Tight junctions: A barrier to the initiation and progression of breast cancer?

Journal of Biomedicine and Biotechnology

Volumn 2010, Issue , 2010, Pages

  Brennan, Kieran ^a   Offiah, Gozie ^a   McSherry, Elaine A ^a   Hopkins, Ann M ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; PROTEIN ZO1; PROTEIN ZO2; SCAFFOLD PROTEIN;

BREAST CANCER; CANCER GROWTH; CELL ADHESION; CELL FATE; CELL MIGRATION; CELL POLARITY; EPITHELIUM CELL; HUMAN; NONHUMAN; PROTEIN ANALYSIS; REVIEW; TIGHT JUNCTION; BREAST TUMOR; DISEASE COURSE; FEMALE; METABOLISM; PATHOLOGY; PRECANCER;

BREAST NEOPLASMS; CELL ADHESION; DISEASE PROGRESSION; FEMALE; HUMANS; PRECANCEROUS CONDITIONS; TIGHT JUNCTIONS;

EID: 74949087490     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2010/460607     Document Type: Review

References (214)

1. M. Kásler, C. Polgár, and J. Fodor, "Current status of treatment for early-stage invasive breast cancer," Orvosi Hetilap, vol. 150, no. 22, pp. 1013-1021, 2009.
2. S. Dey, A. S. Soliman, A. Hablas, et al., "Urban-rural differences in breast cancer incidence by hormone receptor status across 6 years in Egypt," Breast Cancer Research and Treatment 2009, in press.
3. J. M. Dolle, J. R. Daling, E. White, et al., "Risk factors for triple-negative breast cancer in women under the age of 45 years," Cancer Epidemiology Biomarkers and Prevention, vol. 18, no. 4, pp. 1157-1166, 2009.
4. B. S. Hulka and P. G. Moorman, "Breast cancer: hormones and other risk factors," Maturitas, vol. 61, no. 1-2, pp. 203-213, 2008.
5. B. Schlehe and R. Schmutzler, "Hereditary breast cancer," Chirurg, vol. 79, no. 11, pp. 1047-1054, 2008.
6. E. S. Hwang, S. deVries, K. L. Chew, et al., "Patterns of chromosomal alterations in breast ductal carcinoma in situ," Clinical Cancer Research, vol. 10, no. 15, pp. 5160-5167, 2004. (Pubitemid 39099791)
7. F. Farabegoli, M.-H. Champeme, I. Bieche, et al., "Genetic pathways in the evolution of breast ductal carcinoma in situ," Journal of Pathology, vol. 196, no. 3, pp. 280-286, 2002. (Pubitemid 34189416)
8. R. Holland, J. L. Peterse, R. R. Millis, et al., "Ductal carcinoma in situ: a proposal for a new classification," Seminars in Diagnostic Pathology, vol. 11, no. 3, pp. 167-180, 1994. (Pubitemid 24308077)
9. L. Tabar, S. W. Duffy, B. Vitak, et al., "The natural history of breast carcinoma: what have we learned from screening?" Cancer, vol. 86, no. 3, pp. 449-462, 1999. (Pubitemid 29347407)
10. L. Tabar, G. Fagerberg, H. H. Chen, S. W. Duffy, and A. Gad, "Tumour development, histology and grade of breast cancers: prognosis and progression," International Journal of Cancer, vol. 66, no. 4, pp. 413-419, 1996. (Pubitemid 26176764)
11. W. S. Al-Dhaheri, I. Hassouna, S. Al-Salam, and S. M. Karam, "Characterization of breast cancer progression in the rat," Annals of the New York Academy of Sciences, vol. 1138, pp. 121-131, 2008.
12. T. L. Adamovich and R. M. Simmons, "Ductal carcinoma in situ with microinvasion," American Journal of Surgery, vol. 186, no. 2, pp. 112-116, 2003. (Pubitemid 37289079)
13. A. Cavaliere, M. Scheibel, G. Bellezza, et al., "Ductal carcinoma in situ with microinvasion: clinicopathologic study and biopathologic profile," Pathology Research and Practice, vol. 202, no. 3, pp. 131-135, 2006. (Pubitemid 43257306)
14. Y. Okumura, Y. Yamamoto, Z. Zhang, et al., "Identification of biomarkers in ductal carcinoma in situ of the breast with microinvasion," BMC Cancer, vol. 8, article 287, 2008.
15. R. Largillier, J.-M. Ferrero, J. Doyen, et al., "Prognostic factors in 1,038 women with metastatic breast cancer," Annals of Oncology, vol. 19, no. 12, pp. 2012-2019, 2008.
16. M. J. van de Vijver, Y. D. He, L. J. van 't Veer, et al., "A gene-expression signature as a predictor of survival in breast cancer," New England Journal of Medicine, vol. 347, no. 25, pp. 1999-2009, 2002. (Pubitemid 35461656)
17. L. J. van 't Veer, H. Dai, M. J. van de Vijver, et al., "Gene expression profiling predicts clinical outcome of breast cancer," Nature, vol. 415, no. 6871, pp. 530-536, 2002. (Pubitemid 34130608)
18. E. Fuchs, T. Tumbar, and G. Guasch, "Socializing with the neighbors: stem cells and their niche," Cell, vol. 116, no. 6, pp. 769-778, 2004. (Pubitemid 38410723)
19. M. Itoh and M. J. Bissell, "The organization of tight junctions in epithelia: implications for mammary gland biology and breast tumorigenesis," Journal of Mammary Gland Biology and Neoplasia, vol. 8, no. 4, pp. 449-462, 2003. (Pubitemid 39137506)
20. M. Perez-Moreno and E. Fuchs, "Catenins: keeping cells from getting their signals crossed," Developmental Cell, vol. 11, no. 5, pp. 601-612, 2006. (Pubitemid 44644972)
21. W. J. Nelson, "Adaptation of core mechanisms to generate cell polarity," Nature, vol. 422, no. 6933, pp. 766-774, 2003. (Pubitemid 36514120)
22. K. Ebnet, "Organization of multiprotein complexes at cell-cell junctions," Histochemistry and Cell Biology, vol. 130, no. 1, pp. 1-20, 2008.
23. M. Furuse, T. Hirase, M. Itoh, et al., "Occludin: a novel integral membrane protein localizing at tight junctions," The Journal of Cell Biology, vol. 123, no. 6, part 2, pp. 1777-1788, 1993. (Pubitemid 24012933)
24. Y. H. Chen, Q. Lu, D. A. Goodenough, et al., "Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells," Molecular Biology of the Cell, vol. 13, no. 4, pp. 1227-1237, 2002. (Pubitemid 34309618)
25. A. Sakakibara, M. Furuse, M. Saitou, Y. Ando-Akatsuka, and S. Tsukita, "Possible involvement of phosphorylation of occludin in tight junction formation," The Journal of Cell Biology, vol. 137, no. 6, pp. 1393-1401, 1997. (Pubitemid 27265950)
26. A. Y. Andreeva, E. Krause, E. C. Müller, et al., "Protein kinase C regulates the phosphorylation and cellular localization of occludin," The Journal of Biological Chemistry, vol. 276, no. 42, pp. 38480-38486, 2001.
27. M. Cordenonsi, F. Turco, F. D'atri, et al., "Xenopus laevis occludin: identification of in vitro phosphorylation sites by protein kinase CK2 and association with cingulin," European Journal of Biochemistry, vol. 264, no. 2, pp. 374-384, 1999. (Pubitemid 29424441)
28. M. Itoh, M. Furuse, K. Morita, K. Kubota, M. Saitou, and S. Tsukita, "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins," The Journal of Cell Biology, vol. 147, no. 6, pp. 1351-1363, 1999. (Pubitemid 30012818)
29. G. Krause, L. Winkler, S. L. Mueller, et al., "Structure and function of claudins," Biochimica et Biophysica Acta, vol. 1778, no. 3, pp. 631-645, 2008.
30. C. M. Van Itallie and J. M. Anderson, "Claudins and epithelial paracellular transport," Annual Review of Physiology, vol. 68, pp. 403-429, 2006.
31. Y. Sugano, M. Takeuchi, A. Hirata, et al., "Junctional adhesion molecule-A, JAM-A, is a novel cell-surface marker for long-term repopulating hematopoietic stem cells," Blood, vol. 111, no. 3, pp. 1167-1172, 2008. (Pubitemid 351213397)
32. M. R. Cera, M. Fabbri, C. Molendini, et al., "JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recycling," Journal of Cell Science, vol. 122, no. 2, pp. 268-277, 2009.
33. A. Babinska, M. H. Kedees, H. Athar, et al., "F11-receptor (F11R/JAM) mediates platelet adhesion to endothelial cells: role in inflammatory thrombosis," Journal of Thrombosis and Haemostasis, vol. 88, no. 5, pp. 843-850, 2002. (Pubitemid 35350778)
34. K. Ebnet, M. Aurrand-Lions, A. Kuhn, et al., "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity," Journal of Cell Science, vol. 116, no. 19, pp. 3879-3891, 2003. (Pubitemid 37279304)
35. E. A. Severson, W. Y. Lee, C. T. Capaldo, et al., "Junctional adhesion molecule a interacts with afadin and PDZ-GEF2 to activate raplA, regulate j31 integrin levels, and enhance cell migration," Molecular Biology of the Cell, vol. 20, no. 7, pp. 1916-1925, 2009.
36. O. M. Martínez-Estrada, A. Villa, F. Breviario, et al., "Association of junctional adhesion molecule with calcium/calmodulin- dependent serine protein kinase (CASK/LIN-2) in human epithelial Caco-2 cells," The Journal of Biological Chemistry, vol. 276, no. 12, pp. 9291-9296, 2001.
37. K. Ebnet, C. U. Schulz, M. K. Meyer Zu Brickwedde, et al., "Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1," The Journal of Biological Chemistry, vol. 275, no. 36, pp. 27979-27988, 2000.
38. K. Ebnet, A. Suzuki, Y. Horikoshi, et al., "The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)," The EMBO Journal, vol. 20, no. 14, pp. 3738-3748, 2001. (Pubitemid 32691785)
39. C. B. Coyne, T. Voelker, S. L. Pichla, et al., "The coxsack-ievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction," The Journal of Biological Chemistry, vol. 279, no. 46, pp. 48079-48084, 2004. (Pubitemid 39540961)
40. K. J. D. Ashbourne Excoffon, A. Hruska-Hageman, M. Klotz, et al., "A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth," Journal of Cell Science, vol. 117, no. 19, pp. 4401-4409, 2004. (Pubitemid 39360067)
41. C. J. Cohen, J. T. C. Shieh, R. J. Pickles, et al., "The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction," Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 26, pp. 15191-15196, 2001. (Pubitemid 34013991)
42. C. Lemmers, D. Michel, L. Lane-Guermonprez, et al., "CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells," Molecular Biology of the Cell, vol. 15, no. 3, pp. 1324-1333, 2004. (Pubitemid 38316238)
43. C. Lemmers, E. Médina, M.-H. Delgrossi, et al., "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells," The Journal of Biological Chemistry, vol. 277, no. 28, pp. 25408-25415, 2002. (Pubitemid 34951853)
44. O. Makarova, M. H. Roh, C. J. Liu, et al., "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)," Gene, vol. 302, no. 1-2, pp. 21-29, 2003. (Pubitemid 36078394)
45. M. H. Roh, S. Fan, C.-J. Liu, et al., "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells," Journal of Cell Science, vol. 116, no. 14, pp. 2895-2906, 2003. (Pubitemid 36926979)
46. J. Ikenouchi, M. Furuse, K. Furuse, et al., "Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells," The Journal of Cell Biology, vol. 171, no. 6, pp. 939-945, 2005. (Pubitemid 41815826)
47. A. S. Fanning, B. J. Jameson, L. A. Jesaitis, et al., "The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton," The Journal of Biological Chemistry, vol. 273, no. 45, pp. 29745-29753, 1998. (Pubitemid 28509986)
48. E. S. Wittchen, J. Haskins, and B. R. Stevenson, "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3," The Journal of Biological Chemistry, vol. 274, no. 49, pp. 35179-35185, 1999. (Pubitemid 129509574)
49. M. Cordenonsi, F. D'Atri, E. Hammar, et al., "Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin," The Journal of Cell Biology, vol. 147, no. 7, pp. 1569-1582, 1999.
50. M. H. Roh, C. J. Liu, S. Laurinec, et al., "Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to α catenin and actin filaments," Journal of Cell Biology, vol. 138, no. 1, pp. 181-192, 1997.
51. M. H. Roh, C.-J. Liu, S. Laurinec, et al., "The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions," The Journal of Biological Chemistry, vol. 277, no. 30, pp. 27501-27509, 2002. (Pubitemid 34951771)
52. T. Kaihara, H. Kawamata, J. Imura, et al., "Redifferentia-tion and ZO-1 reexpression in liver-metastasized colorectal cancer: possible association with epidermal growth factor receptorinduced tyrosine phosphorylation of ZO-1," Cancer Science, vol. 94, no. 2, pp. 166-172, 2003. (Pubitemid 36575876)
53. T. Yamamoto, N. Harada, Y. Kawano, et al., "In vivo interaction of AF-6 with activated Ras and ZO-1," Biochemical and Biophysical Research Communications, vol. 259, no. 1, pp. 103-107, 1999. (Pubitemid 29264001)
54. K. Matter and M. S. Balda, "Epithelial tight junctions, gene expression and nucleo-junctional interplay," Journal of Cell Science, vol. 120, no. 9, pp. 1505-1511, 2007. (Pubitemid 46831780)
55. A. Tsapara, K. Matter, and M. S. Balda, "The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB," Molecular Biology of the Cell, vol. 17, no. 3, pp. 1322-1330, 2006. (Pubitemid 43376552)
56. L. Su, M. Hattori, M. Moriyama, et al., "AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1," The Journal of Biological Chemistry, vol. 278, no. 17, pp. 15232-15238, 2003. (Pubitemid 36799859)
57. T. Asakura, H. Nakanishi, T. Sakisaka, et al., "Similar and differential behaviour between the nectin-afadin-ponsin and cadherin-catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells," Genes Cells, vol. 4, no. 10, pp. 573-581, 1999.
58. B. Boettner, E.-E. Govek, J. Cross, et al., "The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin," Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 16, pp. 9064-9069, 2000. (Pubitemid 30626674)
59. I. Dobrosotskaya, R. K. Guy, and G. L. James, "MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains," The Journal of Biological Chemistry, vol. 272, no. 50, pp. 31589-31597, 1997. (Pubitemid 28013302)
60. K. Hirao, Y. Hata, N. Ide, et al., "A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins," The Journal of Biological Chemistry, vol. 273, no. 33, pp. 21105-21110, 1998. (Pubitemid 28385397)
61. Y. Wu, D. Dowbenko, S. Spencer, et al., "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase," The Journal of Biological Chemistry, vol. 275, no. 28, pp. 21477-21485, 2000. (Pubitemid 30481851)
62. K. Adamsky, K. Arnold, H. Sabanay, et al., "Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase β (RPTP β) and tyrosine-phosphorylated proteins," Journal of Cell Science, vol. 116, no. 7, pp. 1279-1289, 2003. (Pubitemid 36410666)
63. F. D'Atri, F. Nadalutti, and S. Citi, "Evidence for a functional interaction between cingulin and ZO-1 in cultured cells," The Journal of Biological Chemistry, vol. 277, no. 31, pp. 27757-27764, 2002. (Pubitemid 34966720)
64. F. D'Atri and S. Citi, "Cingulin interacts with F-actin in vitro," FEBS Letters, vol. 507, no. 1, pp. 21-24, 2001. (Pubitemid 33000291)
65. G. Bazzoni, O. M. Martínez-Estrada, F. Orsenigo, et al., "Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin," The Journal of Biological Chemistry, vol. 275, no. 27, pp. 20520-20526, 2000. (Pubitemid 30457633)
66. S. Paschoud and S. Citi, "Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression," Molecular Membrane Biology, vol. 25, no. 1, pp. 1-13, 2008.
67. S. Aijaz, F. D'Atri, M. S. Balda, et al., "Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition," Developmental Cell, vol. 8, no. 5, pp. 777-786, 2005. (Pubitemid 40585299)
68. L. Guillemot and S. Citi, "Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA," Molecular Biology of the Cell, vol. 17, no. 8, pp. 3569-3577, 2006. (Pubitemid 44156449)
69. A. Bratt, W. J. Wilson, B. Troyanovsky, et al., "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains," Gene, vol. 298, no. 1, pp. 69-77, 2002. (Pubitemid 35284264)
70. Y. Sugihara-Mizuno, M. Adachi, Y. Kobayashi, et al., "Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties," Genes to Cells, vol. 12, no. 4, pp. 473-486, 2007. (Pubitemid 46488583)
71. C. D. Wells, J. P. Fawcett, A. Traweger, et al., "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells," Cell, vol. 125, no. 3, pp. 535-548, 2006.
72. K. M. Patrie, "Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1," Biochimica et Biophysica Acta, vol. 1745, no. 1, pp. 131-144, 2005. (Pubitemid 41111976)
73. M. Nishimura, M. Kakizaki, Y. Ono, et al., "JEAP, a novel component of tight junctions in exocrine cells," The Journal of Biological Chemistry, vol. 277, no. 7, pp. 5583-5587, 2002. (Pubitemid 34968611)
74. A. Suzuki, T. Yamanaka, T. Hirose, et al., "Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epitheliaspecific junctional structures," The Journal of Cell Biology, vol. 152, no. 6, pp. 1183-1196, 2001. (Pubitemid 34280176)
75. S. Sotillos, M. T. Díaz-Meco, E. Caminero, et al., "DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila," Journal of Cell Biology, vol. 166, no. 4, pp. 549-557, 2004. (Pubitemid 39097174)
76. J. M. Mullin, K. V. Laughlin, N. Ginanni, et al., "Increased tight junction permeability can result from protein kinase C activation/translocation and act as a tumor promotional event in epithelial cancers," Annals of the New York Academy of Sciences, vol. 915, pp. 231-236, 2000. (Pubitemid 32059384)
77. S. Tsukita, M. Furuse, and M. Itoh, "Multifunctional strands in tight junctions," Nature Reviews Molecular Cell Biology, vol. 2, no. 4, pp. 285-293, 2001. (Pubitemid 33676971)
78. M. Furuse and S. Tsukita, "Claudins in occluding junctions of humans and flies," Trends in Cell Biology, vol. 16, no. 4, pp. 181-188, 2006.
79. M. Furuse, H. Sasaki, K. Fujimoto, et al., "A single gene product, claudin-1 or-2, reconstitutes tight junction strands and recruits occludin in fibroblasts," Journal of Cell Biology, vol. 143, no. 2, pp. 391-401, 1998. (Pubitemid 28487858)
80. K. Umeda, J. Ikenouchi, S. Katahira-Tayama, et al., "ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation," Cell, vol. 126, no. 4, pp. 741-754, 2006. (Pubitemid 44233624)
81. K. Shin, Q. Wang, and B. Margolis, "PATJ regulates directional migration of mammalian epithelial cells," EMBO Reports, vol. 8, no. 2, pp. 158-164, 2007. (Pubitemid 46420844)
82. S. Etienne-Manneville, J. B. Manneville, S. Nicholls, et al., "Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization," The Journal of Cell Biology, vol. 170, no. 6, pp. 895-901, 2005. (Pubitemid 41306289)
83. S. Etienne-Manneville and A. Hall, "Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta," Cell, vol. 106, no. 4, pp. 489-498, 2001. (Pubitemid 32786992)
84. I. Mellman and W. J. Nelson, "Coordinated protein sorting, targeting and distribution in polarized cells," Nature Reviews Molecular Cell Biology, vol. 9, no. 11, pp. 833-845, 2008.
85. K. E. Mostov, M. Verges, and Y. Altschuler, "Membrane traffic in polarized epithelial cells," Current Opinion in Cell Biology, vol. 12, no. 4, pp. 483-490, 2000. (Pubitemid 30453600)
86. G. Berx and F. Van Roy, "The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression," Breast Cancer Research, vol. 3, no. 5, pp. 289-293, 2001. (Pubitemid 32851157)
87. W. Guo and F. G. Giancotti, "Integrin signalling during tumour progression," Nature Reviews Molecular Cell Biology, vol. 5, no. 10, pp. 816-826, 2004. (Pubitemid 39336275)
88. R. Agarwal, T. D'Souza, and P. J. Morin, "Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity," Cancer Research, vol. 65, no. 16, pp. 7378-7385, 2005. (Pubitemid 41161271)
89. M. J. Wheelock, A. P. Soler, and K. A. Knudsen, "Cadherin junctions in mammary tumors," Journal of Mammary Gland Biology and Neoplasia, vol. 6, no. 3, pp. 275-285, 2001.
90. P. W. B. Derksen, X. Liu, F. Saridin, et al., "Somatic inac-tivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis," Cancer Cell, vol. 10, no. 5, pp. 437-449, 2006. (Pubitemid 44693469)
91. J. Palacios, D. Sarrió, M. C. García-Macias, et al., "Frequent E-cadherin gene inactivation by loss of heterozygosity in pleomorphic lobular carcinoma of the breast," Modern Pathology, vol. 16, no. 7, pp. 674-678, 2003. (Pubitemid 36871500)
92. T. A. Martin and W. G. Jiang, "Loss of tight junction barrier function and its role in cancer metastasis," Biochimica et Biophysica Acta, vol. 1788, no. 4, pp. 872-891, 2009.
93. R. Benton and D. St Johnston, "Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells," Cell, vol. 115, no. 6, pp. 691-704, 2003. (Pubitemid 38030298)
94. T. W. Hurd, L. Gao, M. H. Roh, et al., "Direct interaction of two polarity complexes implicated in epthelial tight junction assembly," Nature Cell Biology, vol. 5, no. 2, pp. 137-142, 2003. (Pubitemid 36210848)
95. S. M. Reuver and C. C. Garner, "E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton," Journal of Cell Science, vol. 111, no. 8, pp. 1071-1080, 1998. (Pubitemid 28227107)
96. H. Wu, S. M. Reuver, S. Kuhlendahl, et al., "Subcellular targeting and cytoskeletal attachment of SAP97 to the epithelial lateral membrane," Journal of Cell Science, vol. 111, no. 16, pp. 2365-2376, 1998. (Pubitemid 28434923)
97. D. Bilder and N. Perrimon, "Localization of apical epithelial determinants by the basolateral PDZ protein Scribble," Nature, vol. 403, no. 6770, pp. 676-680, 2000. (Pubitemid 30104011)
98. C. Navarro, S. Nola, S. Audebert, et al., "Junctional recruitment of mammalian Scribble relies on E Cadherin engagement," Oncogene, vol. 24, no. 27, pp. 4330-4339, 2005. (Pubitemid 40961756)
99. K. Aigner, et al., "The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity," Oncogene, vol. 26, no. 49, pp. 6979-6988, 2007. (Pubitemid 350014612)
100. X. Wang, et al., "Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-β during the process of epithelial to mesenchymal transition in rat proximal epithelial cells," Biochimica et Biophysica Acta, vol. 1782, no. 1, pp. 51-59, 2008.
101. D. E. Martin and M. N. Hall, "The expanding TOR signaling network," Current Opinion in Cell Biology, vol. 17, no. 2, pp. 158-166, 2005. (Pubitemid 40380939)
102. R. J. Shaw and L. C. Cantley, "Ras, PI(3)K and mTOR signalling controls tumour cell growth," Nature, vol. 441, no. 7092, pp. 424-430, 2006. (Pubitemid 44050136)
103. C. De Virgilio and R. Loewith, "The TOR signalling network from yeast to man," International Journal of Biochemistry and Cell Biology, vol. 38, no. 9, pp. 1476-1481, 2006. (Pubitemid 43729300)
104. D. Massey-Harroche, M.-H. Delgrossi, L. Lane-Guermonprez, et al., "Evidence for a molecular link between the tuberous sclerosis complex and the Crumbs complex," Human Molecular Genetics, vol. 16, no. 5, pp. 529-536, 2007. (Pubitemid 46522615)
105. D. Michel, J.-P. Arsanto, D. Massey-Harroche, et al., "PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells," Journal of Cell Science, vol. 118, no. 17, pp. 4049-4057, 2005. (Pubitemid 41410286)
106. J. M. Mullin, "Potential interplay between luminal growth factors and increased tight junction permeability in epithelial carcinogenesis," Journal of Experimental Zoology, vol. 279, no. 5, pp. 484-489, 1997. (Pubitemid 27523409)
107. S. W. Straight, J. N. Pieczynski, E. L. Whiteman, et al., "Mammalian Lin-7 stabilizes polarity protein complexes," The Journal of Biological Chemistry, vol. 281, no. 49, pp. 37738-37747, 2006. (Pubitemid 46042077)
108. S. W. Straight, K. Shin, V. C. Fogg, et al., "Loss of PALS1 expression leads to tight junction and polarity defects," Molecular Biology of the Cell, vol. 15, no. 4, pp. 1981-1990, 2004. (Pubitemid 38401844)
109. Q. Wang, X. W. Chen, and B. Margolis, "PALS1 regulates E-cadherin trafficking in mammalian epithelial cells," Molecular Biology of the Cell, vol. 18, no. 3, pp. 874-885, 2007. (Pubitemid 46399493)
110. M. E. Nolan, V. Aranda, S. Lee, et al., "The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer," Cancer Research, vol. 68, no. 20, pp. 8201-8209,2008.
111. V. Aranda, M. E. Nolan, and S. K. Muthuswamy, "Par complex in cancer: a regulator of normal cell polarity joins the dark side," Oncogene, vol. 27, no. 55, pp. 6878-6887,2008.
112. V. Aranda, T. Haire, M. E. Nolan, et al., "Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control," Nature Cell Biology, vol. 8, no. 11, pp. 1235-1245, 2006. (Pubitemid 44660588)
113. D. J. Slamon, et al., "Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene," Science, vol. 235, no. 4785, pp. 177-182, 1987. (Pubitemid 17231334)
114. M. Kim, A. Datta, P. Brakeman, et al., "Polarity proteins PAR6 and aPKC regulate cell death through GSK-3β in 3D epithelial morphogenesis," Journal of Cell Science, vol. 120, no. 14, pp. 2309-2317, 2007. (Pubitemid 47225934)
115. R. P. Regala, C. Weems, L. Jamieson, et al., "Atypical protein kinase Cτ plays a critical role in human lung cancer cell growth and tumorigenicity," The Journal of Biological Chemistry, vol. 280, no. 35, pp. 31109-31115, 2005. (Pubitemid 41291846)
116. L. A. Frederick, J. A. Matthews, L. Jamieson, et al., "Matrix metalloproteinase-10 is a critical effector of protein kinase Cι-Par6α-mediated lung cancer," Oncogene, vol. 27, no. 35, pp. 4841-4853, 2008.
117. K. Zen, et al., "Defective expression of polarity protein PAR-3 gene (PARD3) in esophageal squamous cell carcinoma," Oncogene, vol. 28, no. 32, pp. 2910-2918, 2009.
118. N. Agrawal, S. Joshi, M. Kango, et al., "Epithelial hyperplasia of imaginal discs induced by mutations in Drosophila tumor suppressor genes: growth and pattern formation in genetic mosaics," Developmental Biology, vol. 169, no. 2, pp. 387-398, 1995.
119. D. Bilder, "Epithelial polarity and proliferation control: links from the Drosophila neoplastictumor suppressors," Genes and Development, vol. 18, no. 16, pp. 1909-1925, 2004. (Pubitemid 39071572)
120. D. F. Woods and P. J. Bryant, "The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions," Cell, vol. 66, no. 3, pp. 451-464, 1991. (Pubitemid 121001382)
121. D. Bilder, et al., "Collective nomenclature for LAP proteins," Nature Cell Biology, vol. 2, no. 7, p. E114, 2000.
122. L. Zhan, A. Rosenberg, K. C. Bergami, et al., "Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma," Cell, vol. 135, no. 5, pp. 865-878, 2008.
123. A. Musch, et al., "Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells," Molecular Biology ofthe Cell, vol. 13, no. 1,pp. 158-168,2002. (Pubitemid 34106066)
124. L. X. Liu, Z. H. Liu, H. C. Jiang, et al., "Profiling of differentially expressed genes in human gastric carcinoma by cDNA expression array," World Journal of Gastroenterology, vol. 8, no. 4, pp. 580-585, 2002.
125. N. Hanada, K. Makino, H. Koga, et al., "NE-dlg, a mammalian homolog of Drosophila dlg tumor suppressor, induces growth suppression and impairment of cell adhesion: possible involvement of down-regulation of β-catenin by NE-dlg expression," International Journal of Cancer, vol. 86, no. 4, pp. 480-488, 2000. (Pubitemid 30249726)
126. T. Ishidate, et al., "The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase," Oncogene, vol. 19, no. 3, pp. 365-372, 2000. (Pubitemid 30077336)
127. H. Hering and M. Sheng, "Direct interaction of Frizzled-1,-2,-4, and-7 with PDZ domains of PSD-95," FEBS Letters, vol. 521, no. 1-3, pp. 185-189, 2002. (Pubitemid 34628482)
128. R. Z. Karim, G. Tse, T. Putti, et al., "The significance of the Wnt pathway in the pathology of human cancers," Pathology, vol. 36, no. 2, pp. 120-128, 2004. (Pubitemid 38507872)
129. A. Matsumine, A. Ogai, T. Senda, et al., "Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein," Science, vol. 272, no. 5264, pp. 1020-1023, 1996. (Pubitemid 26259321)
130. F. Mantovani, P. Massimi, and L. Banks, "Proteasome-mediated regulation of the hDlg tumour suppresor protein," Journal of Cell Science, vol. 114, no. 23, pp. 4285-4292, 2001. (Pubitemid 33138665)
131. M. Osanai, M. Murata, N. Nishikiori, et al., "Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells," Cancer Science, vol. 98, no. 7, pp. 1027-1034, 2007. (Pubitemid 46865387)
132. H. Tobioka, H. Isomura, Y. Kokai, et al., "Occludin expression decreases with the progression of human endometrial carcinoma," Human Pathology, vol. 35, no. 2, pp. 159-164, 2004. (Pubitemid 38240897)
133. H. Tobioka, Y. Tokunaga, H. Isomura, et al., "Expression of occludin, a tight-junction-associated protein, in human lung carcinomas," Virchows Archiv, vol. 445, no. 5, pp. 472-476, 2004. (Pubitemid 39592750)
134. Y. Tokunaga, H. Tobioka, H. Isomura, et al., "Expression of occludin in human rectal carcinoid tumours as a possible marker for glandular differentiation," Histopathology, vol. 44, no. 3, pp. 247-250, 2004. (Pubitemid 38406617)
135. M. Osanai, et al., "Epigenetic silencing of occludin promotes tumorigenic and metastatic properties of cancer cells via modulations of unique sets of apoptosisassociated genes," Cancer Research, vol. 66, no. 18, pp. 9125-9133, 2006. (Pubitemid 44521132)
136. T. Hoevel, R. Macek, K. Swisshelm, et al., "Reexpression of the TJ protein CLDN1 induces apoptosis in breast tumor spheroids," International Journal of Cancer, vol. 108, no. 3, pp. 374-383, 2004. (Pubitemid 37549602)
137. P. Michl, et al., "Claudin-4 expression decreases invasive-ness and metastatic potential of pancreatic cancer," Cancer Research, vol. 63, no. 19, pp. 6265-6271, 2003. (Pubitemid 37255173)
138. S. Mima, S. Tsutsumi, H. Ushijima, et al., "Induction of claudin-4 by nonsteroidal anti-inflammatory drugs and its contribution to their chemopreventive effect," Cancer Research, vol. 65, no. 5, pp. 1868-1876, 2005. (Pubitemid 40478615)
139. K. Swisshelm, A. Machl, S. Planitzer, et al., "SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily," Gene, vol. 226, no. 2, pp. 285-295, 1999. (Pubitemid 29087109)
140. M. Osanai, et al., "Epigenetic silencing of claudine-6 promotes anchorage independent growth of breast carcinoma cells," Cancer Science, vol. 98, no. 10, pp. 1557-1562, 2007. (Pubitemid 47308450)
141. J. M. Mullin, "Epithelial barriers, compartmentation, and cancer," Science's STKE, vol. 2004, no. 216, p. pe2, 2004.
142. A. M. Tokés, et al., "Claudin-1,-3 and-4 proteins and mRNA expression in benign and malignant breast lesions: a research study," Breast Cancer Research, vol. 7, no. 2, pp. R296-R305, 2005.
143. S. L. Kominsky, M. Vali, D. Korz, et al., "Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4," American Journal of Pathology, vol. 164, no. 5, pp. 1627-1633, 2004. (Pubitemid 38529765)
144. F. Lanigan, E. McKiernan, D. J. Brennan, et al., "Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer," International Journal of Cancer, vol. 124, no. 9, pp. 2088-2097, 2009.
145. K. J. Hewitt, R. Agarwal, and P. J. Morin, "The claudin gene family: expression in normal and neoplastic tissues," BMC Cancer, vol. 6, article 186, 2006.
146. K. B. Hoover, S. Y. Liao, and P. J. Bryant, "Loss of the tight junction MAGUK ZO-1 in breast cancer: relationship to glandular differentiation and loss of heterozygosity," American Journal of Pathology, vol. 153, no. 6, pp. 1767-1773, 1998. (Pubitemid 28550664)
147. T. Kaihara, et al., "Dedifferentiation and decreased expression of adhesion molecules, E-cadherin and ZO-1, in col-orectal cancer are closely related to liver metastasis," Journal of Experimental and Clinical Cancer Research, vol. 22, no. 1, pp. 117-123, 2003. (Pubitemid 36396666)
148. M. S. Balda, M. D. Garrett, and K. Matter, "The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density," The Journal of Cell Biology, vol. 160, no. 3, pp. 423-432, 2003. (Pubitemid 36182732)
149. P. Frankel, A. Aronheim, E. Kavanagh, et al., "Ra1A interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity," EMBO Journal, vol. 24, no. 1, pp. 54-62, 2005. (Pubitemid 40188463)
150. M. Huerta, R. Muñoz, R. Tapia, et al., "Cyclin D1 is transcriptionally down-regulated by ZO-2 via an E box and the transcription factor c-Myc," Molecular Biology of the Cell, vol. 18, no. 12, pp. 4826-4836, 2007. (Pubitemid 350246685)
151. M. S. Balda and K. Matter, "The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression," EMBO Journal, vol. 19, no. 9, pp. 2024-2033, 2000. (Pubitemid 30237578)
152. H. Wang, et al., "C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4," Molecular Cell, vol. 8, no. 4, pp. 817-828, 2001. (Pubitemid 33030215)
153. S. Samarin and A. Nusrat, "Regulation of epithelial apical junctional complex by Rho family GTPases," Frontiers in Bioscience, vol. 14, pp. 1129-1142, 2009.
154. F. Grise, A. Bidaud, and V. Moreau, "Rho GTPases in hepatocellular carcinoma," Biochimica et Biophysica Acta, vol. 1795, no. 2, pp. 137-151, 2009.
155. M. L. Coleman, C. J. Marshall, and M. F. Olson, "RAS and RHO GTPases in G1-phase cell-cycle regulation," Nature Reviews Molecular Cell Biology, vol. 5, no. 5, pp. 355-366, 2004. (Pubitemid 38579473)
156. S. Mizuarai, K. Yamanaka, and H. Kotani, "Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells," Cancer Research, vol. 66, no. 12, pp. 6319-6326, 2006.
157. M. Mareel and A. Leroy, "Clinical, cellular, and molecular aspects of cancer invasion," Physiological Reviews, vol. 83, no. 2, pp. 337-376, 2003. (Pubitemid 36382891)
158. E. A. McSherry, S. Donatello, A. M. Hopkins, et al., "Molecular basis of invasion in breast cancer," Cellular and Molecular Life Sciences, vol. 64, no. 24, pp. 3201-3218, 2007.
159. B. T. Hennessy, A.-M. Gonzalez-Angulo, K. Stemke-Hale, et al., "Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics," Cancer Research, vol. 69, no. 10, pp. 4116-4124, 2009.
160. A. A. Blanchard, G. P. Skliris, P. H. Watson, et al., "Claudins 1, 3, and 4 protein expression in ER negative breast cancer correlates with markers of the basal phenotype," Virchows Archiv, vol. 454, no. 6, pp. 647-656, 2009.
161. F. Kramer, et al., "Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer," Human Genetics, vol. 107, no. 3, pp. 249-256, 2000.
162. S. Morohashi, T. Kusumi, F. Sato, et al., "Decreased expression of claudin-1 correlates with recurrence status in breast cancer," International Journal of Molecular Medicine, vol. 20, no. 2, pp. 139-143, 2007.
163. T. H. Kim, J. H. Huh, S. Lee, et al., "Down-regulation of claudin-2 in breast carcinomas is associated with advanced disease," Histopathology, vol. 53, no. 1, pp. 48-55, 2008. (Pubitemid 351861978)
164. S. L. Kominsky, P. Argani, D. Korz, et al., "Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast," Oncogene, vol. 22, no. 13, pp. 2021-2033, 2003. (Pubitemid 36523639)
165. T. A. Martin, G. M. Harrison, G. Watkins, et al., "Claudin-16 reduces the aggressive behavior of human breast cancer cells," Journal of Cellular Biochemistry, vol. 105, no. 1, pp. 41-52, 2008.
166. T. Sauer, M. K. Pedersen, K. Ebeltoft, et al., "Reduced expression of Claudin-7 in fine needle aspirates from breast carcinomas correlate with grading and metastatic disease," Cytopathology, vol. 16, no. 4, pp. 193-198, 2005. (Pubitemid 41112978)
167. Y. Soini, "Expression of claudins 1, 2, 3, 4, 5 and 7 in various types of tumours," Histopathology, vol. 46, no. 5, pp. 551-560, 2005. (Pubitemid 40632312)
168. F. Jaulin-Bastard, H. Saito, A. Le Bivic, et al., "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins," The Journal of Biological Chemistry, vol. 276, no. 18, pp. 15256-15263, 2001.
169. T. W. Liang, et al., "Characterization of huJAM: evidence for involvement in cellcell contact and tight junction regulation," American Journal of Physiology, vol. 279, no. 6, pp. C1733-C1743, 2000.
170. K. J. Mandell, B. A. Babbin, A. Nusrat, et al., "Junctional adhesion molecule 1 regulates epithelial cell morphology through effects on β1 integrins and Rap1 activity," The Journal of Biological Chemistry, vol. 280, no. 12, pp. 11665-11674, 2005. (Pubitemid 40418481)
171. I. Martín-Padura, S. Lostaglio, M. Schneemann, et al., "Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration," Journal of Cell Biology, vol. 142, no. 1, pp. 117-127, 1998. (Pubitemid 28341144)
172. G. Ostermann, et al., "AM-1 is a ligand of the β(2) integrin LFA-1 involved in transendothelial migration of leukocyte," Nature Immunology, vol. 3, no. 2, pp. 151-158, 2002. (Pubitemid 34141445)
173. E. A. McSherry, S. F. McGee, K. Jirstrom, et al., "JAM-A expression positively correlates with poor prognosis in breast cancer patients," International Journal of Cancer, vol. 125, no. 6, pp. 1343-1351, 2009.
174. M. U. Naik, T. U. Naik, A. T. Suckow, et al., "Attenuation of junctional adhesion molecule-A is a contributing factor for breast cancer cell invasion," Cancer Research, vol. 68, no. 7, pp. 2194-2203, 2008. (Pubitemid 351521792)
175. M. Bordin, et al., "Histone deacetylase inhibitors up-regulate the expression of tight junction proteins," Molecular Cancer Research, vol. 2, no. 12, pp. 692-701, 2004.
176. G. Mandicourt, S. Iden, K. Ebnet, et al., "JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration," The Journal of Biological Chemistry, vol. 282, no. 3, pp. 1830-1837, 2007. (Pubitemid 47076730)
177. T. A. Martin, G. Watkins, R. E. Mansel, et al., "Loss of tight junction plaque molecules in breast cancer tissues is associated with a poor prognosis in patients with breast cancer," European Journal of Cancer, vol. 40, no. 18, pp. 2717-2725, 2004. (Pubitemid 39574723)
178. M. Polette, et al., "Membrane-type 1 matrix metallopro-teinase expression is regulated by zonula occludens-1 in human breast cancer cells," Cancer Research, vol. 65, no. 17, pp. 7691-7698, 2005. (Pubitemid 41297243)
179. M. S. Balda, C. Flores-Maldonado, M. Cereijido, et al., "Multiple domains of occludin are involved in the regulation of paracellular permeability," The Journal of Cellular Biochemistry, vol. 78, no. 1, pp. 85-96, 2000. (Pubitemid 30346385)
180. A. Chlenski, et al., "Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues," Biochimica et Biophysica Acta, vol. 1493, no. 3, pp. 319-324, 2000.
181. B. A. Glaunsinger, R. S. Weiss, S. S. Lee, et al., "Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2," EMBO Journal, vol. 20, no. 20, pp. 5578-5586, 2001. (Pubitemid 33010035)
182. D. M. Pegtel, S. I. J. Ellenbroek, A. E. E. Mertens, et al., "The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity," Current Biology, vol. 17, no. 19, pp. 1623-1634, 2007. (Pubitemid 47503803)
183. M. E. Minard, L. S. Kim, J. E. Price, et al., "The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression," Breast Cancer Research and Treatment, vol. 84, no. 1, pp. 21-32, 2004. (Pubitemid 38388857)
184. G. Joberty, C. Petersen, L. Gao, et al., "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42," Nature Cell Biology, vol. 2, no. 8, pp. 531-539, 2000.
185. B. Ozdamar, et al., "Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity," Science, vol. 307, no. 5715, pp. 1603-1609, 2005. (Pubitemid 40354739)
186. L. Y. W. Bourguignon, Z. Hongbo, L. Shao, et al., "CD44 interaction with Tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration," The Journal of Biological Chemistry, vol. 275, no. 3, pp. 1829-1838, 2000. (Pubitemid 30060806)
187. P. J. Keely, J. K. Westwick, I. P. Whitehead, et al., "Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K," Nature, vol. 390, no. 6660, pp. 632-636, 1997. (Pubitemid 28016201)
188. M. Itoh, C. M. Nelson, C. A. Myers, et al., "Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells," Cancer Research, vol. 67, no. 10, pp. 4759-4766, 2007. (Pubitemid 46910183)
189. B. H. Shieh, L. Parker, and D. Popescu, "Protein kinase C (PKC) isoforms in Drosophila," The Journal of Biochemistry, vol. 132, no. 4, pp. 523-527, 2002. (Pubitemid 35238904)
190. Y. Kojima, K. Akimoto, Y. Nagashima, et al., "The overexpres-sion and altered localization of the atypical protein kinase C a;/ι in breast cancer correlates with the pathologic type of these tumors," Human Pathology, vol. 39, no. 6, pp. 824-831, 2008. (Pubitemid 351758943)
191. X. G. Sun and S. A. Rotenberg, "Overexpression of protein kinase Calpha in MCF-10A human breast cells engenders dramatic alterations in morphology, proliferation, and motility," Cell Growth & Differentiation, vol. 10, no. 5, pp. 343-352, 1999. (Pubitemid 29242600)
192. Y. Soini, "Claudins 2, 3, 4, and 5 in Paget's disease and breast carcinoma," Human Pathology, vol. 35, no. 12, pp. 1531-1536, 2004. (Pubitemid 40017994)
193. A. A. Blanchard, G. P. Skliris, P. H. Watson, et al., "Claudins 1, 3, and 4 protein expression in ER negative breast cancer correlates with markers of the basal phenotype," Virchows Archiv, vol. 454, no. 6, pp. 647-656, 2009.
194. P. Michl, et al., "Claudin-4: a new target for pancreatic cancer treatment using clostridium perfringens enterotoxin," Gastroenterology, vol. 121, no. 3, pp. 678-684, 2001. (Pubitemid 32822583)
195. A. D. Santin, S. Bellone, M. Marizzoni, et al., "Overexpression of claudin-3 and claudin-4 receptors in uterine serous papillary carcinoma: novel targets for a type-specific therapy using Clostridium perfringens enterotoxin (CPE)," Cancer, vol. 109, no. 7, pp. 1312-1322, 2007. (Pubitemid 46466558)
196. P. J. Morin, "Claudin proteins in human cancer: promising new targets for diagnosis and therapy," Cancer Research, vol. 65, no. 21, pp. 9603-9606, 2005. (Pubitemid 41541431)
197. J. Katahira, H. Sugiyama, N. Inoue, et al., "Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo," The Journal of Biological Chemistry, vol. 272, no. 42, pp. 26652-26658, 1997. (Pubitemid 27458889)
198. J. Katahira, N. Inoue, Y. Horiguchi, et al., "Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin," Journal of Cell Biology, vol. 136, no. 6, pp. 1239-1247, 1997. (Pubitemid 27421912)
199. M. Kondoh, A. Takahashi, M. Fujii, et al., "A novel strategy for a drug delivery system using a claudin modulator," Biological and Pharmaceutical Bulletin, vol. 29, no. 9, pp. 1783-1789, 2006. (Pubitemid 44338395)
200. B. A. McClane and G. Chakrabarti, "New insights into the cytotoxic mechanisms of Clostridium perfringens entero-toxin," Anaerobe, vol. 10, no. 2, pp. 107-114, 2004. (Pubitemid 38519811)
201. C. Ebihara, M. Kondoh, N. Hasuike, et al., "Preparation of a claudin-targeting molecule using a C-terminal fragment of Clostridium perfringens enterotoxin," Journal of Pharmacology and Experimental Therapeutics, vol. 316, no. 1, pp. 255-260, 2006. (Pubitemid 41832604)
202. A. Gadducci, R. Tana, S. Cosio, et al., "Molecular target therapies in endometrial cancer: from the basic research to the clinic," Gynecological Endocrinology, vol. 24, no. 5, pp. 239-249, 2008. (Pubitemid 351891652)
203. S. Offner, A. Hekele, U. Teichmann, et al., "Epithelial tight junction proteins as potential antibody targets for pancarci-noma therapy," Cancer Immunology, Immunotherapy, vol. 54, no. 5, pp. 431-445, 2005. (Pubitemid 40543683)
204. E. Raschperger, et al., "The coxsackie-and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis," Experimental Cell Research, vol. 312, no. 9, pp. 1566-1580, 2006.
205. L. Philipson and R. F. Pettersson, "The coxsackie-adenovirus receptor-a new receptor in the immunoglobulin family involved in cell adhesion," Current Topics in Microbiology and Immunology, vol. 273, pp. 87-111, 2004. (Pubitemid 37209896)
206. T. A. Martin, G. Watkins, and W. G. Jiang, "The Coxsackie-adenovirus receptor has elevated expression in human breast cancer," Clinical and Experimental Medicine, vol. 5, no. 3, pp. 122-128, 2005. (Pubitemid 41597272)
207. C. B. Coyne and J. M. Bergelson, "CAR: a virus receptor within the tight junction," Advanced Drug Delivery Reviews, vol. 57, no. 6, pp. 869-882, 2005. (Pubitemid 40488108)
208. V. Wong and B. M. Gumbiner, "A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier," The Journal of Cell Biology, vol. 136, no. 2, pp. 399-409, 1997. (Pubitemid 27063089)
209. M. Kondoh, T. Yoshida, H. Kakutani, et al., "Targeting tight junction proteins-significance for drug development," Drug Discovery Today, vol. 13, no. 3-4, pp. 180-186, 2008.
210. A. Nusrat, J. A. Chen, C. S. Foley, et al., "The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction," The Journal of Biological Chemistry, vol. 275, no. 38, pp. 29816-29822, 2000. (Pubitemid 32043866)
211. Z. Wang, K. J. Mandell, C. A. Parkos, et al., "The second loop of occludin is required for suppression of Raf1-induced tumor growth," Oncogene, vol. 24, no. 27, pp. 4412-4420, 2005. (Pubitemid 40961764)
212. L. González-Mariscal, P. Nava, and S. Hernández, "Critical role of tight junctions in drug delivery across epithelial and endothelial cell layers," Journal of Membrane Biology, vol. 207, no. 2, pp. 55-68, 2005. (Pubitemid 43237788)
213. K. Matsuhisa, et al., "Tight junction modulator and drug delivery," Expert Opinion on Drug Delivery, vol. 6, no. 5, pp. 509-515, 2009.
214. E. E. Schneeberger and R. D. Lynch, "The tight junction: a multifunctional complex," American Journal of Physiology, vol. 286, no. 6, pp. C1213-C1228, 2004. (Pubitemid 38649971)