Evidence for the induction of apoptosis in thymocytes by 2,3,7,8- tetrachlorodibenzo-p-dioxin in vivo

Toxicology and Applied Pharmacology

Volumn 142, Issue 2, 1997, Pages 367-377

  Kamath, Arati B ^a   Xu, Huimin ^a   Nagarkatti, Prakash S ^b   Nagarkatti, Mitzi ^a  

^a VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DEXAMETHASONE; DNA FRAGMENT; DNA NUCLEOTIDYLEXOTRANSFERASE; DRUG VEHICLE; FLUORESCEIN ISOTHIOCYANATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; IMMUNOTOXICITY; MOUSE; NONHUMAN; THYMOCYTE; THYMUS ATROPHY;

ANIMALIA;

EID: 0031062290     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.8049     Document Type: Article

References (29)

1. Blaylock, B. L., Holladay, S. D., Comment, C. E., Heindell, J. J., and Luster, M. I. (1992). Exposure to tetrachlorodibenzo-p-dioxin (TCDD) alters fetal thymocyte maturation. Toxicol. Appl. Pharmacol. 112, 207-213.
2. Choi, E. J., Toscano, D. J., Ryan, J. A., Reidel, N., and Toscano, W. A., Jr. (1991). Dioxin induces transforming growth factor-alpha in human keratinocytes. J. Biol. Chem. 266, 9591-9597.
3. Clark, G. C., Lucier, G., Luster, M. I., Thomson, M., Mahler, J., and Taylor, M. (1991a). Tumor necrosis factor and dexamethasone treatment reverse acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicologist 11, 37.
4. Clark, G. C., Taylor, M., Tritscher, A. M., and Lucier, G. W. (1991b). Tumor necrosis factor involvement in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated endotoxin hypersensitivity in C57BL/6 mice congenic at the Ah locus. Toxicol. Appl. Pharmacol. 111, 422-431.
5. Comment, C. E., Blaylock, B. L., Germolec, D. R., Pollock, P. L., Kouchi, Y., Brown, H. W., Rosenthal, G. J., and Luster, M. I. (1992). Thymocyte injury after in vitro chemical exposure: Potential mechanisms for thymic atrophy. J. Pharmacol. Exp. Ther. 262, 1267-1273.
6. Fine, J. S., Silverstone, A. E., and Gasiewicz, T. A. (1990). Impairment of prothymocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Immunol. 144, 1169-1176.
7. Gavrieli, Y., Sherman, Y., and Ben-Sasson, S. A. (1992). Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
8. Gorczyca, W., Gong, J., and Darzynkiewicz, Z. (1993). Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res. 53, 1945-1951.
9. Greenlee, W. F., Dold, K. M., Irons, R. D., and Osborne, R. (1985). Evidence for direct action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thymic epithelium. Toxicol. Appl. Pharmacol. 79, 112-120.
10. Hernandez-Caselles, T., and Stutman, O. (1993). Immune functions of tumor necrosis factor. 1. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6 induced proliferation depending on the concentration of mitogenic costimulation. J. Immunol. 151, 3999-4012.
11. Holladay, S. D., Lindstrom, P., Blaylock, B. L., Comment, C. E., Germolec, D. R., Heindell, J. J., and Luster, M. I. (1991). Perinatal thymocyte antigen expression and postnatal immune development altered by gestation exposure to tetrachlorodibenzo-p-dioxin (TCDD). Teratology 144, 385-393.
12. Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S., Sameshima, M., Hase, A., Seto, Y., and Nagata, S. (1991). The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66, 233-243.
13. Kerkvliet, N. I., and Brauner, J. A. (1990). Flow cytometric analysis of lymphocyte subpopulations in the spleen and thymus of mice exposed to an acute immunosuppressive dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Environ. Res. 52, 146-154.
14. Kishimoto, H., Surh, C. D., and Sprent, J. (1995). Upregulation of surface markers on dying thymocytes. J. Exp. Med. 181, 649-655.
15. Lundberg, K., Grovnik, K. O., Goldschmidt, T. J., Klareskog, L., and Dencker, L. (1990). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters intrathymic T cell development in mice. Chem. Biol. Interact. 74, 179-193.
16. Matzinger, P. (1991). The JAM test: A simple assay for DNA fragmentation and cell death. J. Immunol. Methods 145, 185-192.
17. McConkey, D. J., and Orrenius, S. (1989). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) kills glucocorticoid sensitive thymocytes in vivo. Biochem. Biophys. Res. Commun. 160, 1003-1008.
18. McConkey, D. J., Hartzell, P., Duddy, S. K., Hakansson, H., and Orrenius, S. (1988). 2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by calcium mediated endonuclease activation. Science 242, 256-259.
19. McKallip, R. J., Nagarkatti, M., and Nagarkatti, P. S. (1995). Immunotoxicity of AZT: Inhibitory effect on thymocyte differentiation and peripheral T cell responsiveness to gp120 of HIV. Toxicol. Appl. Pharmacol. 131, 53-62.
20. Poland, A., and Glover, E. (1980). 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Ah segregation of toxicity with the Ah locus. Mol. Pharmacol. 17, 86-89.
21. Poland, A., and Knutson, J. C. (1982). 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity. Annu. Rev. Pharmacol Toxicol. 22, 517-554.
22. Rhile, M. J., Nagarkatti, M., and Nagarkatti, P. S. (1996). Role of Fas apoptosis and MHC genes in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity of T cells. Toxicology 110, 153-167.
23. Rotello, R. J., Lieberman, R. C., Purchio, A. F., and Gerschenson, L. E. (1991). Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultures of uterine epithelial cells. Proc. Natl. Acad. Sci. USA 88, 3412-3415.
24. Savill, J., Fadok, V., Henson, P., and Haslett, C. (1993). Phagocyte recognition of cells undergoing apoptosis. Immunol. Today 14, 131-136.
25. Silverstone, A. J., Frazier, D. E., Fiore, N. C., Soults, J. A., and Gasiewicz, T. A. (1994). Dexamethasone, beta-estradiol, and 2,3,7,8-tetrachlorodibenzo-p-dioxin elicit thymic atrophy through different cellular targets. Toxicol. Appl. Pharmacol. 126, 248-259.
26. Surh, C. D., and Sprent, J. (1994). T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372, 100-103.
27. Sutler, T. R., Guzman, K., Dold, K. M., and Greenlee, W. F. (1991). Targets for dioxin: Genes for plasminogen activator inhibitor-2 and interleukin-1 beta. Science 254, 415-418.
28. Xu, H., Tepper, C. G., Jones, J. B., Fernandez, C. E., and Studzinski, G. P. (1993). 1,25-Dehydroxyvitamin D3 protects HL60 cells against apoptosis but down-regulates the expression of bcl-2 gene. Exp. Cell Res. 209, 367-374.
29. Zhu, L., and Anasetti, C. (1995). Cell cycle control of apoptosis in human leukemic T cells. J. Immunol. 154, 192-200.