Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells

Phytomedicine

Volumn 16, Issue 6-7, 2009, Pages 573-580

  Kim, Sangmin ^a   Choi, Jae Hyuck ^a   Lim, Hye In ^a   Lee, Se Kyung ^a   Kim, Wan Wook ^a   Kim, Jee Soo ^a   Kim, Jung Han ^a   Choe, Jun Ho ^a   Yang, Jung Hyun ^a   Nam, Seok Jin ^a   Lee, Jeong Eon ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

12 O tetradecanoyl phorbol 13 acetate (TPA); Matrix metalloproteinase 9 (MMP 9); MCF 7 human breast cancer cells; Silibinin; Silybum marianum; Vascular endothelial growth factor (VEGF)

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; RAF PROTEIN; SILIBININ; UO 126; VASCULOTROPIN;

ADENOVIRUS; ARTICLE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG EFFECT; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REGULATORY MECHANISM;

BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 9; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; SILYMARIN; TETRADECANOYLPHORBOL ACETATE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

SILYBUM MARIANUM;

EID: 67349099566     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2008.11.006     Document Type: Article

References (28)

1. Berra E., Pages G., and Pouyssegur J. MAP kinases and hypoxia in the control of VEGF expression. Cancer Metastasis Rev. 19 (2000) 139-145
2. Bhatia N., Zhao J., Wolf D.M., and Agarwal R. Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin. Cancer Lett. 147 (1999) 77-84
3. Bouck N., Stellmach V., and Hsu S.C. How tumors become angiogenic. Adv. Cancer Res. 69 (1996) 135-174
4. Chambers A.F., and Matrisian L.M. Changing views of the role of matrix metalloproteinases in metastasis. J. Natl. Cancer Inst. 89 (1997) 1260-1270
5. Deryugina E.I., and Quigley J.P. Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev. 25 (2006) 9-34
6. Egeblad M., and Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer 2 (2002) 161-174
7. Ferrara N. Molecular and biological properties of vascular endothelial growth factor. J. Mol. Med. 77 (1999) 527-543
8. Himelstein B.P., Lee E.J., Sato H., Seiki M., and Muschel R.J. Tumor cell contact mediated transcriptional activation of the fibroblast matrix metalloproteinase-9 gene: involvement of multiple transcription factors including Ets and an alternating purine-pyrimidine repeat. Clin. Exp. Metastasis 16 (1998) 169-177
9. Jain R.K., Duda D.G., Clark J.W., and Loeffler J.S. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat. Clin. Pract. Oncol. 3 (2006) 24-40
10. Jensen H.M., Chen I., DeVault M.R., and Lewis A.E. Angiogenesis induced by "normal" human breast tissue: a probable marker for precancer. Science 218 (1982) 293-295
11. Kim S., Kim Y., Lee Y., Cho K.H., Kim K.H., and Chung J.H. Cholesterol inhibits MMP-9 expression in human epidermal keratinocytes and HaCaT cells. FEBS Lett. 581 (2007) 3869-3874
12. Kim S., Kim Y., Kim J.E., Cho K.H., and Chung J.H. Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes. Phytomedicine 15 (2008) 340-347
13. Leung D.W., Cachianes G., Kuang W.J., Goeddel D.V., and Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246 (1989) 1306-1309
14. McLeskey S.W., Tobias C.A., Vezza P.R., Filie A.C., Kern F.G., and Hanfelt J. Tumor growth of FGF or VEGF transfected MCF-7 breast carcinoma cells correlates with density of specific microvessels independent of the transfected angiogenic factor. Am. J. Pathol. 153 (1998) 1993-2006
15. Murphy G., and Docherty A.J. The matrix metalloproteinases and their inhibitors. Am. J. Respir. Cell Mol. Biol. 7 (1992) 120-125
16. Naglich J.G., Jure-Kunkel M., Gupta E., Fargnoli J., Henderson A.J., Lewin A.C., Talbott R., Baxter A., Bird J., Savopoulos R., Wills R., Kramer R.A., and Trail P.A. Inhibition of angiogenesis and metastasis in two murine models by the matrix metalloproteinase inhibitor, BMS-275291. Cancer Res. 61 (2001) 8480-8485
17. Overall C.M., and Dean R.A. Degradomics: systems biology of the protease web. Pleiotropic roles of MMPs in cancer. Cancer Metastasis Rev. 25 (2006) 69-75
18. Pages G., and Pouyssegur J. Transcriptional regulation of the Vascular Endothelial Growth Factor gene-a concert of activating factors. Cardiovasc. Res. 65 (2005) 564-573
19. Peng P.L., Hsieh Y.S., Wang C.J., Hsu J.L., and Chou F.P. Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Toxicol. Appl. Pharmacol. 214 (2006) 8-15
20. Sang Q.X. Complex role of matrix metalloproteinases in angiogenesis. Cell Res. 8 (1998) 171-177
21. Schafer G., Cramer T., Suske G., Kemmner W., Wiedenmann B., and Hocker M. Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements. J. Biol. Chem. 278 (2003) 8190-8198
22. Sharma G., Singh R.P., Chan D.C., and Agarwal R. Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells. Anticancer Res. 23 (2003) 2649-2655
23. Simon C., Simon M., Vucelic G., Hicks M.J., Plinkert P.K., Koitschev A., and Zenner H.P. The p38 SAPK pathway regulates the expression of the MMP-9 collagenase via AP-1-dependent promoter activation. Exp. Cell Res. 271 (2001) 344-355
24. Singh R.P., and Agarwal R. Flavonoid antioxidant silymarin and skin cancer. Antioxid Redox Signal 4 (2002) 655-663
25. Steinbrenner H., Ramos M.C., Stuhlmann D., Sies H., and Brenneisen P. UVA-mediated downregulation of MMP-2 and MMP-9 in human epidermal keratinocytes. Biochem. Biophys. Res. Commun. 308 (2003) 486-491
26. Stetler-Stevenson W.G., Liotta L.A., and Kleiner Jr. D.E. Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. FASEB J. 7 (1993) 1434-1441
27. Zeng Z.S., and Guillem J.G. Colocalisation of matrix metalloproteinase-9-mRNA and protein in human colorectal cancer stromal cells. Br. J. Cancer 74 (1996) 1161-1167
28. Zucker S., Lysik R.M., Zarrabi M.H., and Moll U. M(r) 92,000 type IV collagenase is increased in plasma of patients with colon cancer and breast cancer. Cancer Res. 53 (1993) 140-146