Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

Current Biology

Volumn 6, Issue 7, 1996, Pages 897-899

  Chinnaiyan, Arul M ^a   Hanna, William L ^b   Orth, Kim ^a   Duan, Hangjun ^a   Poirier, Guy G ^c   Froelich, Christopher J ^b   Dixit, Vishva M ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS ELEGANS;

EID: 0030198505     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00614-0     Document Type: Article

References (16)

1. Berke G: The CTL's kiss of death. Cell 1995, 81:9-12.
2. Berke G: Unlocking the secrets of CTL and NK cells, Immunol Today 1995, 16:343-346.
3. Smyth MJ, Trapani JA: Granzymes: exogenous proteinases that induce target cell apoptosis. Immunol Today 1995, 16:202-206.
4. Odake S, Kam CM, Narasimhan L, Poe M, Blake JT, Krahenbuhl O, et al.: Human and murine cytotoxic T lymphocyte serine proteases. Biochemistry 1991, 30:2217-2227.
5. Martin SJ, Green DR: Protease activation during apoptosis: death by a thousand cuts? Cell 1995, 82:349-352.
6. Chinnaiyan AM, Dixit VM: The cell-death machine. Curr Biol 1996, 6:555-562.
7. Darmon AJ, Nicholson DW, Bleackley RC: Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature 1995, 377:446-448.
8. Quan LT, Tewari M, O'Rourke K, Dixit VM, Snipas SJ, Poirier GG, et al.: Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. Proc Natl Acad Sci USA 1996, 93:1972-1976.
9. Duan H, Chinnaiyan AM, Hudson PL, Wing JP, He W, Dixit VM: ICE-LAP3, a novel mammalian homolog of the Caenorhabditis elegans cell death protein CED-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem 1996, 271:35013-35035.
10. Hanna WL, Zhang X, Turbov J, Winkler U, Hudig D, Froelich CJ: Rapid purification of cationic granule proteases: application to human granzymes. Protein Expr Purif 1993, 4:398-404.
11. Fernandes-Alnemri T, Takahashi A, Armstrong R, Krebs J, Fritz L, Tomaselli KJ, et al.: Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res 1995, 55:6045-6052.
12. Shi L, Kam CM, Powers JC, Aebersold R, Greenberg AH: Purification of three cytotoxic lymphocyte granule serine proteases. J Exp Med 1992, 176:1521-1529.
13. Chinnaiyan AM, Orth K, O'Rourke K, Duan H, Poirier GG, Dixit VM: Molecular ordering of the cell death pathway: bcl-2 and bcl-xL function upstream of the CED-3-like apoptotic proteases. J Biol Chem 1996, 271:4573-4576.
14. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, et al.: Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 1995, 81:801-809.
15. Bump NJ, Hackett M, Huginin M, Sheshagiri S, Brady K, Chen P, et al.: Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science 1995, 269:1885-1888.
16. Gorczyca W, Gong J, Darzynkiewicz Z: Detection of DNAstrand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation. Cancer Res 1993, 53:1945-1951.