Inhibition of insulin-like growth factor 1 receptor signaling enhanced silibinin-induced activation of death receptor and mitochondrial apoptotic pathways in human breast cancer MCF-7 cells

Journal of Pharmacological Sciences

Volumn 107, Issue 3, 2008, Pages 260-269

  Wang, Hong Jun ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^b   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Insulin like growth factor 1 receptor (IGF 1R); MCF 7 cell; Silibinin

Indexed keywords

3 BROMO 5 TERT BUTYL 4 HYDROXYBENZYLIDENEMALONONITRILE; CYTOCHROME C; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; LACTATE DEHYDROGENASE; PROTEIN BAX; SILENT INFORMATION REGULATOR PROTEIN 2; SILIBININ; SIRTUIN 1; SOMATOMEDIN C RECEPTOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHOSPHORYLATION; BREAST CANCER; CARCINOGENESIS; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG POTENTIATION; DRUG STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIVER PROTECTION; MITOCHONDRION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

EID: 47749110951     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.08054FP     Document Type: Article

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