Silibinin impairs constitutively active TGFα-EGFR autocrine loop in advanced human prostate carcinoma cells

Pharmaceutical Research

Volumn 25, Issue 9, 2008, Pages 2143-2150

  Tyagi, Alpna ^a   Sharma, Yogesh ^a   Agarwal, Chapla ^a,b   Agarwal, Rajesh ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

EGFR; Erk1 2; Prostate cancer; Silibinin; TGF

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; JANUS KINASE 1; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGENIC AGENT; SILIBININ; TRANSFORMING GROWTH FACTOR ALPHA;

ADVANCED CANCER; ARTICLE; AUTOCRINE EFFECT; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MITOGENESIS; PRIORITY JOURNAL; PROSTATE CARCINOMA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANDROGENS; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AUTOCRINE COMMUNICATION; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; NEOPLASMS, HORMONE-DEPENDENT; PROSTATIC NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; SILYMARIN; TIME FACTORS; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 49549091736     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9545-z     Document Type: Article

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