Mesangial immune complex glomerulonephritis due to complement factor D deficiency

Kidney International

Volumn 71, Issue 11, 2007, Pages 1142-1147

  Abrera Abeleda, M A ^a   Xu, Y ^b   Pickering, M C ^c   Smith, R J H ^a,d   Sethi, S ^e  

^a UNIVERSITY OF IOWA   (United States)

^b University of Alabama at Birmingham   (United States)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^d UNIVERSITY OF IOWA   (United States)

^e MAYO CLINIC   (United States)

Author keywords

Factor D deficiency; Kidney; Mesangial deposits; Mesangial immune complexes; Transgenic mice

Indexed keywords

ALBUMIN; COMPLEMENT FACTOR D; COMPLEMENT FACTOR H; CREATININE; IMMUNOGLOBULIN;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT DEFICIENCY; COMPLEMENT FACTOR D DEFICIENCY; CONTROLLED STUDY; CREATININE CLEARANCE; FEMALE; GENE DELETION; GLOMERULUS CAPILLARY; HISTOPATHOLOGY; IMMUNE COMPLEX DEPOSITION; IMMUNE COMPLEX NEPHRITIS; IMMUNOGLOBULIN DEPOSITION; KIDNEY BIOPSY; KNOCKOUT MOUSE; MALE; MESANGIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROLIFERATIVE GLOMERULONEPHRITIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SECTION;

ALBUMINURIA; ANIMALS; ANTIGENS, DIFFERENTIATION; CAPILLARIES; COMPLEMENT C3; COMPLEMENT FACTOR D; COMPLEMENT FACTOR H; CREATININE; FEMALE; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FLUORESCENT DYES; GENOTYPE; GLOMERULAR MESANGIUM; GLOMERULONEPHRITIS; HISTOCYTOCHEMISTRY; IMMUNE COMPLEX DISEASES; IMMUNOGLOBULIN M; IMMUNOHISTOCHEMISTRY; KIDNEY GLOMERULUS; MALE; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 34249285564     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5002235     Document Type: Article

References (22)

1. Walport MJ. Complement - first of two parts. N Engl J Med 2001; 344: 1058-1066.
2. Lesavre P, Muller-Eberhard H. Mechanism of action of factor D of the alternative complement pathway. J Exp Med 1978; 148: 1498-1509.
3. Gotze O, Muller-Eberhard HJ. The C3-activator system: an alternate pathway of complement activation. J Exp Med 1971; 134: 90-108.
4. Rodriguez de Cordoba S, Esparza-Gordillo J, Goicoechea de Jorge E et al. The human complement factor H: functional roles, genetic variations and disease associations. Mol Immunol 2004; 41: 355x-367x.
5. Song D, Zhou W, Sheerin S, Sacks S. Compartmental localization of complement component transcripts in the normal human kidney. Nephron 1998; 78: 15-22.
6. Xu Y, Ma M, Ippolito GC et al. Complement activation in factor D-deficient mice. Proc Natl Acad Sci 2001; 98: 14577-14582.
7. Pickering MC, Cook HT, Warren J et al. Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. Nat Genet 2002; 31: 424-428.
8. Watanabe H, Garnier G, Circolo A et al. Modulation of renal disease in MRL/lpr mice genetically deficient in the alternative complement pathway factor B. J Immunol 2000; 164: 786-794.
9. Elliott MK, Jarmi T, Ruiz P et al. Effects of complement factor D deficiency on the renal disease of MRL/lpr mice. Kidney Int 2004; 65: 129-138.
10. Levy M, Halbwachs-Mecarelli L, Gubler MC et al. H deficiency in two brothers with atypical dense intramembranous deposit disease. Kidney Int 1986; 30: 949-956.
11. Hogasen K, Jansen JH, Mollnes TE et al. Hereditary porcine membranoproliferative glomerulonephritis type II is caused by factor H deficiency. J Clin Invest 1995; 95: 1054-1061.
12. Thurman JM, Ljubanovic D, Edelstein CL et al. Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice. J Immunol 2003; 170: 1517-1523.
13. Thurman JM, Royer PA, Ljubanovic D et al. Treatment with an inhibitory monoclonal antibody to mouse factor b protects mice from induction of apoptosis and renal ischemia/reperfusion injury. 10.1681/ ASN.2005070698 J Am Soc Nephrol 2006; 17: 707-715.
14. Turnberg D, Cook TH. Complement and glomerulonephritis: new insights. Curr Opin Nephrol Hypertens 2005; 14: 223-228.
15. Welch T, Beischel L, Frenzke M, Witte D. Regulated expression of complement factor B in the human kidney. Kidney Int 1996; 50: 521-525.
16. Bygrave AE, Rose KL, Cortes-Hernandez J et al. Spontaneous autoimmunity in 129 and C57BL/6 mice—implications for autoimmunity described in gene-targeted mice. PLoS Biol 2004; 2: e243.
17. Heidari Y, Bygrave AE, Rigby RJ et al. Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus. Genes Immun 2006; 7: 592-599.
18. Martinsson K, Hultman P. The role of Fc-receptors in murine mercuryinduced systemic autoimmunity. Clin Exp Immunol 2006; 144: 309-318.
19. Jia Q, Shi Y, Bennink MB, Pestka JJ. Docosahexaenoic acid and eicosapentaenoic acid, but not {alpha}-linolen. J Nutr 2004; 134: 1353-1361.
20. Leung JCK, Chan LYY, Tsang AWL et al. Nephrol Dial Transplant 2004; 19: 1976-1985.
21. Schifferli J, Morris S, Dash A, Peters D. Complement-mediated solubilization in patients with systemic lupus erythematosus, nephritis or vasculitis. Clin Exp Immunol 1981; 46: 557-564.
22. Biesma DH, Hannema AJ, van Velzen-Blad H et al. A family with complement factor D deficiency. J Clin Invest 2001; 108: 233-240.