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Volumn 16, Issue 5, 2007, Pages 529-536

Evidence for a molecular link between the tuberous sclerosis complex and the Crumbs complex

Author keywords

[No Author keywords available]

Indexed keywords

CRUMBS 3 COMPLEX; CRUMBS COMPLEX; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE PROTEIN; PDZ 2 PROTEIN; PDZ 3 PROTEIN; PDZ PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN PATJ; RAPAMYCIN; SCAFFOLD PROTEIN; TUBERIN; UNCLASSIFIED DRUG; WORTMANNIN;

EID: 34047126501     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddl485     Document Type: Article
Times cited : (32)

References (45)
  • 1
    • 29244435314 scopus 로고    scopus 로고
    • Apicobasal polarity complexes
    • Margolis, B. and Borg, J.P. (2005) Apicobasal polarity complexes. J. Cell Sci., 118, 5157-5159.
    • (2005) J. Cell Sci. , vol.118 , pp. 5157-5159
    • Margolis, B.1    Borg, J.P.2
  • 2
    • 0037452071 scopus 로고    scopus 로고
    • Adaptation of core mechanisms to generate cell polarity
    • Nelson, W.J. (2003) Adaptation of core mechanisms to generate cell polarity. Nature, 422, 766-774.
    • (2003) Nature , vol.422 , pp. 766-774
    • Nelson, W.J.1
  • 5
    • 0036813857 scopus 로고    scopus 로고
    • Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells
    • Medina, E., Lemmers, C., Lane-Guermonprez, L. and Le Bivic, A. (2002) Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells. Biol. Cell, 94, 305-313.
    • (2002) Biol. Cell , vol.94 , pp. 305-313
    • Medina, E.1    Lemmers, C.2    Lane-Guermonprez, L.3    Le Bivic, A.4
  • 6
    • 0035984637 scopus 로고    scopus 로고
    • Adherens junctions: New insight into assembly, modulation and function
    • Tepass, U. (2002) Adherens junctions: New insight into assembly, modulation and function. Bioessays, 24, 690-695.
    • (2002) Bioessays , vol.24 , pp. 690-695
    • Tepass, U.1
  • 7
    • 0025285657 scopus 로고
    • Crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia
    • Tepass, U., Theres, C. and Knust, E. (1990) Crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell, 61, 787-799.
    • (1990) Cell , vol.61 , pp. 787-799
    • Tepass, U.1    Theres, C.2    Knust, E.3
  • 9
    • 0035666827 scopus 로고    scopus 로고
    • Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain
    • den Hollander, A.I., Ghiani, M., de Kok, Y.J.M., Wijnholds, J., Ballabio, A., Cremers, F.P.M. and Broccoli, V. (2002) Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech. Dev., 110, 203-207.
    • (2002) Mech. Dev. , vol.110 , pp. 203-207
    • den Hollander, A.I.1    Ghiani, M.2    de Kok, Y.J.M.3    Wijnholds, J.4    Ballabio, A.5    Cremers, F.P.M.6    Broccoli, V.7
  • 12
    • 0037413672 scopus 로고    scopus 로고
    • Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)
    • Makarova, O., Roh, M.H., Liu, C.J., Laurinec, S. and Margolis, B. (2003) Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1). Gene, 302, 21-29.
    • (2003) Gene , vol.302 , pp. 21-29
    • Makarova, O.1    Roh, M.H.2    Liu, C.J.3    Laurinec, S.4    Margolis, B.5
  • 13
    • 0041669430 scopus 로고    scopus 로고
    • The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells
    • Roh, M.H., Fan, S., Liu, C.J. and Margolis, B. (2003) The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells. J. Cell Sci., 116, 2895-2906.
    • (2003) J. Cell Sci. , vol.116 , pp. 2895-2906
    • Roh, M.H.1    Fan, S.2    Liu, C.J.3    Margolis, B.4
  • 14
  • 15
    • 1642464585 scopus 로고    scopus 로고
    • Loss of PALS1 expression leads to tight junction and polarity defects
    • Human Molecular Genetics, 2007, Vol. 16, No. 5 535
    • Straight, S.W., Shin, K., Fogg, V.C., Fan, S., Liu, C.-J., Roh, M. and Margolis, B. (2004) Loss of PALS1 expression leads to tight junction and polarity defects. Mol. Biol. Cell, 15, 1981-1990. Human Molecular Genetics, 2007, Vol. 16, No. 5 535
    • (2004) Mol. Biol. Cell , vol.15 , pp. 1981-1990
    • Straight, S.W.1    Shin, K.2    Fogg, V.C.3    Fan, S.4    Liu, C.-J.5    Roh, M.6    Margolis, B.7
  • 16
    • 0036544563 scopus 로고    scopus 로고
    • The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and discs lost
    • Roh, M.H., Makarova, O., Liu, C.J., Shin, K., Lee, S., Laurinec, S., Goyal, M., Wiggins, R. and Margolis, B. (2002) The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and discs lost. J. Cell Biol., 157, 161-172.
    • (2002) J. Cell Biol. , vol.157 , pp. 161-172
    • Roh, M.H.1    Makarova, O.2    Liu, C.J.3    Shin, K.4    Lee, S.5    Laurinec, S.6    Goyal, M.7    Wiggins, R.8    Margolis, B.9
  • 17
    • 0442323560 scopus 로고    scopus 로고
    • Tuberous sclerosis complex: From Drosophila to human disease
    • Pan, D., Dong, J., Zhang, Y. and Gao, X. (2004) Tuberous sclerosis complex: From Drosophila to human disease. Trends Cell Biol., 14, 78-85.
    • (2004) Trends Cell Biol. , vol.14 , pp. 78-85
    • Pan, D.1    Dong, J.2    Zhang, Y.3    Gao, X.4
  • 19
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki, K., Li, Y., Xu, T. and Guan, K.L. (2003) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev., 17, 1829-1834.
    • (2003) Genes Dev. , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 20
    • 0038643484 scopus 로고    scopus 로고
    • Rheb promotes cell growth as a component of the insulin/TOR signalling network
    • Saucedo, L.J., Gao, X., Chiarelli, D.A., Li, L., Pan, D. and Edgar, B.A. (2003) Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat. Cell. Biol., 5, 566-571.
    • (2003) Nat. Cell. Biol. , vol.5 , pp. 566-571
    • Saucedo, L.J.1    Gao, X.2    Chiarelli, D.A.3    Li, L.4    Pan, D.5    Edgar, B.A.6
  • 21
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw, R.J. and Cantley, L.C. (2006) Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature, 441, 424-430.
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 22
    • 33646538482 scopus 로고    scopus 로고
    • The TOR signalling network from yeast to man
    • De Virgilio, C. and Loewith, R. (2006) The TOR signalling network from yeast to man. Int J. Biochem. Cell Biol., 38, 1476-1481.
    • (2006) Int J. Biochem. Cell Biol. , vol.38 , pp. 1476-1481
    • De Virgilio, C.1    Loewith, R.2
  • 23
    • 15044350668 scopus 로고    scopus 로고
    • The expanding TOR signaling network
    • Martin, D.E. and Hall, M.N. (2005) The expanding TOR signaling network. Curr. Opin. Cell Biol., 17, 158-166.
    • (2005) Curr. Opin. Cell Biol. , vol.17 , pp. 158-166
    • Martin, D.E.1    Hall, M.N.2
  • 24
    • 27744588780 scopus 로고    scopus 로고
    • Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways
    • Kwiatkowski, D.J. and Manning, B.D. (2005) Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways. Hum. Mol. Genet., 14 (Spec no. 2), R251-R258.
    • (2005) Hum. Mol. Genet. , vol.14 , Issue.2
    • Kwiatkowski, D.J.1    Manning, B.D.2
  • 25
    • 0033582916 scopus 로고    scopus 로고
    • Discs lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity
    • Bhat, M.A., Izaddoost, S., Lu, Y., Cho, K.O., Choi, K.W. and Bellen, H.J. (1999) Discs lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. Cell, 96, 833-845.
    • (1999) Cell , vol.96 , pp. 833-845
    • Bhat, M.A.1    Izaddoost, S.2    Lu, Y.3    Cho, K.O.4    Choi, K.W.5    Bellen, H.J.6
  • 26
    • 0037067320 scopus 로고    scopus 로고
    • hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells
    • Lemmers, C., Medina, E., Delgrossi, M.H., Michel, D., Arsanto, J.P. and Le Bivic, A. (2002) hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells. J. Biol. Chem., 277, 25408-25415.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25408-25415
    • Lemmers, C.1    Medina, E.2    Delgrossi, M.H.3    Michel, D.4    Arsanto, J.P.5    Le Bivic, A.6
  • 28
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
    • Ma, L., Chen, Z., Erdjument-Bromage, H., Tempst, P. and Pandolfi, P.P. (2005) Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell, 121, 179-193.
    • (2005) Cell , vol.121 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 29
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter, C.J., Pedraza, L.G. and Xu, T. (2002) Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol., 4, 658-665.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 30
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki, K., Li, Y., Zhu, T., Wu, J. and Guan, K.L. (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol., 4, 648-657.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 32
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay, N. and Sonenberg, N. (2004) Upstream and downstream of mTOR. Genes Dev., 18, 1926-1945.
    • (2004) Genes Dev. , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 33
    • 26244441572 scopus 로고    scopus 로고
    • PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells
    • Michel, D., Arsanto, J.P., Massey-Harroche, D., Beclin, C.,Wijnholds, J. and Le Bivic, A. (2005) PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells. J. Cell Sci., 118, 4049-4057.
    • (2005) J. Cell Sci. , vol.118 , pp. 4049-4057
    • Michel, D.1    Arsanto, J.P.2    Massey-Harroche, D.3    Beclin, C.4    Wijnholds, J.5    Le Bivic, A.6
  • 34
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman, J., Movva, N.R. and Hall, M.N. (1991) Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science, 253, 905-909.
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 35
    • 0042466237 scopus 로고    scopus 로고
    • Composition and function of PDZ protein complexes during cell polarization
    • Roh, M.H. and Margolis, B. (2003) Composition and function of PDZ protein complexes during cell polarization. Am. J. Physiol. Renal Physiol., 285, F377-F387.
    • (2003) Am. J. Physiol. Renal Physiol. , vol.285
    • Roh, M.H.1    Margolis, B.2
  • 36
    • 14744275517 scopus 로고    scopus 로고
    • PATJ regulates tight junction formation and polarity in mammalian epithelial cells
    • Shin, K., Straight, S. and Margolis, B. (2005) PATJ regulates tight junction formation and polarity in mammalian epithelial cells. J. Cell Biol., 168, 705-711.
    • (2005) J. Cell Biol. , vol.168 , pp. 705-711
    • Shin, K.1    Straight, S.2    Margolis, B.3
  • 37
    • 0037319350 scopus 로고    scopus 로고
    • Direct interaction of two polarity complexes implicated in epithelial tight junction assembly
    • Hurd, T.W., Gao, L., Roh, M.H., Macara, I.G. and Margolis, B. (2003) Direct interaction of two polarity complexes implicated in epithelial tight junction assembly. Nat. Cell Biol., 5, 137-142.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 137-142
    • Hurd, T.W.1    Gao, L.2    Roh, M.H.3    Macara, I.G.4    Margolis, B.5
  • 38
    • 0037178864 scopus 로고    scopus 로고
    • The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions
    • Roh, M.H., Liu, C.J., Laurinec, S. and Margolis, B. (2002) The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions. J. Biol. Chem., 277, 27501-27509.
    • (2002) J. Biol. Chem. , vol.277 , pp. 27501-27509
    • Roh, M.H.1    Liu, C.J.2    Laurinec, S.3    Margolis, B.4
  • 39
    • 0031727426 scopus 로고    scopus 로고
    • Occludin and the functions of tight junctions
    • Matter, K. and Balda, M.S. (1999) Occludin and the functions of tight junctions. Int. Rev. Cytol., 186, 117-146.
    • (1999) Int. Rev. Cytol. , vol.186 , pp. 117-146
    • Matter, K.1    Balda, M.S.2
  • 40
    • 0034703027 scopus 로고    scopus 로고
    • The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction
    • Nusrat, A., Chen, J.A., Foley, C.S., Liang, T.W., Tom, J., Cromwell, M., Quan, C. and Mrsny, R.J. (2000) The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction. J. Biol. Chem., 275, 29816-29822.
    • (2000) J. Biol. Chem. , vol.275 , pp. 29816-29822
    • Nusrat, A.1    Chen, J.A.2    Foley, C.S.3    Liang, T.W.4    Tom, J.5    Cromwell, M.6    Quan, C.7    Mrsny, R.J.8
  • 41
    • 12344262762 scopus 로고    scopus 로고
    • mTOR, translational control and human disease
    • Tee, A.R. and Blenis, J. (2005) mTOR, translational control and human disease. Semin. Cell Dev. Biol., 16, 29-37.
    • (2005) Semin. Cell Dev. Biol. , vol.16 , pp. 29-37
    • Tee, A.R.1    Blenis, J.2
  • 42
    • 1542777034 scopus 로고    scopus 로고
    • Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
    • Baas, A.F., Kuipers, J., van der Wel, N.N., Batlle, E., Koerten, H.K., Peters, P.J. and Clevers, H.C. (2004) Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell, 116, 457-466.
    • (2004) Cell , vol.116 , pp. 457-466
    • Baas, A.F.1    Kuipers, J.2    van der Wel, N.N.3    Batlle, E.4    Koerten, H.K.5    Peters, P.J.6    Clevers, H.C.7
  • 43
    • 30944433152 scopus 로고    scopus 로고
    • Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells
    • Pinal, N., Goberdhan, D.C., Collinson, L., Fujita, Y., Cox, I.M., Wilson, C. and Pichaud, F. (2006) Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells. Curr. Biol., 16, 140-149.
    • (2006) Curr. Biol. , vol.16 , pp. 140-149
    • Pinal, N.1    Goberdhan, D.C.2    Collinson, L.3    Fujita, Y.4    Cox, I.M.5    Wilson, C.6    Pichaud, F.7
  • 44
    • 17744386543 scopus 로고    scopus 로고
    • Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling
    • von Stein, W., Ramrath, A., Grimm, A., Muller-Borg, M. and Wodarz, A. (2005) Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling. Development, 132, 1675-1686.
    • (2005) Development , vol.132 , pp. 1675-1686
    • von Stein, W.1    Ramrath, A.2    Grimm, A.3    Muller-Borg, M.4    Wodarz, A.5
  • 45
    • 33645746316 scopus 로고    scopus 로고
    • The PAR-aPKC system: Lessons in polarity
    • Suzuki, A. and Ohno, S. (2006) The PAR-aPKC system: Lessons in polarity. J. Cell Sci., 119, 979-987.
    • (2006) J. Cell Sci. , vol.119 , pp. 979-987
    • Suzuki, A.1    Ohno, S.2


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