Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: A potential surrogate marker for patient sensitivity

Molecular Cancer Therapeutics

Volumn 2, Issue 12, 2003, Pages 1265-1272

  Hose, Curtis D ^a   Hollingshead, Melinda ^b   Sausville, Edward A ^b   Monks, Anne ^a  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 AMINO 3 METHYLPHENYL) 5 FLUOROBENZOTHIAZOLE; 2-(4-AMINO-3-METHYLPHENYL)-5-FLUOROBENZOTHIAZOLE; ANTINEOPLASTIC AGENT; CYTOCHROME P450 1A1; MESSENGER RNA; PRIMER DNA; THIAZOLE DERIVATIVE;

ARTICLE; BIOSYNTHESIS; ENZYME INDUCTION; GENETICS; HUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CYTOCHROME P-450 CYP1A1; DNA PRIMERS; ENZYME INDUCTION; HUMANS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; THIAZOLES;

EID: 2942535435     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Hutchinson, I., Chua, M. S., Browne, H. L., Trapani, V., Bradshaw, T. D., Westwell, A. D., and Stevens, M. F. Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles. J. Med. Chem., 244: 1446-1455, 2001. (Pubitemid 32852121)
2. Chua, M. S., Kashiyama, E., Bradshaw, T. D., Stinson, S. F., Brantley, E., Sausville, E. A., and Stevens, M. F. Role of CYP1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells. Cancer Res., 60: 5196-5203, 2000.
3. Bradshaw, T., Leong, C. O., Gaskell, M., Martin, E., Heydon, R., Farmer, P., Bibby, M., Double, J., Cooper, P., and Stevens, M. Potent, selective antitumor 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumors. Proc. Am. Assoc. Cancer Res., 43: A4757, 2002.
4. Bradshaw, T., Bibby, M., Double, J., Fichtner, I., Cooper, P., Alley, M., Donohue, S., Stinson, S., Tomaszewjski, J., Sausville, E., and Stevens, M. Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles. Mol. Cancer Ther., 1: 239-246, 2002.
5. Paull, K. D., Shoemaker, R. H., Hodes, L., Monks, A., Scudiero, D., Rubinstein, L., Plowman, J., and Boyd, M. R. Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm. J. Natl. Cancer Inst., 81: 1088-1092, 1989. (Pubitemid 19175145)
6. Brantley, E., Trapani, V., Stinson, S., and Stevens, M. F. Metabolism and subcellular binding of novel fluorinated 2-(4-amino-3-methylphenyl)- benzothiazoles in human cancer cells. Proc. Am. Assoc. Cancer Res., 42: A1755, 2001.
7. Loaiza-Perez, A. I., Trapani, V., Hose, C., Singh, S. S., Trepel, J. B., Stevens, M. F., Bradshaw, T. D., and Sausville, E. A. Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole. Mol. Pharmacol., 61: 13-19, 2002. (Pubitemid 34049507)
8. Trapani, V., Patel, V., Leong, O. C., Ciolino, H., Yeh, G., Hose, C., Trepel, J., Bradshaw, T., Stevens, M., Sausville, E., and Loaiza-Perez, A. Benzothiazoles mediate MCF-7 cell DNA damage and S phase cell cycle arrest through the aryl hydrocarbon receptor. Proc. Am. Assoc. Cancer Res., 43: A1921, 2002.
9. Monks, A., Scudiero, D., Skehan, P., Shoemaker, R., Paull, K., Vistica, D., Hose, C., Langley, J., Cronise, P., Vaigro-Wolff, A., Gray-Goodrich, M., Campbell, H., Mayo, J., and Boyd, M. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J. Natl. Cancer Inst., 83: 757-766, 1991.
10. Bustin, S. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J. Mol. Endocrinol., 25: 169-193, 2000.
11. Zaharevitz, D. W., Holbeck, S. L., Bowerman, C., and Svetlik, P. A. COMPARE: a web accessible tool for investigating mechanisms of cell growth inhibition. J. Mol. Graph. Model., 20: 297-303, 2002. (Pubitemid 34017547)
12. Plowman, J., Dykes, D. J., Hollingshead, M., Simpson-Herren, L., and Alley, M. C. Human tumor xenograft models in NCI drug development. In: B. Teicher (ed.), Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials and Approval, pp. 101-121. Totowa, NJ: Humana Press Inc., 1997.
13. Lee, J. and Safe, S. Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells. Biochem. Pharmacol., 62: 1113-1124, 2001. (Pubitemid 32971677)
14. Whitlock, J. P. Induction of cytochrome P4501A1. Annu. Rev. Pharmacol. Toxicol., 39: 103-125, 1999.
15. Stevens, M. F., Heyden, R. T., Martin, E. A., Farmer, P. B., Bradshaw, T. D., Hutchinson, I., Westwell, A. D., Browne, H. L., and Trapani, V. Induction of CYP1A1 by 2-(4-aminophenyl) benzothiazole leads to DNA adducts in sensitive tumor cells. Proc. Am. Assoc. Cancer Res., 42: A1754, 2001.
16. Wu, J. T., Zhang, P., and Bentz, J. S. Quantification of HER2 oncoprotein in fine-needle aspirates of the breast. Ann. Clin. Lab. Sci., 30: 49-56, 2000. (Pubitemid 30078304)
17. Creager, A. J., Pitman, M. B., and Geisinger, K. R. Cytologic features of clear cell sarcoma (malignant melanoma) of soft parts: a study of fine-needle aspirates and exfoliative specimens. Am. J. Clin. Pathol., 117: 217-224, 1998. (Pubitemid 34823662)
18. Stanley, M. W. Selected problems in fine needle aspiration of head and neck masses. Mod. Pathol., 15: 342-350, 2002. (Pubitemid 34246627)
19. Hertz, G., Reddy, V. B., Green, L., Spitz, D., Massarani-Wafai, R., Selvaggi, S. M., Kluskens, L., and Gattuso, P. Fine-needle aspiration biopsy of the liver: a multicenter study of 602 radiologically guided FNA. Diagn. Cytopathol., 23: 326-328, 2000.
20. Nayar, R., Bourtsos, E., and DeFrias, D. V. Hyaline globules in renal cell carcinoma and hepatocellular carcinoma. A clue or a diagnostic pitfall on fine-needle aspiration? Am. J. Clin. Pathol., 114: 576-582, 2000. (Pubitemid 33044397)
21. Bradshaw, T., Shi, D., Schultz, R., Paull, K., Kelland, L., Wilson, A., Garner, C., Fiebig, H., Wrigley, S., and Stevens, M. Influence of a 2-(4-aminophenyl)benzothiazoles on growth of human ovarian carcinoma cells in vitro and in vivo . Br. J. Cancer, 78: 421-429, 1998. (Pubitemid 28360627)