Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly inhibits activities of natural killer cells, cytotoxic T lymphocytes and lymphokine-activated killer cells via the Fas-ligand/Fas pathway in perforin-knockout (PKO) mice

Toxicology

Volumn 204, Issue 1, 2004, Pages 41-50

  Li, Qing ^a   Nakadai, Ari ^a   Takeda, Kazuyoshi ^b   Kawada, Tomoyuki ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytotoxic T lymphocyte (CTL); Dimethyl 2,2 dichlorovinyl phosphate (DDVP); Fas ligand Fas pathway; Lymphokine activated killer (LAK); Natural killer (NK); Perforin knockout (PKO) mice

Indexed keywords

DICHLORVOS; FAS LIGAND; ORGANOPHOSPHORUS COMPOUND; PERFORIN; PESTICIDE;

ANIMAL CELL; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVITY; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; IMMUNOTOXICITY; KILLER CELL; KNOCKOUT MOUSE; LYMPHOKINE ACTIVATED KILLER CELL; MALE; MOLECULAR MECHANICS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD95; CELL LINE; DEPRESSION, CHEMICAL; DICHLORVOS; FAS LIGAND PROTEIN; INSECTICIDES; KILLER CELLS, LYMPHOKINE-ACTIVATED; KILLER CELLS, NATURAL; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PORE FORMING CYTOTOXIC PROTEINS; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC;

MURINAE;

EID: 5144220247     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.05.019     Document Type: Article

References (17)

1. Crittenden P.L., Carr R., Pruett S.B. Immunotoxicological assessment of methyl parathion in female B6C3F1 mice. J. Toxicol. Environ. Health. A54:1998;1-20
2. Kagi D., Vignaux F., Ledermann B., Burki K., Depraetere V., Nagata S., Hengartner H., Golstein P. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science. 265:1994a;528-530
3. Kagi D., Ledermann B., Burki K., Seiler P., Odermatt B., Olsen K.J., Podack E.R., Zinkernagel R.M., Hengartner H. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature. 369:1994b;31-37
4. Li Q., Minami M., Hanaoka T., Yamamura Y. Acute immunotoxicity of p-chloronitrobenzene in mice: II. Effect of p-chloronitrobenzene on the immunophenotype of murine splenocytes determined by flow cytometry. Toxicology. 137:1999;35-45
5. Li Q., Hirata Y., Piao S., Minami M. The by-products generated during sarin synthesis in the Tokyo sarin disaster induced inhibition of natural killer and cytotoxic T lymphocyte activity. Toxicology. 146:2000a;209-220
6. Li Q., Hirata Y., Piao S., Minami M. Immunotoxicity of N,N-diethylaniline in mice: effect on natural killer activity, cytotoxic T lymphocyte activity, lymphocyte proliferation response and cellular components of the spleen. Toxicology. 150:2000b;181-191
7. Li Q., Nagahara N., Takahashi H., Takeda K., Okumura K., Minami M. Organophosphorus pesticides markedly inhibit the activities of natural killer, cytotoxic T lymphocyte and lymphokine-activated killer: a proposed inhibiting mechanism via granzyme inhibition. Toxicology. 172:2002;181-190
8. Liu C.C., Walsh C.M., Eto N., Clark W.R., Young J.D. Morphologic and functional characterization of perforin-deficient lymphokine-activated killer cells. J. Immunol. 155:1995;602-608
9. Lowin B., Hahne M., Mattmann C., Tschopp J. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature. 370(6491):1994;650-652
10. Mori S., Jewett A., Murakami-Mori K., Cavalcanti M., Bonavida B. The participation of the Fas-mediated cytotoxic pathway by natural killer cells is tumor-cell-dependent. Cancer Immunol. Immunother. 44:1997;282-290
11. Okada S., Li Q., Whitin J.C., Krensky A.M. Intracellular mediators of granulysin-induced cell death. J. Immunol. 171:2003;2556-2562
12. Rodgers K.E., Leung N., Ware C.F. Effects of acute administration of O,S,S-trimethyl phosphorodithioate on the generation of cellular and humoral immune responses following in vitro stimulation. Toxicology. 51:1988a;241-253
13. Rodgers K.E., Grayson M.H., Ware C.F. Inhibition of cytotoxic T lymphocyte and natural killer cell-mediated lysis by O,S,S-trimethyl phosphorodithioate is at an early postrecognition step. J. Immunol. 140:1988b;564-570
14. Rodgers K.E., Stern M.L., Ware C.F. Effects of subacute administration of O,S,S-trimethyl phosphorodithioate on cellular and humoral immune response systems. Toxicology. 54:1989;183-195
15. Rosen D., Li J.H., Keidar S., Markon I., Orda R., Berke G. Tumor immunity in perforin-deficient mice: a role for CD95 (Fas/APO-1). J. Immunol. 164:2000;3229-3235
16. Sayers T.J., Brooks A.D., Lee J.K., Fenton R.G., Komschlies K.L., Wigginton J.M., Winkler-Pickett R., Wiltrout R.H. Molecular mechanisms of immune-mediated lysis of murine renal cancer: differential contributions of perforin-dependent versus Fas-mediated pathways in lysis by NK and T cells. J. Immunol. 161:1998;3957-3965
17. Smyth M.J., Trapani J.A. Granzymes: exogenous proteinases that induce target cell apoptosis. Immunol. Today. 16:1995;202-206