Alterations of tetrahydrobiopterin biosynthesis and pteridine levels in mouse tissues during growth and aging

Brain and Development

Volumn 22, Issue SUPPL. 1, 2000, Pages 45-49

  Yoshida, Yu Ichi ^a   Eda, Setsuko ^b   Masada, Masahiro ^a  

^a CHIBA UNIVERSITY   (Japan)

^b SAITAMA PREFECTURAL UNIVERSITY   (Japan)

Author keywords

Aging; Development; Guanosine triphosphate cyclohydrolase I; Pteridines; Teterahydrobiopterin

Indexed keywords

GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; NEOPTERIN; PTERIDINE; PTERIN; PYRVOYLTETRAHYDROPTERIN SYNTHASE; SYNTHETASE; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG;

AGING; ANIMAL TISSUE; BIOSYNTHESIS; BLOOD LEVEL; BRAIN; BRAIN DEVELOPMENT; CEREBELLUM; CONFERENCE PAPER; ENZYME ACTIVITY; GROWTH; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY; LIVER; MALE; MOUSE; NONHUMAN;

EID: 0033839281     PISSN: 03877604     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0387-7604(00)00144-3     Document Type: Conference Paper

References (24)

1. Lovenberg W., Victor S.J. Regulation of tryptophan and tyrosine hydroxylase. Life Sci. 14:1974;2337-2353.
2. Weiner N. The role of pterin cofactor in the regulation of catecholamine synthesis. Psychopharmacology. 14:1978;40-44.
3. Fine M.I., Masserano J.M., Weiner N. The effects of reserpine and haloperidol on tyrosine hydroxylase activity in the brains of aged rats. Life Sci. 39:1986;235-241.
4. Nagatsu I. Biopterin cofactor and monoamine synthesizing monooxygenases. Neurochem Int. 5:1983;27-38.
5. Moretti A., Carfagna N., Trunzo F. Effects of aging on monoamines and their metabolites in the rat brain. Neurochem Res. 12:1987;1035-1039.
6. Friedemann M.N., Gerhardt G.A. Regional effects of aging on dopaminergic function in the Fisher-344 rat. Neurobiol Aging. 13:1992;325-332.
7. Watabane H. Differential decrease in the rate of dopamine synthesis in several dopaminergic neurons of aged rat brain. Exp Gerontol. 22:1987;17-25.
8. Abou-Donia M.M., Wilson S.P., Zimmerman J.P., Nichol C.A., Viveros O.H. Regulation of guanosine triphosphate cyclohydrolase and tetrahydrobiopterin levels and the role of cofactor in tyrosine hydroxylation in primary culture of adrenomedullary chromaffin cells. J Neurochem. 46:1986;1190-1199.
9. Miwa S., Watanabe Y., Hayashi O. 6R-Erythro-5,6,7,8-tetrahydrobiopterin as a regulator of dopamine and serotonin biosynthesis in the rat barin. Arch Biochem Biophys. 239:1985;234-241.
10. Wolf W.A., Ziaja E., Arthur R.A., Anastasiadis P.Z., Levine R.A., Kuhn D.M. Effect of tetrahydrobiopterin on serotonin synthesis, release, and metabolism in superfused hippocampal slices. J Neurochem. 57:1991;1191-1197.
11. Hatakeyama K., Harada S., Suzuki S., Watanabe Y., Kagamiyama H. Purification and characterization of rat liver GTP cyclohydrolase 1. Cooperative binding of GTP to the enzyme. J Biol Chem. 264:1989;21660-221644.
12. Hatakeyama K., Harada T., Suzuki S. IMP dehydrogenase inhibitors reduce intracellular tetrahydrobiopterin levels through the reduction of intracellular GTP levels. Indications of the regulation of GTP-cyclohydrolase 1 activity by restriction of GTP available in the cell. J Biol Chem. 267:1992;20734-30739.
13. Kaufman S., Kapatos G., McInns R.R., Shulman J.D., Rizzo W.B. Use of tetrahydropterins in the treatment of hyperphenylalaninemia due to defective synthesis of tetrahydrobiopterin. Evidence that peripherally administered tetrahydropterins enter the brain. Pediatrics. 70:1982;376-380.
14. Zeigler I., Schott K., Schwulera U. Regulation of H4biopterin synthesis in human mononuclear cells during immune response. Contrib Oncol. 46:1994;360-367.
15. Eda S., Yoshida M., Nogawa T., Toyoda R., Masada M. The quantitative variation of neopterin and biopterin in human urine on the age and sex (in Japanese). Bull Saitama Coll Health. 18:1993;101-105.
16. Shintaku H., Isshiki G. Normal pterin values in urine and serum in neonates and age-related change throughout life. J Inherit Metab Dis. 5:1982;241-242.
17. Yoshioka S., Masada M., Yoshida T., Mizokami T., Akino M., Matsuo N. Atypical phenylketouria due to biopterin deficiency: Diagnosis by assay of enzyme involved in the synthesis of sepiapterin from dihydroneopterin triphosphate. Zool Sci. 1:1984;74-81.
18. Armstrong R.A., Cattell R.J., Winsper S.J., Blaer J.A. The levels of neopterin, biopterin and the neopterin/biopterin ratio in urine from control subjects and patients with Alzheimer's disease and Down's syndrome. Pteridines. 6:1995;185-189.
19. Williams A., Eldridge R., Levine R., Lovenberg W., Paulson G. Low CSF hydroxylase cofactor (tetrahyrobiopterin) levels in inherited dystonia. Lancet. 2:1979;410-411.
20. Rokos H., Rokos K., Frisuis H., Aedter H.J.K. Altered urinary excretion of pteridines in neoplastic disease. Determination of biopterin, neopterin, xanthopterin and pterin. Clin Chim Acta. 105:1980;275-286.
21. Yoshioka S., Masada M., Yoshida T., Inoue K., Mizokami T., Akino M. Synthesis of biopterin from dihydroneopterin triphosphate by rat tissues. Biochem Biophys Acta. 756:1983;279-285.
22. Zagalak B., Neuheiser F., Redweik U., Bosshard R., Leimbacher W. Synthesis of enzymatically active D-7,8-dihydroneopterin-3′-triphosphate. Biochem Biophys Res Commun. 152:1988;1193-1199.
23. Masada M., Matsumoto J., Akino M. Biosynthetic pathways of pteridines and their association with phenotypic expression in vitro in normal and neoplastic pigment cells from goldfish. Pigment Cell Res. 3:1990;61-70.
24. Fukushima T., Nixon J.C. Analysis of reduced forms of biopterin in biological tissues and fluids. Anal Biochem. 102:1980;176-188.