Proliferation of immature myeloma cells by interleukin-6 is associated with CD45 expression in human multiple myeloma

Leukemia and Lymphoma

Volumn 39, Issue 1-2, 2000, Pages 51-55

  Ishikawa, H ^a   Mahmoud, M S ^a   Fujii, R ^a   Abroun, S ^a   Kawano, M M ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CD45; Immature myeloma cells; Interleukin 6; Multiple myeloma

Indexed keywords

CD38 ANTIGEN; CD45 ANTIGEN; INTERLEUKIN 6;

ANTIGEN EXPRESSION; CELL HETEROGENEITY; CELL MATURATION; CELL PROLIFERATION; CELL SUBPOPULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; MYELOMA CELL; PATHOGENESIS; PHENOTYPE; PLASMA CELL; PRIORITY JOURNAL; REVIEW;

EID: 0033842074     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428190009053538     Document Type: Review

References (28)

1. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
2. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
3. Identification of immature and mature myeloma cells in the bone marrow of human myeloma
4. Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice
5. Interleukin 6 is essential for in vivo development of B lineage neoplasms
6. Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c mice
7. Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients
8. IL-6 induced homodimerization of gp 130 and associated activation of a tyrosine kinase
9. Activation of JAK2 kinase by the interleukin 6 signal transducer gp130
10. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp 130
11. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6β receptor components
12. Involvement of Janus kinases, p52 Shc, Raf-1, and MEK-1 in the IL-6 induced mitogen-activated protein kinase cascade of a growth-responsive B cell line
13. Signaling by the cytokine receptor superfamily: JAKs and STATs
14. Activation of transcription by IFN-γ: Tyrosine phosphorylation of a 91-kD DNA binding protein
15. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
16. IL-6 induces tyrosine phosphorylation of the Ras activating protein Shc, and its complex formation with Grb2 in the human multiple myeloma cell line LP-1
17. Differentiation factors, including nerve growth factor, fibroblast growth factor, and Interleukin-6, induce an accumulation of an active Ras-GTP complex in rat pheochromocytoma PC12 cells
18. Establishment of a CD45-positive immature plasma cell line from an aggressive multiple myeloma with high serum lactate dehydrogenase
19. Detection of myeloma cells in the peripheral blood by flow cytometry
20. The labelling index of primitive plasma cells determines the clinical behaviour of patients with myelomatosis
21. Two subsets of peripheral blood plasma cells defined by differential expression of CD45 antigen
22. + subpopulations that can proliferate in response to IL-6 in human myelomas
23. Induction of CD45 expression and proliferation in U-266 myeloma cell line by interleukin-6
24. Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens
25. CD45: An emerging role as a protein phosphatase required for lymphocyte activation and development
26. Normal B lymphocyte development but impaired T cell maturation in CD45-exon 6 protein tyrosine phosphatase-deficient mice
27. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45
28. Enforced CD19 expression leads to growth inhibition and reduced tumorigenicity