2004; 64: 7596-603.
    • (2004) Cancer Res , vol.64 , pp. 7596-7603
    • Friese, M.A.1    Wischhusen, J.2    Wick, W.3    Weiler, M.4    Eisele, G.5    Steinle, A.6
  • 131
    • 33645049837 scopus 로고    scopus 로고
    • Proteolytic release of soluble UL16-binding protein 2 from tumor cells
    • Waldhauer I, Steinle A. Proteolytic release of soluble UL16-binding protein 2 from tumor cells. Cancer Res 2006; 66: 2520-6.
    • (2006) Cancer Res , vol.66 , pp. 2520-2526
    • Waldhauer, I.1    Steinle, A.2
  • 133
    • 33646376464 scopus 로고    scopus 로고
    • Release of MICB molecules by tumor cells: Mechanism and soluble MICB in sera of cancer patients
    • Salih HR, Goehlsdorf D, Steinle A. Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients. Hum Immunol 2006; 67: 188-95.
    • (2006) Hum Immunol , vol.67 , pp. 188-195
    • Salih, H.R.1    Goehlsdorf, D.2    Steinle, A.3
  • 134
    • 0347383715 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development
    • Hojilla CV, Mohammed FF, Khokha R. Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development. Br J Cancer 2003; 89: 1817-21.
    • (2003) Br J Cancer , vol.89 , pp. 1817-1821
    • Hojilla, C.V.1    Mohammed, F.F.2    Khokha, R.3
  • 135
    • 34547107592 scopus 로고    scopus 로고
    • Hypoxia-driven selection of the metastatic phenotype
    • Sullivan R, Graham CH. Hypoxia-driven selection of the metastatic phenotype. Cancer Metastasis Rev 2007; 26: 319-31.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 319-331
    • Sullivan, R.1    Graham, C.H.2
  • 136
    • 49649105571 scopus 로고    scopus 로고
    • Hypoxia increases tumor cell shedding of MHC class I chain-related molecule: Role of nitric oxide
    • Siemens DR, Hu N, Sheikhi AK, Chung E, Frederiksen LJ, Pross H, et al. Hypoxia increases tumor cell shedding of MHC class I chain-related molecule: role of nitric oxide. Cancer Res 2008; 68: 4746-53.
    • (2008) Cancer Res , vol.68 , pp. 4746-4753
    • Siemens, D.R.1    Hu, N.2    Sheikhi, A.K.3    Chung, E.4    Frederiksen, L.J.5    Pross, H.6
  • 137
    • 34249295619 scopus 로고    scopus 로고
    • Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands
    • Kaiser BK, Yim D, Chow IT, Gonzalez S, Dai Z, Mann HH, et al. Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands. Nature 2007; 447: 482-6.
    • (2007) Nature , vol.447 , pp. 482-486
    • Kaiser, B.K.1    Yim, D.2    Chow, I.T.3    Gonzalez, S.4    Dai, Z.5    Mann, H.H.6
  • 138
    • 34547132338 scopus 로고    scopus 로고
    • RAET1E2, a Soluble Isoform of the UL16-binding Protein RAET1E Produced by Tumor Cells, Inhibits NKG2D-mediated NK Cytotoxicity
    • Cao W, Xi X, Hao Z, Li W, Kong Y, Cui L, et al. RAET1E2, a Soluble Isoform of the UL16-binding Protein RAET1E Produced by Tumor Cells, Inhibits NKG2D-mediated NK Cytotoxicity. J Biol Chem 2007; 282: 18922-8.
    • (2007) J Biol Chem , vol.282 , pp. 18922-18928
    • Cao, W.1    Xi, X.2    Hao, Z.3    Li, W.4    Kong, Y.5    Cui, L.6
  • 139
    • 44449119045 scopus 로고    scopus 로고
    • Intracellular Retention of the NKG2D Ligand MHC Class I Chain-Related Gene A in Human Melanomas Confers Immune Privilege and Prevents NK Cell-Mediated Cytotoxicity
    • Fuertes MB, Girart MV, Molinero LL, Domaica CI, Rossi LE, Barrio MM, et al. Intracellular Retention of the NKG2D Ligand MHC Class I Chain-Related Gene A in Human Melanomas Confers Immune Privilege and Prevents NK Cell-Mediated Cytotoxicity. J Immunol 2008; 180: 4606-14.
    • (2008) J Immunol , vol.180 , pp. 4606-4614
    • Fuertes, M.B.1    Girart, M.V.2    Molinero, L.L.3    Domaica, C.I.4    Rossi, L.E.5    Barrio, M.M.6
  • 140
    • 33745183385 scopus 로고    scopus 로고
    • Fas ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity
    • Groh V, Smythe K, Dai Z, Spies T. Fas ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity. Nat Immunol 2006; 7: 755-62.
    • (2006) Nat Immunol , vol.7 , pp. 755-762
    • Groh, V.1    Smythe, K.2    Dai, Z.3    Spies, T.4
  • 143
    • 61449083795 scopus 로고    scopus 로고
    • Interferon-γ down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells
    • Schwinn N, Vokhminova D, Sucker A, Textor S, Striegel S, Moll I, et al. Interferon-γ down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells. Int J Cancer 2008; 124: 1594-604.
    • (2008) Int J Cancer , vol.124 , pp. 1594-1604
    • Schwinn, N.1    Vokhminova, D.2    Sucker, A.3    Textor, S.4    Striegel, S.5    Moll, I.6
  • 144
    • 59849122968 scopus 로고    scopus 로고
    • Cutting edge: Down-regulation of MHC class I-related chain A on tumor cells by IFN-γ-induced microRNA
    • Yadav D, Ngolab J, Lim RS, Krishnamurthy S, Bui JD. Cutting edge: down-regulation of MHC class I-related chain A on tumor cells by IFN-γ-induced microRNA. J Immunol 2009; 182: 39-43.
    • (2009) J Immunol , vol.182 , pp. 39-43
    • Yadav, D.1    Ngolab, J.2    Lim, R.S.3    Krishnamurthy, S.4    Bui, J.D.5
  • 145
    • 33750699056 scopus 로고    scopus 로고
    • The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function
    • Della Chiesa M, Carlomagno S, Frumento G, Balsamo M, Cantoni C, Conte R, et al. The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function. Blood 2006; 108: 4118-25.
    • (2006) Blood , vol.108 , pp. 4118-4125
    • Della Chiesa, M.1    Carlomagno, S.2    Frumento, G.3    Balsamo, M.4    Cantoni, C.5    Conte, R.6
  • 146
    • 60749108735 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling
    • Lagadari M, Lehmann K, Ziemer M, Truta-Feles K, Berod L, Idzko M, et al. Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling. Int J Oncol 2009; 34: 287-94.
    • (2009) Int J Oncol , vol.34 , pp. 287-294
    • Lagadari, M.1    Lehmann, K.2    Ziemer, M.3    Truta-Feles, K.4    Berod, L.5    Idzko, M.6
  • 149
    • 34248529706 scopus 로고    scopus 로고
    • Malignant glioma cells counteract antitumor immune responses through expression of lectin-like transcript-1
    • Roth P, Mittelbronn M, Wick W, Meyermann R, Tatagiba M, Weller M. Malignant glioma cells counteract antitumor immune responses through expression of lectin-like transcript-1. Cancer Res 2007; 67: 3540-4.
    • (2007) Cancer Res , vol.67 , pp. 3540-3544
    • Roth, P.1    Mittelbronn, M.2    Wick, W.3    Meyermann, R.4    Tatagiba, M.5    Weller, M.6
  • 150
    • 18944379881 scopus 로고    scopus 로고
    • Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1
    • Stern N, Markel G, Arnon TI, Gruda R, Wong H, Gray-Owen SD, et al. Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1. J Immunol 2005; 174: 6692-701.
    • (2005) J Immunol , vol.174 , pp. 6692-6701
    • Stern, N.1    Markel, G.2    Arnon, T.I.3    Gruda, R.4    Wong, H.5    Gray-Owen, S.D.6
  • 153
    • 43749089136 scopus 로고    scopus 로고
    • NK resistance of tumor cells from multiple myeloma and chronic lymphocytic leukemia patients: Implication of HLA-G
    • Maki G, Hayes GM, Naji A, Tyler T, Carosella ED, Rouas-Freiss N, et al. NK resistance of tumor cells from multiple myeloma and chronic lymphocytic leukemia patients: implication of HLA-G. Leukemia 2008; 22: 998-1006.
    • (2008) Leukemia , vol.22 , pp. 998-1006
    • Maki, G.1    Hayes, G.M.2    Naji, A.3    Tyler, T.4    Carosella, E.D.5    Rouas-Freiss, N.6
  • 154
    • 33746585232 scopus 로고    scopus 로고
    • Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function
    • Roda-Navarro P, Vales-Gomez M, Chisholm SE, Reyburn HT. Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function. Proc Natl Acad Sci USA 2006; 103: 11258-63.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11258-11263
    • Roda-Navarro, P.1    Vales-Gomez, M.2    Chisholm, S.E.3    Reyburn, H.T.4
  • 155
    • 27144524046 scopus 로고    scopus 로고
    • NK cells infiltrating a MHC class I-deficient lung adenocarcinoma display impaired cytotoxic activity toward autologous tumor cells associated with altered NK cell-triggering receptors
    • Le Maux Chansac B, Moretta A, Vergnon I, Opolon P, Lecluse Y, Grunenwald D, et al. NK cells infiltrating a MHC class I-deficient lung adenocarcinoma display impaired cytotoxic activity toward autologous tumor cells associated with altered NK cell-triggering receptors. J Immunol 2005; 175: 5790-8.
    • (2005) J Immunol , vol.175 , pp. 5790-5798
    • Le Maux Chansac, B.1    Moretta, A.2    Vergnon, I.3    Opolon, P.4    Lecluse, Y.5    Grunenwald, D.6
  • 156
    • 59849126377 scopus 로고    scopus 로고
    • Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-β1
    • Li H, Han Y, Guo Q, Zhang M, Cao X. Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-β1. J Immunol 2009; 182: 240-9.
    • (2009) J Immunol , vol.182 , pp. 240-249
    • Li, H.1    Han, Y.2    Guo, Q.3    Zhang, M.4    Cao, X.5
  • 157
    • 58949086448 scopus 로고    scopus 로고
    • Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells
    • Nausch N, Galani IE, Schlecker E, Cerwenka A. Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells. Blood 2008; 112: 4080-9.
    • (2008) Blood , vol.112 , pp. 4080-4089
    • Nausch, N.1    Galani, I.E.2    Schlecker, E.3    Cerwenka, A.4
  • 158
    • 32944474058 scopus 로고    scopus 로고
    • Effective cancer therapy through immunomodulation
    • Waldmann TA. Effective cancer therapy through immunomodulation. Annu Rev Med 2006; 57: 65-81.
    • (2006) Annu Rev Med , vol.57 , pp. 65-81
    • Waldmann, T.A.1
  • 160
    • 0025055406 scopus 로고
    • A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance
    • Torre-Amione G, Beauchamp RD, Koeppen H, Park BH, Schreiber H, Moses HL, et al. A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. Proc Natl Acad Sci USA 1990; 87: 1486-90.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1486-1490
    • Torre-Amione, G.1    Beauchamp, R.D.2    Koeppen, H.3    Park, B.H.4    Schreiber, H.5    Moses, H.L.6
  • 161
    • 0034770605 scopus 로고    scopus 로고
    • Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells
    • Gorelik L, Flavell RA. Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells. Nat Med 2001; 7: 1118-22.
    • (2001) Nat Med , vol.7 , pp. 1118-1122
    • Gorelik, L.1    Flavell, R.A.2
  • 162
    • 27644457376 scopus 로고    scopus 로고
    • TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
    • Thomas DA, Massague J. TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell 2005; 8: 369-80.
    • (2005) Cancer Cell , vol.8 , pp. 369-380
    • Thomas, D.A.1    Massague, J.2
  • 163
    • 3242799553 scopus 로고    scopus 로고
    • A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and transporter associated with antigen processing 1/2 in human melanoma cells
    • Kurte M, Lopez M, Aguirre A, Escobar A, Aguillon JC, Charo J, et al. A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and transporter associated with antigen processing 1/2 in human melanoma cells. J Immunol 2004; 173: 1731-7.
    • (2004) J Immunol , vol.173 , pp. 1731-1737
    • Kurte, M.1    Lopez, M.2    Aguirre, A.3    Escobar, A.4    Aguillon, J.C.5    Charo, J.6
  • 165
    • 0031914321 scopus 로고    scopus 로고
    • Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2
    • Agrawal B, Krantz MJ, Reddish MA, Longenecker BM. Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2. Nat Med 1998; 4: 43-9.
    • (1998) Nat Med , vol.4 , pp. 43-49
    • Agrawal, B.1    Krantz, M.J.2    Reddish, M.A.3    Longenecker, B.M.4
  • 166
    • 27644552384 scopus 로고    scopus 로고
    • Interleukin-10 and the immune response against cancer: A counterpoint
    • Mocellin S, Marincola FM, Young HA. Interleukin-10 and the immune response against cancer: a counterpoint. J Leukoc Biol 2005; 78: 1043-51.
    • (2005) J Leukoc Biol , vol.78 , pp. 1043-1051
    • Mocellin, S.1    Marincola, F.M.2    Young, H.A.3
  • 167
    • 27144479807 scopus 로고    scopus 로고
    • IL-12 and IL-10 expression synergize to induce the immunemediated eradication of established colon and mammary tumors and lung metastasis
    • Lopez MV, Adris SK, Bravo AI, Chernajovsky Y, Podhajcer OL. IL-12 and IL-10 expression synergize to induce the immunemediated eradication of
    • (2005) J Immunol , vol.175 , pp. 5885-5894
    • Lopez, M.V.1    Adris, S.K.2    Bravo, A.I.3    Chernajovsky, Y.4    Podhajcer, O.L.5
  • 168
    • 13744253833 scopus 로고    scopus 로고
    • Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: Implications for tumor immunotherapy
    • Blank C, Gajewski TF, Mackensen A. Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy. Cancer Immunol Immunother 2005; 54: 307-14.
    • (2005) Cancer Immunol Immunother , vol.54 , pp. 307-314
    • Blank, C.1    Gajewski, T.F.2    Mackensen, A.3
  • 169
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000; 192: 1027-34.
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3    Bourque, K.4    Chernova, T.5    Nishimura, H.6
  • 170
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002; 8: 793-800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6
  • 171
    • 0034097042 scopus 로고    scopus 로고
    • Immunology at the maternal-fetal interface: Lessons for T cell tolerance and suppression
    • Mellor AL, Munn DH. Immunology at the maternal-fetal interface: lessons for T cell tolerance and suppression. Annu Rev Immunol 2000; 18: 367-91.
    • (2000) Annu Rev Immunol , vol.18 , pp. 367-391
    • Mellor, A.L.1    Munn, D.H.2
  • 172
    • 0142137237 scopus 로고    scopus 로고
    • Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
    • Uyttenhove C, Pilotte L, Theate I, Stroobant V, Colau D, Parmentier N, et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med 2003; 9: 1269-74.
    • (2003) Nat Med , vol.9 , pp. 1269-1274
    • Uyttenhove, C.1    Pilotte, L.2    Theate, I.3    Stroobant, V.4    Colau, D.5    Parmentier, N.6
  • 173
    • 0034574306 scopus 로고    scopus 로고
    • The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity
    • Siegel RM, Chan FK, Chun HJ, Lenardo MJ. The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. Nat Immunol 2000; 1: 469-74.
    • (2000) Nat Immunol , vol.1 , pp. 469-474
    • Siegel, R.M.1    Chan, F.K.2    Chun, H.J.3    Lenardo, M.J.4
  • 174
    • 2442484053 scopus 로고    scopus 로고
    • + regulatory t cells for immunologic self-tolerance and negative control of immune responses
    • + regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004; 22: 531-62.
    • (2004) Annu Rev Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 175
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Zou W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 2005, 5: 263-74.
    • (2005) Nat Rev Cancer , vol.5 , pp. 263-274
    • Zou, W.1
  • 178
    • 58149345676 scopus 로고    scopus 로고
    • NK cells and Treg cells: A fascinating dance cheek to cheek
    • Zimmer J, Andres E, Hentges F. NK cells and Treg cells: a fascinating dance cheek to cheek. Eur J Immunol 2008; 38: 2942-5.
    • (2008) Eur J Immunol , vol.38 , pp. 2942-2945
    • Zimmer, J.1    Andres, E.2    Hentges, F.3
  • 179
    • 26844464792 scopus 로고    scopus 로고
    • + regulatory T cells inhibit natural killer cell functions in a transforming growth factor-β-dependent manner
    • + regulatory T cells inhibit natural killer cell functions in a transforming growth factor-β-dependent manner. J Exp Med 2005; 202: 1075-85.
    • (2005) J Exp Med , vol.202 , pp. 1075-1085
    • Ghiringhelli, F.1    Menard, C.2    Terme, M.3    Flament, C.4    Taieb, J.5    Chaput, N.6
  • 180
    • 44049095632 scopus 로고    scopus 로고
    • Protein-glycan interactions in the control of innate and adaptive immune responses
    • van Kooyk Y, Rabinovich GA. Protein-glycan interactions in the control of innate and adaptive immune responses. Nat Immunol 2008; 9: 593-601.
    • (2008) Nat Immunol , vol.9 , pp. 593-601
    • van Kooyk, Y.1    Rabinovich, G.A.2
  • 181
    • 67349258025 scopus 로고    scopus 로고
    • Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation
    • Rabinovich GA, Toscano MA. Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation. Nat Rev Immunol 2009; 9: 338-52.
    • (2009) Nat Rev Immunol , vol.9 , pp. 338-352
    • Rabinovich, G.A.1    Toscano, M.A.2
  • 182
    • 18044374479 scopus 로고    scopus 로고
    • Rabinovich GA. Galectin-1 as a potential cancer target. British J Cancer 2005; 92: 1188-92.
    • Rabinovich GA. Galectin-1 as a potential cancer target. British J Cancer 2005; 92: 1188-92.
  • 183
    • 14844334137 scopus 로고    scopus 로고
    • Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission
    • Matarrese P, Tinari A, Mormone E, Bianco GA, Toscano MA, Ascione B, et al. Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. J Biol Chem 2005; 280: 6969-85.
    • (2005) J Biol Chem , vol.280 , pp. 6969-6985
    • Matarrese, P.1    Tinari, A.2    Mormone, E.3    Bianco, G.A.4    Toscano, M.A.5    Ascione, B.6
  • 184
    • 0034292424 scopus 로고    scopus 로고
    • Galectin-1 induces partial TCR zeta-chain phosphorylation and antagonizes processive TCR signal transduction
    • Chung CD, Patel VP, Moran M, Lewis LA, Miceli MC. Galectin-1 induces partial TCR zeta-chain phosphorylation and antagonizes processive TCR signal transduction. J Immunol 2000; 165: 3722-9.
    • (2000) J Immunol , vol.165 , pp. 3722-3729
    • Chung, C.D.1    Patel, V.P.2    Moran, M.3    Lewis, L.A.4    Miceli, M.C.5
  • 185
    • 33646491737 scopus 로고    scopus 로고
    • Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatorymediated anti-inflammatory responses
    • Toscano MA, Commodaro AG, Ilarregui JM, Bianco GA, Liberman A, Serra HM, et al. Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatorymediated anti-inflammatory responses. J Immunol 2006; 176: 6323-32.
    • (2006) J Immunol , vol.176 , pp. 6323-6332
    • Toscano, M.A.1    Commodaro, A.G.2    Ilarregui, J.M.3    Bianco, G.A.4    Liberman, A.5    Serra, H.M.6
  • 186
    • 34547099820 scopus 로고    scopus 로고
    • Differential glycosylation of T(H)1, T(H)2 and T(H)-17 effector cells selectively regulates susceptibility to cell death
    • Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, et al. Differential glycosylation of T(H)1, T(H)2 and T(H)-17 effector cells selectively regulates susceptibility to cell death. Nat Immunol 2007; 8: 825-34.
    • (2007) Nat Immunol , vol.8 , pp. 825-834
    • Toscano, M.A.1    Bianco, G.A.2    Ilarregui, J.M.3    Croci, D.O.4    Correale, J.5    Hernandez, J.D.6
  • 187
    • 0037320747 scopus 로고    scopus 로고
    • Opposite effects of galectin-1 on alternative metabolic pathways of L-arginine in resident, inflammatory, and activated macrophages
    • Correa SG, Sotomayor CE, Aoki MP, Maldonado CA, Rabinovich G. Opposite effects of galectin-1 on alternative metabolic pathways of L-arginine in resident, inflammatory, and activated macrophages. Glycobiology 2003; 13: 119-28.
    • (2003) Glycobiology , vol.13 , pp. 119-128
    • Correa, S.G.1    Sotomayor, C.E.2    Aoki, M.P.3    Maldonado, C.A.4    Rabinovich, G.5
  • 188
    • 33845958124 scopus 로고    scopus 로고
    • A novel function for galectin-1 at the crossroad of innate and adaptive immunity: Galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway
    • Barrionuevo P, Beigier-Bompadre M, Ilarregui JM, Toscano MA, Bianco GA, Isturiz MA, et al. A novel function for galectin-1 at the crossroad of innate and adaptive immunity: galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway. J Immunol 2007; 178: 436-45.
    • (2007) J Immunol , vol.178 , pp. 436-445
    • Barrionuevo, P.1    Beigier-Bompadre, M.2    Ilarregui, J.M.3    Toscano, M.A.4    Bianco, G.A.5    Isturiz, M.A.6
  • 190
    • 34548740090 scopus 로고    scopus 로고
    • The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma
    • Juszczynski P, Ouyang J, Monti S, Rodig SJ, Takeyama K, Abramson J, et al. The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma. Proc Natl Acad Sci USA 2007; 104: 13134-9.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 13134-13139
    • Juszczynski, P.1    Ouyang, J.2    Monti, S.3    Rodig, S.J.4    Takeyama, K.5    Abramson, J.6
  • 191
    • 33144460217 scopus 로고    scopus 로고
    • Galectin-1: A link between tumor hypoxia and tumor immune privilege
    • Le QT, Shi G, Cao H, Nelson DW, Wang Y, Chen EY, et al. Galectin-1: a link between tumor hypoxia and tumor immune privilege. J Clin Oncol 2005; 23: 8932-41.
    • (2005) J Clin Oncol , vol.23 , pp. 8932-8941
    • QT, L.1    Shi, G.2    Cao, H.3    Nelson, D.W.4    Wang, Y.5    Chen, E.Y.6
  • 192
    • 33846811722 scopus 로고    scopus 로고
    • Regulation of galectin-1 expression by transforming growth factor β1 in metastatic mammary adenocarcinoma cells: Implications for tumor-immune escape
    • Daroqui CM, Ilarregui JM, Rubinstein N, Salatino M, Toscano MA, Vazquez P, et al. Regulation of galectin-1 expression by transforming growth factor β1 in metastatic mammary adenocarcinoma cells: implications for tumor-immune escape. Cancer Immunol Immunother 2007; 56: 491-9.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 491-499
    • Daroqui, C.M.1    Ilarregui, J.M.2    Rubinstein, N.3    Salatino, M.4    Toscano, M.A.5    Vazquez, P.6
  • 194
    • 52049118288 scopus 로고    scopus 로고
    • Tumor-associated galectin-3 modulates the function of tumor-reactive T cells
    • Peng W, Wang HY, Miyahara Y, Peng G, Wang RF. Tumor-associated galectin-3 modulates the function of tumor-reactive T cells. Cancer Res 2008; 68: 7228-36.
    • (2008) Cancer Res , vol.68 , pp. 7228-7236
    • Peng, W.1    Wang, H.Y.2    Miyahara, Y.3    Peng, G.4    Wang, R.F.5
  • 195
    • 61849139471 scopus 로고    scopus 로고
    • Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells
    • Klibi J, Niki T, Riedel A, Pioche-Durieu C, Souquere S, Rubinstein E, et al. Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells. Blood 2009; 113: 1957-66.
    • (2009) Blood , vol.113 , pp. 1957-1966
    • Klibi, J.1    Niki, T.2    Riedel, A.3    Pioche-Durieu, C.4    Souquere, S.5    Rubinstein, E.6
  • 197
    • 40249098634 scopus 로고    scopus 로고
    • Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes
    • Demotte N, Stroobant V, Courtoy PJ, Van Der Smissen P, Colau D, Luescher IF, et al. Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes. Immunity 2008; 28: 414-24.
    • (2008) Immunity , vol.28 , pp. 414-424
    • Demotte, N.1    Stroobant, V.2    Courtoy, P.J.3    Van Der Smissen, P.4    Colau, D.5    Luescher, I.F.6
  • 199
    • 57149117848 scopus 로고    scopus 로고
    • A decade of tissue microarrays: Progress in the discovery and validation of cancer biomarkers
    • Camp RL, Neumeister V, Rimm DL. A decade of tissue microarrays: progress in the discovery and validation of cancer biomarkers. J Clin Oncol 2008; 26: 5630-7.
    • (2008) J Clin Oncol , vol.26 , pp. 5630-5637
    • Camp, R.L.1    Neumeister, V.2    Rimm, D.L.3
  • 201
    • 0032984496 scopus 로고    scopus 로고
    • CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
    • Diehl L, den Boer AT, Schoenberger SP, van der Voort EI, Schumacher TN, Melief CJ, et al. CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy. Nat Med 1999; 5: 774-9.
    • (1999) Nat Med , vol.5 , pp. 774-779
    • Diehl, L.1    den Boer, A.T.2    Schoenberger, S.P.3    van der Voort, E.I.4    Schumacher, T.N.5    Melief, C.J.6
  • 202
    • 0034881390 scopus 로고    scopus 로고
    • Signaling through OX40 (CD134) breaks peripheral T-cell tolerance
    • Bansal-Pakala P, Jember AG, Croft M. Signaling through OX40 (CD134) breaks peripheral T-cell tolerance. Nat Med 2001; 7: 907-12.
    • (2001) Nat Med , vol.7 , pp. 907-912
    • Bansal-Pakala, P.1    Jember, A.G.2    Croft, M.3
  • 204
    • 51349123892 scopus 로고    scopus 로고
    • Cancer immunotherapy by dendritic cells
    • Melief CJ. Cancer immunotherapy by dendritic cells. Immunity 2008; 29: 372-83.
    • (2008) Immunity , vol.29 , pp. 372-383
    • Melief, C.J.1
  • 206
    • 52049123065 scopus 로고    scopus 로고
    • Chimeric NKG2D receptor-expressing T cells as an immunotherapy for multiple myeloma
    • Barber A, Zhang T, Megli CJ, Wu J, Meehan KR, Sentman CL. Chimeric NKG2D receptor-expressing T cells as an immunotherapy for multiple myeloma. Exp Hematol 2008; 36: 1318-28.
    • (2008) Exp Hematol , vol.36 , pp. 1318-1328
    • Barber, A.1    Zhang, T.2    Megli, C.J.3    Wu, J.4    Meehan, K.R.5    Sentman, C.L.6
  • 207
    • 34249677845 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
    • Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007; 13: 552-9.
    • (2007) Nat Med , vol.13 , pp. 552-559
    • Kanzler, H.1    Barrat, F.J.2    Hessel, E.M.3    Coffman, R.L.4
  • 209
    • 33947110880 scopus 로고    scopus 로고
    • Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape
    • Salazar-Onfray F, Lopez MN, Mendoza-Naranjo A. Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape. Cytokine Growth Factor Rev 2007; 18: 171-82.
    • (2007) Cytokine Growth Factor Rev , vol.18 , pp. 171-182
    • Salazar-Onfray, F.1    Lopez, M.N.2    Mendoza-Naranjo, A.3
  • 210
    • 0033613173 scopus 로고    scopus 로고
    • In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
    • Sotomayor EM, Borrello I, Tubb E, Allison JP, Levitsky HI. In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance. Proc Natl Acad Sci USA 1999; 96: 11476-81.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11476-11481
    • Sotomayor, E.M.1    Borrello, I.2    Tubb, E.3    Allison, J.P.4    Levitsky, H.I.5
  • 211
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    • Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci USA 2003; 100: 8372-7.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8372-8377
    • Phan, G.Q.1    Yang, J.C.2    Sherry, R.M.3    Hwu, P.4    Topalian, S.L.5    Schwartzentruber, D.J.6
  • 212
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colonystimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
    • van Elsas A, Hurwitz AA, Allison JP. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colonystimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med 1999; 190: 355-66.
    • (1999) J Exp Med , vol.190 , pp. 355-366
    • van Elsas, A.1    Hurwitz, A.A.2    Allison, J.P.3
  • 213
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996; 271: 1734-6.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 214
    • 0344341626 scopus 로고    scopus 로고
    • Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
    • Hodi FS, Mihm MC, Soiffer RJ, Haluska FG, Butler M, Seiden MV, et al. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc Natl Acad Sci USA 2003; 100: 4712-7.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4712-4717
    • Hodi, F.S.1    Mihm, M.C.2    Soiffer, R.J.3    Haluska, F.G.4    Butler, M.5    Seiden, M.V.6
  • 215
    • 16244408626 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
    • Muller AJ, DuHadaway JB, Donover PS, Sutanto-Ward E, Prendergast GC. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat Med 2005; 11: 312-9.
    • (2005) Nat Med , vol.11 , pp. 312-319
    • Muller, A.J.1    DuHadaway, J.B.2    Donover, P.S.3    Sutanto-Ward, E.4    Prendergast, G.C.5
  • 217
    • 33746575650 scopus 로고    scopus 로고
    • The GITR-GITRL interaction: Costimulation or contrasuppression of regulatory activity?
    • Shevach EM, Stephens GL. The GITR-GITRL interaction: costimulation or contrasuppression of regulatory activity? Nat Rev Immunol 2006; 6: 613-8.
    • (2006) Nat Rev Immunol , vol.6 , pp. 613-618
    • Shevach, E.M.1    Stephens, G.L.2
  • 218
    • 0033168037 scopus 로고    scopus 로고
    • Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody
    • Onizuka S, Tawara I, Shimizu J, Sakaguchi S, Fujita T, Nakayama E. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res 1999; 59: 3128-33.
    • (1999) Cancer Res , vol.59 , pp. 3128-3133
    • Onizuka, S.1    Tawara, I.2    Shimizu, J.3    Sakaguchi, S.4    Fujita, T.5    Nakayama, E.6
  • 219
    • 0033571105 scopus 로고    scopus 로고
    • Induction of tumor immunity by removing CD25+CD4+ T cells: A common basis between tumor immunity and autoimmunity
    • Shimizu J, Yamazaki S, Sakaguchi S. Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Immunol 1999; 163: 5211-8.
    • (1999) J Immunol , vol.163 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 220
    • 33745125681 scopus 로고    scopus 로고
    • Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity
    • Jinushi M, Hodi FS, Dranoff G. Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity. Proc Natl Acad Sci USA 2006; 103: 9190-5.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9190-9195
    • Jinushi, M.1    Hodi, F.S.2    Dranoff, G.3
  • 221
    • 61849145128 scopus 로고    scopus 로고
    • Protein disulfide isomerases are antibody targets during immunemediated tumor destruction
    • Fonseca C, Soiffer R, Ho V, Vanneman M, Jinushi M, Ritz J, et al. Protein disulfide isomerases are antibody targets during immunemediated tumor destruction. Blood 2008; 113: 1681-8.
    • (2008) Blood , vol.113 , pp. 1681-1688
    • Fonseca, C.1    Soiffer, R.2    Ho, V.3    Vanneman, M.4    Jinushi, M.5    Ritz, J.6
  • 222
    • 41149132390 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape
    • Katz JB, Muller AJ, Prendergast GC. Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Immunol Rev 2008; 222: 206-21.
    • (2008) Immunol Rev , vol.222 , pp. 206-221
    • Katz, J.B.1    Muller, A.J.2    Prendergast, G.C.3
  • 223
    • 17144398046 scopus 로고    scopus 로고
    • Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection
    • Guiducci C, Vicari AP, Sangaletti S, Trinchieri G, Colombo MP. Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection. Cancer Res 2005; 65: 3437-46.
    • (2005) Cancer Res , vol.65 , pp. 3437-3446
    • Guiducci, C.1    Vicari, A.P.2    Sangaletti, S.3    Trinchieri, G.4    Colombo, M.P.5
  • 224
  • 225
    • 64249124174 scopus 로고    scopus 로고
    • Regulation of angiogenesis by macrophages, dendritic cells, and circulating myelomonocytic cells
    • David Dong ZM, Aplin AC, Nicosia RF. Regulation of angiogenesis by macrophages, dendritic cells, and circulating myelomonocytic cells. Curr Pharm Des 2009; 15(4): 365-79.
    • (2009) Curr Pharm Des , vol.15 , Issue.4 , pp. 365-379
    • David Dong, Z.M.1    Aplin, A.C.2    Nicosia, R.F.3
  • 226
    • 64249106791 scopus 로고    scopus 로고
    • Cellular immunotherapy for neuroblastoma: A review of current vaccine and adoptive T cell therapeutics
    • Louis CU, Brenner MK. Cellular immunotherapy for neuroblastoma: a review of current vaccine and adoptive T cell therapeutics. Curr Pharm Des 2009; 15(4): 424-9.
    • (2009) Curr Pharm Des , vol.15 , Issue.4 , pp. 424-429
    • Louis, C.U.1    Brenner, M.K.2
  • 227
    • 64549139270 scopus 로고    scopus 로고
    • Cytokine/Antibody complexes: An emerging class of immunostimulants
    • Mostbock S. Cytokine/Antibody complexes: an emerging class of immunostimulants. Curr Pharm Des 2009; 15(7): 809-25.
    • (2009) Curr Pharm Des , vol.15 , Issue.7 , pp. 809-825
    • Mostbock, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.