-
1
-
-
33646794425
-
Keeping p53 in check: Essential and synergistic functions of Mdm2 and Mdm4
-
Marine JC, Francoz S, Maetens M, Wahl G, Toledo F, Lozano G. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Diff 2006; 13:927-34.
-
(2006)
Cell Death Diff
, vol.13
, pp. 927-934
-
-
Marine, J.C.1
Francoz, S.2
Maetens, M.3
Wahl, G.4
Toledo, F.5
Lozano, G.6
-
2
-
-
34447098700
-
MDM2 and MDM4: P53 regulators as targets in anticancer therapy
-
Toledo F, Wahl GM. MDM2 and MDM4: p53 regulators as targets in anticancer therapy. Int J Biochem Cell Biol 2007; 39:1476-82.
-
(2007)
Int J Biochem Cell Biol
, vol.39
, pp. 1476-1482
-
-
Toledo, F.1
Wahl, G.M.2
-
3
-
-
0028823020
-
-
Montes de Oca-Luna R, Wagner DS, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995; 378:203-6.
-
Montes de Oca-Luna R, Wagner DS, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995; 378:203-6.
-
-
-
-
4
-
-
0028834902
-
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
-
Jones SN, Roe AE, Donehower LA, Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 1995; 378:206-8.
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
Bradley, A.4
-
5
-
-
0034863683
-
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
-
Parant J, Chavez-Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG, et al. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet 2001; 29:92-5.
-
(2001)
Nat Genet
, vol.29
, pp. 92-95
-
-
Parant, J.1
Chavez-Reyes, A.2
Little, N.A.3
Yan, W.4
Reinke, V.5
Jochemsen, A.G.6
-
6
-
-
0036311067
-
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
-
Migliorini D, Lazzerini Denchi E, Danovi D, Jochemsen A, Capillo M, Gobbi A, et al. Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol 2002; 22:5527-38.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5527-5538
-
-
Migliorini, D.1
Lazzerini Denchi, E.2
Danovi, D.3
Jochemsen, A.4
Capillo, M.5
Gobbi, A.6
-
7
-
-
0036606416
-
Mdmx is a negative regulator of p53 activity in vivo
-
Finch RA, Donoviel DB, Potter D, Shi M, Fan A, Freed DD, et al. Mdmx is a negative regulator of p53 activity in vivo. Cancer Res 2002; 62:3221-5.
-
(2002)
Cancer Res
, vol.62
, pp. 3221-3225
-
-
Finch, R.A.1
Donoviel, D.B.2
Potter, D.3
Shi, M.4
Fan, A.5
Freed, D.D.6
-
8
-
-
33644778697
-
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo
-
Francoz S, Froment P, Bogaerts S, De Clercq S, Maetens M, Doumont G, et al. Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Proc Natl Acad Sci USA 2006; 103:3232-7.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 3232-3237
-
-
Francoz, S.1
Froment, P.2
Bogaerts, S.3
De Clercq, S.4
Maetens, M.5
Doumont, G.6
-
9
-
-
33644757727
-
Synergistic role of Mdm2 and mdm4 for p53 inhibition in central nervous system development
-
Xiong S, Van Pelt CS, Elizondo-Fraire AC, Liu G, Lozano G. Synergistic role of Mdm2 and mdm4 for p53 inhibition in central nervous system development. Proc Natl Acad Sci USA 2006; 103:3226-31.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 3226-3231
-
-
Xiong, S.1
Van Pelt, C.S.2
Elizondo-Fraire, A.C.3
Liu, G.4
Lozano, G.5
-
10
-
-
33644772395
-
Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4
-
Grier JD, Xiong S, Elizondo-Fraire AC, Parant JM, Lozano G. Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. Mol Cell Biol 2006; 26:192-8.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 192-198
-
-
Grier, J.D.1
Xiong, S.2
Elizondo-Fraire, A.C.3
Parant, J.M.4
Lozano, G.5
-
11
-
-
33751011894
-
Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death
-
Boesten LS, Zadelaar SM, De Clercq S, Francoz S, van Nieuwkoop A, Biessen EA, et al. Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death. Cell Death Differ 2006; 13:2089-98.
-
(2006)
Cell Death Differ
, vol.13
, pp. 2089-2098
-
-
Boesten, L.S.1
Zadelaar, S.M.2
De Clercq, S.3
Francoz, S.4
van Nieuwkoop, A.5
Biessen, E.A.6
-
12
-
-
33947250363
-
Distinct roles of Mdm2 and Mdm4 in red cell production
-
Maetens M, Doumont G, Clercq SD, Francoz S, Froment P, Bellefroid E, et al. Distinct roles of Mdm2 and Mdm4 in red cell production. Blood 2007; 109:2630-3.
-
(2007)
Blood
, vol.109
, pp. 2630-2633
-
-
Maetens, M.1
Doumont, G.2
Clercq, S.D.3
Francoz, S.4
Froment, P.5
Bellefroid, E.6
-
13
-
-
54049109574
-
The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival
-
Valentin-Vega YA, Okano H, Lozano G. The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival. Cell Death Differ 2008; 15:1772-81.
-
(2008)
Cell Death Differ
, vol.15
, pp. 1772-1781
-
-
Valentin-Vega, Y.A.1
Okano, H.2
Lozano, G.3
-
14
-
-
67349112114
-
Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities
-
Valentin-Vega YA, Box N, Terzian T, Lozano G. Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities. Differentiation 2009; 77:442-9.
-
(2009)
Differentiation
, vol.77
, pp. 442-449
-
-
Valentin-Vega, Y.A.1
Box, N.2
Terzian, T.3
Lozano, G.4
-
15
-
-
0142123127
-
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
-
Linares LK, Hengstermann A, Ciechanover A, Müller S, Scheffner M. HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Proc Natl Acad Sci USA 2003; 100:12009-14.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 12009-12014
-
-
Linares, L.K.1
Hengstermann, A.2
Ciechanover, A.3
Müller, S.4
Scheffner, M.5
-
16
-
-
34447123808
-
RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity
-
Kawai H, Lopez-Pajares V, Kim MM, Wiederschain D, Yuan ZM. RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity. Cancer Res 2007; 67:6026-30.
-
(2007)
Cancer Res
, vol.67
, pp. 6026-6030
-
-
Kawai, H.1
Lopez-Pajares, V.2
Kim, M.M.3
Wiederschain, D.4
Yuan, Z.M.5
-
17
-
-
42149105590
-
Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
-
Linke K, Mace PD, Smith CA, Vaux DL, Silke J, Day CL. Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death Differ 2008; 15:841-8.
-
(2008)
Cell Death Differ
, vol.15
, pp. 841-848
-
-
Linke, K.1
Mace, P.D.2
Smith, C.A.3
Vaux, D.L.4
Silke, J.5
Day, C.L.6
-
18
-
-
69249202241
-
Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase
-
Okamoto K, Taya Y, Nakagama H. Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase. FEBS Lett 2009; 583:2710-4.
-
(2009)
FEBS Lett
, vol.583
, pp. 2710-2714
-
-
Okamoto, K.1
Taya, Y.2
Nakagama, H.3
-
19
-
-
0033963335
-
MdmX protects p53 from Mdm2-mediated degradation
-
Jackson MW, Berberich SJ. MdmX protects p53 from Mdm2-mediated degradation. Mol Cell Biol 2000; 20:1001-7.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1001-1007
-
-
Jackson, M.W.1
Berberich, S.J.2
-
20
-
-
0034623074
-
Hdmx stabilizes Mdm2 and p53
-
Stad R, Ramos YF, Little N, Grivell S, Attema J, van Der Eb AJ, et al. Hdmx stabilizes Mdm2 and p53. J Biol Chem 2000; 275:28039-44.
-
(2000)
J Biol Chem
, vol.275
, pp. 28039-28044
-
-
Stad, R.1
Ramos, Y.F.2
Little, N.3
Grivell, S.4
Attema, J.5
van Der, E.A.6
-
21
-
-
50349088876
-
Mdm2 and Mdm4 loss regulates distinct p53 activities
-
Barboza JA, Iwakuma T, Terzian T, El-Naggar AK, Lozano G. Mdm2 and Mdm4 loss regulates distinct p53 activities. Mol Cancer Res 2008; 6:947-54.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 947-954
-
-
Barboza, J.A.1
Iwakuma, T.2
Terzian, T.3
El-Naggar, A.K.4
Lozano, G.5
-
22
-
-
70350308428
-
The susceptibility of the p53 unstructured N-terminus to 20S proteasomal degradation programs stress response
-
Tsvetkov P, Reuven N, Prives C, Shaul Y. The susceptibility of the p53 unstructured N-terminus to 20S proteasomal degradation programs stress response. J Biol Chem 2009.
-
(2009)
J Biol Chem
-
-
Tsvetkov, P.1
Reuven, N.2
Prives, C.3
Shaul, Y.4
-
23
-
-
28344454072
-
Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development
-
Steinman HA, Hoover KM, Keeler ML, Sands AT, Jones SN. Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development. Oncogene 2005; 24:7935-40.
-
(2005)
Oncogene
, vol.24
, pp. 7935-7940
-
-
Steinman, H.A.1
Hoover, K.M.2
Keeler, M.L.3
Sands, A.T.4
Jones, S.N.5
-
24
-
-
38949124679
-
MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice
-
Matijasevic Z, Steinman HA, Hoover K, Jones SN. MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice. Mol Cell Biol 2008; 28:1265-73.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 1265-1273
-
-
Matijasevic, Z.1
Steinman, H.A.2
Hoover, K.3
Jones, S.N.4
-
25
-
-
53649084945
-
MdmX regulates transformation and chromosomal stability in p53-deficient cells
-
Matijasevic Z, Krzywicka-Racka A, Sluder G, Jones SN. MdmX regulates transformation and chromosomal stability in p53-deficient cells. Cell Cycle 2008; 7:2967-73.
-
(2008)
Cell Cycle
, vol.7
, pp. 2967-2973
-
-
Matijasevic, Z.1
Krzywicka-Racka, A.2
Sluder, G.3
Jones, S.N.4
-
26
-
-
67650501132
-
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
-
Mancini F, Di Conza G, Pellegrino M, Rinaldo C, Prodosmo A, Giglio S, et al. MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway. EMBO J 2009; 28:1926-39.
-
(2009)
EMBO J
, vol.28
, pp. 1926-1939
-
-
Mancini, F.1
Di Conza, G.2
Pellegrino, M.3
Rinaldo, C.4
Prodosmo, A.5
Giglio, S.6
-
27
-
-
0036510399
-
Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation
-
Migliorini D, Danovi D, Colombo E, Carbone R, Pelicci PG, Marine JC. Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation. J Biol Chem 2002; 277:7318-23.
-
(2002)
J Biol Chem
, vol.277
, pp. 7318-7323
-
-
Migliorini, D.1
Danovi, D.2
Colombo, E.3
Carbone, R.4
Pelicci, P.G.5
Marine, J.C.6
-
28
-
-
0027525536
-
Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence
-
Nguyen M, Millar DG, Yong VW, Korsmeyer SJ, Shore GC. Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence. J Biol Chem 1993; 268:25265-8.
-
(1993)
J Biol Chem
, vol.268
, pp. 25265-25268
-
-
Nguyen, M.1
Millar, D.G.2
Yong, V.W.3
Korsmeyer, S.J.4
Shore, G.C.5
-
29
-
-
68749112707
-
Importing mitochondrial proteins: Machineries and mechanisms
-
Chacinska A, Koehler CM, Milenkovic D, Lithgow T, Pfanner N. Importing mitochondrial proteins: machineries and mechanisms. Cell 2009; 138:628-44.
-
(2009)
Cell
, vol.138
, pp. 628-644
-
-
Chacinska, A.1
Koehler, C.M.2
Milenkovic, D.3
Lithgow, T.4
Pfanner, N.5
-
30
-
-
85047699938
-
MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts
-
Gentiletti F, Mancini F, D'Angelo M, Sacchi A, Pontecorvi A, Jochemsen AG, et al. MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts. Oncogene 2002; 21:867-77.
-
(2002)
Oncogene
, vol.21
, pp. 867-877
-
-
Gentiletti, F.1
Mancini, F.2
D'Angelo, M.3
Sacchi, A.4
Pontecorvi, A.5
Jochemsen, A.G.6
-
33
-
-
18244379872
-
Homeodomaininteracting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
-
D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S, et al. Homeodomaininteracting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 2002; 4:11-9.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 11-19
-
-
D'Orazi, G.1
Cecchinelli, B.2
Bruno, T.3
Manni, I.4
Higashimoto, Y.5
Saito, S.6
-
34
-
-
0036141392
-
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
-
Hofmann TG, Möller A, Sirma H, Zentgraf H, Taya Y, Dröge W, et al. Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol 2002; 4:1-10.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 1-10
-
-
Hofmann, T.G.1
Möller, A.2
Sirma, H.3
Zentgraf, H.4
Taya, Y.5
Dröge, W.6
-
35
-
-
0037349289
-
p53 has a direct apoptogenic role at the mitochondria
-
Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell 2003; 11:577-90.
-
(2003)
Mol Cell
, vol.11
, pp. 577-590
-
-
Mihara, M.1
Erster, S.2
Zaika, A.3
Petrenko, O.4
Chittenden, T.5
Pancoska, P.6
-
36
-
-
33745017872
-
BCL2's flexible loop domain regulates p53 binding and survival
-
Deng X, Gao F, Flagg T, Anderson J, May S. BCL2's flexible loop domain regulates p53 binding and survival. Mol Cell Biol 2006; 26:4421-34.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 4421-4434
-
-
Deng, X.1
Gao, F.2
Flagg, T.3
Anderson, J.4
May, S.5
-
37
-
-
33646826684
-
WT p53, but not tumorderived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization
-
Tomita Y, Marchenko N, Erster S, Nemajerova A, Dehner A, Klein C, et al. WT p53, but not tumorderived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization. J Biol Chem 2006; 281:8600-6.
-
(2006)
J Biol Chem
, vol.281
, pp. 8600-8606
-
-
Tomita, Y.1
Marchenko, N.2
Erster, S.3
Nemajerova, A.4
Dehner, A.5
Klein, C.6
-
39
-
-
66449099052
-
p53 acetylation is crucial for its transcription-independent proapoptotic functions
-
Yamaguchi H, Woods NT, Piluso LG, Lee HH, Chen J, Bhalla KN, et al. p53 acetylation is crucial for its transcription-independent proapoptotic functions. J Biol Chem 2009; 284:11171-83.
-
(2009)
J Biol Chem
, vol.284
, pp. 11171-11183
-
-
Yamaguchi, H.1
Woods, N.T.2
Piluso, L.G.3
Lee, H.H.4
Chen, J.5
Bhalla, K.N.6
-
40
-
-
67749103995
-
Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53
-
Sykes SM, Stanek TJ, Frank A, Murphy ME, McMahon SB. Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53. J Biol Chem 2009; 284:20197-205.
-
(2009)
J Biol Chem
, vol.284
, pp. 20197-20205
-
-
Sykes, S.M.1
Stanek, T.J.2
Frank, A.3
Murphy, M.E.4
McMahon, S.B.5
-
41
-
-
0034717014
-
Death signalinduced localization of p53 protein to mitochondria
-
Marchenko ND, Zaika A, Moll UM. Death signalinduced localization of p53 protein to mitochondria. J Biol Chem 2000; 275:16202-12.
-
(2000)
J Biol Chem
, vol.275
, pp. 16202-16212
-
-
Marchenko, N.D.1
Zaika, A.2
Moll, U.M.3
-
42
-
-
46749117587
-
p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity
-
Wolff S, Erster S, Palacios G, Moll UM. p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity. Cell Res 2008; 18:733-44.
-
(2008)
Cell Res
, vol.18
, pp. 733-744
-
-
Wolff, S.1
Erster, S.2
Palacios, G.3
Moll, U.M.4
-
43
-
-
0035910385
-
Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells
-
Sansome C, Zaika A, Marchenko ND, Moll UM. Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells. FEBS Lett 2001; 488:110-5.
-
(2001)
FEBS Lett
, vol.488
, pp. 110-115
-
-
Sansome, C.1
Zaika, A.2
Marchenko, N.D.3
Moll, U.M.4
-
44
-
-
46749115781
-
Mitochondrially targeted wild-type p53 induces apoptosis in a solid human tumor xenograft model
-
Palacios G, Crawford HC, Vaseva A, Moll UM. Mitochondrially targeted wild-type p53 induces apoptosis in a solid human tumor xenograft model. Cell Cycle 2008; 7:2584-90.
-
(2008)
Cell Cycle
, vol.7
, pp. 2584-2590
-
-
Palacios, G.1
Crawford, H.C.2
Vaseva, A.3
Moll, U.M.4
-
45
-
-
21444432928
-
Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria
-
Arima Y, Nitta M, Kuninaka S, Zhang D, Fujiwara T, Taya Y, et al. Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria. J Biol Chem 2005; 280:19166-76.
-
(2005)
J Biol Chem
, vol.280
, pp. 19166-19176
-
-
Arima, Y.1
Nitta, M.2
Kuninaka, S.3
Zhang, D.4
Fujiwara, T.5
Taya, Y.6
-
46
-
-
0037372005
-
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
-
Dumont P, Leu JI, Della Pietra AC, 3rd, George DL, Murphy M. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet 2003; 33:357-65.
-
(2003)
Nat Genet
, vol.33
, pp. 357-365
-
-
Dumont, P.1
Leu, J.I.2
Della Pietra 3rd, A.C.3
George, D.L.4
Murphy, M.5
-
47
-
-
2142694056
-
Cisplatin and platinum drugs at the molecular level
-
Boulikas T, Vougiouka M. Cisplatin and platinum drugs at the molecular level. Oncol Rep 2003; 10:1663-82.
-
(2003)
Oncol Rep
, vol.10
, pp. 1663-1682
-
-
Boulikas, T.1
Vougiouka, M.2
-
48
-
-
10744230086
-
Mdm4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis
-
Mancini F, Gentiletti F, D'Angelo M, Giglio S, Nanni S, D'Angelo C, et al. Mdm4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis. J Biol Chem 2004; 279:8169-80.
-
(2004)
J Biol Chem
, vol.279
, pp. 8169-8180
-
-
Mancini, F.1
Gentiletti, F.2
D'Angelo, M.3
Giglio, S.4
Nanni, S.5
D'Angelo, C.6
-
49
-
-
33750590095
-
Inactivation of the p53 pathway in retinoblastoma
-
Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, et al. Inactivation of the p53 pathway in retinoblastoma. Nature 2006; 444:61-6.
-
(2006)
Nature
, vol.444
, pp. 61-66
-
-
Laurie, N.A.1
Donovan, S.L.2
Shih, C.S.3
Zhang, J.4
Mills, N.5
Fuller, C.6
-
50
-
-
36249009886
-
Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis
-
Benosman S, Gross I, Clarke N, Jochemsen AG, Okamoto K, Loeffler JP, et al. Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis. Cell Death Differ 2007; 14:2047-57.
-
(2007)
Cell Death Differ
, vol.14
, pp. 2047-2057
-
-
Benosman, S.1
Gross, I.2
Clarke, N.3
Jochemsen, A.G.4
Okamoto, K.5
Loeffler, J.P.6
-
51
-
-
74849102603
-
Stress-induced p53 runs a direct mitochondrial death program
-
Erster S, Moll UM. Stress-induced p53 runs a direct mitochondrial death program. Cell Cycle 2004; 3:86-9.
-
(2004)
Cell Cycle
, vol.3
, pp. 86-89
-
-
Erster, S.1
Moll, U.M.2
-
52
-
-
36048973184
-
Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons
-
Uo T, Kinoshita Y, Morrison RS. Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons. J Neurosci 2007; 27:12198-210.
-
(2007)
J Neurosci
, vol.27
, pp. 12198-12210
-
-
Uo, T.1
Kinoshita, Y.2
Morrison, R.S.3
-
53
-
-
0034003005
-
Stress signals utilize multiple pathways to stabilize p53
-
Ashcroft M, Taya Y, Vousden KH. Stress signals utilize multiple pathways to stabilize p53. Mol Cell Biol 2000; 20:224-33.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 224-233
-
-
Ashcroft, M.1
Taya, Y.2
Vousden, K.H.3
-
54
-
-
0035845853
-
UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts
-
Latonen L, Taya Y, Laiho M. UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts. Oncogene 2001; 20:6784-93.
-
(2001)
Oncogene
, vol.20
, pp. 6784-6793
-
-
Latonen, L.1
Taya, Y.2
Laiho, M.3
-
55
-
-
33847365838
-
Mdm2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis
-
Rinaldo C, Prodosmo A, Mancini F, Iacovelli S, Sacchi A, Moretti F, et al. Mdm2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Mol Cell 2007; 25:794-806.
-
(2007)
Mol Cell
, vol.25
, pp. 794-806
-
-
Rinaldo, C.1
Prodosmo, A.2
Mancini, F.3
Iacovelli, S.4
Sacchi, A.5
Moretti, F.6
-
56
-
-
34447645484
-
WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288)
-
WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288). Oncogene 2007; 26:4806-16.
-
(2007)
Oncogene
, vol.26
, pp. 4806-4816
-
-
Meng, L.H.1
Kohn, K.W.2
Pommier, Y.3
-
57
-
-
34548832505
-
Mdm2 plays a positive role as an effector of p53-dependent responses
-
Giono LE, Manfredi JJ. Mdm2 plays a positive role as an effector of p53-dependent responses. Cell Cycle 2007; 6:2143-7.
-
(2007)
Cell Cycle
, vol.6
, pp. 2143-2147
-
-
Giono, L.E.1
Manfredi, J.J.2
-
58
-
-
33847276654
-
Monoubiquitylation promotes mitochondrial p53 translocation
-
Marchenko ND, Wolff S, Erster S, Becker K, Moll UM. Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J 2007; 26:923-34.
-
(2007)
EMBO J
, vol.26
, pp. 923-934
-
-
Marchenko, N.D.1
Wolff, S.2
Erster, S.3
Becker, K.4
Moll, U.M.5
-
59
-
-
0348134742
-
Mono- versus polyubiquitination: Differential control of p53 fate by Mdm2
-
Li M, Brooks CL, Wu-Baer F, Chen D, Baer R, Gu W. Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science 2003; 302:1972-5.
-
(2003)
Science
, vol.302
, pp. 1972-1975
-
-
Li, M.1
Brooks, C.L.2
Wu-Baer, F.3
Chen, D.4
Baer, R.5
Gu, W.6
-
60
-
-
67649361514
-
Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases
-
Wang YV, Leblanc M, Wade M, Jochemsen AG, Wahl GM. Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases. Cancer Cell 2009; 16:33-43.
-
(2009)
Cancer Cell
, vol.16
, pp. 33-43
-
-
Wang, Y.V.1
Leblanc, M.2
Wade, M.3
Jochemsen, A.G.4
Wahl, G.M.5
-
61
-
-
0033963335
-
MdmX protects p53 from Mdm2-mediated degradation
-
Jackson MW, Berberich SJ. MdmX protects p53 from Mdm2-mediated degradation. Mol Cell Biol 2000; 20:1001-7.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1001-1007
-
-
Jackson, M.W.1
Berberich, S.J.2
-
62
-
-
67449095882
-
Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2
-
Ohtsubo C, Shiokawa D, Kodama M, Gaiddon C, Nakagama H, Jochemsen AG, et al. Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2. Cancer Sci 2009; 100:1291-9.
-
(2009)
Cancer Sci
, vol.100
, pp. 1291-1299
-
-
Ohtsubo, C.1
Shiokawa, D.2
Kodama, M.3
Gaiddon, C.4
Nakagama, H.5
Jochemsen, A.G.6
-
63
-
-
0242668421
-
Evaluation of clinical significance of TP53, BCL-2, BAX and MEK1 expression in 229 ovarian carcinomas treated with platinum-based regimen
-
Kupryjanczyk J, Szymanska T, Madry R, Timorek A, Stelmachów J, Karpinska G, et al. Evaluation of clinical significance of TP53, BCL-2, BAX and MEK1 expression in 229 ovarian carcinomas treated with platinum-based regimen. Br J Cancer 2003; 88:848-54.
-
(2003)
Br J Cancer
, vol.88
, pp. 848-854
-
-
Kupryjanczyk, J.1
Szymanska, T.2
Madry, R.3
Timorek, A.4
Stelmachów, J.5
Karpinska, G.6
-
65
-
-
58749094954
-
Targeting Mdm2 and Mdmx in cancer therapy: Better living through medicinal chemistry?
-
Wade M, Wahl GM. Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? Mol Cancer Res 2009; 7:1-11.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 1-11
-
-
Wade, M.1
Wahl, G.M.2
-
66
-
-
43049150355
-
Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties
-
Prodosmo A, Giglio S, Moretti S, Mancini F, Barbi F, Avenia N, et al. Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties. J Mol Med 2008; 86:585-96.
-
(2008)
J Mol Med
, vol.86
, pp. 585-596
-
-
Prodosmo, A.1
Giglio, S.2
Moretti, S.3
Mancini, F.4
Barbi, F.5
Avenia, N.6
-
67
-
-
33645123129
-
Epithelial-restricted gene profile of primary cultures from human prostate tumors: A molecular approach to predict clinical behavior of prostate cancer
-
Nanni S, Priolo C, Grasselli A, D'Eletto M, Merola R, Moretti F, et al. Epithelial-restricted gene profile of primary cultures from human prostate tumors: a molecular approach to predict clinical behavior of prostate cancer. Mol Cancer Res 2006; 4:79-92.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 79-92
-
-
Nanni, S.1
Priolo, C.2
Grasselli, A.3
D'Eletto, M.4
Merola, R.5
Moretti, F.6
-
68
-
-
33646703574
-
Altered protein profile in chronic myeloid leukemia chronic phase identified by a comparative proteomic study
-
Pizzatti L, Sá LA, de Souza JM, Bisch PM, Abdelhay E. Altered protein profile in chronic myeloid leukemia chronic phase identified by a comparative proteomic study. Biochim Biophys Acta 2006; 1764:929-42.
-
(2006)
Biochim Biophys Acta
, vol.1764
, pp. 929-942
-
-
Pizzatti, L.1
Sá, L.A.2
de Souza, J.M.3
Bisch, P.M.4
Abdelhay, E.5
-
69
-
-
60649094957
-
Proapoptotic function of the retinoblastoma tumor suppressor protein
-
Ianari A, Natale T, Calo E, Ferretti E, Alesse E, Screpanti I, et al. Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell 2009; 15:184-94.
-
(2009)
Cancer Cell
, vol.15
, pp. 184-194
-
-
Ianari, A.1
Natale, T.2
Calo, E.3
Ferretti, E.4
Alesse, E.5
Screpanti, I.6
-
70
-
-
0038022602
-
Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells
-
Rallapalli R, Strachan G, Tuan RS, Hall DJ. Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells. J Cell Biochem 2003; 89:563-75.
-
(2003)
J Cell Biochem
, vol.89
, pp. 563-575
-
-
Rallapalli, R.1
Strachan, G.2
Tuan, R.S.3
Hall, D.J.4
-
71
-
-
26444599546
-
Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis
-
Bartel F, Schulz J, Bohnke A, Blumke K, Kappler M, Bache M, et al. Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis. Int J Cancer 2005; 117:469-75.
-
(2005)
Int J Cancer
, vol.117
, pp. 469-475
-
-
Bartel, F.1
Schulz, J.2
Bohnke, A.3
Blumke, K.4
Kappler, M.5
Bache, M.6
-
72
-
-
47749128118
-
Targeting p53 to mitochondria for cancer therapy
-
Galluzzi L, Morselli E, Kepp O, Tajeddine N, Kroemer G. Targeting p53 to mitochondria for cancer therapy. Cell Cycle 2008; 7:1949-55.
-
(2008)
Cell Cycle
, vol.7
, pp. 1949-1955
-
-
Galluzzi, L.1
Morselli, E.2
Kepp, O.3
Tajeddine, N.4
Kroemer, G.5
-
73
-
-
33947277697
-
Mdm2: P53's lifesaver?
-
Shmueli A, Oren M. Mdm2: p53's lifesaver? Mol Cell 2007; 25:794-6.
-
(2007)
Mol Cell
, vol.25
, pp. 794-796
-
-
Shmueli, A.1
Oren, M.2
|