Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells

Cancer Science

Volumn 98, Issue 7, 2007, Pages 1027-1034

  Osanai, Makoto ^a   Murata, Masaki ^a   Nishikiori, Nami ^a   Chiba, Hideki ^a   Kojima, Takashi ^a   Sawada, Norimasa ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; HISTONE DEACETYLASE INHIBITOR; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OCCLUDIN; PROTEIN P16INK4A; PROTEIN P53; RETINOIC ACID RECEPTOR ALPHA; RETINOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOIKIS; APOPTOSIS; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CARCINOGENICITY; CELL AGING; CELL CYCLE; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME INHIBITION; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE SILENCING; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; TIGHT JUNCTION; UPREGULATION;

AGING, PREMATURE; ANIMALS; BETA-GALACTOSIDASE; CELL AGING; CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; FEMALE; MAMMARY NEOPLASMS, ANIMAL; MEMBRANE PROTEINS; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 34249882821     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2007.00494.x     Document Type: Article

References (36)

1. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25: 585-621.
2. Serrano M, Lin AW, McCurrach ME et al. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16 INK4a. Cell 1997; 88: 593-602.
3. Dimri GP, Lee X, Basile G et al. A biomarker that identifies senescent human cells in culture and in aging skin in.vivo. Proc Natl Acad Sci USA 1995; 92: 9363-7.
4. Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol 2001; 11: S27-31.
5. Michaloglou C, Vredeveld LC, Soengas MS et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 2005; 436: 720-4.
6. Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature 2001; 411: 342-8.
7. Gozani O, Boyce M, Yoo L et al. Life and death in paradise. Nat Cell Biol 2002; 4: E159-62.
8. Ben-Porath I, Weinberg RA. When cells get stressed: An integrative view of cellular senescence. J Clin Invest 2004; 113: 8-13.
9. Braig M, Schmitt CA. Oncogene-induced senescence: Putting the brakes on tumor development. Cancer Res 2006; 66: 2881-4.
10. Gumbiner EE. Breaking through the tight junction barrier. J Cell Biol 1993; 123: 1631-3.
11. Tsukita S, Furuse M, Itoh M. Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol 2001; 2: 285-93.
12. Furuse M, Furuse M, Hirase T et al. Occludin: A novel integral membrane protein localizing at tight junctions. J Cell Biol 1993; 123: 1777-88.
13. Saitou M, Fujimoto K, Doi Y et al. Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J Cell Biol 1998; 141: 397-408.
14. Saitou M, Furuse M, Sasaki H et al. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell 2000; 11: 4131-42.
15. Osanai M, Murata M, Nishikiori N et al. Epigenetic silencing of occludin promotes tumorigenic and metastatic properties of cancer cells via modulations of unique sets of apoptosis-associated genes. Cancer Res 2006; 66: 9125-33.
16. Wang Z, Mandell KJ, Parkos CA et al. The second loop of occludin is required for suppression of Raf-1-induced tumor growth. Oncogene 2005; 24: 4412-20.
17. Morin PJ. Claudin proteins in human cancer: Promising new targets for diagnosis and therapy. Cancer Res 2005; 65: 9603-6.
18. Tobioka H, Isomura H, Kokai Y et al. Occludin expression decreases with the progression of human endometrial carcinoma. Hum Pathol 2004; 35: 159-64.
19. Elliott BE, Maxwell L, Arnold M et al. Expression of epithelial-like markers and class-I major histocompatibility antigens by a murine carcinoma growing in the mammary gland and in metastases: Orthotopic site effects. Cancer Res 1988; 48: 7237-45.
20. Osanai M, Petkovich M. Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharamacol 2005; 67: 1808-17.
21. Murata M, Kojima T, Yamamoto T et al. Down-regulation of survival signaling through MAPK and Akt in occludin-deficient mouse hepatocytes in.vitro. Exp Cell Res 2005; 310: 140-51.
22. Kamada M, Suzuki K, Kato Y et al. von Hippel-Lindau protein promotes the assembly of actin and vinculin and inhibits cell motility. Cancer Res 2001; 61: 4184-9.
23. Severino J, Allen RG, Balin S et al. Is beta-galactosidase staining a marker of senescence in.vitro and in.vivo ? Exp Cell Res 2000; 257: 162-71.
24. Lin AW, Barradas M, Stone JC et al. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 1998; 12: 3008-19.
25. Zhu J, Woods D, McMahon M et al. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev 1998; 12: 2997-3007.
26. Nusrat A, Chen JA, Foley CS et al. The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction. J Biol Chem 2000; 275: 29.816-22.
27. Sheth P, Basuroy S, Li C et al. Role of phosphatidylinositol 3-kinase in oxidative-stress-induced disruption of tight junctions. J Biol Chem 2003; 278: 49.239-45.
28. Sharma GD, He J, Bazan HE. p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: Evidence of cross-talk activation between MAP kinase cascades. J Biol Chem 2003; 278: 21.989-97.
29. Balda MS, Matter K. The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression. EMBO J 2000; 19: 2024-33.
30. Barrios-Rodiles M, Brown KR, Ozdamar B et al. High-throughput mapping of a dynamic signaling network in mammalian cells. Science 2005; 307: 1621-5.
31. McConnell BB, Starborg M, Brookes S et al. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr Biol 1998; 8: 351-4.
32. Trost TM, Lausch EU, Fees SA et al. Premature senescence is a primary fail-safe mechanism of ERRBB2-driven tumorigenesis in breast carcinoma cells. Cancer Res 2005; 65: 840-9.
33. te Poele RH, Okorokov AL, Jardine L et al. DNA damage is able to induce senescence in tumor cells in.vitro and in.vivo. Cancer Res 2002; 62: 1876-83.
34. Narita M, Nuñez S, Heard E et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003; 113: 703-16.
35. Sherr CJ, DePinho RA. Cellular senescence: Mitotic clock or culture shock? Cell 2000; 102: 407-10.
36. Chang BD, Broude EV, Dokmanovic M et al. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res 1999; 59: 3761-7.