KLOTHO allele status and the risk of early-onset occult coronary artery disease

American Journal of Human Genetics

Volumn 72, Issue 5, 2003, Pages 1154-1161

  Arking, Dan E ^a   Becker, Diane M ^a   Yanek, Lisa R ^a   Fallin, Daniele ^b   Judge, Daniel P ^a   Moy, Taryn F ^a   Becker, Lewis C ^b   Dietz, Harry C ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; THALLIUM;

ADULT; ALLELE; AMINO ACID SUBSTITUTION; ARTERIOSCLEROSIS; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CAUCASIAN; CONTROLLED STUDY; CORONARY ARTERY DISEASE; EXERCISE ELECTROCARDIOGRAPHY; EXERCISE TEST; FEMALE; GENE; GENE KLOTHO; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC VARIABILITY; HEART SCINTISCANNING; HUMAN; HYPERTENSION; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; NEGRO; ONSET AGE; PRIORITY JOURNAL; RISK FACTOR; SIBLING; SMOKING;

EID: 0038744264     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/375035     Document Type: Article

References (30)

1. Ahijevych K (1999) Nicotine metabolism variability and nicotine addiction. Nicotine Tob Res Suppl 1:S59-S62
2. Aizawa H, Saito Y, Nakamura T, Inoue M, Imanari T, Ohyama Y, Matsumura Y, Masuda H, Oba S, Mise N, Kimura K, Hasegawa A, Kurabayashi M, Kuro-o M, Nabeshima Y, Nagai R (1998) Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats. Biochem Biophys Res Commun 249:865-871
3. American Heart Association (1990) Human blood pressure determination by sphygmomanometry. American Heart Association, Dallas, pp 2460-2467
4. Arking DE, Krebsova A, Macek M Sr, Macek M Jr, Arking A, Mian IS, Fried L, Hamosh A, Dey S, McIntosh I, Dietz HC (2002) Association of human aging with a functional variant of klotho. Proc Natl Acad Sci USA 99:856-861
5. Becker DM, Yook RM, Moy TF, Blumenthal RS, Becker LC (1998) Markedly high prevalence of coronary risk factors in apparently healthy African-American and white siblings of persons with premature coronary heart disease. Am J Cardiol 82:1046-1051
6. Blumenthal RS, Becker DM, Moy TF, Coresh J, Wilder LB, Becker LC (1996) Exercise thallium tomography predicts future clinically manifest coronary heart disease in a high-risk asymptomatic population. Circulation 93:915-923
7. Brunner HR (2001) Experimental and clinical evidence that angiotensin II is an independent risk factor for cardiovascular disease. Am J Cardiol 87:3C-9C
8. Clark LT (1999) Primary prevention of cardiovascular disease in high-risk patients: physiologic and demographic risk factor differences between African American and white American populations. Am J Med 107:22S-24S
9. Denke MA, Adams-Huet B, Nguyen AT (2000) Individual cholesterol variation in response to a margarine- or butter- based diet: a study in families. JAMA 284:2740-2747
10. Fintel DJ, Links JM, Brinker JA, Frank TL, Parker M, Becker LC (1989) Improved diagnostic performance of exercise thallium-201 single photon emission computed tomography over planar imaging in the diagnosis of coronary artery disease: a receiver operating characteristic analysis. J Am Coll Cardiol 13:600-612
11. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499-502
12. Fukino K, Suzuki T, Saito Y, Shindo T, Amaki T, Kurabayashi M, Nagai R (2002) Regulation of angiogenesis by the aging suppressor gene klotho. Biochem Biophys Res Commun 293:332-337
13. Gavras I, Gavras H (2002) Angiotensin II as a cardiovascular risk factor. J Hum Hypertens Suppl 2 16:S2-S6
14. Hines LM, Stampfer MJ, Ma J, Gaziano JM, Ridker PM, Hankinson SE, Sacks F, Rimm EB, Hunter DJ (2001) Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction. N Engl J Med 344:549-555
15. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45-51
16. Kuvin JT, Ramet ME, Patel AR, Pandian NG, Mendelsohn ME, Karas RH (2002) A novel mechanism for the beneficial vascular effects of high-density lipoprotein cholesterol: enhanced vasorelaxation and increased endothelial nitric oxide synthase expression. Am Heart J 144:165-172
17. Liang KY, Zeger SL (1993) Regression analysis for correlated data. Annu Rev Public Health 14:43-68
18. McCombs RJ, Marcadis DE, Ellis J, Weinberg RB (1994) Attenuated hypercholesterolemic response to a high-cholesterol diet in subjects heterozygous for the apolipoprotein AIV-2 allele. N Engl J Med 331:706-710
19. Mitani H, Ishizaka N, Aizawa T, Ohno M, Usui S, Suzuki T, Amaki T, Mori I, Nakamura Y, Sato M, Nangaku M, Hirata Y, Nagai R (2002) In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension 39:838-843
20. Morabia A, Bernstein MS, Curtin F, Berode M (2001) Validation of self-reported smoking status by simultaneous measurement of carbon monoxide and salivary thiocyanate. Prev Med 32:82-88
21. Nagai R, Saito Y, Ohyama Y, Aizawa H, Suga T, Nakamura T, Kurabayashi M, Kuroo M (2000) Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases. Cell Mol Life Sci 57:738-746
22. Ordovas JM (1999) The genetics of serum lipid responsiveness to dietary interventions. Proc Nutr Soc 58:171-187
23. Saito Y, Nakamura T, Ohyama Y, Suzuki T, Iida A, Shiraki-Iida T, Kuro-o M, Nabeshima Y, Kurabayashi M, Nagai R (2000) In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochem Biophys Res Commun 276:767-772
24. Saito Y, Yamagishi T, Nakamura T, Ohyama Y, Aizawa H, Suga T, Matsumura Y, Masuda H, Kurabayashi M, Kuro-o M, Nabeshima Y, Nagai R (1998) Klotho protein protects against endothelial dysfunction. Biochem Biophys Res Commun 248:324-329
25. Schildkraut JM, Myers RH, Cupples LA, Kiely DK, Kannel WB (1989) Coronary risk associated with age and sex of parental heart disease in the Framingham Study. Am J Cardiol 64:555-559
26. Shea S, Ottman R, Gabrieli C, Stein Z, Nichols A (1984) Family history as an independent risk factor for coronary artery disease. J Am Coll Cardiol 4:793-801
27. Shiraki-Iida T, Iida A, Nabeshima Y, Anazawa H, Nishikawa S, Noda M, Kuro-o M (2000) Improvement of multiple pathophysiological phenotypes of klotho (kl/kl) mice by adenovirus-mediated expression of the klotho gene. J Gene Med 2:233-242
28. Talmud PJ, Bujac SR, Hall S, Miller GJ, Humphries SE (2000) Substitution of asparagine for aspartic acid at residue 9 (D9N) of lipoprotein lipase markedly augments risk of ischaemic heart disease in male smokers. Atherosclerosis 149:75-81
29. Woods MN, Harris KJ, Ahluwalia JS, Schmelzle KH, Mayo MS (2001) Smoking in urban African Americans: behaviors, gender differences, and motivation to quit. Ethn Dis 11:532-539
30. Yuhanna IS, Zhu Y, Cox BE, Hahner LD, Osborne-Lawrence S, Lu P, Marcel YL, Anderson RG, Mendelsohn ME, Hobbs HH, Shaul PW (2001) High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. Nat Med 7:853-857