CD45: All is not yet crystal clear

Immunology

Volumn 117, Issue 2, 2006, Pages 145-155

  Holmes, Nick ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

CD45; Isoforms; Phosphatase; Polymorphism; Protein structure

Indexed keywords

CD45 ANTIGEN; ISOENZYME; ISOPROTEIN; PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE;

AMINO ACID SUBSTITUTION; AUTOIMMUNE HEPATITIS; ENZYME ACTIVITY; GENE LOCUS; GENE STRUCTURE; GENETIC SUSCEPTIBILITY; GRAVES DISEASE; HETEROZYGOSITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MULTIPLE SCLEROSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURE ANALYSIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANTIGENS, CD45; EVOLUTION, MOLECULAR; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ISOENZYMES; POLYMORPHISM, GENETIC; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION;

EID: 33645071581     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2005.02265.x     Document Type: Review

References (105)

1. Hermiston ML Xu Z Weiss A CD45: a critical regulator of signaling thresholds in immune cells Annu Rev Immunol 2003 21 107 37
2. Alexander DR The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function Semin Immunol 2000 12 349 59
3. Nam H-J Poy F Saito H Frederick CA Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45 J Exp Med 2005 201 441 52
4. Okumara M Matthews RJ Robb B Litman GW Bork P Thomas ML Comparison of CD45 extracellular domain sequences from divergent vertebrate species suggestes the conservation of three fibronectin type III domains J Immunol 1996 157 1569 75
5. Nagata T Suzuki T Ohta Y Flajnik MF Kasahara M The leukocyte common antigen (CD45) of the Pacific Hagfish, Eptatretus stoutii: implications for the primordial function of CD45 Immunogenetics 2002 54 286 91
6. Symons A Willis AC Barclay AN Domain organisation of the extracellular region of CD45 Protein Eng 1999 12 885 92
7. Woollett GR Williams AF Shotton DM Visualisation by low angle shadowing of the leucocyte-common antigen. A major cell surface glycoprotein of lymphocytes EMBO J 1985 4 2827 30
8. McCall MN Shotton DM Barclay AN Expression of soluble isoforms of rat CD45. Analysis by electron microscopy and use in epitope mapping of anti-CD45R monoclonal antibodies Immunology 1992 76 310 7
9. Julenius K Mølgaard A Gupta R Brunak S Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites Glycobiology 2004 15 153 64
10. Furukawa K Funakoshi Y Autero M Horejsi V Kobata A Gahmberg CG Structural study of the O-linked sugar chains of human leukocyte tyrosine phosphatase CD45 Eur J Biochem 1998 251 288 94
11. Sato T Furukawa K Autero M Gahmberg CG Kobata A Structural study of the sugar chains of human leukocyte common antigen CD45 Biochemistry 1993 32 12694 704 q13
12. Nam H-J Poy F Kreuger NX Saito H Frederick CA Crystal structure of the tandem phosphatase domains of RPTP LAR Cell 1999 97 521 30
13. Bilwes AM den Hertog J Hunter T Noel JP Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization Nature 1996 382 555 9
14. Sonnenburg ED Bilwes A Hunter T Noel JP The structure of the membrane distal phosphatase domain of RPTPα reveals interdomain flexibility and an SH2 domain interaction region Biochemistry 2003 42 7904 14
15. Fang KS Barker K Sudol M Hanafusa H A transmembrane protein-tyrosine phosphatase contains spectrin-like repeats in its extracellular domain J Biol Chem 1994 269 14056 63
16. Fujiki K Shin DH Nakao M Yano T Molecular cloning of carp (Cyprinus carpio) leukocyte cell-derived chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by use of suppression subtractive hybridization Fish Shellfish Immunol 2000 10 643 50
17. Diaz del Pozo E Beverley PCL Timon M Genomic structure and sequence of the leukocyte common antigen (CD45) from the pufferfish Fugu rubripes and comparison with its mammalian homologue Immunogenetics 2000 51 838 46
18. Kountikov E Wilson M Miller N Clem W Bengten E Organisation and expression of thirteen alternatively spliced exons in catfish CD45 homologs Dev Comparative Immunol 2004 28 1023 35
19. Chang H-L Lefrancois L Zaroukian H Esselman WJ Developmental expression of CD45 alternate exons in murine T cells. Evidence of additional alternate exon use J Immunol 1991 147 1687 93
20. Virts E Barritt D Raschke WC Expression of CD45 isoforms lacking exons 7, 8 and 10 Mol Immunol 1998 35 167 76
21. McNeill L Cassady RL Sarkardei S Cooper JC Morgan G Alexander DR CD45 isoforms in T cell signalling and development Immunol Lett 2004 92 125 34
22. Li D Brackenridge S Screaton GR A novel CD45 transcript involving the alternative splicing of a new exon is widely distributed in lymphoid tissues Hum Immunol 2004 65 1539 45
23. Novak TJ Farber D Leitenberg D Hong SC Johnson P Bottomly K Isoforms of the transmembrane tyrosine phosphatase CD45 differentially affect T cell recognition Immunity 1994 1 109 19
24. lck tyrosine kinase in T cell antigen receptor signal transduction J Biol Chem 2002 277 1912 8
25. McKenney DW Onodera H Gorman L Mimura T Rothstein DM Distinct isoforms of the CD45 protein-tyrosine phosphatase differentially regulate interleukin 2 secretion and activation signal pathways involving Vav in T cells J Biol Chem 1995 270 24949 54
26. Chui D Ong CJ Johnson P Teh HS Marth JD Specific CD45 isoforms differentially regulate T cell receptor signaling EMBO J 1994 13 798 807
27. Kozieradzki I Kundig T Kishihara K et al. T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45 J Immunol 1997 158 3130 9
28. Ogilvy S Louis-Dit-Sully C Cooper J Cassady RL Alexander DR Holmes N Either of the CD45RB and CD45RO isoforms are effective in restoring T cell, but not B cell, development and function in CD45-null mice J Immunol 2003 171 1792 800
29. Tchilian EZ Dawes R Hyland L et al. Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice Int Immunol 2004 16 1323 32
30. Virts EL Diago O Raschke WC A CD45 minigene restores regulated isoform expression and immune function in CD45 deficient mice: Therapeutic implications for human CD45-null Severe Combined Immunodeficiency Blood 2003 101 849 55
31. Daniels MA Hogquist KA Jameson SC Sweet 'n' sour: the impact of differential glycosylation on T cell responses Nat Immunol 2002 2 903 10
32. Zebedee SL Barritt DS Raschke WC Comparison of mouse Ly5a and Ly5b leucocyte common antigen alleles Dev Immunol 1991 1 243 54
33. Symons A Barclay AN Molecular basis of antigenic differences between the RT7 alleles of rat CD45 Immunogenetics 2000 51 747 50
34. Ballingall KT Waibochi L Holmes EC Woelk CH MacHugh ND Lutje V McKeever DJ The CD45 locus in cattle: allelic polymorphism and evidence for exceptional positive natural selection Immunogenetics 2001 52 276 83
35. Thude H Hundreiser J Wonigeit K Schwinzer R A point mutation in the CD45 gene associated with defective splicing of exon A Eur J Immunol 1995 25 2101 6
36. Jacobsen M Hoffman S Cepok S Stei S Ziegler A Sommer N Hemmer B A novel mutation in PTPRC interferes with splicing and alters the structure of the human CD45 molecule Immunogenetics 2002 54 158 63
37. Stanton T Boxall S Hirai K et al. A high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression Proc Natl Acad Sci USA 2003 100 5997 6002
38. Gomez-Lira M Liguori M Magnani C et al. CD45 and multiple sclerosis: the exon 4 C77G polymorphism (additional studies and meta-analysis) and new markers J Neuroimmunol 2003 140 216 21
39. Stanton T Boxall S Bennett A et al. CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans Immunogenetics 2004 56 107 10
40. Kung C Pingel JT Heikinheimo M et al. Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease Nat Med 2000 6 343 5
41. Tchilian EZ Wallace DL Wells RS Flower DR Morgan G Beverley PC A deletion in the gene encoding the CD45 antigen in a patient with SCID J Immunol 2001 166 1308 13
42. Filip LC Mundy NI Rapid evolution by positive Darwinian selection in the extracellular domain of the abundant lymphocyte protein CD45 in primates Mol Biol Evol 2004 21 1504 11
43. Montoya GE Vernot JP Patarroyo ME Comparative analysis of CD45 proteins in primate context: owl monkeys vs humans Tissue Antigens 2004 64 165 72 q14
44. Boxall S Stanton T Hirai K et al. Disease association and altered immune function in CD45 138G variant carriers Hum Mol Genet 2004 13 2377 84
45. Symons A Cooper DN Barclay AN Characterization of the interaction between galectin-1 and lymphocyte glycoproteins CD45 and Thy-1 Glycobiology 2000 10 559 63
46. Van der Merwe PA Crocker PR Vinson M Barclay AN Schauer R Kelm S Localization of the putative sialic acid-binding site on the immunoglobulin superfamily cell-surface molecule CD22 J Biol Chem 1996 271 9273 80
47. Martínez-Pomares L Crocker PR Da Silva R Holmes N Colominas C Rudd P Dwek R Gordon S Cell-specific glycoforms of Sialoadhesin and CD45 are counter-receptors for the cysteine-rich domain of the Mannose Receptor J Biol Chem 1999 274 35211 8
48. Jacobsen M Schweer D Ziegler A et al. A point mutation in PTPRC is associated with the development of multiple sclerosis Nat Genet 2000 26 495 9
49. Vyskina T Leist TP Shugart YY Kalman B CD45 (PTPRC) as a candidate gene in multiple sclerosis Mult Scler 2004 10 614 7
50. Vorechovsky I Kralovicova J Tchilian E et al. Does 77C-G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus? Nat Genet 2001 29 22 3
51. Wood JP Bieda K Segni M Herwig J Krause M Usadel KH Badenhoop K CD45 exon 4 point mutation does not confer susceptibility to type 1 diabetes mellitus or Graves' disease Eur J Immunogenet 2002 29 73 4
52. Thude H Rosenhahn S Hunger-Dathe W Muller UA Barz D A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population Eur J Immunogenet 2004 31 245 7
53. Johanneson B Lima G von Salome J Alarcon-Segovia D Alarcon-Riquelme ME A major susceptibility locus for systemic lupus erythematosus maps to chromosome 1q31 Am J Hum Genet 2002 71 1060 71
54. Vogel A Strassburg CP Manns MP 77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmmune hepatitis: evidence for a genetic link Genes Immun 2003 4 79 81
55. Tchilian EZ Wallace DL Dawes R Imami N Burton C Gotch F Beverley PC A point mutation in CD45 may be associated with an increased risk of HIV-1 infection AIDS 2001 15 1892 4
56. Stone JD Conroy LA Byth KF Hederer RA Howlett S Takemoto Y Holmes N Alexander DR Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta and ZAP-70 J Immunol 1997 158 5773 82
57. L deamidation in T cell transformation Cancer Cell 2004 5 37 49
58. D'Oro U Ashwell JD The CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes J Immunol 1999 162 1879 83
59. Majeti R Bilwes AM Noel JP Hunter T Weiss A Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge Science 1998 279 88 91
60. Katagiri T Ogimoto M Hasegawa K Mizuno K Yakura H Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells J Biol Chem 1995 270 27987 90
61. Yanagi S Sugawara H Kurosaki M Sabe H Yamamura H Kurosaki T CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells J Biol Chem 1996 271 30487 92
62. Katagiri T Ogimoto M Hasegawa K et al. CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells J Immunol 1999 163 1321 6
63. Shrivastava P Katagiri T Ogimoto M Mizuno K Yakura H Dynamic regulation of Src-family kinases by CD45 in B cells Blood 2004 103 1425 32
64. Cornall RJ Cyster JG Hibbs ML Dunn AR Otipoby KL Clark EA Goodnow CC Polygenic autoimmune traits. Lyn, CD22 and SHP-1 are limiting elements of a biochemical pathway regulating BCR signalling and selection Immunity 1998 8 497 508
65. Chan VWF Meng F Soriano P DeFranco AL Lowell CA Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation Immunity 1997 7 69 81
66. Meade J Fernandez C Turner M The tyrosine kinase Lyn is required for B cell development beyond the T1 stage in the spleen: rescue by overexpression of Bcl-2 Eur J Immunol 2002 31 1029 34
67. Saijo K Schmedt C Su IH et al. Essential role of Src-family protein tyrosine kinases in NF-kappa B activation during B cell development Nat Immunol 2003 4 274 9
68. Xu Y Harder KW Huntington ND Hibbs ML Tarlinton DM Lyn tyrosine kinase. accentuating the positive and the negative Immunity 2005 22 9 18
69. - B cells J Immunol 1997 158 2663 9
70. Benatar T Carsetti R Furlonger C Kamalia N Mak TW Paige CJ Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice J Exp Med 1996 183 329 34 q15
71. Cyster JG Healy JI Kishihara K Mak TW Thomas ML Goodnow CC Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45 Nature 1996 381 325 8
72. Kong Y-Y Kishihara K Sumichika H Nakamura T Kaneko M Nomoto K Differential requirements of CD45 for lymphocyte development and function Eur J Immunol 1995 25 3431 6
73. Huntington ND Xu Y Nutt SL Tarlinton DM A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells J Exp Med 2005 201 1421 33
74. + T cells in CD45-deficient mice J Immunol 2001 166 6066 73
75. Roach T Slater S Koval M White L Cahir McFarland E Okumura M Thomas M Brown E CD45 regulates Src family member kinase activity associated with macrophage integrin mediated adhesion Curr Biol 1997 7 408 17
76. Furukawa T Itoh M Krueger NX Streuli M Saito H Specific interaction of the CD45-protein tyrosine phosphatase with tyrosine phosphorylated CD3ζ chain Proc Natl Acad Sci USA 1994 91 10928 32
77. Kashio N Watsumoto W Parker S Rothstein DM The second domain of the CD45 protein tyrosine phosphatase is critical for interleukin-2 secretion and substrate recruitment of TCR-ζin vivo J Biol Chem 1998 273 33856 63
78. Wu L Fu J Shen SH SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription Mol Cell Biol 2002 22 2673 86
79. Irie-Sasaki J Sasaki T Matsumoto W et al. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling Nature 2001 409 349 54
80. Davidson D Bakinowski M Thomas ML Horejsi V Veillette A Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adapter Mol Cell Biol 2003 23 2017 28
81. Jiang G den Hertog J Su J Noel J Sap J Hunter T Dimerization inhibits the activity of receptor-like protein tyrosine phosphatase α Nature 1999 401 606 10
82. Jiang G den Hertog J Hunter T Receptor-like protein tyrosine phosphatase α homodimerizes on the cell surface Mol Cell Biol 2000 20 5917 29
83. Majeti R Xu Z Parslow TG Olson JL Daikh DI Killeen N Weiss A An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity Cell 2000 103 1059 70
84. Hermiston ML Tan A Weiss A Perturbation of B cell homeostasis and function in mice expressing an inactivating point mutation in the inhibitory wedge of CD45 Blood 2003 102 160
85. Felberg J Johnson P Characterization of recombinant CD45 cytoplasmic domain proteins. Evidence for intramolecular and intermolecular interactions J Biol Chem 1998 273 17839 45
86. Xu Z Weiss A Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms Nat Immunol 2002 3 674 1
87. Kung C Okumura M Seavitt JR et al. CD45 associated protein is not essential for the regulation of antigen receptor-mediated signal transduction Eur J Immunol 1999 29 3951 5
88. Ding I Bruyns E Li P et al. Biochemical and functional analysis of mice deficient in expression of the CD45-associated phosphoprotein LPAP Eur J Immunol 1999 29 3956 61
89. Matsuda A Motoya S Kimura S McInnis R Maizel AL Takeda A Disruption of lymphocyte function and signaling in CD45-associated protein-null mice J Exp Med 1998 187 1863 70
90. + thymocytes, and in B-cell maturation J Exp Med 1996 183 1707 18
91. Takeda A Matsuda A Paul RML Yaseen NR CD45-associated protein inhibits CD45 dimerization and up-regulates its protein tyrosine phosphatase activity Blood 2004 103 3440 7
92. Leitenberg D Novak T Farber D Smith B Bottomly K The extracellular domain of CD45 controls association with the CD4 T cell receptor complex and the response to antigen-specific stimulation J Exp Med 1996 183 249 59
93. Edmonds SD Ostergaard HL Dynamic association of CD45 with detergent insoluble microdomains in T lymphocytes J Immunol 2002 169 5036 42
94. Zhang M Moran M Round J Low TA Patel VP Tomassian T Hernandez JD Miceli MC CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production J Immunol 2005 174 1479 90
95. Irles C Symons A Michel F Bakker TR van der Merwe PA Acuto O CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling Nat Immunol 2003 4 189 97
96. He X Woodford-Thomas TA Johnson KG Shah DD Thomas ML Targeting of CD45 protein tyrosine phosphatase activity to lipid microdomains on the T cell surface inhbits TCR signaling Eur J Immunol 2002 32 2578 87 q16
97. Su MW-C Yu C-L Burakoff SJ Jin Y-L Targeting Src homology 2 domain-containing tyrosine phosphatase (SHP-1) into lipid rafts inhibits CD3-induced T cell activation J Immunol 2001 166 2975 82
98. Johnson KG Bromley SK Dustin ML Thomas ML A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation Proc Natl Acad Sci USA 2000 97 10138 43
99. Dustin ML Membrane domains and the immunological synapse: keeping T cells resting and ready J Clin Invest 2002 109 155 60
100. Wang Y Guo W Liang L Esselman WJ Phosphorylation of CD45 by casein kinase 2. Modulation of activity and mutational analysis J Biol Chem 1999 274 7454 61
101. Autero M Saharinen J Pessa-Morikawa T et al. Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck kinase and activates the phosphatase Mol Cell Biol 1994 14 1308 21
102. Greer SF Wang Y Raman C Justement LB CD45 function is regulated by an acidic 19-amino acid insert in domain II that serves as a binding and phospho-acceptor site for casein kinase 2 J Immunol 2001 166 7208 18
103. Barclay AN Jackson DI Willis AC Williams AF Lymphocyte specific heterogeneity in the rat leucocyte common antigen (T200) is due to differences in polypeptide sequences near the NH2-terminus EMBO J 1987 6 1259 64
104. Martz E Protein Explorer: easy yet powerful macromolecular vizualization Trends Biochem Sci 2002 27 107 9. ()
105. 2+ and an oxidant signal Cell 2005 121 281 93