-
1
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
67650874081
-
Cancer statistics, 2009
-
Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin 2009;59:225-249
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
-
3
-
-
34147214716
-
Multiple molecular mechanisms for multidrug resistance transporters
-
Higgins CF. Multiple molecular mechanisms for multidrug resistance transporters. Nature 2007;446:749-757
-
(2007)
Nature
, vol.446
, pp. 749-757
-
-
Higgins, C.F.1
-
4
-
-
0142166328
-
Cancer chemoprevention with dietary phytochemicals
-
Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003;3:768-780
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 768-780
-
-
Surh, Y.J.1
-
5
-
-
35348879054
-
Silymarin and epithelial cancer chemoprevention: How close we are to bedside?
-
Kaur M, Agarwal R. Silymarin and epithelial cancer chemoprevention: how close we are to bedside? Toxicol Appl Pharmacol 2007;224:350-359
-
(2007)
Toxicol Appl Pharmacol
, vol.224
, pp. 350-359
-
-
Kaur, M.1
Agarwal, R.2
-
6
-
-
33847265733
-
Silybin and silymarin-new and emerging applications in medicine
-
Gazak R, Walterova D, Kren V. Silybin and silymarin-new and emerging applications in medicine. Curr Med Chem 2007;14:315-338
-
(2007)
Curr Med Chem
, vol.14
, pp. 315-338
-
-
Gazak, R.1
Walterova, D.2
Kren, V.3
-
7
-
-
0035211762
-
The use of silymarin in the treatment of liver diseases
-
Saller R, Meier R, Brignoli R. The use of silymarin in the treatment of liver diseases. Drugs 2001;61:2035-2063
-
(2001)
Drugs
, vol.61
, pp. 2035-2063
-
-
Saller, R.1
Meier, R.2
Brignoli, R.3
-
8
-
-
0032008339
-
Milk thistle (Silybum marianum) for the therapy of liver disease
-
Flora K, Hahn M, Rosen H, Benner K. Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol 1998;93:139-143
-
(1998)
Am J Gastroenterol
, vol.93
, pp. 139-143
-
-
Flora, K.1
Hahn, M.2
Rosen, H.3
Benner, K.4
-
9
-
-
27644439523
-
Mechanisms and preclinical efficacy of silibinin in preventing skin cancer
-
Singh RP, Agarwal R. Mechanisms and preclinical efficacy of silibinin in preventing skin cancer. Eur J Cancer 2005;41:1969-1979
-
(2005)
Eur J Cancer
, vol.41
, pp. 1969-1979
-
-
Singh, R.P.1
Agarwal, R.2
-
10
-
-
51349164386
-
Multitargeted therapy of cancer by silymarin
-
Ramasamy K, Agarwal R. Multitargeted therapy of cancer by silymarin. Cancer Lett 2008;269:352-362
-
(2008)
Cancer Lett
, vol.269
, pp. 352-362
-
-
Ramasamy, K.1
Agarwal, R.2
-
11
-
-
33845941617
-
Anticancer potential of silymarin: From bench to bed side
-
Agarwal R, Agarwal C, Ichikawa H, et al. Anticancer potential of silymarin: from bench to bed side. Anticancer Res 2006;26:4457-4498
-
(2006)
Anticancer Res
, vol.26
, pp. 4457-4498
-
-
Agarwal, R.1
Agarwal, C.2
Ichikawa, H.3
-
13
-
-
23944478449
-
Mitochondria: A novel target for the chemoprevention of cancer
-
Hail N Jr. Mitochondria: a novel target for the chemoprevention of cancer. Apoptosis 2005;10:687-705
-
(2005)
Apoptosis
, vol.10
, pp. 687-705
-
-
Hail Jr., N.1
-
14
-
-
33745002041
-
Prostate cancer chemoprevention by silibinin: Bench to bedside
-
DOI 10.1002/mc.20223
-
Singh RP, Agarwal R. Prostate cancer chemoprevention by silibinin: bench to bedside. Mol Carcinog 2006;45:436-442 (Pubitemid 43865852)
-
(2006)
Molecular Carcinogenesis
, vol.45
, Issue.6
, pp. 436-442
-
-
Singh, R.P.1
Agarwal, R.2
-
15
-
-
5144224381
-
A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer
-
Singh RP, Agarwal R. A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer. Mutat Res 2004;555:21-32
-
(2004)
Mutat Res
, vol.555
, pp. 21-32
-
-
Singh, R.P.1
Agarwal, R.2
-
16
-
-
59449097284
-
Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling
-
Singh RP, Raina K, Deep G, et al. Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling. Clin Cancer Res 2009;15:613-621
-
(2009)
Clin Cancer Res
, vol.15
, pp. 613-621
-
-
Singh, R.P.1
Raina, K.2
Deep, G.3
-
17
-
-
68349113541
-
Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression
-
Wu KJ, Zeng J, Zhu GD, et al. Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression. Acta Pharmacol Sin 2009;30:1162-1168
-
(2009)
Acta Pharmacol Sin
, vol.30
, pp. 1162-1168
-
-
Wu, K.J.1
Zeng, J.2
Zhu, G.D.3
-
18
-
-
59449085306
-
Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice
-
Singh RP, Raina K, Sharma G, Agarwal R. Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice. Clin Cancer Res 2008;14:7773-7780
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7773-7780
-
-
Singh, R.P.1
Raina, K.2
Sharma, G.3
Agarwal, R.4
-
19
-
-
36348976518
-
Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model
-
Raina K, Blouin MJ, Singh RP, et al. Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res 2007;67:11083-11091
-
(2007)
Cancer Res
, vol.67
, pp. 11083-11091
-
-
Raina, K.1
Blouin, M.J.2
Singh, R.P.3
-
20
-
-
67649322190
-
Silibinin inhibits translation initiation: Implications for anticancer therapy
-
Lin CJ, Sukarieh R, Pelletier J. Silibinin inhibits translation initiation: implications for anticancer therapy. Mol Cancer Ther 2009;8:1606-1612
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1606-1612
-
-
Lin, C.J.1
Sukarieh, R.2
Pelletier, J.3
-
21
-
-
67349099566
-
Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells
-
Kim S, Choi JH, Lim HI, et al. Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells. Phytomedicine 2009;16:573-580
-
(2009)
Phytomedicine
, vol.16
, pp. 573-580
-
-
Kim, S.1
Choi, J.H.2
Lim, H.I.3
-
22
-
-
3242786628
-
Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells
-
Tyagi AK, Agarwal C, Chan DC, Agarwal R. Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells. Oncol Rep 2004;11:493-499
-
(2004)
Oncol Rep
, vol.11
, pp. 493-499
-
-
Tyagi, A.K.1
Agarwal, C.2
Chan, D.C.3
Agarwal, R.4
-
23
-
-
34248192416
-
Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice
-
Gu M, Singh RP, Dhanalakshmi S, et al. Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice. Cancer Res 2007;67:3483-3491
-
(2007)
Cancer Res
, vol.67
, pp. 3483-3491
-
-
Gu, M.1
Singh, R.P.2
Dhanalakshmi, S.3
-
24
-
-
0036210452
-
Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis
-
Singh RP, Tyagi AK, Zhao J, Agarwal R. Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis. Carcinogenesis 2002;23:499-510
-
(2002)
Carcinogenesis
, vol.23
, pp. 499-510
-
-
Singh, R.P.1
Tyagi, A.K.2
Zhao, J.3
Agarwal, R.4
-
25
-
-
68849113912
-
Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft
-
Kaur M, Velmurugan B, Tyagi A, et al. Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft. Mol Cancer Ther 2009;8:2366-2374
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2366-2374
-
-
Kaur, M.1
Velmurugan, B.2
Tyagi, A.3
-
26
-
-
40949106128
-
Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis
-
Singh RP, Gu M, Agarwal R. Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis. Cancer Res 2008;68:2043-2050
-
(2008)
Cancer Res
, vol.68
, pp. 2043-2050
-
-
Singh, R.P.1
Gu, M.2
Agarwal, R.3
-
27
-
-
35248818831
-
Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer
-
Hogan FS, Krishnegowda NK, Mikhailova M, Kahlenberg MS. Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer. J Surg Res 2007;143:58-65
-
(2007)
J Surg Res
, vol.143
, pp. 58-65
-
-
Hogan, F.S.1
Krishnegowda, N.K.2
Mikhailova, M.3
Kahlenberg, M.S.4
-
28
-
-
0344827261
-
Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells
-
Agarwal C, Singh RP, Dhanalakshmi S, et al. Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene 2003;22:8271-8282
-
(2003)
Oncogene
, vol.22
, pp. 8271-8282
-
-
Agarwal, C.1
Singh, R.P.2
Dhanalakshmi, S.3
-
29
-
-
62349117597
-
Growth inhibition and regression of lung tumors by silibinin: Modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3
-
Tyagi A, Singh RP, Ramasamy K, et al. Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Cancer Prev Res (Phila Pa) 2009;2:74-83
-
(2009)
Cancer Prev Res (Phila Pa)
, vol.2
, pp. 74-83
-
-
Tyagi, A.1
Singh, R.P.2
Ramasamy, K.3
-
30
-
-
33745239300
-
Effect of silibinin on the growth and progression of primary lung tumors in mice
-
Singh RP, Deep G, Chittezhath M, et al. Effect of silibinin on the growth and progression of primary lung tumors in mice. J Natl Cancer Inst 2006;98:846-855
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 846-855
-
-
Singh, R.P.1
Deep, G.2
Chittezhath, M.3
-
31
-
-
3142765979
-
Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2
-
Chu SC, Chiou HL, Chen PN, et al. Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Mol Carcinog 2004;40:143-149
-
(2004)
Mol Carcinog
, vol.40
, pp. 143-149
-
-
Chu, S.C.1
Chiou, H.L.2
Chen, P.N.3
-
32
-
-
53949096956
-
Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma
-
Li L, Gao Y, Zhang L, et al. Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma. Cancer Lett 2008;272:61-69
-
(2008)
Cancer Lett
, vol.272
, pp. 61-69
-
-
Li, L.1
Gao, Y.2
Zhang, L.3
-
33
-
-
34447130474
-
Therapeutic value of orally administered silibinin in renal cell carcinoma: Manipulation of insulin-like growth factor binding protein-3 levels
-
Cheung CW, Taylor PJ, Kirkpatrick CM, et al. Therapeutic value of orally administered silibinin in renal cell carcinoma: manipulation of insulin-like growth factor binding protein-3 levels. BJU Int 2007;100:438-444
-
(2007)
BJU Int
, vol.100
, pp. 438-444
-
-
Cheung, C.W.1
Taylor, P.J.2
Kirkpatrick, C.M.3
-
34
-
-
33846211547
-
Silibinin inhibits renal cell carcinoma via mechanisms that are independent of insulin-like growth factor-binding protein 3
-
Cheung CW, Vesey DA, Nicol DL, Johnson DW. Silibinin inhibits renal cell carcinoma via mechanisms that are independent of insulin-like growth factor-binding protein 3. BJU Int 2007;99:454-460
-
(2007)
BJU Int
, vol.99
, pp. 454-460
-
-
Cheung, C.W.1
Vesey, D.A.2
Nicol, D.L.3
Johnson, D.W.4
-
35
-
-
37549009050
-
Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin
-
Singh RP, Tyagi A, Sharma G, et al. Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. Clin Cancer Res 2008;14:300-308
-
(2008)
Clin Cancer Res
, vol.14
, pp. 300-308
-
-
Singh, R.P.1
Tyagi, A.2
Sharma, G.3
-
36
-
-
37549017366
-
Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice
-
Tyagi A, Raina K, Singh RP, et al. Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice. Mol Cancer Ther 2007;6:3248-3255
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 3248-3255
-
-
Tyagi, A.1
Raina, K.2
Singh, R.P.3
-
37
-
-
33750468718
-
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: Evidence for a regulatory loop between p53 and caspase 2
-
Tyagi A, Singh RP, Agarwal C, Agarwal R. Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. Carcinogenesis 2006;27:2269-2280
-
(2006)
Carcinogenesis
, vol.27
, pp. 2269-2280
-
-
Tyagi, A.1
Singh, R.P.2
Agarwal, C.3
Agarwal, R.4
-
38
-
-
4544287556
-
Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages
-
Tyagi A, Agarwal C, Harrison G, et al. Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. Carcinogenesis 2004;25:1711-1720
-
(2004)
Carcinogenesis
, vol.25
, pp. 1711-1720
-
-
Tyagi, A.1
Agarwal, C.2
Harrison, G.3
-
39
-
-
0344495296
-
Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells
-
Tyagi AK, Agarwal C, Singh RP, et al. Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells. Biochem Biophys Res Commun 2003;312:1178-1184
-
(2003)
Biochem Biophys Res Commun
, vol.312
, pp. 1178-1184
-
-
Tyagi, A.K.1
Agarwal, C.2
Singh, R.P.3
-
40
-
-
67649595826
-
Apoptosis and cancer: The genesis of a research field
-
Cotter TG. Apoptosis and cancer: the genesis of a research field. Nat Rev Cancer 2009;9:501-507
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 501-507
-
-
Cotter, T.G.1
-
41
-
-
33749072019
-
Nuclear signaling by receptor tyrosine kinases: The first robin of spring
-
Schlessinger J, Lemmon MA. Nuclear signaling by receptor tyrosine kinases: the first robin of spring. Cell 2006;127:45-48
-
(2006)
Cell
, vol.127
, pp. 45-48
-
-
Schlessinger, J.1
Lemmon, M.A.2
-
42
-
-
33847696075
-
Receptor tyrosine kinases: Mechanisms of activation and signaling
-
Hubbard SR, Miller WT. Receptor tyrosine kinases: mechanisms of activation and signaling. Curr Opin Cell Biol 2007;19:117-123
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 117-123
-
-
Hubbard, S.R.1
Miller, W.T.2
-
43
-
-
2342591455
-
The discovery of receptor tyrosine kinases: Targets for cancer therapy
-
Gschwind A, Fischer OM, Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 2004;4:361-370 (Pubitemid 38579482)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.5
, pp. 361-370
-
-
Gschwind, A.1
Fischer, O.M.2
Ullrich, A.3
-
44
-
-
0036139884
-
Receptor tyrosine kinases as targets for anticancer drugs
-
Zwick E, Bange J, Ullrich A. Receptor tyrosine kinases as targets for anticancer drugs. Trends Mol Med 2002;8:17-23
-
(2002)
Trends Mol Med
, vol.8
, pp. 17-23
-
-
Zwick, E.1
Bange, J.2
Ullrich, A.3
-
46
-
-
0028556758
-
Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells
-
Korutla L, Kumar R. Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochim Biophys Acta 1994;1224:597-600
-
(1994)
Biochim Biophys Acta
, vol.1224
, pp. 597-600
-
-
Korutla, L.1
Kumar, R.2
-
48
-
-
0035034624
-
Inhibitory effect of silibinin on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cells
-
Sharma Y, Agarwal C, Singh AK, Agarwal R. Inhibitory effect of silibinin on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cells. Mol Carcinog 2001;30:224-236
-
(2001)
Mol Carcinog
, vol.30
, pp. 224-236
-
-
Sharma, Y.1
Agarwal, C.2
Singh, A.K.3
Agarwal, R.4
-
49
-
-
49549091736
-
Silibinin impairs constitutively active TGFalpha-EGFR autocrine loop in advanced human prostate carcinoma cells
-
Tyagi A, Sharma Y, Agarwal C, Agarwal R. Silibinin impairs constitutively active TGFalpha-EGFR autocrine loop in advanced human prostate carcinoma cells. Pharm Res 2008;25:2143-2150
-
(2008)
Pharm Res
, vol.25
, pp. 2143-2150
-
-
Tyagi, A.1
Sharma, Y.2
Agarwal, C.3
Agarwal, R.4
-
50
-
-
0347121831
-
Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line
-
Qi L, Singh RP, Lu Y, et al. Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line. Cancer Biol Ther 2003;2:526-531
-
(2003)
Cancer Biol Ther
, vol.2
, pp. 526-531
-
-
Qi, L.1
Singh, R.P.2
Lu, Y.3
-
51
-
-
56749184290
-
Insulin and insulin-like growth factor signalling in neoplasia
-
Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 2008;8:915-928
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 915-928
-
-
Pollak, M.1
-
52
-
-
0141786950
-
Suppression of advanced human prostate tumor growth in athymic mice by silibinin feeding is associated with reduced cell proliferation, increased apoptosis, and inhibition of angiogenesis
-
Singh RP, Sharma G, Dhanalakshmi S, et al. Suppression of advanced human prostate tumor growth in athymic mice by silibinin feeding is associated with reduced cell proliferation, increased apoptosis, and inhibition of angiogenesis. Cancer Epidemiol Biomarkers Prev 2003;12:933-939
-
(2003)
Cancer Epidemiol Biomarkers Prev
, vol.12
, pp. 933-939
-
-
Singh, R.P.1
Sharma, G.2
Dhanalakshmi, S.3
-
53
-
-
0036606413
-
Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels
-
Singh RP, Dhanalakshmi S, Tyagi AK, et al. Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels. Cancer Res 2002;62:3063-3069
-
(2002)
Cancer Res
, vol.62
, pp. 3063-3069
-
-
Singh, R.P.1
Dhanalakshmi, S.2
Tyagi, A.K.3
-
54
-
-
47749110951
-
Inhibition of insulin-like growth factor 1 receptor signaling enhanced silibinin-induced activation of death receptor and mitochondrial apoptotic pathways in human breast cancer MCF-7 cells
-
Wang HJ, Tashiro S, Onodera S, Ikejima T. Inhibition of insulin-like growth factor 1 receptor signaling enhanced silibinin-induced activation of death receptor and mitochondrial apoptotic pathways in human breast cancer MCF-7 cells. J Pharmacol Sci 2008;107:260-269
-
(2008)
J Pharmacol Sci
, vol.107
, pp. 260-269
-
-
Wang, H.J.1
Tashiro, S.2
Onodera, S.3
Ikejima, T.4
-
55
-
-
33645839013
-
Signal transducers and activators of transcription (STATs): Novel targets of chemopreventive and chemotherapeutic drugs
-
Klampfer L. Signal transducers and activators of transcription (STATs): novel targets of chemopreventive and chemotherapeutic drugs. Curr Cancer Drug Targets 2006;6:107-121
-
(2006)
Curr Cancer Drug Targets
, vol.6
, pp. 107-121
-
-
Klampfer, L.1
-
56
-
-
5444237088
-
STAT proteins as novel targets for cancer drug discovery
-
Turkson J. STAT proteins as novel targets for cancer drug discovery. Expert Opin Ther Targets 2004;8:409-422
-
(2004)
Expert Opin Ther Targets
, vol.8
, pp. 409-422
-
-
Turkson, J.1
-
57
-
-
0036554816
-
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
-
Buettner R, Mora LB, Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 2002;8:945-954
-
(2002)
Clin Cancer Res
, vol.8
, pp. 945-954
-
-
Buettner, R.1
Mora, L.B.2
Jove, R.3
-
58
-
-
34547829030
-
Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells
-
Agarwal C, Tyagi A, Kaur M, Agarwal R. Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells. Carcinogenesis 2007;28:1463-1470
-
(2007)
Carcinogenesis
, vol.28
, pp. 1463-1470
-
-
Agarwal, C.1
Tyagi, A.2
Kaur, M.3
Agarwal, R.4
-
59
-
-
62349117597
-
Growth inhibition and regression of lung tumors by silibinin: Modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3
-
Tyagi A, Singh RP, Ramasamy K, et al. Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Cancer Prev Res (Phila PA) 2009;2:74-83
-
(2009)
Cancer Prev Res (Phila PA)
, vol.2
, pp. 74-83
-
-
Tyagi, A.1
Singh, R.P.2
Ramasamy, K.3
-
60
-
-
58249122148
-
Androgen receptor and growth factor signaling cross-talk in prostate cancer cells
-
Zhu ML, Kyprianou N. Androgen receptor and growth factor signaling cross-talk in prostate cancer cells. Endocr Relat Cancer 2008;15:841-849
-
(2008)
Endocr Relat Cancer
, vol.15
, pp. 841-849
-
-
Zhu, M.L.1
Kyprianou, N.2
-
61
-
-
2342558431
-
Androgen receptor in prostate cancer
-
Heinlein CA, Chang C. Androgen receptor in prostate cancer. Endocr Rev 2004;25:276-308
-
(2004)
Endocr Rev
, vol.25
, pp. 276-308
-
-
Heinlein, C.A.1
Chang, C.2
-
62
-
-
50449088732
-
Androgen receptor is a tumor suppressor and proliferator in prostate cancer
-
Niu Y, Altuwaijri S, Lai KP, et al. Androgen receptor is a tumor suppressor and proliferator in prostate cancer. Proc Natl Acad Sci USA 2008;105:12182-12187
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 12182-12187
-
-
Niu, Y.1
Altuwaijri, S.2
Lai, K.P.3
-
63
-
-
0034067029
-
The role of prostate specific antigen measurement in the detection and management of prostate cancer
-
Nash AF, Melezinek I. The role of prostate specific antigen measurement in the detection and management of prostate cancer. Endocr Relat Cancer 2000;7:37-51
-
(2000)
Endocr Relat Cancer
, vol.7
, pp. 37-51
-
-
Nash, A.F.1
Melezinek, I.2
-
64
-
-
0033594891
-
Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: Implications for prostate cancer intervention
-
Zi X, Agarwal R. Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention. Proc Natl Acad Sci USA 1999;96:7490-7495
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 7490-7495
-
-
Zi, X.1
Agarwal, R.2
-
65
-
-
0034812087
-
Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP
-
Zhu W, Zhang JS, Young CY. Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP. Carcinogenesis 2001;22:1399-1403
-
(2001)
Carcinogenesis
, vol.22
, pp. 1399-1403
-
-
Zhu, W.1
Zhang, J.S.2
Young, C.Y.3
-
66
-
-
16544387068
-
Inhibition of telomerase activity and secretion of prostate specific antigen by silibinin in prostate cancer cells
-
Thelen P, Wuttke W, Jarry H, et al. Inhibition of telomerase activity and secretion of prostate specific antigen by silibinin in prostate cancer cells. J Urol 2004;171:1934-1938
-
(2004)
J Urol
, vol.171
, pp. 1934-1938
-
-
Thelen, P.1
Wuttke, W.2
Jarry, H.3
-
67
-
-
51649110439
-
NF-kappa-B in carcinoma therapy and prevention
-
Brown M, Cohen J, Arun P, et al. NF-kappa-B in carcinoma therapy and prevention. Expert Opin Ther Targets 2008;12:1109-1122
-
(2008)
Expert Opin Ther Targets
, vol.12
, pp. 1109-1122
-
-
Brown, M.1
Cohen, J.2
Arun, P.3
-
68
-
-
36749091741
-
Nuclear factor-kappa B: From clone to clinic
-
Ahn KS, Sethi G, Aggarwal BB. Nuclear factor-kappa B: from clone to clinic. Curr Mol Med 2007;7:619-637
-
(2007)
Curr Mol Med
, vol.7
, pp. 619-637
-
-
Ahn, K.S.1
Sethi, G.2
Aggarwal, B.B.3
-
69
-
-
43749098070
-
NF-kappa-B and cancer-identifying targets and mechanisms
-
Naugler WE, Karin M. NF-kappa-B and cancer-identifying targets and mechanisms. Curr Opin Genet Dev 2008;18:19-26
-
(2008)
Curr Opin Genet Dev
, vol.18
, pp. 19-26
-
-
Naugler, W.E.1
Karin, M.2
-
70
-
-
33947202249
-
Nuclear factor-kappa-B in development, prevention, and therapy of cancer
-
van Waes C. Nuclear factor-kappa-B in development, prevention, and therapy of cancer. Clin Cancer Res 2007;13:1076-1082
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1076-1082
-
-
Van Waes, C.1
-
71
-
-
0036546501
-
NF-kappa-B in cancer: From innocent bystander to major culprit
-
Karin M, Cao Y, Greten FR, Li ZW. NF-kappa-B in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2002;2:301-310
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 301-310
-
-
Karin, M.1
Cao, Y.2
Greten, F.R.3
Li, Z.W.4
-
72
-
-
0037034863
-
Silibinin inhibits constitutive and TNFα-induced activation of NF-κB and sensitizes human prostate carcinoma DU145 cells to TNFα-induced apoptosis
-
DOI 10.1038/sj/onc/1205240
-
Dhanalakshmi S, Singh RP, Agarwal C, Agarwal R. Silibinin inhibits constitutive and TNF-alpha-induced activation of NF-kappa-B and sensitizes human prostate carcinoma DU145 cells to TNF-alpha-induced apoptosis. Oncogene 2002;21:1759-1767 (Pubitemid 34259039)
-
(2002)
Oncogene
, vol.21
, Issue.11
, pp. 1759-1767
-
-
Dhanalakshmi, S.1
Singh, R.P.2
Agarwal, C.3
Agarwal, R.4
-
73
-
-
1542438807
-
Involvement of NF-kappa-B and caspases in silibinin-induced apoptosis of endothelial cells
-
Yoo HG, Jung SN, Hwang YS, et al. Involvement of NF-kappa-B and caspases in silibinin-induced apoptosis of endothelial cells. Int J Mol Med 2004;13:81-86
-
(2004)
Int J Mol Med
, vol.13
, pp. 81-86
-
-
Yoo, H.G.1
Jung, S.N.2
Hwang, Y.S.3
-
74
-
-
14644410403
-
Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: Implications for angioprevention and antiangiogenic therapy
-
Singh RP, Dhanalakshmi S, Agarwal C, Agarwal R. Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapy. Oncogene 2005;24:1188-1202
-
(2005)
Oncogene
, vol.24
, pp. 1188-1202
-
-
Singh, R.P.1
Dhanalakshmi, S.2
Agarwal, C.3
Agarwal, R.4
-
75
-
-
67651171486
-
Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice
-
Cui W, Gu F, Hu KQ. Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice. World J Gastroenterol 2009;15:1943-1950
-
(2009)
World J Gastroenterol
, vol.15
, pp. 1943-1950
-
-
Cui, W.1
Gu, F.2
Hu, K.Q.3
-
76
-
-
60749109846
-
Cell cycle, CDKs and cancer: A changing paradigm
-
Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009;9:153-166
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 153-166
-
-
Malumbres, M.1
Barbacid, M.2
-
77
-
-
34250865564
-
CDC25 phosphatases in cancer cells: Key players? Good targets?
-
Boutros R, Lobjois V, Ducommun B. CDC25 phosphatases in cancer cells: key players? Good targets? Nat Rev Cancer 2007;7:495-507
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 495-507
-
-
Boutros, R.1
Lobjois, V.2
Ducommun, B.3
-
78
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature 2004;432:316-323
-
(2004)
Nature
, vol.432
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
79
-
-
67650073265
-
Cell cycle kinases as therapeutic targets for cancer
-
Lapenna S, Giordano A. Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov 2009;8:547-566
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 547-566
-
-
Lapenna, S.1
Giordano, A.2
-
80
-
-
33644830944
-
Targeting the cell cycle: A new approach to cancer therapy
-
Schwartz GK, Shah MA. Targeting the cell cycle: a new approach to cancer therapy. J Clin Oncol 2005;23:9408-9421
-
(2005)
J Clin Oncol
, vol.23
, pp. 9408-9421
-
-
Schwartz, G.K.1
Shah, M.A.2
-
81
-
-
33244472101
-
Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: A comparison of flavanone silibinin with flavanolignan mixture silymarin
-
Deep G, Singh RP, Agarwal C, et al. Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene 2006;25:1053-1069
-
(2006)
Oncogene
, vol.25
, pp. 1053-1069
-
-
Deep, G.1
Singh, R.P.2
Agarwal, C.3
-
84
-
-
34548590339
-
Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin
-
Son YG, Kim EH, Kim JY, et al. Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin. Cancer Res 2007;67:8274-8284
-
(2007)
Cancer Res
, vol.67
, pp. 8274-8284
-
-
Son, Y.G.1
Kim, E.H.2
Kim, J.Y.3
-
85
-
-
63149129655
-
Bcl-2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy
-
Kang MH, Reynolds CP. Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res 2009;15:1126-1132
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1126-1132
-
-
Kang, M.H.1
Reynolds, C.P.2
-
86
-
-
34547126428
-
The inhibitors of apoptosis (IAPs) as cancer targets
-
Hunter AM, LaCasse EC, Korneluk RG. The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis 2007;12:1543-1568
-
(2007)
Apoptosis
, vol.12
, pp. 1543-1568
-
-
Hunter, A.M.1
Lacasse, E.C.2
Korneluk, R.G.3
-
87
-
-
0037267333
-
Validating survivin as a cancer therapeutic target
-
Altieri DC. Validating survivin as a cancer therapeutic target. Nat Rev Cancer 2003;3:46-54
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 46-54
-
-
Altieri, D.C.1
-
89
-
-
33646028804
-
Molecular targets of dietary agents for prevention and therapy of cancer
-
Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 2006;71:1397-1421
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1397-1421
-
-
Aggarwal, B.B.1
Shishodia, S.2
-
90
-
-
36949029439
-
Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft
-
Singh RP, Deep G, Blouin MJ, et al. Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft. Carcinogenesis 2007;28:2567-2574
-
(2007)
Carcinogenesis
, vol.28
, pp. 2567-2574
-
-
Singh, R.P.1
Deep, G.2
Blouin, M.J.3
-
91
-
-
54249120311
-
Cell growth inhibition and down-regulation of survivin by silibinin in a laryngeal squamous cell carcinoma cell line
-
Bang CI, Paik SY, Sun DI, et al. Cell growth inhibition and down-regulation of survivin by silibinin in a laryngeal squamous cell carcinoma cell line. Ann Otol Rhinol Laryngol 2008;117:781-785
-
(2008)
Ann Otol Rhinol Laryngol
, vol.117
, pp. 781-785
-
-
Bang, C.I.1
Paik, S.Y.2
Sun, D.I.3
-
92
-
-
0032717556
-
Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: Implications in cancer chemoprevention
-
Zhao J, Agarwal R. Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention. Carcinogenesis 1999;20:2101-2108
-
(1999)
Carcinogenesis
, vol.20
, pp. 2101-2108
-
-
Zhao, J.1
Agarwal, R.2
-
93
-
-
25644448238
-
A review of the bioavailability and clinical efficacy of milk thistle phytosome: A silybin-phosphatidylcholine complex (Siliphos)
-
Kidd P, Head K. A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). Altern Med Rev 2005;10:193-203
-
(2005)
Altern Med Rev
, vol.10
, pp. 193-203
-
-
Kidd, P.1
Head, K.2
-
94
-
-
33646739493
-
Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: Silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences
-
Hoh C, Boocock D, Marczylo T, et al. Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences. Clin Cancer Res 2006;12:2944-2950
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2944-2950
-
-
Hoh, C.1
Boocock, D.2
Marczylo, T.3
-
95
-
-
33845899681
-
A phase i and pharmacokinetic study of silybin-phytosome in prostate cancer patients
-
Flaig TW, Gustafson DL, Su LJ, et al. A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients. Invest New Drugs 2007;25:139-146
-
(2007)
Invest New Drugs
, vol.25
, pp. 139-146
-
-
Flaig, T.W.1
Gustafson, D.L.2
Su, L.J.3
-
97
-
-
3142679267
-
Nutrition and cancer prevention: A multidisciplinary perspective on human trials
-
Forman MR, Hursting SD, Umar A, Barrett JC. Nutrition and cancer prevention: a multidisciplinary perspective on human trials. Annu Rev Nutr 2004;24:223-254
-
(2004)
Annu Rev Nutr
, vol.24
, pp. 223-254
-
-
Forman, M.R.1
Hursting, S.D.2
Umar, A.3
Barrett, J.C.4
-
98
-
-
33645743524
-
Using chemopreventive agents to enhance the efficacy of cancer therapy
-
Sarkar FH, Li Y. Using chemopreventive agents to enhance the efficacy of cancer therapy. Cancer Res 2006;66:3347-3350
-
(2006)
Cancer Res
, vol.66
, pp. 3347-3350
-
-
Sarkar, F.H.1
Li, Y.2
-
99
-
-
34548407732
-
Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents: Efficacy and mechanisms
-
Raina K, Agarwal R. Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents: efficacy and mechanisms. Acta Pharmacol Sin 2007;28:1466-1475
-
(2007)
Acta Pharmacol Sin
, vol.28
, pp. 1466-1475
-
-
Raina, K.1
Agarwal, R.2
|