A spontaneously arising pancreatic tumor does not promote the differentiation of naive CD8+ T lymphocytes into effector CTL 1

Journal of Immunology

Volumn 172, Issue 11, 2004, Pages 6558-6567

  Lyman, Michael A ^a   Aung, Sandra ^a   Biggs, Judith A ^a   Sherman, Linda A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON;

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVITY; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; HELPER CELL; INFLAMMATION; LYMPH NODE; LYMPHOCYTE CLONE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PANCREAS TUMOR; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TUMOR GROWTH;

EID: 2442661581     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.11.6558     Document Type: Article

References (50)

1. Dunn, G. P., A. T. Bruce, H. Ikeda, L. J. Old, and R. D. Schreiber. 2002. Cancer immunoediting: from immunosurveillance to tumor escape. Nat. Immunol. 3:991.
2. + T cell- and IL-2-dependent mechanism. Immunity 11:483.
3. + T cells have a major "post-licensing" role in CTL mediated anti-tumor immunity. J. Immunol. 165:6047.
4. + T cell adoptive immunotherapy. Immunity 13:265.
5. Nguyen, L. T., A. R. Elford, K. Murakami, K. M. Garza, S. P. Schoenberger, B. Odermatt, D. E. Speiser, and P. S. Ohashi. 2002. Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance. J. Exp. Med. 195:423.
6. Spiotto, M. T., P. Yu, D. A. Rowley, M. I. Nishimura, S. C. Meredith, T. F. Gajewski, Y. X. Fu, and H. Schreiber. 2002. Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells. Immunity 17:737.
7. + T cell tolerance to peripherally expressed antigens. J. Immunol. 163:723.
8. + T cells undergoing peripheral deletion in response to cross-presentation of self-antigen. J. Exp. Med. 194:707.
9. + T cells responding to self-antigens. J. Exp. Med. 196:323.
10. Heath, W. R., Kurts, C., Miller, J. F. A. P., Carbone, F. R. 1998. Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens. J. Exp. Med. 187:1549.
11. Steinman, R. M., S. Turley, I. Mellman, and K. Inaba. 2000. The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 191:411.
12. + T cells. J. Exp. Med. 186:239.
13. + T cell tolerance. Immunity 18:713.
14. + T cell tolerance. J. Exp. Med. 196:1627.
15. Liu, K., T. Iyoda, M. Saternus, Y. Kimura, K. Inaba, and R. M. Steinman. 2002. Immune tolerance after delivery of dying cells to dendritic cells in situ. J. Exp. Med. 196:1091.
16. Mellman, I., and R. M. Steinman. 2001. Dendritic cells: specialized and regulated antigen processing machines. Cell 106:255.
17. Kaisho, T., and S. Akira. 2001. Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice. Trends Immunol. 22:78.
18. Bennett, S. R., F. R. Carbone, F. Karamalis, R. A. Flavell, J. F. Miller, and W. R. Heath. 1998. Help for cytotoxic-T-cell responses is mediated by CD40 signaling. Nature 393:478.
19. + T-helper and T-killer cell. Nature 393:474.
20. Schoenberger, S. P., Toes, R. E. M., van der Voort, E. I. H., Offringe, R., Melief, J. M. 1998. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393:480.
21. Pardoll, D. 2003. Does the immune system see tumors as foreign or self? Annu. Rev. Immunol. 21:807.
22. + T cells. Eur. J. Immunol. 22:1013.
23. + cell-mediated spontaneous diabetes in neonatal mice. J. Immunol. 157:978.
24. Hanahan, D. 1985. Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315:115.
25. + single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 180:25.
26. Oehen, S., and K. Brduscha-Riem. 1998. Differentiation of naive CTL to effector and memory CTL: correlation of effector function with phenotype and cell division. J. Immunol. 161:5338.
27. Adams, T. E., S. Alpert, and D. Hanahan. 1987. Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells. Nature 325:223.
28. + T cells. J. Immunol. 172:1000.
29. + T lymphocytes that persist after peripheral tolerance to a self antigen expressed in the pancreas. J. Immunol. 164:191.
30. Curtsinger, J. M., D. C. Lins, and M. F. Mescher. 2003. Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function. J. Exp. Med. 197:1141.
31. + T cells mediate CD40-independent maturation of dendritic cells in vivo. J. Exp. Med. 189:1875.
32. + T cells: CD4-independent help. J. Immunol. 167:1283.
33. Mintern, J. D., G. M. Davey, G. T. Belz, F. R. Carbone, and W. R. Heath. 2002. Cutting edge: precursor frequency affects the helper dependence of cytotoxic T cells. J. Immunol. 168:977.
34. + T cells induce maturation of dendritic cells. J. Mol. Med. 80:533.
35. Terabe, M., S. Matsui, N. Noben-Trauth, H. Chen, C. Watson, D. D. Donaldson, D. P. Carbone, W. E. Paul, and J. A. Berzofsky. 2000. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat. Immunol. 1:515.
36. + T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163:5211.
37. Onizuka, S., I. Tawara, J. Shimizu, S. Sakaguchi, T. Fujita, and E. Nakayama. 1999. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor α) monoclonal antibody. Cancer Res. 59:3128.
38. + immunoregulatory cells. J. Immunol. 167:1137.
39. Speiser, D. E., R. Miranda, A. Zakarian, M. F. Bachmann, K. McKall-Faienza, B. Odermatt, D. Hanahan, R. M. Zinkernagel, and P. S. Ohashi. 1997. Self antigens expressed by solid tumors do not efficiently stimulate naive or activated T cells: implications for immunotherapy. J. Exp. Med. 186:645.
40. Ohashi, P. S., S. Oehen, K. Buerki, H. Pircher, C. T. Ohashi, B. Odermatt, B. Malissen, R. M. Zinkernagel, and H. Hengartner. 1991. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65:305.
41. + T cells: it may get by with a little help from its friends. J. Clin. Invest. 110:1415.
42. + T cells. Eur. J. Immunol. 32:374.
43. + cytotoxic T-cell responses during chronic viral infection. J. Virol. 68:8056.
44. + T-cell-deficient mice. J. Virol. 76:12388.
45. + T lymphocytes. Nature 421:852.
46. Shedlock, D. J., and H. Shen. 2003. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300:337.
47. Sun, J. C., and M. J. Bevan. 2003. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300:339.
48. Klein, L., L. Trautman, S. Psarras, S. Schnell, A. Siermann, R. Liblau, H. von Boehmer, and K. Khazaie. 2003. Visualizing the course of antigen-specific CD8 and CD4 T cell responses to a growing tumor. Eur. J. Immunol. 33:806.
49. + T cell memory. Science 297:2060.
50. + T cells in the antitumor immune response. J. Exp. Med. 188:2357.