Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP

Carcinogenesis

Volumn 22, Issue 9, 2001, Pages 1399-1403

  Zhu, W ^a   Zhang, J S ^a   Young, C Y F ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANTINEOPLASTIC AGENT; CELL NUCLEUS RECEPTOR; FLAVONOID; IMMUNOPHILIN; KALLIKREIN; POLYPHENOL DERIVATIVE; PROSTATE SPECIFIC ANTIGEN; SILIBININ; SILYMARIN;

ADRENERGIC RECEPTOR BLOCKING; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER PREVENTION; CELL CYCLE; CELL CYCLE G1 PHASE; CELL DEATH; CELL NUCLEUS; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; GENE CONSTRUCT; GENE TRANSFER; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LIGAND BINDING; MALE; MODULATION; MOLECULAR BIOLOGY; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; REGULATORY MECHANISM; STEROID BINDING; TRANSACTIVATION; WESTERN BLOTTING;

EID: 0034812087     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.9.1399     Document Type: Article

References (21)

1. Expression of androgen receptor and growth factors in premalignant lesions of the prostate
2. The role of the androgen receptor in the development and progression of prostate cancer
3. Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: Induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of and associated cyclins
4. A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in the SENCAR mouse skin tumorigenesis model
5. Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: Comparison with silymarin
6. Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: Implications for prostate cancer intervention
7. Pharmacology and toxicology of silymarin, the anti-hepatotoxic agent of Silybum marianum (L)
8. Silybum marianum (milk thistle)
9. Interactive effects of triiodothyronine and androgens on prostate cell growth and gene expression
10. A nonsteroidal anti-inflammatory drug, flufenamic acid, inhibits the expression of the androgen receptor in LNCaP cells
11. Defining a functional androgen responsive element in the 5′ far upstream flanking region of the prostate-specific antigen gene
12. Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells
13. Human kallikrein 2 (hK2) and prostate-specific antigen (PSA): Two closely related, but distinct, kallikreins in the prostate
14. Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor
15. The chemistry and analysis of silymarin from Silybum marianum
16. Prostate cancer cell cycle regulators: Response to androgen withdrawal and development of androgen independence
17. Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells
18. Steroid receptor interactions with heat shock protein and immunophilin chaperones
19. Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes
20. cdc37
21. Domains of the human androgen receptor and glucocorticoid receptor involved in binding to the nuclear matrix