Changes in antioxidant enzymes in humans with long-term exposure to pesticides

Toxicology Letters

Volumn 171, Issue 3, 2007, Pages 146-153

  López, Olga ^a   Hernández, Antonio F ^a   Rodrigo, Lourdes ^a   Gil, Fernando ^a   Pena, Gloria ^b   Serrano, José Luis ^c   Parrón, Tesifón ^c   Villanueva, Enrique ^a   Pla, Antonio ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b Centro de Salud Motril Centro   (Spain)

^c JUNTA DE ANDALUCÍA   (Spain)

Author keywords

Catalase; Glutathione reductase; Oxidative stress; Paraoxonase; Pesticides; Superoxide dismutase

Indexed keywords

ACETYLCHOLINESTERASE; ARYLDIALKYLPHOSPHATASE; CATALASE; ERYTHROCYTE ENZYME; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; PESTICIDE; SUPEROXIDE DISMUTASE;

AGRICULTURAL WORKER; ALCOHOL CONSUMPTION; ALLELE; ARTICLE; BLOOD SAMPLING; BODY MASS; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC POLYMORPHISM; HUMAN; LONG TERM EXPOSURE; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL EXPOSURE; PESTICIDE SPRAYING; PRIORITY JOURNAL; SMOKING HABIT;

ACETYLCHOLINESTERASE; ADULT; AGRICULTURAL WORKERS' DISEASES; ANTIOXIDANTS; ARYLDIALKYLPHOSPHATASE; CATALASE; ENZYMES; ERYTHROCYTES; FEMALE; GLUCOSEPHOSPHATE DEHYDROGENASE; GLUTATHIONE PEROXIDASE; HUMANS; MALE; OCCUPATIONAL EXPOSURE; PESTICIDES; PHOSPHORIC ACID ESTERS; POLYMORPHISM, GENETIC; SPAIN; SUPEROXIDE DISMUTASE;

EID: 34447341185     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2007.05.004     Document Type: Article

References (37)

1. Abdollahi M., Ranjbar A., Shadnia S., Nikfar S., and Rezaiee A. Pesticides and oxidative stress: a review. Med. Sci. Monit. 10 (2004) RA141-RA147
2. Aebi H. Catalase in vitro. Methods Enzymol. 105 (1984) 121-126
3. Agrawal D., Sultana P., and Gupta G.S. Oxidative damage and changes in the glutathione redox system in erythrocytes from rats treated with hexachlorocyclohexane. Food Chem. Toxicol. 29 (1991) 459-462
4. Alavanja M.C., Hoppin J.A., and Kamel F. Health effects of chronic pesticide exposure: cancer and neurotoxicity. Annu. Rev. Public Health 25 (2004) 155-197
5. Aliciguzel Y., Ozdem S., Demir A.Y., Unal F., Kumbul D., Ozdem S.S., Perry G., and Smith M.A. Effect of the herbicide 4-CPA on human erythrocyte antioxidant enzymes in vitro. Redox Rep. 6 (2001) 153-154
6. Andersen H., Nielsen J., Nielsen F., and Grandjean P. Antioxidative enzyme activities in human erythrocytes. Clin. Chem. 43 (1997) 562-568
7. Banerjee B.D., Seth V., Bhattacharya A., Pasha S.T., and Chakraborty A.K. Biochemical effects of some pesticides on lipid peroxidation and free-radical scavengers. Toxicol. Lett. 107 (1999) 33-47
8. Cereser C., Boget S., Parvaz P., and Revol A. Thiram-induced cytotoxicity is accompanied by a rapid and drastic oxidation of reduced glutathione with consecutive lipid peroxidation and cell death. Toxicology 163 (2001) 153-162
9. Datta C., Gupta J., Sarkar A., and Sengupta D. Effects of organophosphorus insecticide phosphomidon on antioxidant defence components of human erythrocyte and plasma. Indian J. Exp. Biol. 30 (1992) 65-67
10. Deutsch S.I., Mohs R.C., Levy M.I., Rothpearl A.B., Stockton D., Horvath T., Coco A., and Davis K.L. Acetylcholinesterase activity in CSF in schizophrenia, depression, Alzheimer's disease and normals. Biol. Psychiatry 18 (1983) 1363-1373
11. Dowla H.A., Panemangalore M., and Byers M.E. Comparative inhibition of enzymes of human erythrocytes and plasma in vitro by agricultural chemicals. Arch. Environ. Contam. Toxicol. 31 (1996) 107-114
12. Ellman G.L., Courtney D.K., Andres Jr. V., and Featherstone R.M. A new rapid colorimetric determinacion of acetylcholinesterase activity. Biochem. Pharmacol. 7 (1961) 88-95
13. el-Sharkawy A.M., Abdel-Rahman S.Z., Hassan A.A., Gabr M.H., el-Zoghby S.M., and el-Sewedy S.M. Biochemical effects of some insecticides on the metabolic enzymes regulating glutathione metabolism. Bull. Environ. Contam. Toxicol. 52 (1994) 505-510
14. Goldberg D.M., and Spooner R.J. Glutathione reductase. In: Bergmeyer H.U., Bergmeyer J., and Graßi M. (Eds). Methods of Enzymatic Analysis vol. III (1984), Verlag Chemie, Weinheim 258-265
15. Gultekin F., Delibas N., Yasar S., and Kilinc I. In vivo changes in antioxidant systems and protective role of melatonin and a combination of vitamin C and vitamin E on oxidative damage in erythrocytes induced by chlorpyrifos-ethyl in rats. Arch. Toxicol. 75 (2001) 88-96
16. Gupta A., Gupta A., and Shukla G.S. Effects of neonatal quinalphos exposure and subsequent withdrawal on free radical generation and antioxidative defenses in developing rat brain. J. Appl. Toxicol. 18 (1998) 71-77
17. Heinzow B.G.J., and McLean A. Critical evaluation of current concepts in exposure assessment. Clin. Chem. 40 (1994) 1368-1375
18. Hernández A.F., López O., Rodrigo L., Gil F., Pena G., Serrano J.L., Parrón T., Alvarez J.C., Lorente J.A., and Pla A. Changes in erythrocyte enzymes in humans long-term exposed to pesticides: influence of several markers of individual susceptibility. Toxicol. Lett. 159 (2005) 13-21
19. Hernández A.F., Gómez M.A., Pérez V., García-Lario J.V., Pena G., Gil F., López O., Rodrigo L., Pino G., and Pla A. Influence of exposure to pesticides on serum components and enzyme activities of cytotoxicity among intensive agriculture farmers. Environ. Res. 102 (2006) 70-76
20. John S., Kale M., Rathore N., and Bhatnagar D. Protective effect of vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocytes. J. Nutr. Biochem. 12 (2001) 500-504
21. Kale M., Rathore N., John S., and Bhatnagar D. Lipid peroxidative damage on pyrethroid exposure and alterations in antioxidant status in rat erythrocytes: a possible involvement of reactive oxygen species. Toxicol. Lett. 105 (1999) 197-205
22. Kono Y., and Fridovich I. Superoxide radical inhibits catalase. J. Biol. Chem. 257 (1982) 5751-5754
23. Lee C.H., Kamijima M., Kim H., Shibata E., Ueyama J., Suzuki T., Takagi K., Saito I., Gotoh M., Hibi H., Naito H., and Nakajima T. 8-Hydroxydeoxyguanosine levels in human leukocyte and urine according to exposure to organophosphorus pesticides and paraoxonase 1 genotype. Int. Arch. Occup. Environ. Health (2006) (Epub ahead of print)
24. Naqvi S.M., and Vaishnavi C. Bioaccumulative potential and toxicity of endosulfan insecticide to non-target animals. Comp. Biochem. Physiol. C 105 (1993) 347-361
25. Paglia D.E., and Valentine W.N. Studies on quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70 (1967) 158-169
26. Panemangalore M., Dowla H.A., and Byers M.E. Occupational exposure to agricultural chemicals: effect on the activities of some enzymes in the blood of farm workers. Int. Arch. Occup. Environ. Health 72 (1999) 84-88
27. Prakasam A., Sethupathy S., and Lalitha S. Plasma and RBCs antioxidant status in occupational male pesticide sprayers. Clin. Chim. Acta 310 (2001) 107-112
28. Ranjbar A., Pasalar P., and Abdollahi M. Induction of oxidative stress and acetylcholinesterase inhibition in organophosphorus pesticide manufacturing workers. Hum. Exp. Toxicol. 21 (2002) 179-182
29. Richter R.J., and Furlong C.E. Determination of paraoxonase (PON1) status requires more than genotyping. Pharmacogenetics 9 (1999) 745-753
30. Singh M., Sandhir R., and Kiran R. Erythrocyte antioxidant enzymes in toxicological evaluation of commonly used organophosphate pesticides. Indian J. Exp. Biol. 44 (2006) 580-583
31. Slaughter M.R., Thakkar H., and O'Brien P.J. Effect of diquat on the antioxidant system and cell growth in human neuroblastoma cells. Toxicol. Appl. Pharmacol. 178 (2002) 63-70
32. Sozmen E.Y., Sozmen B., Girgin F.K., Delen Y., Azarsiz E., Erdener D., and Ersoz B. Antioxidant enzymes and paraoxonase show a co-activity in preserving low-density lipoprotein from oxidation. Clin. Exp. Med. 1 (2001) 195-199
33. Stevenson D.E., Kehrer J.P., Kolaja K.L., Walborg E.F., and Klaunig Jr. J.E. Effect of dietary antioxidants on dieldrin-induced hepato-toxicity in mice. Toxicol. Lett. 75 (1995) 177-183
34. Thapar A., Sandhir R., and Kiran R. Acephate induced oxidative damage in erythrocytes. Indian J. Exp. Biol. 40 (2002) 963-996
35. Valko M., Leibfritz D., Moncol J., Cronin M.T., Mazur M., and Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39 (2007) 44-84
36. Zhou J.F., Xu G.B., and Fang W.J. Relationship between acute organophosphorus pesticide poisoning and damages induced by free radicals. Biomed. Environ. Sci. 15 (2002) 177-186
37. Zhou J.F., Zhou W., Zhang S.M., Luo Y.E., and Chen H.H. Oxidative stress and free radical damage in patients with acute dipterex poisoning. Biomed. Environ. Sci. 17 (2004) 223-233