Modelling tissues in 3D: The next future of pharmaco-toxicology and food research?

Genes and Nutrition

Volumn 4, Issue 1, 2009, Pages 13-22

  Mazzoleni, Giovanna ^a   Di Lorenzo, D ^b   Steimberg, N ^a  

^a Division of Internal Medicine   (Italy)

^b Civic Hospital of Brescia   (Italy)

Author keywords

3 D in vitro models; Food research; Microenvironment; Microgravity; Pharmaco toxicology; Rotating Wall Vessel bioreactors; Tissue engineering

Indexed keywords

EID: 77049124474     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-008-0107-0     Document Type: Review

References (95)

1. Anderson C, Dodd C, Anderson M (2002) Inventors. Improved culture vessel having non-flat surfaces for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using same. WO Patent WO 02/42409A1
2. Andrei G (2006) Three-dimensional culture models for human viral diseases and antiviral drug development. Antiviral Res 71:96-107 (Pubitemid 44223779)
3. Ayyaswamy PS, Mukundakrishnan K (2007) Optimal conditions for simulating microgravity employing NASA designed rotating wall vessels. Acta Astronaut 60:397-405 (Pubitemid 46176069)
4. Balis FM (2002) Evolution of anticancer drug discovery and the role of cell-based screening. J Natl Cancer Inst 94:78-79 (Pubitemid 34121279)
5. Bell SJ, Grochoski GT (2008) How safe is vitamin E supplementation? Crit Rev Food Sci Nutr 48:760-774
6. Bhadriraju K, Chen CS (2002) Engineering cellular microenvironments to improve cell-based drug testing. Drug Discov Today 7:612-620 (Pubitemid 34606016)
7. Bhogal N, Grindon C, Combes R, Balls M (2005) Toxicity testing: creating a revolution based on new technologies. Trends Biotechnol 23:299-307 (Pubitemid 40726271)
8. Birgersdotter A, Sandberg R, Ernberg I (2005) Gene expression perturbation in vitro-a growing case for three-dimensional (3D) culture systems. Semin Cancer Biol 15:405-412 (Pubitemid 41140308)
9. Bissell MJ (1981) The differentiated state of normal and malignant cells or how to define a "normal" cell in culture. Int Rev Cytol 70:27-100 (Pubitemid 11144610)
10. Bissell MJ, Hall HG, Parry G (1982) How does the extracellular matrix direct gene expression? J Theor Biol 99:31-68 (Pubitemid 13209096)
11. Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW (2002) The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation 70:537-546 (Pubitemid 36194318)
12. Bissell MJ, Rizki A, Mian IS (2003) Tissue architecture: the ultimate regulator of breast epithelial function. Curr Opin Cell Biol 15:753-762 (Pubitemid 37487969)
13. Boyce ST, Warden GD (2002) Principles and practices for treatment of cutaneous wounds with cultured skin substitutes. Am J Surg 183:445-456 (Pubitemid 34442512)
14. Butcher EC, Berg EL, Kunkel EJ (2004) Systems biology in drug discovery. Nat Biotechnol 22:1253-1259 (Pubitemid 39336778)
15. Chang TT, Hughes-Fulford M (2008) Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes. Tissue Eng Part A 14:1-9
16. Cefalu WT, Ye J, Wang ZQ (2008) Efficacy of dietary supplementation with botanicals on carbohydrate metabolism in humans. Endocr Metab Immune Disord Drug Targets 8:78-81
17. Chen SS, Revoltella RP, Papini S, Michelini M, Fitzgerald W, Zimmerberg J, Margolis L (2003) Multilineage differentiation of rhesus monkey embryonic stem cells in three-dimensional culture systems. Stem Cells 21:281-295 (Pubitemid 36623170)
18. Cosgrove BD, Griffith LG, Lauffenburger DA (2008) Fusing tissue engineering and systems biology toward fulfilling their promise. Cell Mol Bioeng 1:33-41
19. Cukierman E, Pankov R, Stevens DR, Yamada KM (2001) Taking cell-matrix adhesions to the third dimension. Science 294:1708-1712 (Pubitemid 33104840)
20. De Bartolo L, Jarosch-Von Schweder G, Haverich A, Bader A (2000) A novel full-scale flat membrane bioreactor utilizing porcine hepatocytes: cell viability and tissue-specific functions. Biotechnol Prog 16:102-108 (Pubitemid 30097658)
21. Edelman DB, Keefer EW (2005) A cultural renaissance: in vitro cell biology embraces three-dimensional context. Exp Neurol 192:1-6 (Pubitemid 40208532)
22. GMO EFSA, Panel Working Group on Animal Feeding Trials (2008) Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials. Food Chem Toxicol 46(Suppl 1):2-70
23. El-Ali J, Sorger PK, Jensen KF (2006) Cells on chips. Nature 442:403-411 (Pubitemid 44264784)
24. Elsdale T, Bard J (1972) Collagen substrata for studies on cell behavior. J Cell Biol 54:626-637
25. Fischbach C, Chen R, Matsumoto T, Schmelzle T, Brugge JS, Polverini PJ, Mooney DJ (2007) Engineering tumors with 3D scaffolds. Nat Methods 4:855-860 (Pubitemid 350055585)
26. Fournier MV, Martin KJ (2006) Transcriptome profiling in clinical breast cancer: from 3D culture models to prognostic signatures. J Cell Physiol 209:625-630 (Pubitemid 44665679)
27. Freshney RI (2000) Culture of animal cells-a manual of basic techniques, 4th edn. Wiley, New York
28. Ghosh S, Spagnoli GC, Martin I, Ploegert S, Demougin P, Heberer M, Reschner A (2005) Three-dimensional culture of melanoma cells profoundly affects gene expression profile: a high density oligonucleotide array study. J Cell Physiol 204:522-531 (Pubitemid 40934647)
29. Gilani GS, Xiao C, Lee N (2008) Need for accurate and standardized determination of amino acids and bioactive peptides for evaluating protein quality and potential health effects of foods and dietary supplements. J AOAC Assoc Anal Commun Int 91:894-900
30. Gomez-Lechon MJ, Jover R, Donato T, Ponsoda X, Rodriguez C, Stenzel KG, Klocke R, Paul D, Guillen I, Bort R, Castell JV (1998) Long-term expression of differentiated functions in hepatocytes cultured in three-dimensional collagen matrix. J Cell Physiol 177:553-562 (Pubitemid 28541580)
31. Green H, Kehinde O, Thomas J (1979) Growth of cultured human epidermal cells into multiple epithelia suitable for grafting. Proc Natl Acad Sci USA 76:5665-5668 (Pubitemid 10161674)
32. Green JA, Yamada KM (2007) Three-dimensional microenvironments modulate fibroblast signaling responses. Adv Drug Deliv Rev 59:1293-1298 (Pubitemid 350088253)
33. Griffith LG, Swartz MA (2006) Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7:211-224
34. Gudjonsson T, Ronnov-Jessen L, Villadsen R, Rank F, Bissell MJ, Petersen OW (2002) Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J Cell Sci 115:39-50 (Pubitemid 34105527)
35. Hammond TG, Hammond JM (2001) Optimized suspension culture: the rotating-wall vessel. Am J Physiol Renal Physiol 281:12-25
36. Hay ED, Dodson JW (1973) Secretion of collagen by corneal epithelium. I. Morphology of the collagenous products produced by isolated epithelia grown on frozen-killed lens. J Cell Biol 57:190-213
37. Hoffman RM (1993) To do tissue culture in two or three dimensions? That is the question. Stem Cells 11:105-111 (Pubitemid 23086975)
38. Hutmacher DW, Singh H (2008) Computational fluid dynamics for improved bioreactor design and 3D culture. Trends Biotechnol 26:166-172
39. Ingber DE, Folkman J (1989) How does extracellular matrix control capillary morphogenesis? Cell 58:803-805 (Pubitemid 19227890)
40. Jessup JM, Goodwin TJ, Spaulding G (1993) Prospects for use of microgravity-based bioreactors to study three-dimensional host-tumor interactions in human neoplasia. J Cell Biochem 51:290-300 (Pubitemid 23103605)
41. Katoh M, Matsui T, Okumura H, Nakajima M, Nishimura M, Naito S, Tateno C, Yoshizato K, Yokoi T (2005) Expression of human phase II enzymes in chimeric mice with humanized liver. Drug Metab Dispos 33:1333-1340 (Pubitemid 41196976)
42. Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, Lorenz K, Lee EH, Barcellos-Hoff MH, Petersen OW, Gray JW, Bissel MJ (2007) The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol 1:84-96 (Pubitemid 46776616)
43. Kerbel RS, Kobayashi H, Graham CH (1994) Intrinsic or acquired drug resistance and metastasis: are they linked phenotypes? J Cell Biochem 56:37-47 (Pubitemid 24288108)
44. Khademhosseini A, Langer R, Borenstein J, Vacanti JP (2006) Microscale technologies for tissue engineering and biology. Proc Natl Acad Sci USA 103:2480-2487
45. Kim JB (2005) Three-dimensional tissue culture models in cancer biology. Semin Cancer Biol 15:365-377
46. Klaus DM (2001) Clinostats and bioreactors. Gravit Space Biol Bull 14:55-64
47. Kloss D, Fischer M, Rothermel A, Simon JC, Robitzki AA (2008) Drug testing on 3D in vitro tissues trapped on a microcavity chip. Lab Chip 8:879-884 (Pubitemid 351746712)
48. Kunz-Schughart LA, Freyer JP, Hofstaedter F, Ebner R (2004) The use of 3-D cultures for high-throughput screening: the multicellular spheroid model. J Biomol Screen 9:273-285
49. Larsen M, Artym VV, Green JA, Yamada KM (2006) The matrix reorganized: extracellular matrix remodeling and integrin signaling. Curr Opin Cell Biol 18:463-471 (Pubitemid 44332914)
50. Lee J, Cuddihy MJ, Kotov NA (2008) Three-dimensional cell culture matrices: state of the art. Tissue Eng Part B 14:61-86
51. Lee MY, Kumar RA, Sukumaran SM, Hogg MG, Clark DS, Dordick JS (2008) Three-dimensional cellular microarray for high-throughput toxicology assays. Proc Natl Acad Sci USA 105:59-63
52. Lelievre SA, Weaver VM, Nickerson JA, Larabell CA, Bhaumik A, Petersen OW, Bissell MJ (1998) Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus. Proc Natl Acad Sci USA 95:14711-14716 (Pubitemid 29003695)
53. Lilienblum W, Dekant W, Foth H, Gebel T, Hengstler JG, Kahl R, Kramer PJ, Schweinfurth H, Wollin KM (2008) Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH). Arch Toxicol 82:211-236
54. Louekari K (2004) Status and prospects of in vitro tests in risk assessment. Altern Lab Anim 32:431-435 (Pubitemid 40139221)
55. Martin Y, Vermette P (2005) Bioreactors for tissue mass culture: design, characterization, and recent advances. Biomaterials 26:7481-7503 (Pubitemid 41133599)
56. Meyvantsson I, Beebe DJ (2008) Cell culture models in microfluidic systems. Annu Rev Anal Chem 1:14.1-14.27
57. Meshel AS, Wei Q, Adelstein RS, Sheetz MP (2005) Basic mechanism of three-dimensional collagen fibre transport by fibroblasts. Nat Cell Biol 7:157-164 (Pubitemid 40268130)
58. Meuwly F, Ruffieux PA, Kadouri A, von Stockar U (2007) Packed-bed bioreactors for mammalian cell culture: bioprocess and biomedical applications. Biotechnol Adv 25:45-56 (Pubitemid 46038035)
59. Nickerson CA, Richter EG, Ott CM (2007) Studying host-pathogen interactions in 3-D: organotypic models for infectious disease and drug development. J Neuroimmune Pharmacol 2:26-31
60. O'Brien LE, Jou TS, Pollack AL, Zhang Q, Hansen SH, Yurchenco P, Mostov KE (2001) Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly. Nat Cell Biol 3:831-838 (Pubitemid 32842689)
61. O'Brien LE, Zegers MM, Mostov KE (2002) Opinion: Building epithelial architecture: insights from three-dimensional culture models. Nat Rev Mol Cell Biol 3:531-537 (Pubitemid 34733434)
62. O'Brien LE, Yu W, Tang K, Jou TS, Zegers MM, Mostov KE (2006) Morphological and biochemical analysis of Rac1 in threedimensional epithelial cell cultures. Methods Enzymol 406:676-691 (Pubitemid 43207478)
63. Ohashi K, Yokoyama T, Yamato M, Kuge H, Kanehiro H, Tsutsumi M, Amanuma T, Iwata H, Yang J, Okano T, Nakajima Y (2007) Engineering functional two- and three-dimensional liver systems in vivo using hepatic tissue sheets. Nat Med 13:880-885 (Pubitemid 47038184)
64. Pampaloni F, Reynaud EG, Stelzer EH (2007) The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol 8:839-845 (Pubitemid 47462131)
65. Pankov R, Endo Y, Even-Ram S, Araki M, Clark K, Cukierman E, Matsumoto K, Yamada KM (2005) A Rac switch regulates random versus directionally persistent cell migration. J Cell Biol 170:793-802 (Pubitemid 41242111)
66. Paszek MJ, Weaver VM (2004) The tension mounts: mechanics meets morphogenesis and malignancy. J Mammary Gland Biol Neoplasia 9:325-342 (Pubitemid 41149140)
67. Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM (2005) Tensional homeostasis and the malignant phenotype. Cancer Cell 8:241-254 (Pubitemid 41317594)
68. Petersen OW, Lind Nielsen H, Gudjonsson T, Villadsen R, Ronnov-Jessen L, Bissell MJ (2001) The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion. Breast Cancer Res 3:213-217 (Pubitemid 32631699)
69. Powers MJ, Janigian DM, Wack KE, Baker CS, Beer Stolz D, Griffith LG (2002) Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor. Tissue Eng 8:499-513 (Pubitemid 34747805)
70. Rangarajan A, Hong SJ, Gifford A, Weinberg RA (2004) Species- and cell type-specific requirements for cellular transformation. Cancer Cell 6:171-183 (Pubitemid 39485689)
71. REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), Official Journal of the EU, L 396, vol 49, 30.12.2006
72. Roskelley CD, Desprez PY, Bissell MJ (1994) Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction. Proc Natl Acad Sci USA 91:12378-12382
73. Ruhrberg C, Gerhardt H, Golding M, Watson R, Ioannidou S, Fujisawa H, Betsholtz C, Shima DT (2002) Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev 16:2684-2698
74. Sahai E, Marshall CJ (2003) Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol 5:711-719 (Pubitemid 36986778)
75. Schindler M, Nur EKA, Ahmed I, Kamal J, Liu HY, Amor N, Ponery AS, Crockett DP, Grafe TH, Chung HY, Weik T, Jones E, Meiners S (2006) Living in three dimensions: 3D nanostructured environments for cell culture and regenerative medicine. Cell Biochem Biophys 45:215-227 (Pubitemid 43997996)
76. Schmeichel KL, Bissell MJ (2003) Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci 116:2377-2388 (Pubitemid 36790120)
77. Schwachofer JH (1990) Multicellular tumor spheroids in radiotherapy research (review). Anticancer Res 10:963-969
78. Schwarz RP, Goodwin TJ, Wolf DA (1992) Cell culture for threedimensional modeling in rotating-wall vessels: an application of simulated microgravity. J Tissue Cult Methods 14:51-57
79. Semino CE, Merok JR, Crane GG, Panagiotakos G, Zhang S (2003) Functional differentiation of hepatocyte-like spheroid structures from putative liver progenitor cells in three-dimensional peptide scaffolds. Differentiation 71:262-270 (Pubitemid 36819111)
80. Sivaraman A, Leach JK, Townsend S, Iida T, Hogan BJ, Stolz DB, Fry R, Samson LD, Tannenbaum SR, Griffith LG (2005) A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction. Curr Drug Metab 6:569-591 (Pubitemid 41672495)
81. Smalley KS, Lioni M, Herlyn M (2006) Life isn't flat: taking cancer biology to the next dimension. In vitro Cell Dev Biol Anim 42:242-247 (Pubitemid 44851881)
82. Sodian R, Lemke T, Loebe M, Hoerstrup SP, Potapov EV, Hausmann H, Meyer R, Hetzer R (2001) New pulsatile bioreactor for fabrication of tissue-engineered patches. J Biomed Mater Res 58:401-405 (Pubitemid 32643188)
83. St Croix B, Kerbel RS (1997) Cell adhesion and drug resistance in cancer. Curr Opin Oncol 9:549-556 (Pubitemid 27480858)
84. Stoker AW, Streuli CH, Martins-Green M, Bissell MJ (1990) Designer microenvironments for the analysis of cell and tissue function. Curr Opin Cell Biol 2:864-874
85. Suuronen EJ, Sheardown H, Newman KD, McLaughlin CR, Griffith M (2005) Building in vitro models of organs. Int Rev Cytol 244:137-173 (Pubitemid 41264850)
86. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA (2002) Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3:349-363 (Pubitemid 34619269)
87. Unsworth BR, Lelkes PI (1998) Growing tissues in microgravity. Nat Med 4:901-907 (Pubitemid 28364028)
88. Walpita D, Hay E (2002) Studying actin-dependent processes in tissue culture. Nat Rev Mol Cell Biol 3:137-141
89. Ward RK, Hubbard AW, Sulley H, Garle MJ, Clothier RH (1998) Human keratinocyte cultures in an in vitro approach for the assessment of surfactant-induced irritation. Toxicol In Vitro 12:163-173 (Pubitemid 28196184)
90. Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ (1997) Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 137:231-245 (Pubitemid 27167310)
91. Weaver VM, Lelievre S, Lakins JN, Chrenek MA, Jones JC, Giancotti F, Werb Z, Bissell MJ (2002) beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2:205-216 (Pubitemid 41043976)
92. Whitebread S, Hamon J, Bojanic D, Urban L (2005) In vitro safety pharmacology profiling: an essential tool for successful drug development. Drug Discov Today 10:1421-1433 (Pubitemid 41483871)
93. Yamada KM, Clark K (2002) Cell biology: survival in three dimensions. Nature 419:790-791 (Pubitemid 35238549)
94. Yamada KM, Cukierman E (2007) Modeling tissue morphogenesis and cancer in 3D. Cell 130:601-610 (Pubitemid 47268064)
95. Zegers MM, O'Brien LE, Yu W, Datta A, Mostov KE (2003) Epithelial polarity and tubulogenesis in vitro. Trends Cell Biol 13:169-176 (Pubitemid 36351532)