1,2,4-Benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: Synthesis, DNA-binding affinity and cytotoxicity

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 19, 2007, Pages 5345-5348

  Kamal, Ahmed ^a   Khan, M Naseer A ^a   Reddy, K Srinivasa ^a   Ahmed, S Kaleem ^a   Kumar, M Shiva ^a   Juvekar, Aarti ^b   Sen, Subrata ^b   Zingde, Surekha ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b Research and Education in Cancer   (India)

Author keywords

Benzothiadiazines; Cytoxicity; DNA binding; Pyrrolobenzodiazepines

Indexed keywords

BENZOTHIADIAZINE DERIVATIVE; DOXORUBICIN; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA DENATURATION; DNA HELIX; DRUG BINDING; DRUG CONJUGATION; DRUG DNA BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INCUBATION TEMPERATURE; INCUBATION TIME; MALE;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZODIAZEPINES; BENZOTHIADIAZINES; BREAST NEOPLASMS; CATTLE; CELL LINE, TUMOR; DNA; DNA RESTRICTION ENZYMES; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INDICATORS AND REAGENTS; MALE; NUCLEIC ACID DENATURATION; PROSTATIC NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34548563728     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.08.018     Document Type: Article

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