Characterization of tailor-made copolymers of oligo(ethylene glycol) methyl ether methacrylate and N,N-dimethylaminoethyl methacrylate as nonviral gene transfer agents: Influence of macromolecular structure on gene vector particle properties and transfection efficiency

Biomacromolecules

Volumn 11, Issue 1, 2010, Pages 39-50

  Üzgün, Senta ^a,b   Akdemir, Özgür ^c   Hasenpusch, Günther ^a   Maucksch, Christof ^a,b   Golas, Monika M ^d,e   Sander, Bjoern ^d,e   Stark, Holger ^d,f   Imker, Rabea ^a   Lutz, Jean François ^c   Rudolph, Carsten ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c FRAUNHOFER INSTITUTE FOR APPLIED POLYMER RESEARCH   (Germany)

^d MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^e AARHUS UNIVERSITY   (Denmark)

^f UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACES; CELLULAR INTERNALIZATION; DEGREE OF POLYMERIZATION; GENE VECTORS; HIGH CONCENTRATION; IN-VIVO; ISOTONIC SOLUTION; MACROMOLECULAR STRUCTURES; MOLAR FRACTIONS; N ,N-DIMETHYLAMINOETHYL METHACRYLATE; NONVIRAL GENE TRANSFER; OLIGO(ETHYLENE GLYCOL) METHYL ETHER METHACRYLATE; PLASMID DNA (PDNA); POLYETHYLENIMINES; TRANSFECTION EFFICIENCY;

CELL MEMBRANES; CHAIN LENGTH; COPOLYMERIZATION; COPOLYMERS; ETHERS; ETHYLENE; ETHYLENE GLYCOL; FREE RADICAL REACTIONS; GENE EXPRESSION; GENE TRANSFER; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PLASTIC PRODUCTS; POLYMER BLENDS; VECTORS; ZETA POTENTIAL;

ATOM TRANSFER RADICAL POLYMERIZATION;

COPOLYMER; METHACRYLIC ACID DERIVATIVE; METHACRYLIC ACID DIMETHYLAMINOETHYL ESTER; OLIGO(ETHYLENE GLYCOL)METHYL ETHER METHACRYLATE; PLASMID DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATOM TRANSFER RADICAL POLYMERIZATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMALE; GENE TRANSFER; GENE VECTOR; GENETIC TRANSFECTION; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BRONCHI; CELL SURVIVAL; DNA; DRUG CARRIERS; ELECTROPHORESIS, AGAR GEL; EPITHELIAL CELLS; FEMALE; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LUCIFERASES; METHACRYLATES; METHYLMETHACRYLATE; MICE; MICE, INBRED BALB C; POLYETHYLENEIMINE; POLYMERS; PULMONARY ALVEOLI; TRANSFECTION;

EID: 73949122181     PISSN: 15257797     EISSN: None     Source Type: Journal    
DOI: 10.1021/bm9008759     Document Type: Article

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