Apoptosis in immunocytes induced by several types of pesticides

Journal of Immunotoxicology

Volumn 7, Issue 1, 2010, Pages 39-56

  Fukuyama, Tomoki ^a   Tajima, Yukari ^a   Ueda, Hideo ^a   Hayashi, Koichi ^a   Shutoh, Yasufumi ^a   Harada, Takanori ^a   Kosaka, Tadashi ^a  

^a INSTITUTE OF ENVIRONMENTAL TOXICOLOGY   (Japan)

Author keywords

Apoptosis; Dexamethasone; J45.01 cell line; Metamidopos; Methoxychlor; Parathion; PNMC; Thymocyte

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; DEXAMETHASONE; DNA; LIPOCORTIN 5; METHAMIDOPHOS; METHOXYCHLOR; ORGANOCHLORINE DERIVATIVE; ORGANOPHOSPHATE; PARATHION; PESTICIDE;

ALLERGY; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL COUNT; CELL TYPE; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; FEMALE; HUMAN; HUMAN CELL; IMMUNE SYSTEM; LEUKEMIA CELL LINE; LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T CELL LEUKEMIA; T LYMPHOCYTE; THYMOCYTE; THYMUS ATROPHY;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DNA FRAGMENTATION; DNA, NEOPLASM; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; PESTICIDES; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; T-LYMPHOCYTES; THYMUS GLAND;

EID: 77649155238     PISSN: 1547691X     EISSN: 1547691X     Source Type: Journal    
DOI: 10.3109/15476910903321704     Document Type: Article

References (66)

1. Airborne Particles Expert Group. 1999. Source Apportionment of Airborne Particulate Matter in the United Kingdom. United Kingdom Department of the Environment, Transport and Regions, the Welsh ESTROGENIC ACTIVITIES OF NITROPHENOLS IN DEP 1533 Office, the Scottish Office and the Department of Environment (North Ireland); 1999:9-37.
2. Ashwell, J. D., Lu, F. W., and Vacchio, M. S. 2000. Glucocorticoids in T-cell development and function. Annu. Rev. Immunol. 18:309-345.
3. Bhushan, B., Samanta, S. K., Chauhan, A., Chakraborti, A. K., and Jain, R. K. 2000. Chemotaxis and biodegradation of 3-methyl- 4-nitrophenol by Ralstonia sp. SJ98. Biochem. Biophys. Res. Commun. 275:129-133. (Pubitemid 30663641)
4. Blaylock, B. L., Holladay, S. D., Comment, C. E., Heindel, J. J., and Luster, M. I. 1992. Exposure to tetrachlorodibenzo-p-dioxin (TCDD) alters fetal thymocyte maturation. Toxicol. Appl. Pharmacol. 112:207-213.
5. Brown, D. G., Sun, X. M., and Cohen, G. M. 1993. Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation. J. Biol. Chem. 268:3037-3039.
6. Camacho, I. A., Nagarkatti, M., and Nagarkatti, P. S. 2004. Evidence for induction of apoptosis in T-cells from murine fetal thymus following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol. Sci. 78:96-106.
7. Chapin, R. E., Harris, M. W., Davis, B. J., Ward, S. M., Wilson, R. E., Mauney, M. A., Lockhart, A. C., Smialowicz, R. J., Moser, V. C., Burka, L. T., and Collins, B. J. 1997. The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function. Fundam. Appl. Toxicol. 40:138-157.
8. Chinnaiyan, A. M., and Dixit, V. M. 1996. The cell-death machine. Curr. Biol. 6: 555-562.
9. Chinnaiyan, A. M., Hanna, W. L., Orth, K., Duan, H., Poirier, G. G., Froelich, C. J., and Dixit, V. M. 1996a. Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3. Curr. Biol. 6:897-899.
10. Chinnaiyan, A. M., O'Rourke, K., Yu, G. L., Lyons, R. H., Garg, M., Duan, D. R., Xing, L., Gentz, R., Ni, J., and Dixit, V. M. 1996b. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 274:990-992.
11. Chinnaiyan, A. M., Tepper, C. G., Seldin, M. F., O'Rourke, K., Kischkel, F. C., Hellbardt, S., Krammer, P. H., Peter, M. E., and Dixit, V. M. 1996c. FADD/ MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J. Biol. Chem. 271:4961-4965.
12. Cohen, J. J., and Duke, R. C. 1984. Glucocorticoid activation of a calciumdependent endonuclease in thymocyte nuclei leads to cell death. J. Immunol. 132:38-42.
13. Drela, N. 2006. Xenobiotic-induced alterations in thymocyte development. Apmis 114:399-419.
14. Ellenhorn, M. J., and Barceloux, D. G. 1988. Chapter 38: Pesticides. In: Medical Toxicology. (Ellenhorn, M. J. and Barceloux, D. G., Eds.), New York: Elsevier, pp. 1069-1077.
15. Fadok, V. A., Savill, J. S., Haslett, C., Bratton, D. L., Doherty, D. E., Campbell, P. A., and Henson, P. M. 1992a. Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. J. Immunol. 149:4029-4035.
16. Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J. J., Bratton, D. L., and Henson, P. M. 1992b. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 148:2207-2216.
17. Furuta, C., Suzuki, A. K., Taneda, S., Kamata, K., Hayashi, H., Mori, Y., Li, C., Watanabe, G., and Taya, K. 2004. Estrogenic activities of nitrophenols in diesel exhaust particles. Biol. Reprod. 70:1527-1533.
18. Furuta, C., Noda, S., Li, C., Suzuki, A.K., Taneda, S., Watanabe, G., and Taya, K. 2008a. Nitrophenols isolated from diesel exhaust particles regulate steroidogenic gene expression and steroid synthesis in the human H295R adrenocortical cell line. Toxicol. Appl. Pharmacol. 229:109-120.
19. Furuta, C., Suzuki, A. K., Watanabe, G., Li, C., Taneda, S., and Taya, K. 2008b. Nitrophenols isolated from diesel exhaust particles promote the growth of MCF-7 breast adenocarcinoma cells. Toxicol. Appl. Pharmacol. 230:320-326.
20. Guo, T. L., Zhang, X. L., Bartolucci, E., McCay, J. A., White, K. L., Jr., and You, L. 2002. Genistein and methoxychlor modulate the activity of natural killer cells and the expression of phenotypic markers by thymocytes and splenocytes in F0 and F1 generations of Sprague-Dawley rats. Toxicology 172:205-215.
21. Gurtu, V., Kain, S. R., and Zhang, G. 1997. Fluorometric and colorimetric detection of caspase activity associated with apoptosis. Anal. Biochem. 251:98-102. (Pubitemid 27352149)
22. Hirai, M., and Ichikawa, M. 1991. Changes in serum glucocorticoid levels and thymic atrophy induced by phenytoin administration in mice. Toxicol. Lett. 56:1-6.
23. Japan Environmental Agency. The Research Report on the Total Amount of Emission and Automobile Exhaust Source Unit-the NOX According to Object Automobile in the Usual Transit [in Japanese]. 1998:200-203.
24. Japanese Association for Laboratory Animal Science 1987. Guidelines for animal experimentation. Exp. Anim. 36:285-288.
25. Jones, D. C., and Miller, G. W. 2008. The effects of environmental neurotoxicants on the dopaminergic system: A possible role in drug addiction. Biochem. Pharmacol. 76:569-581.
26. Kamath, A. B., Xu, H., Nagarkatti, P. S., and Nagarkatti, M. 1997. Evidence for the induction of apoptosis in thymocytes by 2,3,7,8- tetrachlorodibenzop-dioxin in vivo. Toxicol. Appl. Pharmacol. 142:367-377.
27. Kawashima, I., Sakabe, K., Seiki, K., and Fujii-Hanamoto, H. 1990. Hormone and immune response, with special reference to steroid hormone. 3. Sex steroid effect on T-cell differentiation. Tokai. J. Exp. Clin. Med. 15:213-218.
28. Kohler, C., Jeanvoine, G., Pierrez, J., Olive, D., and Gerard, H. 1987. Modifications of the thymus and splenic thymic dependent zones after in utero exposure to phenytoin: Qualitative and quantitative analysis in C3H mice. Dev. Pharmacol. Ther. 10:405-412.
29. Kosuda, L. L., Hannigan, M. O., Bigazzi, P. E., Leif, J. H., and Greiner, D. L. 1996. Thymus atrophy and changes in thymocyte subpopulations of BN rats with mercury-induced renal autoimmune disease. Autoimmunity 23:77-89.
30. Ladi, E., Yin, X., Chtanova, T., and Robey, E. A. 2006. Thymic microenvironments for T-cell differentiation and selection. Nat. Immunol. 7:338-343.
31. Li, Q., Hirata, Y., Piao, S., and Minami, M. 2000. The by-products generated during sarin synthesis in the Tokyo sarin disaster induced inhibition of natural killer and cytotoxic T-lymphocyte activity. Toxicology 146:209-220.
32. Li, Q., Nagahara, N., Takahashi, H., Takeda, K., Okumura, K., and Minami, M. 2002. Organophosphorus pesticides markedly inhibit the activities of natural killer, cytotoxic T-lymphocyte and lymphokine-activated killer: A proposed inhibiting mechanism via granzyme inhibition. Toxicology 172:181-190.
33. Li, Q., Nakadai, A., Takeda, K., and Kawada, T. 2004. Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly inhibits activities of natural killer cells, cytotoxic T-lymphocytes and lymphokine-activated killer cells via the Fas-ligand/Fas pathway in perforin-knockout (PKO) mice. Toxicology 204:41-50.
34. Li, Q., Kobayashi, M., and Kawada, T. 2007. Organophosphorus pesticides induce apoptosis in human NK cells. Toxicology 239:89-95.
35. Li, Q., Kobayashi, M., and Kawada, T. 2009. Chlorpyrifos induces apoptosis in human T-cells. Toxicology 255:53-57.
36. Lopez, O., Hernandez, A. F., Rodrigo, L., Gil, F., Pena, G., Serrano, J. L., Parron, T., Villanueva, E., and Pla, A. 2007. Changes in antioxidant enzymes in humans with long-term exposure to pesticides. Toxicol. Lett. 171:146-153.
37. Miyabara, Y., Ichinose, T., Takano, H., and Sagai, M. 1998. Diesel exhaust inhalation enhances airway hyper-responsiveness in mice. Int. Arch. Allergy Immunol. 116:124-131. (Pubitemid 28246370)
38. Morris, R. G., Hargreaves, A. D., Duvall, E., and Wyllie, A. H. 1984. Hormoneinduced cell death. 2. Surface changes in thymocytes undergoing apoptosis. Am. J. Pathol. 115:426-436.
39. Muranaka, M., Suzuki, S., Koizumi, K., Takafuji, S., Miyamoto, T., Ikemori, R., and Tokiwa, H. 1986. Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice. J. Allergy Clin. Immunol. 77:616-623.
40. Muzio, M., Salvesen, G. S., and Dixit, V. M. 1997. FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J. Biol. Chem. 272:2952-2956.
41. Nakadai, A., Li, Q., and Kawada, T. 2006. Chlorpyrifos induces apoptosis in human monocyte cell line U937. Toxicology 224:202-209.
42. Nishioka, M. G., Howard C. C., and Contos D. A. 1988. Detection of hydroxylated nitro aromatic and hydroxylated nitro-polycyclic aromatic compounds in an ambient air particulate extract using bioassay-directed fractionation. Environ. Sci. Technol. 22:908-915.
43. Nishioka, M. G., and Lewtas J. 1992. Quantification of nitro- and hydroxylated nitro-aromatic/polycyclic aromatic hydrocarbons in selected ambient air daytime winter samples. Atomosph. Environ. 26A:2077-2087.
44. Nohara, K., Ao, K., Miyamoto, Y., Suzuki, T., Imaizumi, S., Tateishi, Y., Omura, S., Tohyama, C., and Kobayashi, T. 2008. Arsenite-induced thymus atrophy is mediated by cell cycle arrest: A characteristic down-regulation of E2F-related genes revealed by a microarray approach. Toxicol. Sci. 101:226-238.
45. Oberhammer, F., Fritsch, G., Schmied, M., Pavelka, M., Printz, D., Purchio, T., Lassmann, H., and Schulte-Hermann, R. 1993. Condensation of the chromatin at the membrane of an apoptotic nucleus is not associated with activation of an endonuclease. J. Cell Sci. 104:317-326.
46. OECD, 2008. Environmental Performance of Agriculture Since 1990: Main Report, Organization for Economic Cooperation and Development, Paris, France
47. Pieters, R. H., Kampinga, J., Snoeij, N. J., Bol-Schoenmakers, M., Lam, A. W., Penninks, A. H., and Seinen, W. 1989. An immunohistochemical study of dibutyltin-induced thymus atrophy. Arch. Toxicol. Suppl. 13:175-178.
48. Pryputniewicz, S. J., Nagarkatti, M., and Nagarkatti, P. S. 1998. Differential induction of apoptosis in activated and resting T-cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and its repercussion on T-cell responsiveness. Toxicology 129:211-226.
49. Sagai, M., Saito, H., Ichinose, T., Kodama, M., and Mori, Y. 1993. Biological effects of diesel exhaust particles. I. In vitro production of superoxide and in vivo toxicity in mouse. Free Rad. Biol. Med. 14:37-47.
50. Sakahira, H., Enari, M., Ohsawa, Y., Uchiyama, Y., and Nagata, S. 1999. Apoptotic nuclear morphological change without DNA fragmentation. Curr. Biol. 9:543-546.
51. Savill, J. 1995a. Apoptosis: From worm to wonder-drug? Br. J. Rheumatol. 34:95-98.
52. Savill, J. 1995b. Apoptosis: Will cell death add life to nephrology? Nephrol. Dial. Transplant. 10:1977-1979.
53. Savill, J., and Haslett, C. 1995. Granulocyte clearance by apoptosis in the resolution of inflammation. Semin. Cell Biol. 6:385-393.
54. Shanker, A. 2004. Is thymus redundant after adulthood? Immunol. Lett. 91:79-86.
55. Staples, J. E., Fiore, N. C., Frazier, D. E., Jr., Gasiewicz, T. A., and Silverstone, A. E. 1998. Overexpression of the anti-apoptotic oncogene, bcl-2, in the thymus does not prevent thymic atrophy induced by estradiol or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 151:200-210.
56. Takafuji, S., Suzuki, S., Koizumi, K., Tadokoro, K., Miyamoto, T., Ikemori, R., and Muranaka, M. 1987. Diesel-exhaust particulates inoculated by the intranasal route have an adjuvant activity for IgE production in mice. J. Allergy Clin. Immunol. 79:639-645.
57. Takeuchi, Y., Kosaka, T., Hayashi, K., Takeda, M., Yoshida, T., Fujisawa, H., Teramoto, S., Maita, K., and Harada, T. 2002. Thymic atrophy induced by methoxychlor in rat pups. Toxicol. Lett. 135:199-207.
58. Takeuchi, Y., Kosaka, T., Hayashi, K., Ishimine, S., Ohtsuka, R., Kuwahara, M., Yoshida, T., Takahashi, N., Takeda, M., Maita, K., and Harada, T. 2004. Alterations in the developing immune system of the rat after perinatal exposure to methoxychlor. J. Toxicol. Pathol. 17:165-170.
59. United Nations Environmental Programme Chemicals Branch. 2006. OECD Initial Assessment Reports for High Production Volume Chemicals including Screening Information Datasets (SIDS) 1999; Washington, D. C., EPA420-R-99-029:120.
60. United States Environmental Protection Agency. 1999. Analysis of the Impacts of Control Program on Motor Vehicle Toxics Emissions and Exposure in Urban Areas and Nationwide. 1999; Washington, D. C., EPA420-R-99-029:120.
61. Vermes, I., Haanen, C., Steffens-Nakken, H., and Reutelingsperger, C. 1995. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods 184:39-51.
62. Wessels, D., Barr, D. B., and Mendola, P. 2003. Use of biomarkers to indicate exposure of children to organophosphate pesticides: Implications for a longitudinal study of children's environmental health. Environ. Health Perspect. 111:1939-1946.
63. Wyllie, A. H., and Morris, R. G. 1982. Hormone-induced cell death. Purification and properties of thymocytes undergoing apoptosis after glucocorticoid treatment. Am. J. Pathol. 109:78-87.
64. Zelikoff, J. T., Smialowicz, R., Bigazzi, P. E., Goyer, R. A., Lawrence, D. A., Maibach, H. I., and Gardner, D. 1994. Immunomodulation by metals. Fundam. Appl. Toxicol. 22:1-7.
65. Zhang, N., Hartig, H., Dzhagalov, I., Draper, D., and He, Y. W. 2005. The role of apoptosis in the development and function of T-lymphocytes. Cell Res. 15:749-769.
66. Zoller, A. L., and Kersh, G. J. 2006. Estrogen induces thymic atrophy by eliminating early thymic progenitors and inhibiting proliferation of β-selected thymocytes. J. Immunol. 176:7371-7378.