Effects of physicochemical characteristics of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes on cellular association and internalization

Journal of Drug Targeting

Volumn 8, Issue 1, 2000, Pages 51-66

  Zuidam, Nicolaas J ^a   Posthuma, George ^b   De Vries, Else T J ^a   Crommelin, Daan J A ^a   Hennink, Wim E ^a   Storm, Gert ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NONE

Author keywords

Cationic polymer; Cellular interaction; Non viral gene delivery; Physicochemical characteristics; Polyplex

Indexed keywords

DNA; POLYMETHACRYLIC ACID; QUATERNARY AMMONIUM DERIVATIVE; TERTIARY AMINE;

ARTICLE; CELL INTERACTION; CELL NUCLEUS; CELL TRANSPORT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CULTURE MEDIUM; DNA BINDING; DNA TRANSFECTION; ELECTRON MICROSCOPY; ENDOCYTOSIS; ENDOSOME; FLUORESCENCE ACTIVATED CELL SORTER; HUMAN; HUMAN CELL; INTERNALIZATION; OVARY CARCINOMA; PHYSICAL CHEMISTRY; PLASMID; PRIORITY JOURNAL; ZETA POTENTIAL;

EID: 0034085963     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611860009009209     Document Type: Article

References (35)

1. Arigita, C., Zuidam, N.J., Crommelin, D.J.A. and Hennink, W.E. (1999) Association and dissociation characteristics of polymer/DNA complexes used for gene delivery. Pharm. Res., 16, 1534-1541.
2. Boulikas, T. (1998) Status of gene therapy in 1997: molecular mechanisms, disease targets, and clinical applications. Gene Ther. Mol. Biol., 1, 1-172.
3. Boussif, O., Lezoualc'h, F., Zanta, M.A., Mergny, M.D., Scherman, D., Demeneix, B. and Behr, J.P. (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethyleneimine. Proc. Natl. Acad. Sci. USA. 92, 7297-7301.
4. Carlsson, S.R., Roth, J., Piller, F. and Fukuda, M. (1988) Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Major sialoglycoproteins carrying polylactosaminoglycan. J. Biol. Chem., 263, 2137-2148.
5. Cherng, J.-Y. Van de Wetering, P., Talsma, H., Crommelin, D.J.A. and Hennink, W.E. (1996) Effect of size and serum proteins on transfection efficiency of (poly-(2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles. Pharm. Res., 13, 1038-1042.
6. Cherng, J.-Y., Talsma, H., Verrijk, R., Crommelin, D.J.A. and Hennink, W. E.(1999) The effect of formulation parameters on the size of poly(2-dimethylamino)ethyl methacrylate)-plasmid complexes. Eur. J. Pharm. Biopharm., 47, 215-224.
7. Choi, Y.H., Liu, E., Kim, J.S., Choi, Y.K., Park, J.S. and Kim, S.W. (1998) Polyethylene glycol-grafted poly-L-lysine as polymeric gene carrier. J. Cont. Release. 54, 39-48.
8. Chonn, A. and Cullis, P.R. (1998) Recent advances in liposome technologies and their applications for systemic gene delivery. Adv. Drug Delivery Rev., 30, 73-83.
9. Coonrod, A., Li, F.Q. and Horwitz, M.(1997) On the mechanism of DNA transfection: efficient gene transfer without viruses. Gene Ther., 4, 1313-1321.
10. Felgner, P.L., Barenholz, Y., Behr, J.P., Cheng, S.H., Cullis, P., Huang, L., Jessee, J.A., Seymour, L., Szoka, F., Thierry, A.R., Wagner, E. and Wu, G. (1997) Nomenclature for synthetic gene delivery systems. Hum. Gene Ther., 8, 511-512.
11. Friend, D.S., Papahadjopoulos, D. and Debs, R.J. (1996) Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes. Biochim. Biophys. Acta, 1278, 41-50.
12. Hamilton, T.C., Young, R.C., McKoy, W.M., Grotzinger, K.R., Green, J.A., Chu, E.W., Whang-Penn, J., Rogan, A.M., Green, W.R. and Ozols, R.F. (1983) Characterization of a human ovarian carcinoma cell line (NIH:OVCAR-3) with androgen and estrogen receptors. Cancer Res., 43, 5379-5389.
13. Kabanov, A.V., Astafieva, I.V., Maksimova, I.V., Lukanidin, E.M., Georgiev, G.P. and Kabanov, V.A. (1993) Efficient transformation of mammalian cells using DNA interpolyelectrolyte complexes with carbon chain polycations. Bioconjugate Chem., 4, 448-454.
14. Kabanov, A.V. and Kabanov, V.A. (1995) DNA complexes with polycations for the delivery of genetic material into cells. Bioconjugate Chem., 6, 7-20.
15. Katayose, S. and Kataoka, K. (1997) Water-soluble polyion complex associates of DNA and poly(ethylene glycol) poly-(L-lysine) block copolymer. Bioconjugate Chem., 8, 702-707.
16. Kichler, A., Mechtler, K., Behr, J.P. and Wagner, E. (1997) Influence of membrane-active peptides on lipospermine DNA complex mediated gene transfer. Bioconjugate Chem., 8, 213-221.
17. Labat-Moleur, F., Steffan, A.M., Brisson, C., Perron, H., Feugeas, O., Furstenberger, P., Oberling, F., Brambilla, E. and Behr, J.P. (1996) An electron microscopy study into the mechanism of gene transfer with lipopolyamines. Gene Ther., 3, 1010-1017.
18. Lloyd, J.B. and Mason, R.W. (Eds.) (1996) Subcellular Biochemistry: Biology of the Lysosome. Vol. 27, New York, Plenum Press.
19. Mechtler, K. and Wagner, E. (1997) Gene transfer mediated by influenza virus peptides: the role of peptide sequences. New J. Chem., 7, 105-111.
20. Remy, J.S., Abdallah, B., Zanta, M.A., Boussif, O., Behr, J.P. and Demeneix, B. (1998) Gene transfer with lipospermines and polyethyleneimines. Adv. Drug Delivery Rev., 30, 85-95.
21. Rothman, J.E. (1994) Mechanisms of intracellular protein transport. Nature, 372, 55-63.
22. Slot, J.W., Geuze, H.J., Gigengack, S., Lienhard, G.E. and James, D.E. (1991) Immuno-localisation of the insulin regulatable glucose transporter in brown adipose tissue of the rat. J. Cell Biol., 113, 123-135.
23. Storm, G., Belliot, S.O., Daemen, T. and Lasic, D.D. (1995) Surface modification of nanoparticles to oppose uptake by the mononucleur phagocyte system. Adv. Drug Delivery Rev., 17, 31-48.
24. Tang, M.X. and Szoka, F.C. (1997) The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther., 4, 823-832.
25. Tomlinson, E. and Rolland, A.P. (1996) Controllable gene therapy. Pharmaceutics of non-viral gene delivery systems. J. Cont. Release, 39, 357-372.
26. Toncheva, V., Wolfert, M.A., Dash, P.R., Oupicky, D., Ulbrich, K., Seymour, L.W. and Schacht, E.H. (1998) Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers. Biochim. Biophys. Acta, 1380, 354-368.
27. Van de Wetering, P., Cherng, J.Y., Talsma, H. and Hennink, W.E. (1997) Relation between transfection efficiency and cytotoxicity of poly(2-dimethylamino)ethyl methacrylate/ plasmid complexes. J. Cont. Release, 49, 59-69.
28. Van de Wetering, P., Cherng, J.Y., Talsma, H., Crommelin, D.J.A. and Hennink, W.E. (1998) 2-dimethylamino(ethyl methacrylate(-based (co) polymers as gene transfer agents. J. Cont. Release, 53, 145-153.
29. Van de Wetering, P., Moret, E.E., Schuurmans-Nieuwenbroek, N.M.E., Van Steenbergen, M.J. and Hennink, W.E. (1999a) Structure activity relationships of water-soluble cationic methacrylate/methacrylamide polymers for nonviral gene delivery. Bioconjugate Chem., 10, 589-597.
30. Van de Wetering, P., Schuurmans-Nieuwenbroek, N.M.E., Hennink, W.E. and Storm, G. (1999b) Comparative transfection studies of human ovarian carcinoma cells in vitro, ex vivo and in vivo with poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes. J. Gene Med., 1, 156-165.
31. Van Dijk-Wolthuis, W.N.E., Van de Wetering, P., Hinrichs, W.L.J., Hofmeyer, L.J.F., Liskamp, R.M.J., Crommelin, D.J.A. and Hennink, W.E. (1999) A versatile method for the conjugation of proteins and peptidcs to poly-(2-(dimethylamino)ethyl) methacrylate. Bioconjugate Chem., 10, 687-692.
32. Wink, T., De Beer, J., Hennink, W.E., Bull, A. and Van Bennekom, W.P. (1999) Interaction between plasmid DNA and cationic polymers studied by surface plasmon resonance spectrometry. Anal. Chem., 71, 801-805.
33. Zabner, J., Fasbender, A.J., Moninger, T., Poellinger, K.A. and Welsh, M.J. (1995) Cellular and molecular barriers to gene transfer by a cationic lipid. J. Biol. Chem., 270, 18997-19007.
34. Zauner, W., Ogris, M. and Wagner, E. (1998) Polylysine-based transfection systems utilizing receptor-mediated delivery. Adv. Drug Delivery Rev., 30, 97-113.
35. Zelphati, O. and Szoka, F.C. (1996) Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids. Pharm. Res., 13, 1367-1372.