Involvement of tyrosine phosphatase CD45 in apoptosis

Apoptosis

Volumn 15, Issue 1, 2010, Pages 1-13

  Dupéré Minier, Geneviève ^a   Desharnais, Philippe ^a   Bernier, Jacques ^a  

^a INRS INSTITUT ARMAND FRAPPIER   (Canada)

Author keywords

Apoptosis; CD45; DFF40; DNA fragmentation; Nuclear apoptosis; Tyrosine phosphatase

Indexed keywords

CD45 ANTIGEN; GALECTIN 1; MONOCLONAL ANTIBODY; PROTEIN TYROSINE PHOSPHATASE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; APOPTOSIS; B LYMPHOCYTE; CROSS LINKING; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LYMPHOMA; MULTIPLE MYELOMA; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SEVERE COMBINED IMMUNODEFICIENCY; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD45; APOPTOSIS; HUMANS; LYMPHOCYTES; PROTEIN ISOFORMS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77949270802     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-009-0413-z     Document Type: Review

References (149)

1. JM Penninger J Irie-Sasaki T Sasaki AJ Oliveira-dos-Santos 2001 CD45: new jobs for an old acquaintance Nat Immunol 2 389 396 1:CAS:528: DC%2BD3MXjtlShtL4%3D 11323691
2. IS Trowbridge ML Thomas 1994 CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development Annu Rev Immunol 12 85 116 1:CAS:528:DyaK2cXivFKjurg%3D 8011300
3. ML Hermiston Z Xu A Weiss 2003 CD45: a critical regulator of signaling thresholds in immune cells Annu Rev Immunol 21 107 137 1:CAS:528: DC%2BD3sXjtF2ju7c%3D 12414720
4. L McNeill RL Cassady S Sarkardei JC Cooper G Morgan DR Alexander 2004 CD45 isoforms in T cell signalling and development Immunol Lett 92 125 134 1:CAS:528:DC%2BD2cXjtV2gtrY%3D 15081536
5. LA Earl LG Baum 2008 CD45 glycosylation controls T-cell life and death Immunol Cell Biol 86 608 615 1:CAS:528:DC%2BD1cXhtF2jsrzJ 18607388
6. N Kashio W Matsumoto S Parker DM Rothstein 1998 The second domain of the CD45 protein tyrosine phosphatase is critical for interleukin-2 secretion and substrate recruitment of TCR-zeta in vivo J Biol Chem 273 33856 33863 1:CAS:528:DyaK1MXlt1c%3D 9837977
7. VB Lokeshwar LY Bourguignon 1992 Tyrosine phosphatase activity of lymphoma CD45 (GP180) is regulated by a direct interaction with the cytoskeleton J Biol Chem 267 21551 21557 1:CAS:528:DyaK38Xls12isbc%3D 1400466
8. N Iida VB Lokeshwar LY Bourguignon 1994 Mapping the fodrin binding domain in CD45, a leukocyte membrane-associated tyrosine phosphatase J Biol Chem 269 28576 28583 1:CAS:528:DyaK2cXmsV2ntL8%3D 7961804
9. K Fukuhara M Okumura H Shiono M Inoue Y Kadota S Miyoshi H Matsuda 2002 A study on CD45 isoform expression during T-cell development and selection events in the human thymus Hum Immunol 63 394 404 1:CAS:528:DC%2BD38XjtVejsL0%3D 11975983
10. E Virts D Barritt WC Raschke 1998 Expression of CD45 isoforms lacking exons 7, 8 and 10 Mol Immunol 35 167 176 1:CAS:528:DyaK1cXks12jur0%3D 9694517
11. A Symons AC Willis AN Barclay 1999 Domain organization of the extracellular region of CD45 Protein Eng 12 885 892 1:CAS:528:DyaK1MXns1yht7s%3D 10556250
12. CW Arendt HL Ostergaard 1997 Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II J Biol Chem 272 13117 13125 1:CAS:528:DyaK2sXjtlaktro%3D 9148925
13. EZ Tchilian PC Beverley 2006 Altered CD45 expression and disease Trends Immunol 27 146 153 1:CAS:528:DC%2BD28XitVeitb0%3D 16423560
14. R Majeti Z Xu TG Parslow JL Olson DI Daikh N Killeen A Weiss 2000 An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity Cell 103 1059 1070 1:CAS:528: DC%2BD3MXit1Wqtw%3D%3D 11163182
15. D Leitenberg TJ Novak D Farber BR Smith K Bottomly 1996 The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation J Exp Med 183 249 259 1:CAS:528:DyaK28XjsVCnsA%3D%3D 8551228
16. D Leitenberg Y Boutin DD Lu K Bottomly 1999 Biochemical association of CD45 with the T cell receptor complex: regulation by CD45 isoform and during T cell activation Immunity 10 701 711 1:CAS:528:DyaK1MXksVSmsb8%3D 10403645
17. I Kozieradzki T Kundig K Kishihara CJ Ong D Chiu VA Wallace K Kawai E Timms J Ionescu P Ohashi JD Marth TW Mak JM Penninger 1997 T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45 J Immunol 158 3130 3139 1:CAS:528:DyaK2sXit1Cntb4%3D 9120266
18. JT Pingel ML Thomas 1989 Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation Cell 58 1055 1065 1:CAS:528:DyaL1MXmtlShtrw%3D 2550143
19. GA Koretzky J Picus T Schultz A Weiss 1991 Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production Proc Natl Acad Sci USA 88 2037 2041 1:CAS:528:DyaK3MXhs1ais7o%3D 1672451
20. K Kishihara J Penninger VA Wallace TM Kundig K Kawai A Wakeham E Timms K Pfeffer PS Ohashi ML Thomas, et al. 1993 Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice Cell 74 143 156 1:CAS:528:DyaK3sXltlOhtbw%3D 8334701
21. KF Byth LA Conroy S Howlett AJ Smith J May DR Alexander N Holmes 1996 CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation J Exp Med 183 1707 1718 1:CAS:528:DyaK28XisFems7o%3D 8666928
22. S Trop J Charron C Arguin S Lesage P Hugo 2000 Thymic selection generates T cells expressing self-reactive TCRs in the absence of CD45 J Immunol 165 3073 3079 1:CAS:528:DC%2BD3cXmslynsb0%3D 10975818
23. GA Koretzky J Picus ML Thomas A Weiss 1990 Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway Nature 346 66 68 1:CAS:528:DyaK3cXlsFShsLc%3D 2164155
24. ND Huntington DM Tarlinton 2004 CD45: direct and indirect government of immune regulation Immunol Lett 94 167 174 1:CAS:528:DC%2BD2cXlvFyrsL8%3D 15275963
25. SM Thomas JS Brugge 1997 Cellular functions regulated by Src family kinases Annu Rev Cell Dev Biol 13 513 609 1:CAS:528:DyaK1cXisFSrsQ%3D%3D 9442882
26. CM Cale NJ Klein V Novelli P Veys AM Jones G Morgan 1997 Severe combined immunodeficiency with abnormalities in expression of the common leucocyte antigen, CD45 Arch Dis Child 76 163 164 1:STN:280:DyaK2s3itFaltw%3D%3D 9068311
27. C Kung JT Pingel M Heikinheimo T Klemola K Varkila LI Yoo K Vuopala M Poyhonen M Uhari M Rogers SH Speck T Chatila ML Thomas 2000 Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease Nat Med 6 343 345 1:CAS:528:DC%2BD3cXhslygs7k%3D 10700239
28. EZ Tchilian DL Wallace RS Wells DR Flower G Morgan PC Beverley 2001 A deletion in the gene encoding the CD45 antigen in a patient with SCID J Immunol 166 1308 1313 1:CAS:528:DC%2BD3MXlvVWmuw%3D%3D 11145714
29. PJ Mee M Turner MA Basson PS Costello R Zamoyska VL Tybulewicz 1999 Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice Eur J Immunol 29 2923 2933 1:CAS:528:DyaK1MXlvFOqtbg%3D 10508267
30. JD Ashwell U D'Oro 1999 CD45 and Src-family kinases: and now for something completely different Immunol Today 20 412 416 1:CAS:528: DyaK1MXls1ygt7Y%3D 10462741
31. ML Thomas EJ Brown 1999 Positive and negative regulation of Src-family membrane kinases by CD45 Immunol Today 20 406 411 1:CAS:528:DyaK1MXls1ygt7g%3D 10462740
32. JR Seavitt LS White KM Murphy DY Loh RM Perlmutter ML Thomas 1999 Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development Mol Cell Biol 19 4200 4208 1:CAS:528:DyaK1MXjt1yju74%3D 10330160
33. JA Frearson DR Alexander 1996 Protein tyrosine phosphatases in T-cell development, apoptosis and signalling Immunol Today 17 385 391 1:CAS:528:DyaK28XkvFGktbg%3D 8783500
34. T Mustelin S Williams P Tailor C Couture G Zenner P Burn JD Ashwell A Altman 1995 Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase Eur J Immunol 25 942 946 1:CAS:528: DyaK2MXltFOmsbk%3D 7737297
35. J Irie-Sasaki T Sasaki W Matsumoto A Opavsky M Cheng G Welstead E Griffiths C Krawczyk CD Richardson K Aitken N Iscove G Koretzky P Johnson P Liu DM Rothstein JM Penninger 2001 CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling Nature 409 349 354 1:CAS:528: DC%2BD3MXms12lug%3D%3D 11201744
36. S Kirchberger O Majdic S Bluml C Schrauf J Leitner C Gerner W Paster N Gundacker M Sibilia J Stockl 2008 The cytoplasmic tail of CD45 is released from activated phagocytes and can act as an inhibitory messenger for T cells Blood 112 1240 1248 1:CAS:528:DC%2BD1cXpvVOkt70%3D 18511809
37. A Yamada M Streuli H Saito DM Rothstein SF Schlossman C Morimoto 1990 Effect of activation of protein kinase C on CD45 isoform expression and CD45 protein tyrosine phosphatase activity in T cells Eur J Immunol 20 1655 1660 1:CAS:528:DyaK3cXmtV2nurY%3D 2170146
38. DR Stover H Charbonneau NK Tonks KA Walsh 1991 Protein-tyrosine- phosphatase CD45 is phosphorylated transiently on tyrosine upon activation of Jurkat T cells Proc Natl Acad Sci USA 88 7704 7707 1:CAS:528:DyaK3MXlvVSqurk%3D 1652760
39. HL Ostergaard IS Trowbridge 1991 Negative regulation of CD45 protein tyrosine phosphatase activity by ionomycin in T cells Science 253 1423 1425 1:CAS:528:DyaK3MXmtVGnurw%3D 1654595
40. Y Wang W Guo L Liang WJ Esselman 1999 Phosphorylation of CD45 by casein kinase 2. Modulation of activity and mutational analysis J Biol Chem 274 7454 7461 1:CAS:528:DyaK1MXhvFWqu7s%3D 10066810
41. SF Greer Y Wang C Raman LB Justement 2001 CD45 function is regulated by an acidic 19-amino acid insert in domain II that serves as a binding and phosphoacceptor site for casein kinase 2 J Immunol 166 7208 7218 1:CAS:528:DC%2BD3MXksVOntbc%3D 11390469
42. S Motoya K Kitamura A Matsuda AL Maizel H Yamamoto A Takeda 1999 Interaction between CD45-AP and protein-tyrosine kinases involved in T cell receptor signaling J Biol Chem 274 1407 1414 1:CAS:528:DyaK1MXpsFOjtA%3D%3D 9880514
43. R Majeti AM Bilwes JP Noel T Hunter A Weiss 1998 Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge Science 279 88 91 1:CAS:528:DyaK1cXjtVansg%3D%3D 9417031 (Pubitemid 28079161)
44. DM Desai J Sap J Schlessinger A Weiss 1993 Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase Cell 73 541 554 1:CAS:528:DyaK3sXksVOgs7c%3D 8490965
45. AM Bilwes J den Hertog T Hunter JP Noel 1996 Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization Nature 382 555 559 1:CAS:528:DyaK28XkvFGjtL8%3D 8700232
46. TJ Novak D Farber D Leitenberg SC Hong P Johnson K Bottomly 1994 Isoforms of the transmembrane tyrosine phosphatase CD45 differentially affect T cell recognition Immunity 1 109 119 1:CAS:528:DyaK2cXmvFylsbk%3D 7889403
47. S Dornan Z Sebestyen J Gamble P Nagy A Bodnar L Alldridge S Doe N Holmes LK Goff P Beverley J Szollosi DR Alexander 2002 Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction J Biol Chem 277 1912 1918 1:CAS:528:DC%2BD38XosFegtg%3D%3D 11694532
48. Z Xu A Weiss 2002 Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms Nat Immunol 3 764 771 1:CAS:528:DC%2BD38Xls1Snu7o%3D 12134145
49. N Holmes 2006 CD45: all is not yet crystal clear Immunology 117 145 155 1:CAS:528:DC%2BD28Xit1Siuro%3D 16423050
50. ML Birkeland P Johnson IS Trowbridge E Pure 1989 Changes in CD45 isoform expression accompany antigen-induced murine T-cell activation Proc Natl Acad Sci USA 86 6734 6738 1:CAS:528:DyaL1MXlsFWlt70%3D 2528147
51. HJ Nam F Poy H Saito CA Frederick 2005 Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45 J Exp Med 201 441 452 1:CAS:528:DC%2BD2MXhtlegs7c%3D 15684325
52. JC Reed 2000 Mechanisms of apoptosis Am J Pathol 157 1415 1430 1:CAS:528:DC%2BD3cXosFyiu7w%3D 11073801
53. MO Hengartner 2000 The biochemistry of apoptosis Nature 407 770 776 1:CAS:528:DC%2BD3cXnsFWrsLc%3D 11048727
54. E Gulbins A Jekle K Ferlinz H Grassme F Lang 2000 Physiology of apoptosis Am J Physiol Renal Physiol 279 F605 F615 1:CAS:528:DC%2BD3cXns1egurs%3D 10997910
55. P Widlak 2000 The DFF40/CAD endonuclease and its role in apoptosis Acta Biochim Pol 47 1037 1044 1:CAS:528:DC%2BD3MXhsVWqsbk%3D 11996094
56. MG Blaylock DW Sexton GM Walsh 1999 Ligation of CD45 and the isoforms CD45RA and CD45RB accelerates the rate of constitutive apoptosis in human eosinophils J Allergy Clin Immunol 104 1244 1250 1:CAS:528: DC%2BD3cXjt1yjug%3D%3D 10589008
57. S Lesage AM Steff F Philippoussis M Page S Trop V Mateo P Hugo 1997 CD4+CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway J Immunol 159 4762 4771 1:CAS:528:DyaK2sXntlKnt70%3D 9366400
58. M Ogimoto T Katagiri K Mashima K Hasegawa K Mizuno H Yakura 1994 Negative regulation of apoptotic death in immature B cells by CD45 Int Immunol 6 647 654 1:CAS:528:DyaK2cXktVKrt78%3D 8018601
59. SJ Klaus SP Sidorenko EA Clark 1996 CD45 ligation induces programmed cell death in T and B lymphocytes J Immunol 156 2743 2753 1:CAS:528: DyaK28Xit1eit7c%3D 8609392
60. M Fortin AM Steff J Felberg I Ding B Schraven P Johnson P Hugo 2002 Apoptosis mediated through CD45 is independent of its phosphatase activity and association with leukocyte phosphatase-associated phosphoprotein J Immunol 168 6084 6089 1:CAS:528:DC%2BD38XksFWmtrg%3D 12055218
61. N Blank M Kriegel T Hieronymus T Geiler S Winkler JR Kalden HM Lorenz 2001 CD45 tyrosine phosphatase controls common gamma-chain cytokine-mediated STAT and extracellular signal-related kinase phosphorylation in activated human lymphoblasts: inhibition of proliferation without induction of apoptosis J Immunol 166 6034 6040 1:CAS:528:DC%2BD3MXjsFCqsL0%3D 11342620
62. V Vas R Fajka-Boja G Ion V Dudics E Monostori F Uher 2005 Biphasic effect of recombinant galectin-1 on the growth and death of early hematopoietic cells Stem Cells 23 279 287 1:CAS:528:DC%2BD2MXit1Gktrg%3D 15671150
63. NL Perillo ME Marcus LG Baum 1998 Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death J Mol Med 76 402 412 1:CAS:528:DyaK1cXjsleku7k%3D 9625297
64. A Symons DN Cooper AN Barclay 2000 Characterization of the interaction between galectin-1 and lymphocyte glycoproteins CD45 and Thy-1 Glycobiology 10 559 563 1:CAS:528:DC%2BD3cXktF2qsL0%3D 10814697
65. JT Nguyen DP Evans M Galvan KE Pace D Leitenberg TN Bui LG Baum 2001 CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycans J Immunol 167 5697 5707 1:CAS:528:DC%2BD3MXotlamtLk%3D 11698442
66. NL Perillo KE Pace JJ Seilhamer LG Baum 1995 Apoptosis of T cells mediated by galectin-1 Nature 378 736 739 1:CAS:528:DyaK2MXhtVSnt7vI 7501023
67. NL Perillo CH Uittenbogaart JT Nguyen LG Baum 1997 Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes J Exp Med 185 1851 1858 1:CAS:528:DyaK2sXjsFeisLg%3D 9151710
68. GN Vespa LA Lewis KR Kozak M Moran JT Nguyen LG Baum MC Miceli 1999 Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation J Immunol 162 799 806 1:CAS:528:DyaK1MXovFOrsg%3D%3D 9916701
69. H Walzel U Schulz P Neels J Brock 1999 Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45 Immunol Lett 67 193 202 1:CAS:528:DyaK1MXis1aqs7s%3D 10369126
70. M Pang J He P Johnson LG Baum 2009 CD45-mediated fodrin cleavage during galectin-1 T cell death promotes phagocytic clearance of dying cells J Immunol 182 7001 7008 1:CAS:528:DC%2BD1MXmtVKqsLY%3D 19454697
71. VA Wallace WP Fung-Leung E Timms D Gray K Kishihara DY Loh J Penninger TW Mak 1992 CD45RA and CD45RB high expression induced by thymic selection events J Exp Med 176 1657 1663 1:STN:280:DyaK3s%2FpsVOksw%3D%3D 1460424
72. LG Baum M Pang NL Perillo T Wu A Delegeane CH Uittenbogaart M Fukuda JJ Seilhamer 1995 Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells J Exp Med 181 877 887 1:CAS:528:DyaK2MXjvVWltLg%3D 7869048
73. GA Rabinovich RE Ramhorst N Rubinstein A Corigliano MC Daroqui EB Kier-Joffe L Fainboim 2002 Induction of allogenic T-cell hyporesponsiveness by galectin-1-mediated apoptotic and non-apoptotic mechanisms Cell Death Differ 9 661 670 1:CAS:528:DC%2BD38Xlt1Cls7c%3D 12032675
74. R Fajka-Boja M Szemes G Ion A Legradi M Caron E Monostori 2002 Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not mediate its apoptotic signal in T cell lines Immunol Lett 82 149 154 1:CAS:528:DC%2BD38XjsVSqu7c%3D 12008046
75. KE Pace C Lee PL Stewart LG Baum 1999 Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1 J Immunol 163 3801 3811 1:CAS:528:DyaK1MXmt1yjurg%3D 10490978
76. JM Serrador M Nieto JL Alonso-Lebrero MA del Pozo J Calvo H Furthmayr R Schwartz-Albiez F Lozano R Gonzalez-Amaro P Sanchez-Mateos F Sanchez-Madrid 1998 CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts Blood 91 4632 4644 1:CAS:528:DyaK1cXjvVGht7k%3D 9616160
77. M Amano M Galvan J He LG Baum 2003 The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death J Biol Chem 278 7469 7475 1:CAS:528:DC%2BD3sXhsVKitLo%3D 12499376
78. M Fouillit R Joubert-Caron F Poirier P Bourin E Monostori M Levi-Strauss M Raphael D Bladier M Caron 2000 Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells Glycobiology 10 413 419 1:CAS:528:DC%2BD3cXit1yisrc%3D 10764829
79. BN Stillman DK Hsu M Pang CF Brewer P Johnson FT Liu LG Baum 2006 Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death J Immunol 176 778 789 1:CAS:528:DC%2BD28Xht1Cqtg%3D%3D 16393961
80. S Bi LA Earl L Jacobs LG Baum 2008 Structural features of galectin-9 and galectin-1 that determine distinct T cell death pathways J Biol Chem 283 12248 12258 1:CAS:528:DC%2BD1cXltVyrtb4%3D 18258591
81. J Wada K Ota A Kumar EI Wallner YS Kanwar 1997 Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin J Clin Invest 99 2452 2461 1:CAS:528:DyaK2sXjsVGqtrc%3D 9153289
82. D Sgroi A Varki S Braesch-Andersen I Stamenkovic 1993 CD22, a B cell-specific immunoglobulin superfamily member, is a sialic acid-binding lectin J Biol Chem 268 7011 7018 1:CAS:528:DyaK3sXktVKkt7k%3D 8463234
83. D Sgroi GA Koretzky I Stamenkovic 1995 Regulation of CD45 engagement by the B-cell receptor CD22 Proc Natl Acad Sci USA 92 4026 4030 1:CAS:528:DyaK2MXlsVSksb0%3D 7537381
84. P Altevogt J Schreck B Schraven S Meuer V Schirrmacher A Mitsch 1990 Association of CD2 and T200 (CD45) in mouse T lymphocytes Int Immunol 2 353 360 1:STN:280:DyaK3M7itVGgtg%3D%3D 1980615 (Pubitemid 20150942)
85. BY Ma K Yoshida M Baba M Nonaka S Matsumoto N Kawasaki S Asano T Kawasaki 2009 The lectin Jacalin induces human B-lymphocyte apoptosis through glycosylation-dependent interaction with CD45 Immunology 127 477 488 1:CAS:528:DC%2BD1MXptFeiurg%3D 19175793
86. M Baba B Yong Ma M Nonaka Y Matsuishi M Hirano N Nakamura N Kawasaki N Kawasaki T Kawasaki 2007 Glycosylation-dependent interaction of Jacalin with CD45 induces T lymphocyte activation and Th1/Th2 cytokine secretion J Leukoc Biol 81 1002 1011 1:CAS:528:DC%2BD2sXkt1Oit7s%3D 17242371
87. CM Eischen CJ Dick PJ Leibson 1994 Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis J Immunol 153 1947 1954 1:CAS:528:DyaK2cXlslOls7g%3D 7519637
88. L Zhong CH Wu WH Lee CP Liu 2004 Zeta-associated protein of 70 kDa (ZAP-70), but not Syk, tyrosine kinase can mediate apoptosis of T cells through the Fas/Fas ligand, caspase-8 and caspase-3 pathways J Immunol 172 1472 1482 1:CAS:528:DC%2BD2cXptlyrsQ%3D%3D 14734724
89. I Szabo E Gulbins H Apfel X Zhang P Barth AE Busch K Schlottmann O Pongs F Lang 1996 Tyrosine phosphorylation-dependent suppression of a voltage-gated K+ channel in T lymphocytes upon Fas stimulation J Biol Chem 271 20465 20469 1:CAS:528:DyaK28Xlt1ygurY%3D 8702786
90. SP Hehner TG Hofmann F Ratter W Droge ML Schmitz 1999 Inhibition of tyrosine phosphatases antagonizes CD95-mediated apoptosis Eur J Biochem 264 132 139 1:CAS:528:DyaK1MXlsVyrt7s%3D 10447681 (Pubitemid 29385875)
91. B Schraven ME Peter 1995 APO-1(CD95)-mediated apoptosis in Jurkat cells does not involve src kinases or CD45 FEBS Lett 368 491 494 1:CAS:528: DyaK2MXntl2hu7Y%3D 7543423
92. KM Latinis GA Koretzky 1996 Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells Blood 87 871 875 1:CAS:528:DyaK28XnsFGhsQ%3D%3D 8562955
93. JJ Bleesing MR Morrow G Uzel TA Fleisher 2001 Human T cell activation induces the expression of a novel CD45 isoform that is analogous to murine B220 and is associated with altered O-glycan synthesis and onset of apoptosis Cell Immunol 213 72 81 1:CAS:528:DC%2BD3MXptFWrtL0%3D 11747358
94. DR Alexander 2000 The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function Semin Immunol 12 349 359 1:CAS:528: DC%2BD3cXmsFKlsbk%3D 10995582
95. ME Peter S Hellbardt R Schwartz-Albiez MO Westendorp H Walczak G Moldenhauer M Grell PH Krammer 1995 Cell surface sialylation plays a role in modulating sensitivity towards APO-1-mediated apoptotic cell death Cell Death Differ 2 163 171 1:CAS:528:DyaK2MXnslSjtLY%3D 17180039
96. OT Keppler ME Peter S Hinderlich G Moldenhauer P Stehling I Schmitz R Schwartz-Albiez W Reutter M Pawlita 1999 Differential sialylation of cell surface glycoconjugates in a human B lymphoma cell line regulates susceptibility for CD95 (APO-1/Fas)-mediated apoptosis and for infection by a lymphotropic virus Glycobiology 9 557 569 1:CAS:528:DyaK1MXjtlKgs7c%3D 10336988
97. G Dupere-Minier C Hamelin P Desharnais J Bernier 2004 Apoptotic volume decrease, pH acidification and chloride channel activation during apoptosis requires CD45 expression in HPB-ALL T cells Apoptosis 9 543 551 1:CAS:528:DC%2BD2cXms12isbo%3D 15314282
98. P Desharnais G Dupere-Minier C Hamelin P Devine J Bernier 2008 Involvement of CD45 in DNA fragmentation in apoptosis induced by mitochondrial perturbing agents Apoptosis 13 197 212 1:CAS:528:DC%2BD1cXht1SisLY%3D 18157742
99. M Raffray GM Cohen 1993 Thymocyte apoptosis as a mechanism for tributyltin-induced thymic atrophy in vivo Arch Toxicol 67 231 236 1:CAS:528:DyaK3sXksVaqu74%3D 8517778
100. A Gennari M Potters W Seinen R Pieters 1997 Organotin-induced apoptosis as observed in vitro is not relevant for induction of thymus atrophy at antiproliferative doses Toxicol Appl Pharmacol 147 259 266 1:CAS:528: DyaK1cXjt1ShsA%3D%3D 9439721
101. H Stridh M Kimland DP Jones S Orrenius MB Hampton 1998 Cytochrome c release and caspase activation in hydrogen peroxide- and tributyltin-induced apoptosis FEBS Lett 429 351 355 1:CAS:528:DyaK1cXjvFOhsr8%3D 9662447
102. H Stridh S Orrenius MB Hampton 1999 Caspase involvement in the induction of apoptosis by the environmental toxicants tributyltin and triphenyltin Toxicol Appl Pharmacol 156 141 146 1:CAS:528:DyaK1MXit1yktLk%3D 10198279
103. TA Thompson JM Lewis NS Dejneka WB Severs R Polavarapu ML Billingsley 1996 Induction of apoptosis by organotin compounds in vitro: neuronal protection with antisense oligonucleotides directed against stannin J Pharmacol Exp Ther 276 1201 1216 1:CAS:528:DyaK28XhslSgurw%3D 8786553
104. E Maeno Y Ishizaki T Kanaseki A Hazama Y Okada 2000 Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis Proc Natl Acad Sci USA 97 9487 9492 1:CAS:528:DC%2BD3cXmtVensLw%3D 10900263
105. I Szabo A Lepple-Wienhues KN Kaba M Zoratti E Gulbins F Lang 1998 Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes Proc Natl Acad Sci USA 95 6169 6174 1:CAS:528:DyaK1cXjtlKnsbk%3D 9600936
106. GW Meisenholder SJ Martin DR Green J Nordberg BM Babior RA Gottlieb 1996 Events in apoptosis. Acidification is downstream of protease activation and BCL-2 protection J Biol Chem 271 16260 16262 1:CAS:528:DyaK28XktFahtrw%3D 8663307
107. JI Elliott A Surprenant FM Marelli-Berg JC Cooper RL Cassady-Cain C Wooding K Linton DR Alexander CF Higgins 2005 Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes Nat Cell Biol 7 808 816 1:CAS:528:DC%2BD2MXmvVClur4%3D 16025105
108. JI Elliott A Sardini JC Cooper DR Alexander S Davanture G Chimini CF Higgins 2006 Phosphatidylserine exposure in B lymphocytes: a role for lipid packing Blood 108 1611 1617 1:CAS:528:DC%2BD28Xpt1Sltb8%3D 16684961
109. Y Okada E Maeno 2001 Apoptosis, cell volume regulation and volume-regulatory chloride channels Comp Biochem Physiol A Mol Integr Physiol 130 377 383 1:STN:280:DC%2BD387nvFOktQ%3D%3D 11913451
110. K Kawane H Fukuyama H Yoshida H Nagase Y Ohsawa Y Uchiyama K Okada T Iida S Nagata 2003 Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation Nat Immunol 4 138 144 1:CAS:528:DC%2BD3sXmslKjtQ%3D%3D 12524536
111. A Lepple-Wienhues I Szabo T Laun NK Kaba E Gulbins F Lang 1998 The tyrosine kinase p56lck mediates activation of swelling-induced chloride channels in lymphocytes J Cell Biol 141 281 286 1:CAS:528:DyaK1cXis1ejsL4%3D 9531565
112. JC Edwards S Kapadia 2000 Regulation of the bovine kidney microsomal chloride channel p64 by p59fyn, a Src family tyrosine kinase J Biol Chem 275 31826 31832 1:CAS:528:DC%2BD3cXnsFejs78%3D 10930415
113. U D'Oro JD Ashwell 1999 Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes J Immunol 162 1879 1883 9973453
114. YG Hur Y Yun J Won 2004 Rosmarinic acid induces p56lck-dependent apoptosis in Jurkat and peripheral T cells via mitochondrial pathway independent from Fas/Fas ligand interaction J Immunol 172 79 87 1:CAS:528: DC%2BD3sXpvFegsb4%3D 14688312
115. SK Manna NK Sah BB Aggarwal 2000 Protein tyrosine kinase p56lck is required for ceramide-induced but not tumor necrosis factor-induced activation of NF-kappa B, AP-1, JNK, and apoptosis J Biol Chem 275 13297 13306 1:CAS:528:DC%2BD3cXjtFyksLg%3D 10788436
116. E Sharif-Askari D Gaucher R Halwani J Ma K Jao A Abdallah EK Haddad RP Sekaly 2007 p56Lck tyrosine kinase enhances the assembly of death-inducing signaling complex during Fas-mediated apoptosis J Biol Chem 282 36048 36056 1:CAS:528:DC%2BD2sXhtlKrsbvL 17932036
117. AR Anand RK Ganju 2006 HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45 J Biol Chem 281 12289 12299 1:CAS:528:DC%2BD28XjvFKksro%3D 16524887
118. S Liu H Ishikawa N Tsuyama FJ Li S Abroun KI Otsuyama X Zheng Z Ma Y Maki MS Iqbal M Obata MM Kawano 2006 Increased susceptibility to apoptosis in CD45(+) myeloma cells accompanied by the increased expression of VDAC1 Oncogene 25 419 429 1:CAS:528:DC%2BD28Xlt1ehsg%3D%3D 16247487
119. DJ Shedlock D Hwang AY Choo CW Chung K Muthumani DB Weiner 2008 HIV-1 viral genes and mitochondrial apoptosis Apoptosis 13 1088 1099 1:CAS:528:DC%2BD1cXps1ajsLw%3D 18622704
120. C Guntermann N Amft BJ Murphy KE Nye 1998 Impaired CD45-associated tyrosine phosphatase activity during HIV-1 infection: implications for CD3 and CD4 receptor signalling Biochem Biophys Res Commun 252 69 77 1:CAS:528:DyaK1cXnsVKnurw%3D 9813148
121. A Giovannetti M Pierdominici F Mazzetta AM Mazzone G Ricci A Prozzo F Pandolfi R Paganelli F Aiuti 2000 HIV type 1-induced inhibition of CD45 tyrosine phosphatase activity correlates with disease progression and apoptosis, but not with anti-CD3-induced T cell proliferation AIDS Res Hum Retroviruses 16 211 219 1:CAS:528:DC%2BD3cXhvVyhsL8%3D 10710209
122. AA Azad 2000 Could Nef and Vpr proteins contribute to disease progression by promoting depletion of bystander cells and prolonged survival of HIV-infected cells? Biochem Biophys Res Commun 267 677 685 1:CAS:528: DC%2BD3cXhtVKmsrg%3D 10673351
123. M Roshal Y Zhu V Planelles 2001 Apoptosis in AIDS Apoptosis 6 103 116 1:CAS:528:DC%2BD3MXivVGrsLs%3D 11321033
124. NK Banda J Bernier DK Kurahara R Kurrle N Haigwood RP Sekaly TH Finkel 1992 Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis J Exp Med 176 1099 1106 1:CAS:528: DyaK38Xls12gsb0%3D 1402655
125. MO Westendorp R Frank C Ochsenbauer K Stricker J Dhein H Walczak KM Debatin PH Krammer 1995 Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120 Nature 375 497 500 1:STN:280:DyaK2M3psFygsA%3D%3D 7539892
126. A Mamoune A Saraux JL Delaunay P Le Goff P Youinou R Le Corre 1998 Autoantibodies to CD45 in systemic lupus erythematosus J Autoimmun 11 485 488 1:STN:280:DyaK1M%2FitFGrtA%3D%3D 9802933 (Pubitemid 28520205)
127. A Mamoune S Kerdreux V Durand A Saraux PL Goff P Youinou RL Corre 2000 CD45 autoantibodies mediate neutralization of activated T cells from lupus patients through anergy or apoptosis Lupus 9 622 631 1:CAS:528: DC%2BD3cXnsFCitbc%3D 11035438
128. J Tan T Town T Mori Y Wu M Saxe F Crawford M Mullan 2000 CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase J Neurosci 20 7587 7594 1:CAS:528: DC%2BD3cXns1eisLw%3D 11027218
129. J Tan T Town M Mullan 2000 CD45 inhibits CD40L-induced microglial activation via negative regulation of the Src/p44/42 MAPK pathway J Biol Chem 275 37224 37231 1:CAS:528:DC%2BD3cXoslWltL8%3D 10978311
130. R Ratei C Sperling L Karawajew G Schott M Schrappe J Harbott H Riehm WD Ludwig 1998 Immunophenotype and clinical characteristics of CD45-negative and CD45-positive childhood acute lymphoblastic leukemia Ann Hematol 77 107 114 1:STN:280:DyaK1M%2FhtFWjsQ%3D%3D 9797079 (Pubitemid 28434902)
131. M Ozdemirli HJ Mankin AC Aisenberg NL Harris 1996 Hodgkin's disease presenting as a solitary bone tumor. A report of four cases and review of the literature Cancer 77 79 88 1:STN:280:DyaK283itlegtw%3D%3D 8630944
132. H Ishikawa MS Mahmoud R Fujii S Abroun MM Kawano 2000 Proliferation of immature myeloma cells by interleukin-6 is associated with CD45 expression in human multiple myeloma Leuk Lymphoma 39 51 55 1:CAS:528:DC%2BD3MXht1ygu78%3D 10975383
133. S Kumar SV Rajkumar T Kimlinger PR Greipp TE Witzig 2005 CD45 expression by bone marrow plasma cells in multiple myeloma: clinical and biological correlations Leukemia 19 1466 1470 1:CAS:528:DC%2BD2MXmtlSjs7w%3D 15959533
134. K Asosingh A Willems I Van Riet B Van Camp K Vanderkerken 2003 Delayed in vivo disease progression is associated with high proportions of CD45+ myeloma cells in the 5T2MM murine model Cancer Res 63 3019 3020 1:CAS:528: DC%2BD3sXks1eit7g%3D 12810619
135. P Moreau N Robillard H Avet-Loiseau D Pineau N Morineau N Milpied JL Harousseau R Bataille 2004 Patients with CD45 negative multiple myeloma receiving high-dose therapy have a shorter survival than those with CD45 positive multiple myeloma Haematologica 89 547 551 15136217
136. A de la Taille MW Chen M Burchardt DK Chopin R Buttyan 1999 Apoptotic conversion: evidence for exchange of genetic information between prostate cancer cells mediated by apoptosis Cancer Res 59 5461 5463 10554018
137. S Nagata 2000 Apoptotic DNA fragmentation Exp Cell Res 256 12 18 1:CAS:528:DC%2BD3cXitVajs7c%3D 10739646
138. C Friesen G Glatting B Koop K Schwarz A Morgenstern C Apostolidis KM Debatin SN Reske 2007 Breaking chemoresistance and radioresistance with anti-CD45 antibodies in leukemia cells Cancer Res 67 1950 1958 1:CAS:528:DC%2BD2sXit12qurs%3D 17332322
139. JM Pagel N Hedin L Drouet BL Wood A Pantelias Y Lin DK Hamlin DS Wilbur AK Gopal D Green FR Appelbaum OW Press 2008 Eradication of disseminated leukemia in a syngeneic murine leukemia model using pretargeted anti-CD45 radioimmunotherapy Blood 111 2261 2268 1:CAS:528:DC%2BD1cXisVeit7s%3D 18042793
140. G Descamps C Pellat-Deceunynck Y Szpak R Bataille N Robillard M Amiot 2004 The magnitude of Akt/phosphatidylinositol 3′-kinase proliferating signaling is related to CD45 expression in human myeloma cells J Immunol 173 4953 4959 1:CAS:528:DC%2BD2cXotFCqtbY%3D 15470037
141. L del Peso M Gonzalez-Garcia C Page R Herrera G Nunez 1997 Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt Science 278 687 689 1:CAS:528:DyaK2sXmvVyns7o%3D 9381178
142. E Fujita A Jinbo H Matuzaki H Konishi U Kikkawa T Momoi 1999 Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9 Biochem Biophys Res Commun 264 550 555 1:CAS:528:DyaK1MXms12qsrw%3D 10529400
143. HC Dan M Sun S Kaneko RI Feldman SV Nicosia HG Wang BK Tsang JQ Cheng 2004 Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP) J Biol Chem 279 5405 5412 1:CAS:528:DC%2BD2cXhtFeqtL8%3D 14645242
144. PK Majumder P Pandey X Sun K Cheng R Datta S Saxena S Kharbanda D Kufe 2000 Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis J Biol Chem 275 21793 21796 1:CAS:528:DC%2BD3cXltFGjtrk%3D 10818086
145. T Cross G Griffiths E Deacon R Sallis M Gough D Watters JM Lord 2000 PKC-delta is an apoptotic lamin kinase Oncogene 19 2331 2337 1:CAS:528:DC%2BD3cXjslelsLY%3D 10822384
146. A Bharti SK Kraeft M Gounder P Pandey S Jin ZM Yuan SP Lees-Miller R Weichselbaum D Weaver LB Chen D Kufe S Kharbanda 1998 Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis Mol Cell Biol 18 6719 6728 1:CAS:528:DyaK1cXmvF2nsLw%3D 9774685
147. X Wang JL Martindale NJ Holbrook 2000 Requirement for ERK activation in cisplatin-induced apoptosis J Biol Chem 275 39435 39443 1:CAS:528: DC%2BD3cXptFSrtr0%3D 10993883
148. M Alvarado-Kristensson F Melander K Leandersson L Ronnstrand C Wernstedt T Andersson 2004 p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils J Exp Med 199 449 458 1:CAS:528: DC%2BD2cXhsFKhurs%3D 14970175
149. C Yu Y Minemoto J Zhang J Liu F Tang TN Bui J Xiang A Lin 2004 JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD Mol Cell 13 329 340 1:CAS:528:DC%2BD2cXhs1CgtrY%3D 14967141