The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion

Breast Cancer Research

Volumn 3, Issue 4, 2001, Pages 213-217

  Petersen, Ole William ^a   Nielsen, Helga Lind ^a,b   Gudjonsson, Thorarinn ^a   Villadsen, René ^a   Rønnov Jessen, Lone ^b   Bissell, Mina J ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Breast cancer; Differentiation programs; Epithelial to mesenchymal transition; Myoepithelial cells; Myofibroblasts

Indexed keywords

CELL MARKER;

BREAST CARCINOMA; BREAST EPITHELIUM; CANCER CELL CULTURE; CANCER INHIBITION; CELL DIFFERENTIATION; CELL LINEAGE; CELL TYPE; EPITHELIUM CELL; HUMAN; HUMAN CELL; MESENCHYME CELL; MYOEPITHELIUM CELL; MYOFIBROBLAST; NOTE; OUTCOMES RESEARCH; PHENOTYPE; PLASTICITY; TUMOR GROWTH;

BREAST NEOPLASMS; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; FEMALE; HUMANS; MESODERM; PHENOTYPE; TUMOR MARKERS, BIOLOGICAL;

EID: 0034936766     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr298     Document Type: Note

References (57)

1. Cellular changes involved in conversion of normal to malignant breast: The importance of the stromal reaction
2. Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours
3. Monoclonal antibodies against human milk-fat globule membranes detecting differentiation antigens of the mammary gland and its tumors
4. Tissue structure, nuclear organization, and gene expression in normal and malignant breast
5. Differentiation and cancer in the mammary gland: Shedding new light on an old dichotomy
6. Human mammary luminal epithelial cells contain progenitors to myoepithelial cells
7. Loss of production of myoepithelial cells and basement membrane proteins but retention of response to certain growth factors and hormones by a new malignant human breast cancer cell strain
8. Investigation of the oxytocin receptor expression in human breast cancer tissue using newly established monoclonal antibodies
9. Expression of gap junction proteins connexin 26 and connexin 43 in normal human breast and in breast tumours
10. Presence and possible significance of immunocytochemically demonstrable metallothionein over-expression in primary invasive ductal carcinoma of the breast
11. The human myoepithelial cell is a natural tumor suppressor
12. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells
13. Genetic alterations in the fibroblastic stroma of invasive colon and breast carcinomas
14. Presence of genetic alterations in microdissected stroma of human colon and breast cancers
15. Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type ('clinging ductal carcinoma in situ')
16. Epithelial-mesenchymal transitions in cancer progression
17. Induction and regulation of epithelial-mesenchymal transitions
18. Epithelial cell plasticity in development and tumor progression
19. Expression of c-ets-1 mRNA is associated with an invasive, EMT-derived phenotype in breast carcinoma cell lines
20. The epithelial to mesenchymal transition and metastatic progression in carcinoma
21. TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
22. The myothelia (myoepithelial cells). Normal state; regressive changes; hyperplasia; tumors
23. Basement membrane changes in breast cancer detected by immunohistochemical staining for laminin
24. Distribution of myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast diseases
25. Detection of basement membrane components and basal cell keratin 14 in noninvasive and invasive carcinomas of the breast
26. Vimentin expression in benign and malignant lesions in the human mammary gland
27. Findings of myoepithelial cells in human breast cancer. Ultrastructural and immunohistochemical study by means of anti-myosin antibody
28. Expression genetics in cancer; Shifting the focus from DNA to RNA
29. Identification by differential display of alpha 6 integrin as a candidate tumor suppressor gene
30. Suppression of tumor-forming ability and related traits in MCF-7 human breast cancer cells by fusion with immortal mammary epithelial cells
31. Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential
32. Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells
33. The induction of smooth muscle α actin in a transformed rat cell line suppresses malignant properties in vitro and in vivo
34. Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells
35. Inhibitory effects of activin on the growth and morphogenesis of primary and transformed mammary epithelial cells
36. Differentiation of breast cancer cells in vitro is promoted by the concurrent influence of myoepithelial cells and relaxin
37. Myoepithelial-specific CD44 shedding contributes to the anti-invasive and antiangiogenic phenotype of myoepithelial cells
38. The origin of the myofibroblasts in breast cancer: Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells
39. Large, central acellular zones indicating myoepithelial tumor differentiation in high-grade invasive ductal carcinomas as markers of prediposition to lung and brain metastasis
40. DNA measurement and immunohistochemical characterization of epithelial and mesenchymal cells in canine mixed mammary tumors: Putative evidence for a common histogenesis
41. An overview of epithelio-mesenchymal transformation
42. Model systems of epithelium-mesenchymal transitions
43. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
44. Rearrangement of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells
45. Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogene-transformed mammary epithelial cells
46. Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines
47. Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that lead to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells
48. Activation of alpha2beta1 integrin prevents c-erbB2-induced scattering and apoptosis of human mammary epithelial cells in collagen gel
49. Morphogenetic behaviour of simian virus 40-transformed human mmamry epithelial stem cell lines on collagen gels
50. Phenotypic characteristics of cell lines derived from dessiminated cancer cells in bone marrow of patients with solid epithelial tumors: Establishment of working models for human micrometastases
51. Carcinomas of the breast showing myoepithelial cell differentiation
52. Vimentin expression is not associated with poor prognosis in breast cancer
53. Fibrotic focus in infiltrating ductal carcinoma of the breast: A significant histopathological prognostic parameter for predicting the long-term survival of the patients
54. Human breast carcinoma desmoplasia is PDGF initiated
55. Concurrent and independent genetic alterations in the stromal and epithelial cells of the mammary carcinoma: Implications for tumorigenesis
56. Quantitative variation of proto-oncogene and cytokine gene expression in isolated breast fibroblasts
57. Malignant breast epithelium selects for insulin-like growth factor II expression in breast stroma: Evidence for paracrine function