Use of biomarkers to indicate exposure of children to organophosphate pesticides: Implications for a longitudinal study of children's environmental health

Environmental Health Perspectives

Volumn 111, Issue 16, 2003, Pages 1939-1946

  Wessels, Denise ^a   Barr, Dana B ^b   Mendola, Pauline ^c  

^a INDIANA UNIVERSITY   (United States)

^b NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Biomarkers; Blood; Children; Exposure; Meconium; Organophosphate; Pesticides; Study design; Urine

Indexed keywords

ACEPHATE; AZINPHOS METHYL; BIOLOGICAL MARKER; CHLORPYRIFOS; CHOLINESTERASE; COUMAFOS; DICHLORVOS; DIMETHOATE; DIMPYLATE; DISULFOTON; ETHION; ETHOPROP; FENAMIPHOS; FENITROTHION; FENTHION; METHAMIDOPHOS; METHIDATHION; METRIFONATE; NALED; ORGANOPHOSPHATE PESTICIDE; PARATHION; PARATHION METHYL; PHORATE; PHOSALONE; PHOSMET; PROFENOFOS; STIROFOS; TEMEFOS; TERBUFOS;

AMNION FLUID ANALYSIS; ARTICLE; BLOOD ANALYSIS; BLOOD LEVEL; CHILD; CHILD HEALTH; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL HEALTH; ENVIRONMENTAL MONITORING; ENZYME INHIBITION; HUMAN; LONGITUDINAL STUDY; MECONIUM; METABOLISM; METABOLITE; PRENATAL EXPOSURE; PRIORITY JOURNAL; PUERPERIUM; SALIVA ANALYSIS; TIME; UNITED STATES; URINALYSIS;

EID: 0346752071     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.6179     Document Type: Article

References (72)

1. Adgate JL, Barr DB, Clayton CA, Eberly LE, Freeman NC, Lioy PJ, et al. 2001. Measurement of children's exposure to pesticides: analysis of urinary metabolite levels in a probability-based sample. Environ Health Perspect 109:583-590.
2. Aprea C, Strabi M, Novelli MT, Lunghini L, Bozzi N. 2000. Biologic monitoring of exposure to organophosphorus pesticides in 195 Italian children. Environ Health Perspect 108:521-525.
3. Barr DB, Barr JR, Maggio VL, Whitehead RD Jr, Sadowski MA, Whatt RM, et al. 2002. A multi-analyte method for quantification of contemporary pesticides in human serum and plasma using high resolution mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 778:99-111.
4. Bearer CF, Lee S, Salvator AE, Minnes S, Swick A, Yamashita T, et al. 1999. Ethyl linoleate in meconium: a biomarker for prenatal ethanol exposure. Alcohol Clin Exp Res 23:487-493.
5. Bissbort SH, Vermaak WJ, Elias J, Bester MJ, Dhatt GS, Pum JK. 2001. Novel test and its automation for the determination of erythrocyte acetylcholinesterase and its application to organophosphate exposure. Clin Chim Acta 303:139-145.
6. Bradman A, Barr DB, Claus Henn BG, Brumheller T, Curry C, Eskenazi B. 2003. Measurement of pesticides and other toxicants in amniotic fluid as a potential biomarker of prenatal exposure: a validation study. Environ Health Perspect 111:1779-1782.
7. Branum AM, Collman GW, Correa A, Keim SA, Kassel W, Kimmel CA, et al. 2003. The National Children's Study of environmental effects on child health and development. Environ Health Perspect 111:642-646.
8. Browne S, Moore C, Negrusz A, Tebbett I, Covert R, Dusick A. 1994. Detection of cocaine, norcocaine, and cocaethylene in the meconium of premature neonates. J Forensic Sci 39:1515-1519.
9. Callahan CM, Grant TM, Phipps P, Clark G, Novack AH, Streissguth AP, et al. 1992. Measurement of gestational cocaine exposure: sensitivity of infants' hair, meconium, and urine. J Pediatr 120:763-768.
10. Callahan MA, Clickner RP, Whitmore RW, Kalton G, Sexton K. 1995. Overview of important design issues for a National Human Exposure Assessment Survey. J Expo Anal Environ Epidemiol 5:257-282.
11. Castorina R, Bradman A, McKone TE, Barr DB, Harnly ME, Eskenazi B. 2003. Cumulative organaphosphate pesticide exposure and risk assessment among pregnant women living in an agricultural community: a case study from the CHAMACOS cohort. Environ Health Perspect 111:1640-1648.
12. CEPA. 2002. Guidelines for Physicians Who Supervise Workers Exposed to Cholinesterase-Inhibiting Pesticides. 4th ed. Sacramento, CA:California Environmental Protection Agency.
13. Children's Health Act of 2000. 2000. Public Law 106-310.
14. Clark GD, Rosenzweig IB, Raisys VA, Callahan CM, Grant TM, Streissguth AP. 1992. The analysis of cocaine and benzoylecgonine in meconium. J Anal Toxicol 16:261-263.
15. Coye MJ, Lowe JA, Maddy KJ. 1986. Biological monitoring of agricultural workers exposed to pesticides. II. Monitoring of intact pesticides and their metabolites. J Occup Med 28:628-636.
16. Dempsey D, Moore C, Deitermann D, Lewis D, Feeley B, Niedbala RS. 1999. The detection of cotinine in hydrolyzed meconium samples. Forensic Sci Int 102:167-171.
17. De Peyster A, Willis WO, Molgaard CA, MacKendrick TM, Walker C. 1993. Cholinesterase and self-reported pesticide exposure among pregnant women. Arch Environ Health 48:348-352.
18. Eskenazi B, Bradman A, Castorina R. 1999. Exposure of children to organophosphate pesticides and their potential adverse health effects. Environ Health Perspect 107(suppl 3):409-419.
19. Fenske RA, Lu C, Barr D, Needham L. 2002. Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington State. Environ Health Perspect 110:549-553.
20. Fenske RA, Lu C, Simcox NJ, Loewenherz C, Touchstone J, Moate TF, et al. 2000. Strategies for assessing children's organophosphorus pesticide exposures in agricultural communities. J Expo Anal Environ Epidemiol 10:662-671.
21. Fidder A, Hulst AG, Noort D, de Ruiter R, van der Schans MJ, Benschop HP, et al. 2002. Restrospective detection of exposure to organophosphorus anti-cholinesterases: mass spectrometric analysis of phosphylated human butyryl-cholinesterase. Chem Res Toxicol 15:582-590.
22. Food Quality Protection Act of 1996. 1996. Public Law 104-170.
23. Fournier E, Sonnier M, Dally S. 1978. Detection and assay of organophosphate pesticides in human blood by gas chromatography. Clin Toxicol 12:457-462.
24. Freeman NC, Weinman T, Lioy PJ, Stern AH, Shupack SI. 1995. The effect of remediation of chromium waste sites on chromium levels in urine of children living in the surrounding neighborhood. J Air Waste Manag Assoc 45:604-614.
25. Frenzel T, Sochor H, Speer K, Uihlein M. 2000. Rapid multimethod for verification and determination of toxic pesticides in whole blood by means of capillary GC-MS. J Anal Toxicol 24365-371.
26. Griffin P, Mason H, Heywood K, Cocker J. 1999. Oral and dermal absorption of chlorpyrifos: a human volunteer study. Occup Environ Med 56:10-13.
27. He F. 1999 , Biological monitoring of exposures to pesticides: current issues. Toxicol Lett 108:277-283.
28. Heudorf U, Angerer J. 2001. Metabolites of organophosphorous insecticides in urine specimens from inhabitants of a residential area. Environ Res 86:80-87.
29. Hong Z, Gunter M, Randow FF. 2002. Meconium: a matrix reflecting potential fetal exposure to organochlorine pesticides and its metabolites. Ecotoxicol Environ Saf 51:60-64.
30. Jeyaratnam J, Maroni M. 1994. Organophosphorous compounds. Toxicology 91:15-27.
31. Karalliedde L, Feldman S, Henry J, Marrs T, ads. 2001. Organophosphates and Health. River Edge, NJ:World Scientific Publishing.
32. Karlsen RL, Sterri S, Lyngaas S, Fonnum F. 1981. Reference values for erythrocyte acetylcholinesterase and plasma cholinesterase activities in children, implications for organophosphate intoxication. Scand J Clin Lab Invest 41:301-302.
33. Kawasaki S, Ueda H, Itoh H, Tadano J. 1992. Screening of organophosphorus pesticides using liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. J Chromatogr 595:193-202.
34. Kwong TC. 2002. Organophosphate pesticides: biochemistry and clinical toxicology. Ther Drug Monit 24:144-149.
35. Lauwerys RR, Hoet P. 1993. Industrial Chemical Exposure: Guidelines for Biological Monitoring. Boca Raton, FL:Lewis Publishers.
36. Lessenger JE, Reese BE. 1999. Rational use of cholinesterase activity testing in pesticide poisoning. J Am Board Fam Pract 12:307-314.
37. Liu J, Suzuki O, Kumazawa T, Seno H. 1989. Rapid isolation with Sep-Pak C18 cartridges and wide-bore capillary gas chromatography of organophosphate pesticides. Forensic Sci Int 41:67-72.
38. Liu S, Pleil JD. 2002. Human blood and environmental media screening method for pesticides and polychlorinated biphenyl compounds using liquid extraction and gas chromatography-mass spectrometry analysis. J Chromatogr B Analyt Technol Biomed Life Sci 769:155-167.
39. Loewenherz C, Fenske RA, Simcox NJ, Bellamy G, Kalman D. 1997. Biological monitoring of organophosphorus pesticide exposure among children of agricultural workers in central Washington State. Environ Health Perspect 105:1344-1353.
40. Lu C, Knutson DE, Fisker-Andersen J, Fenske RA. 2001. Biological monitoring survey of organophosphorus pesticide exposure among pre-school children in the Seattle metropolitan area. Environ Health Perspect 109:299-303.
41. MacIntosh DL, Kabiru C, Echols SL, Ryan PB. 2001. Dietary exposure to chlorpyrifos and levels of 3,5,6-trichloro-2-pyridinol in urine. J Expo Anal Environ Epidemiol 11:279-285.
42. Magnotti RA Jr, Dowling K, Eberly JP, McConnell RS. 1988. Field measurement of plasma and erythrocyte cholinesterases. Clin Chim Acta 176:315-332.
43. Maroni M, Catenacci G, Galli D, Cavallo D, Ravazzani G. 1990. Biological monitoring of human exposure to acephate. Arch Environ Contam Toxicol 19:782-788.
44. Marques EG. 1990. Acute intoxication by azinphos-ethyl. J Anal Toxicol 14:243-246.
45. Maynard EC, Amoruso LP, Oh W. 1991. Meconium for drug testing. Am J Dis Child 145:650-652.
46. Meyer E, Borrey D, Lambert W, Van Peteghem C, Piette M, De Leenheer A. 1998. Analysis of fenthion in postmortem samples by HPLC with diode-array detection and GC-MS using solid-phase extraction. J Anal Toxicol 22:248-252.
47. Mileson BE, Chambers JE, Chen WL, Dettbarn W, Ehrich M, Eldefrawi AT, et al. 1998. Common mechanism of toxicity: a case study of organophosphorus pesticides. Toxicol Sci 41:8-20.
48. Mills PK, Zahm SH. 2001. Organophosphate pesticide residues in urine of farmworkers and their children in Fresno County, California. Am J Ind Med 40:571-577.
49. Moate TF, Lu C, Fenske RA, Hahne RM, Kalman DA. 1999. Improved cleanup and determination of dialkyl phosphates in urine of children exposed to organophosphorus insecticides. J Anal Toxicol 23:230-236.
50. Moore C, Negrusz A, Laws D. 1998. Determination of drugs of abuse in meconium. J Chromatogr B Biomed Sci Appl 713:137-146.
51. Moriya F, Chan KM, Noguchi TT, Wu PY. 1994. Testing for drugs of abuse in meconium of newborn infants. J Anal Toxicol 18:41-45.
52. National Children's Study October Assembly Meeting. 2001. Exposure to Chemical Agents Working Group Report. Washington, DC:National Institute of Child Health and Development. Available: http://nationalchildrensstudy.gov/committees/chemical_agents/report.cfm [accessed 14 August 2002].
53. National Research Council. 1993. Pesticides in the Diets of Infants and Children. Washington, DC:National Academy Press.
54. O'Rourke MK, Lizardi PS, Rogan SP, Freeman NC, Aguirre A, Saint CG. 2000. Pesticide exposure and creatinine variation among young children. J Expo Anal Environ Epidemiol 10:672-681.
55. Ostrea EM Jr. 1999. Testing for exposure to illicit drugs and other agents in the neonate: a review of laboratory methods and the role of meconium analysis. Curr Probl Pediatr 29:37-56.
56. Ostrea EM Jr, Romero A, Yee H. 1993. Adaptation of the meconium drug test for mass screening. J Pediatr 122:152-154.
57. Quackenboss JJ, Pellizzari ED, Shubat P, Whitmore RW, Adgate JL, Thomas KW, et al. 2000. Design strategy for assessing multi-pathway exposure for children: the Minnesota Children's Pesticide Exposure Study (MNCPES). J Expo Anal Environ Epidemiol 10:145-158.
58. Ramirez GB, Cruz MC, Pagulayan O, Ostrea E, Dalisay C. 2000. The Tagum study I: analysis and clinical correlates of mercury in maternal and cord blood, breast milk, meconium, and infants' hair. Pediatrics 106:774-781.
59. Ray DE, Richards PG. 2001. The potential for toxic effects of chronic, low-dose exposure to organophosphates. Toxicol Lett 120:343-351.
60. Rigas ML, Okino MS, Quakenboss JJ. 2001. Use of a pharmacokinetic model to assess chlorpyrifos exposure and dose in children, based on urinary biomarker measurements. Toxicol Sci 61:374-381.
61. Ryan RM, Wagner CL, Schultz JM, Varley J, DiPreta J, Sharer DM, et al. 1994. Meconium analysis for improved identification of infants exposed to cocaine in utero. J Pediatr 125:435-440.
62. Selevan SG, Kimmel CA, Mendola P. 2000. Identifying critical windows of exposure for children's health. Environ Health Perspect 108(suppl 3):451-455.
63. Sexton K, Adgate JL, Eberly LE, Clayton CA, Whitmore RW, Pellizzari ED, et al. 2003. Predicting children's short-term exposure to pesticides: results of a questionnaire screening approach. Environ Health Perspect 110:123-128.
64. Sharma VK, Jadhav RK, Rao GJ, Saraf AK, Chandra H. 1990. High performance liquid chromatographic method for the analysis of organophosphorus and carbamate pesticides. Forensic Sci Int 48:21-25.
65. U.S. EPA. 1999. Organophosphorous Pesticides in Food - A Primer on Reassessment of Residue Limits. 735-F-99-014. Washington, DC:U.S. Environmental Protection Agency.
66. U.S. EPA. 2000. Science Policy on the Use of Data on Cholinesterase Inhibition for Risk Assessments of Organophosphorous and Carbamate Pesticides. Washington, DC:U.S. Environmental Protection Agency, Office of Pesticide Programs. Available: http://www.epa.gov/pesticides/trac/science/cholin.pdf [accessed 12 November 2002].
67. U.S. EPA. 2003. Organophosphate Review: Chemical Status. Washington, DC:U.S. Environmental Protection Agency. Available: http://www.epa.gov/oppsrrd1/cumulativenew/status.htm [accessed 24 October 2003].
68. Vandekar M. 1980. Minimizing occupational exposure to pesticides: cholinesterase determination and organophosphorus poisoning. Residue Rev 75:67-80.
69. Whitmore RW, Kelly JE, Reading PL. 1992. National Home and Garden Pesticide Survey: Final Report. Vol 1. Research Triangle Park, NC:Research Triangle Institute.
70. Whyatt RM, Barr DB. 2001. Measurement of organophosphate metabolites in postpartum meconium as a potential biomarker of prenatal exposure: a validation study. Environ Health Perspect 109:417-420.
71. Whyatt RM, Barr DB, Camann DE, Kinney PL, Barr JR, Andrews HF, et al. 2003. Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns. Environ Health Perspect 111:749-756.
72. WHO. 1996. Biological Monitoring of Chemical Exposure in the Workplace. Vol 1. Geneva:World Health Organization.