Coordinate regulation of drug metabolism by xenobiotic nuclear receptors: UGTs acting together with CYPs and glucuronide transporters

Drug Metabolism Reviews

Volumn 36, Issue 3-4, 2004, Pages 595-615

  Bock, Karl Walter ^a   Köhle, Christoph ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Ah receptor; CAR; CYPs; Glucuronide transporters; PXR; UGTs

Indexed keywords

AROMATIC AMINE; AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; BILE SALT; BILIRUBIN; CARCINOGEN; CARRIER PROTEIN; CLOTRIMAZOLE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; DEXAMETHASONE; ESTRADIOL; GLUCURONIDE TRANSPORTER; GLUCURONOSYLTRANSFERASE; LITHOCHOLIC ACID; MORPHINE; PHENOBARBITAL; PHENYTOIN; PREGNANE X RECEPTOR; PROPAFENONE; RIFAMPICIN; STEROID HORMONE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; BILIRUBIN METABOLISM; CONJUGATION; DRUG COMPETITION; DRUG GLUCURONIDATION; DRUG METABOLISM; ENZYME INDUCTION; ENZYME MECHANISM; ENZYME REGULATION; GENE INDUCTION; GENETIC VARIABILITY; HISTORY; HOMEOSTASIS; HUMAN; MOLECULAR EVOLUTION; NONHUMAN; PROTEIN DOMAIN; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STEROID METABOLISM; XENOBIOTIC METABOLISM;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; XENOBIOTICS;

EID: 7544222964     PISSN: 03602532     EISSN: None     Source Type: Journal    
DOI: 10.1081/DMR-200033455     Document Type: Review

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