Thymic atrophy induced by methoxychlor in rat pups

Toxicology Letters

Volumn 135, Issue 3, 2002, Pages 199-207

  Takeuchi, Yukiko ^a   Kosaka, Tadashi ^a   Hayashi, Koichi ^a   Takeda, Makio ^a   Yoshida, Toshinori ^a   Fujisawa, Hideki ^a   Teramoto, Shoji ^a   Maita, Keizo ^a   Harada, Takanori ^a  

^a INSTITUTE OF ENVIRONMENTAL TOXICOLOGY   (Japan)

Author keywords

Apoptosis; Flow cytometry; Methoxychlor; Morphometry; Thymus; TUNEL

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; METHOXYCHLOR; TRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; EUTHANASIA; FEMALE; FLOW CYTOMETRY; GESTATION PERIOD; HISTOPATHOLOGY; LACTATION; LYMPHOCYTE; MORPHOMETRICS; NICK END LABELING; NONHUMAN; PERINATAL PERIOD; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; THYMUS ATROPHY;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; APOPTOSIS; ATROPHY; BODY WEIGHT; FEMALE; MALE; METHOXYCHLOR; ORGAN SIZE; PREGNANCY; RATS; THYMUS GLAND;

EID: 0037026864     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00259-X     Document Type: Article

References (43)

1. Bal H.S. Effect of methoxychlor on reproductive systems of the rat. Proc. Soc. Exp. Biol. Med. 176:1984;187-196.
2. Blaylock B.L., Holladay S.D., Comment C.E., Heindel J.J., Luster M.I. Exposure to tetrachlorodibenzo-p-dioxin (TCDD) alters fetal thymocyte maturation. Toxicol. Appl. Pharmacol. 112:1992;207-213.
3. Bolger R., Wiese T.E., Ervin K., Nestich S., Checovich W. Rapid screening of environmental chemicals for estrogen receptor binding capacity. Environ. Health Perspect. 106:1998;551-557.
4. Bulger W.H., Muccitelli R.M., Kupfer D. Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation. Biochem. Pharmacol. 27:1978;2417-2423.
5. Chapin R.E., Harris M.W., Davis B.J., Ward S.M., Wilson R.E., Mauney M.A., Lockhart A.C., Smialowicz R.J., Moser V.C., Burka L.T., Collins B.J. The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function. Fundam. Appl. Toxicol. 40:1997;138-157.
6. Cohen J.J. Glucocorticoid-induced apoptosis in the thymus. Semin. Immunol. 4:1992;363-369.
7. Colborn T., vom Saal F.S., Soto A.M. Development effects of endocrine-disrupting chemicals in wildlife and humans. Environ. Health Perspect. 101:1993;378-384.
8. Erlandsson M.C., Ohlsson C., Gustafsson J.A., Carlsten H. Role of oestrogen alpha and beta in immune organ development and in oestrogen-mediated effects on thymus. Immunology. 103:2001;17-25.
9. Gad S.C., Weil C.S. Statistics for toxicologists. Hayes A.W., Principles and Methods of Toxicology. Third Ed. 1994;221-274 Raven Press, New York.
10. Gavarieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:1992;493-501.
11. Gehrs B.C., Riddle M.M., Williams W.C., Smialowicz R.J. Alterations in the developing immune system of the F344 rat after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin II. Effects on the pup and adult. Toxicology. 122:1997;229-240.
12. Gratiot-Deans J., Merio R., Nunez G., Turka L.A. Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival. Proc. Natl. Acad. Sci. USA. 91:1994;10685-10689.
13. Gray L.E., Ostby J., Ferrell J., Rehnberg G., Linder R., Cooper R., Goldman J., Slott V., Laskey J. A dose-response analysis of methoxychlor-induced alterlations of reproductive development and function in the rat. Fundam. Appl. Toxicol. 12:1989;92-108.
14. Hattori A., Kunz H.W., Gill T.J. III, Shinozuka H. Thymic and lymphoid changes and serum immunoglobulin abnormalities in mice receiving cyclospoline. Am. J. Pathol. 128:1987;111-120.
15. Hirai M., Ichikawa M. Changes in serum glucocorticoid levels and thymic atrophy induced by phenytoin administration. Toxicol. Lett. 56:1991;1-6.
16. Itoh S., Hirota R. Atrophy of adrenal gland and thymus following cortisol treatment in newborn rats. Nippon Naibunpi Gakkai Zassi. 52:1976;1230-1242.
17. Japanese Association for Laboratory Animal Science . Guidelines for animal experimentation. Exp. Anim. 36:1987;285-288.
18. Kamath A.B., Nagarkatti P.S., Nagarkatti M. Characterization of phenotypic alterlations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocytes in vivo and its effect on apoptosis. Toxicol. Appl. Pharmacol. 150:1998;117-124.
19. Kapoor I.P., Metcalf R.L., Nystrom R.F., Sangha G.K. Comparative metabolism of methoxychlor, methiochlor, and DDT in mouse, insects, and in a model ecosystem. J. Agric. Food Chem. 18:1970;1145-1152.
20. Kawashima I., Sakabe K., Seiki K., Fujii-Hanamoto H. Hormone and immune response, with special reference to steroid hormone. 3. Sex steroid effect on T-cell differentiation. Tokai J. Exp. Clin. Med. 15:1990;213-218.
21. 3H mice. Dev. Pharmacol. Ther. 10:1987;405-412.
22. Kosuda L.L., Hannigan M.O., Bigazzi P.E., Leif J.H., Greiner D.L. Thymus atrophy and changes in thymocyte subpopulations of BN rats with mercury-induced renal autoimmune disease. Autoimmunity. 23:1996;77-89.
23. Lai Z.W., Fiore N.C., Gasiewicz T.A., Silverstone A.E. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diethylstilbestrol affect thymocytes at different stages of development in fetal thymus organ culture. Toxicol. Appl. Pharmacol. 149:1998;167-177.
24. Laws S.C., Carey S.A., Ferrell J.M., Bodman G.J., Cooper R.L. Estrogenic activity of octylphenol, nonylphenol, bisphenol A and mothoxychlor in rats. Toxicol. Sci. 54:2000;154-167.
25. Maurer J.K., Gibbons B.A., Bruce R.D. Morphometric assessment of thymic size variation in laboratory rabbits. Toxicol. Pathol. 18:1990;407-411.
26. +-mediated endonuclease activation. Science. 242:1988;256-259.
27. Moore N.C., Anderson G., Williams G.T., Owen J.J., Jenkinson E.J. Developmental regulation of bcl-2 expression in the thymus. Immunology. 81:1994;115-119.
28. Oberdörster E., Cheek A.O. Gender benders at the beach: endocrine disruption in marine and estuarine organisms. Environ. Toxicol. Chem. 20:2001;23-36.
29. Ogata R., Omura M., Shimasaki Y., Kubo K., Oshima Y., Aou S., Inoue N. Two-generation reproductive toxicity study of tributyltin chloride in female rats. J. Toxicol. Environ. Health A. 63:2001;127-144.
30. Pickford D.B., Morris D. Effect of endocrine-disrupting cintaminants on amphibian oogenesis: methoxychlor inhibits progesterone-induced maturation of Xenopus laevis oocytes in vitro. Environ. Health Perspect. 107:1999;285-292.
31. + immature thymocytes. Relation to the interaction between early thymocytes and thymic epithelial cells? Thymus. 14:1989;79-88.
32. Pieters R.H., Bol M., Penninks A.H. Immunotoxic organotins as possible model compounds in studying apoptosis and thymocyte differentiation. Toxicology. 91:1994;189-202.
33. Raffray M., Cohen G.M. Bis(tri-n-butyltin)oxide induces programmed cell death (apoptosis) in immature rat thymocytes. Arch. Toxicol. 2:1991;135-139.
34. Reuber M.D. Carcinogenicity and toxicity of methoxychlor. Environ. Health Perspect. 36:1980;205-219.
35. Shelby M.D., Newbold R.R., Tully D.B., Chae K., Davis V.L. Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays. Environ. Health Perspect. 104:1996;1296-1300.
36. Silverstone A.E., Frazier D.E. Jr, Fiore N.C., Soults J.A., Gasiewicz T.A. Dexamethasone, β-estradiol, and 2,3,7,8-Tetrachlorodibenzo-p-dioxin elicit thymic atrophy through different cellular targets. Toxicol. Appl. Pharmacol. 126:1994;248-259.
37. Soto A.M., Sonnenschein C., Chung K.L., Fernandez M.F., Olea N., Serrano F.O. The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ. Health Perspect. 103:1995;113-122.
38. Staples J.E., Fiore N.C., Fraizer D.E. Jr., Gaisiewicz T.A., Silverstone A.E. Overexpression of the anti-apoptotic oncogene, bcl-2, in the thymus does not prevent thymic atrophy induced by estradiol or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 151:1998;200-210.
39. Staples J.E., Gasiewicz T.A., Fiore N.C., Lubahn D.B., Korach K.S., Silverstone A.E. Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alteration. J. Immunol. 163:1999;4168-4174.
40. Ueno Y., Makita Y., Nagata S., Tsutsumi T., Yoshida F., Tamura S., Sekijima M., Tashiro F., Harada T., Yoshida T. No chronic toxicity of a low dose of microcystin-LR, a cyanobacterial hepatotoxin, in female BALB/c mice. Environ. Toxicol. 14:1999;45-55.
41. Umbreit T.H., Gallo M.A. Phisiological implications of estrogen receptor modulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Lett. 42:1990;5-14.
42. Wyllie A.H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature. 284:1980;555-556.
43. Zelikoff J.T., Smialowicz R., Bigazzi P.E., Goyer R.A., Lawrence D.A., Maibach H.I., Gardner D. Immunomodulation by metals. Fundam. Appl. Toxicol. 4:1975;31-32.