The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 17, 2008, Pages 7888-7893

  Hu, Changkun ^a   Solomon, V Raja ^a   Ulibarri, Gerardo ^b   Lee, Hoyun ^a  

^a Northeastern Ontario Regional Cancer Centre   (Canada)

^b LAURENTIAN UNIVERSITY   (Canada)

Author keywords

Breast cancer; Cell killing; Chemotherapeutics; Chloroquine; PI3K Akt inhibitors; Sensitization

Indexed keywords

1,3 DIHYDRO 1 [1 [[4 (6 PHENYL 1H IMIDAZO[4,5]QUINOXALIN 7 YL)PHENYL]METHYL] 4 PIPERIDINYL] 2H BENZIMIDAZOL 2 ONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CHLOROQUINE; PROTEIN KINASE B INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL KILLING; CHEMOSENSITIZATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; HUMAN; HUMAN CELL;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BENZIMIDAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; CHLOROQUINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; QUINOXALINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 50349093480     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.076     Document Type: Article

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