메뉴 건너뛰기




Volumn 25, Issue 4, 2008, Pages 245-261

Targeted therapies in breast cancer

Author keywords

Breast cancer; Estrogen receptor; FISH; HER2; Immunohistochemistry; Targeted therapy

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; ANASTROZOLE; AROMATASE INHIBITOR; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; ERLOTINIB; ESTROGEN RECEPTOR; EVEROLIMUS; EXEMESTANE; FLUOROURACIL; GEFITINIB; LAPATINIB; LETROZOLE; METHOTREXATE; N (5 CHLORO 1,3 BENZODIOXOL 4 YL) 7 [2 (4 METHYL 1 PIPERAZINYL)ETHOXY] 5 (TETRAHYDRO 2H PYRAN 4 YLOXY) 4 QUINAZOLINAMINE; NAVELBINE; PACLITAXEL; PERTUZUMAB; PLACEBO; PROGESTERONE RECEPTOR; SORAFENIB; TAMOXIFEN; TEMSIROLIMUS; TIPIFARNIB; TRASTUZUMAB; TYCERB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB;

EID: 53749084762     PISSN: 07402570     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semdp.2008.08.001     Document Type: Article
Times cited : (48)

References (102)
  • 1
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • Mendelsohn J., and Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene 19 (2000) 6550-6565
    • (2000) Oncogene , vol.19 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2
  • 2
    • 37049183697 scopus 로고
    • Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon D.J., Clark G.M., Wong S.G., et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235 (1987) 177-182
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 3
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon D.J., Leyland-Jones B., Shak S., et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344 (2001) 783-792
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 4
    • 19044380618 scopus 로고    scopus 로고
    • Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
    • Agus D.B., Akita R.W., Fox W.D., et al. Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2 (2002) 127-137
    • (2002) Cancer Cell , vol.2 , pp. 127-137
    • Agus, D.B.1    Akita, R.W.2    Fox, W.D.3
  • 5
    • 30544450275 scopus 로고    scopus 로고
    • Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells
    • Xia W., Gerard C.M., Liu L., et al. Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene 24 (2005) 6213-6221
    • (2005) Oncogene , vol.24 , pp. 6213-6221
    • Xia, W.1    Gerard, C.M.2    Liu, L.3
  • 6
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K., Wang M., Gralow J., et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 357 (2007) 2666-2676
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 7
    • 38449090853 scopus 로고    scopus 로고
    • Pharmacodynamics: biological activity of targeted therapies in clinical trials
    • Rojo F., Dalmases A., Corominas J.M., et al. Pharmacodynamics: biological activity of targeted therapies in clinical trials. Clin Transl Oncol 9 (2007) 634-644
    • (2007) Clin Transl Oncol , vol.9 , pp. 634-644
    • Rojo, F.1    Dalmases, A.2    Corominas, J.M.3
  • 8
    • 7444264020 scopus 로고    scopus 로고
    • The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer
    • Allred D.C., Brown P., and Medina D. The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer. Breast Cancer Res 6 (2004) 240-245
    • (2004) Breast Cancer Res , vol.6 , pp. 240-245
    • Allred, D.C.1    Brown, P.2    Medina, D.3
  • 9
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365 (2005) 1687-1717
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 10
    • 0032896905 scopus 로고    scopus 로고
    • Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer
    • Harvey J.M., Clark G.M., Osborne C.K., et al. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncol 17 (1999) 1474-1481
    • (1999) J Clin Oncol , vol.17 , pp. 1474-1481
    • Harvey, J.M.1    Clark, G.M.2    Osborne, C.K.3
  • 11
    • 4344564294 scopus 로고    scopus 로고
    • Significance of immunohistochemical assessment of steroid hormone receptor status for breast cancer patients
    • Kurosumi M. Significance of immunohistochemical assessment of steroid hormone receptor status for breast cancer patients. Breast Cancer 10 (2003) 97-104
    • (2003) Breast Cancer , vol.10 , pp. 97-104
    • Kurosumi, M.1
  • 12
    • 34548536058 scopus 로고    scopus 로고
    • Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98
    • Viale G., Regan M.M., Maiorano E., et al. Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98. J Clin Oncol 25 (2007) 3846-3852
    • (2007) J Clin Oncol , vol.25 , pp. 3846-3852
    • Viale, G.1    Regan, M.M.2    Maiorano, E.3
  • 13
    • 33744487398 scopus 로고    scopus 로고
    • Improving the accuracy of hormone receptor assays in breast cancer: an unmet medical need
    • Ross J.S. Improving the accuracy of hormone receptor assays in breast cancer: an unmet medical need. Future Oncol 1 (2005) 439-441
    • (2005) Future Oncol , vol.1 , pp. 439-441
    • Ross, J.S.1
  • 14
    • 0035884636 scopus 로고    scopus 로고
    • Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer. Seventh International Conference on Adjuvant Therapy of Primary Breast Cancer
    • Goldhirsch A., Glick J.H., Gelber R.D., et al. Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer. Seventh International Conference on Adjuvant Therapy of Primary Breast Cancer. J Clin Oncol 19 (2001) 3817-3827
    • (2001) J Clin Oncol , vol.19 , pp. 3817-3827
    • Goldhirsch, A.1    Glick, J.H.2    Gelber, R.D.3
  • 15
    • 0035751374 scopus 로고    scopus 로고
    • Traditional and newer pathologic factors
    • Schnitt S.J. Traditional and newer pathologic factors. J Natl Cancer Inst Monogr (2001) 22-26
    • (2001) J Natl Cancer Inst Monogr , pp. 22-26
    • Schnitt, S.J.1
  • 16
    • 33646373728 scopus 로고    scopus 로고
    • Estrogen receptor testing of breast cancer in current clinical practice: what's the question?
    • Schnitt S.J. Estrogen receptor testing of breast cancer in current clinical practice: what's the question?. J Clin Oncol 24 (2006) 1797-1799
    • (2006) J Clin Oncol , vol.24 , pp. 1797-1799
    • Schnitt, S.J.1
  • 17
    • 85047688517 scopus 로고    scopus 로고
    • Minimum formalin fixation time for consistent estrogen receptor immunohistochemical staining of invasive breast carcinoma
    • Goldstein N.S., Ferkowicz M., Odish E., et al. Minimum formalin fixation time for consistent estrogen receptor immunohistochemical staining of invasive breast carcinoma. Am J Clin Pathol 120 (2003) 86-92
    • (2003) Am J Clin Pathol , vol.120 , pp. 86-92
    • Goldstein, N.S.1    Ferkowicz, M.2    Odish, E.3
  • 18
    • 0030699244 scopus 로고    scopus 로고
    • Consensus Conference on the classification of ductal carcinoma in situ
    • The Consensus Conference Committee
    • The Consensus Conference Committee. Consensus Conference on the classification of ductal carcinoma in situ. Cancer 80 (1997) 1798-1802
    • (1997) Cancer , vol.80 , pp. 1798-1802
  • 19
    • 0036330147 scopus 로고    scopus 로고
    • Histological category and expression of hormone receptors in ductal carcinoma in situ of the breast
    • Lebrecht A., Buchmann J., Hefler L., et al. Histological category and expression of hormone receptors in ductal carcinoma in situ of the breast. Anticancer Res 22 (2002) 1909-1911
    • (2002) Anticancer Res , vol.22 , pp. 1909-1911
    • Lebrecht, A.1    Buchmann, J.2    Hefler, L.3
  • 20
    • 0038304773 scopus 로고    scopus 로고
    • Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ of the breast in the UK, Australia, and New Zealand: randomised controlled trial
    • Houghton J., George W.D., Cuzick J., et al. Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ of the breast in the UK, Australia, and New Zealand: randomised controlled trial. Lancet 362 (2003) 95-102
    • (2003) Lancet , vol.362 , pp. 95-102
    • Houghton, J.1    George, W.D.2    Cuzick, J.3
  • 21
    • 0034639637 scopus 로고    scopus 로고
    • Radiotherapy in breast-conserving treatment for ductal carcinoma in situ: first results of the EORTC randomised phase III trial 10853. EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group
    • Julien J.P., Bijker N., Fentiman I.S., et al. Radiotherapy in breast-conserving treatment for ductal carcinoma in situ: first results of the EORTC randomised phase III trial 10853. EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group. Lancet 355 (2000) 528-533
    • (2000) Lancet , vol.355 , pp. 528-533
    • Julien, J.P.1    Bijker, N.2    Fentiman, I.S.3
  • 22
    • 0034162884 scopus 로고    scopus 로고
    • Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02
    • Wolmark N., Wieand H.S., Hyams D.M., et al. Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02. J Natl Cancer Inst 92 (2000) 388-396
    • (2000) J Natl Cancer Inst , vol.92 , pp. 388-396
    • Wolmark, N.1    Wieand, H.S.2    Hyams, D.M.3
  • 23
    • 0034766736 scopus 로고    scopus 로고
    • Biology of HER2 and its importance in breast cancer
    • Yarden Y. Biology of HER2 and its importance in breast cancer. Oncology 61 suppl 2 (2001) 1-13
    • (2001) Oncology , vol.61 , Issue.SUPPL. 2 , pp. 1-13
    • Yarden, Y.1
  • 24
    • 0035350113 scopus 로고    scopus 로고
    • The role of EGF-related peptides in tumor growth
    • Normanno N., Bianco C., De Luca A., et al. The role of EGF-related peptides in tumor growth. Front Biosci 6 (2001) D685-D707
    • (2001) Front Biosci , vol.6
    • Normanno, N.1    Bianco, C.2    De Luca, A.3
  • 25
    • 0034600849 scopus 로고    scopus 로고
    • The ErbB signaling network: receptor heterodimerization in development and cancer
    • Olayioye M.A., Neve R.M., Lane H.A., et al. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J 19 (2000) 3159-3167
    • (2000) EMBO J , vol.19 , pp. 3159-3167
    • Olayioye, M.A.1    Neve, R.M.2    Lane, H.A.3
  • 26
    • 0030944455 scopus 로고    scopus 로고
    • ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
    • Graus-Porta D., Beerli R.R., Daly J.M., et al. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J 16 (1997) 1647-1655
    • (1997) EMBO J , vol.16 , pp. 1647-1655
    • Graus-Porta, D.1    Beerli, R.R.2    Daly, J.M.3
  • 27
    • 2142843806 scopus 로고    scopus 로고
    • Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions
    • Pinkas-Kramarski R., Soussan L., Waterman H., et al. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J 15 (1996) 2452-2467
    • (1996) EMBO J , vol.15 , pp. 2452-2467
    • Pinkas-Kramarski, R.1    Soussan, L.2    Waterman, H.3
  • 28
    • 0029053716 scopus 로고
    • Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas
    • Alimandi M., Romano A., Curia M.C., et al. Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. Oncogene 10 (1995) 1813-1821
    • (1995) Oncogene , vol.10 , pp. 1813-1821
    • Alimandi, M.1    Romano, A.2    Curia, M.C.3
  • 29
    • 0037242466 scopus 로고    scopus 로고
    • New mechanisms of signal transduction inhibitor action: receptor tyrosine kinase down-regulation and blockade of signal transactivation
    • Lee A.V., Schiff R., Cui X., et al. New mechanisms of signal transduction inhibitor action: receptor tyrosine kinase down-regulation and blockade of signal transactivation. Clin Cancer Res 9 (2003) 516S-523S
    • (2003) Clin Cancer Res , vol.9
    • Lee, A.V.1    Schiff, R.2    Cui, X.3
  • 30
    • 33745206649 scopus 로고    scopus 로고
    • Open label, randomized, phase II study of pertuzumab in patients with metastatic breast cancer with low expression of HER2
    • Cortes J., Baselga J., Kellokumpu-Lehtinen P., et al. Open label, randomized, phase II study of pertuzumab in patients with metastatic breast cancer with low expression of HER2. J Clin Oncol 23 (2005) 3068
    • (2005) J Clin Oncol , vol.23 , pp. 3068
    • Cortes, J.1    Baselga, J.2    Kellokumpu-Lehtinen, P.3
  • 31
    • 36248938567 scopus 로고    scopus 로고
    • Objective response rate in a phase II multicenter trial of pertuzumab, a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab in patients with HER2-positive metastatic breast cancer which has progressed during treatment with T
    • Baselga J., Cameron D., Miles D., et al. Objective response rate in a phase II multicenter trial of pertuzumab, a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab in patients with HER2-positive metastatic breast cancer which has progressed during treatment with T. J Clin Oncol 25 (2007) 1004
    • (2007) J Clin Oncol , vol.25 , pp. 1004
    • Baselga, J.1    Cameron, D.2    Miles, D.3
  • 32
    • 0141645488 scopus 로고    scopus 로고
    • Mechanism of action of anti-HER2 monoclonal antibodies: scientific update on trastuzumab and 2C4
    • Albanell J., Codony J., Rovira A., et al. Mechanism of action of anti-HER2 monoclonal antibodies: scientific update on trastuzumab and 2C4. Adv Exp Med Biol 532 (2003) 253-268
    • (2003) Adv Exp Med Biol , vol.532 , pp. 253-268
    • Albanell, J.1    Codony, J.2    Rovira, A.3
  • 33
    • 2942603264 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: why does the current process of clinical development not apply to them?
    • Arteaga C.L., and Baselga J. Tyrosine kinase inhibitors: why does the current process of clinical development not apply to them?. Cancer Cell 5 (2004) 525-531
    • (2004) Cancer Cell , vol.5 , pp. 525-531
    • Arteaga, C.L.1    Baselga, J.2
  • 34
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer C.E., Forster J., Lindquist D., et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 355 (2006) 2733-2743
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 35
    • 0025177290 scopus 로고
    • Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer
    • Paik S., Hazan R., Fisher E.R., et al. Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer. J Clin Oncol 8 (1990) 103-112
    • (1990) J Clin Oncol , vol.8 , pp. 103-112
    • Paik, S.1    Hazan, R.2    Fisher, E.R.3
  • 36
    • 0032772856 scopus 로고    scopus 로고
    • Effect of c-erbB(2) and estrogen receptor status on survival of women with primary breast cancer treated with adjuvant cyclophosphamide/methotrexate/fluorouracil
    • Miles D.W., Harris W.H., Gillett C.E., et al. Effect of c-erbB(2) and estrogen receptor status on survival of women with primary breast cancer treated with adjuvant cyclophosphamide/methotrexate/fluorouracil. Int J Cancer 84 (1999) 354-359
    • (1999) Int J Cancer , vol.84 , pp. 354-359
    • Miles, D.W.1    Harris, W.H.2    Gillett, C.E.3
  • 37
    • 0028354305 scopus 로고
    • c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer
    • Muss H.B., Thor A.D., Berry D.A., et al. c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer. N Engl J Med 330 (1994) 1260-1266
    • (1994) N Engl J Med , vol.330 , pp. 1260-1266
    • Muss, H.B.1    Thor, A.D.2    Berry, D.A.3
  • 38
    • 33846341486 scopus 로고    scopus 로고
    • The 17q12-q21 amplicon: Her2 and topoisomerase-IIalpha and their importance to the biology of solid tumours
    • Mano M.S., Rosa D.D., De Azambuja E., et al. The 17q12-q21 amplicon: Her2 and topoisomerase-IIalpha and their importance to the biology of solid tumours. Cancer Treat Rev 33 (2007) 64-77
    • (2007) Cancer Treat Rev , vol.33 , pp. 64-77
    • Mano, M.S.1    Rosa, D.D.2    De Azambuja, E.3
  • 39
    • 0141614011 scopus 로고    scopus 로고
    • Topoisomerase II alpha as a marker predicting the efficacy of anthracyclines in breast cancer: are we at the end of the beginning?
    • Di Leo A., and Isola J. Topoisomerase II alpha as a marker predicting the efficacy of anthracyclines in breast cancer: are we at the end of the beginning?. Clin Breast Cancer 4 (2003) 179-186
    • (2003) Clin Breast Cancer , vol.4 , pp. 179-186
    • Di Leo, A.1    Isola, J.2
  • 40
    • 45149122291 scopus 로고    scopus 로고
    • The value of TOP2A gene copy number variation as a biomarker in breast cancer: update of DBCG trial 89D
    • Nielsen K.V., Ejlertsen B., Moller S., et al. The value of TOP2A gene copy number variation as a biomarker in breast cancer: update of DBCG trial 89D. Acta Oncol 47 (2008) 725-734
    • (2008) Acta Oncol , vol.47 , pp. 725-734
    • Nielsen, K.V.1    Ejlertsen, B.2    Moller, S.3
  • 41
    • 39149126730 scopus 로고    scopus 로고
    • HER-2 and topoisomerase II as predictors of response to chemotherapy
    • Pritchard K.I., Messersmith H., Elavathil L., et al. HER-2 and topoisomerase II as predictors of response to chemotherapy. J Clin Oncol 26 (2008) 736-744
    • (2008) J Clin Oncol , vol.26 , pp. 736-744
    • Pritchard, K.I.1    Messersmith, H.2    Elavathil, L.3
  • 42
    • 59449086379 scopus 로고    scopus 로고
    • Impact, mechanisms, and novel chemotherapy strategies for overcoming resistance to anthracyclines and taxanes in metastatic breast cancer
    • (in press)
    • Perez E.A. Impact, mechanisms, and novel chemotherapy strategies for overcoming resistance to anthracyclines and taxanes in metastatic breast cancer. Breast Cancer Res Treat (2008) (in press)
    • (2008) Breast Cancer Res Treat
    • Perez, E.A.1
  • 43
    • 36849081991 scopus 로고    scopus 로고
    • HER-2, TOP2A and chromosome 17 alterations in breast cancer
    • Beser A.R., Tuzlali S., Guzey D., et al. HER-2, TOP2A and chromosome 17 alterations in breast cancer. Pathol Oncol Res 13 (2007) 180-185
    • (2007) Pathol Oncol Res , vol.13 , pp. 180-185
    • Beser, A.R.1    Tuzlali, S.2    Guzey, D.3
  • 44
    • 33646681444 scopus 로고    scopus 로고
    • HER2 and responsiveness of breast cancer to adjuvant chemotherapy
    • Pritchard K.I., Shepherd L.E., O'Malley F.P., et al. HER2 and responsiveness of breast cancer to adjuvant chemotherapy. N Engl J Med 354 (2006) 2103-2111
    • (2006) N Engl J Med , vol.354 , pp. 2103-2111
    • Pritchard, K.I.1    Shepherd, L.E.2    O'Malley, F.P.3
  • 45
    • 4444320915 scopus 로고    scopus 로고
    • Her-2/neu gene amplification and response to paclitaxel in patients with metastatic breast cancer
    • Konecny G.E., Thomssen C., Luck H.J., et al. Her-2/neu gene amplification and response to paclitaxel in patients with metastatic breast cancer. J Natl Cancer Inst 96 (2004) 1141-1151
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1141-1151
    • Konecny, G.E.1    Thomssen, C.2    Luck, H.J.3
  • 46
    • 35248895346 scopus 로고    scopus 로고
    • HER2 and response to paclitaxel in node-positive breast cancer
    • Hayes D.F., Thor A.D., Dressler L.G., et al. HER2 and response to paclitaxel in node-positive breast cancer. N Engl J Med 357 (2007) 1496-1506
    • (2007) N Engl J Med , vol.357 , pp. 1496-1506
    • Hayes, D.F.1    Thor, A.D.2    Dressler, L.G.3
  • 47
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • Vogel C.L., Cobleigh M.A., Tripathy D., et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 20 (2002) 719-726
    • (2002) J Clin Oncol , vol.20 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 48
    • 20544460650 scopus 로고    scopus 로고
    • Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer
    • Buzdar A.U., Ibrahim N.K., Francis D., et al. Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer. J Clin Oncol 23 (2005) 3676-3685
    • (2005) J Clin Oncol , vol.23 , pp. 3676-3685
    • Buzdar, A.U.1    Ibrahim, N.K.2    Francis, D.3
  • 49
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond E.H., Perez E.A., Bryant J., et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 353 (2005) 1673-1684
    • (2005) N Engl J Med , vol.353 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 50
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    • Piccart-Gebhart M.J., Procter M., Leyland-Jones B., et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 353 (2005) 1659-1672
    • (2005) N Engl J Med , vol.353 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 51
    • 0029662337 scopus 로고    scopus 로고
    • c-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases
    • Carlomagno C., Perrone F., Gallo C., et al. c-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases. J Clin Oncol 14 (1996) 2702-2708
    • (1996) J Clin Oncol , vol.14 , pp. 2702-2708
    • Carlomagno, C.1    Perrone, F.2    Gallo, C.3
  • 52
    • 0026502860 scopus 로고
    • Relationship between c-erbB-2 protein product expression and response to endocrine therapy in advanced breast cancer
    • Wright C., Nicholson S., Angus B., et al. Relationship between c-erbB-2 protein product expression and response to endocrine therapy in advanced breast cancer. Br J Cancer 65 (1992) 118-121
    • (1992) Br J Cancer , vol.65 , pp. 118-121
    • Wright, C.1    Nicholson, S.2    Angus, B.3
  • 53
    • 0035884620 scopus 로고    scopus 로고
    • Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial
    • Ellis M.J., Coop A., Singh B., et al. Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial. J Clin Oncol 19 (2001) 3808-3816
    • (2001) J Clin Oncol , vol.19 , pp. 3808-3816
    • Ellis, M.J.1    Coop, A.2    Singh, B.3
  • 54
    • 0042208398 scopus 로고    scopus 로고
    • The Her-2/neu gene and protein in breast cancer 2003: biomarker and target of therapy
    • Ross J.S., Fletcher J.A., Linette G.P., et al. The Her-2/neu gene and protein in breast cancer 2003: biomarker and target of therapy. Oncologist 8 (2003) 307-325
    • (2003) Oncologist , vol.8 , pp. 307-325
    • Ross, J.S.1    Fletcher, J.A.2    Linette, G.P.3
  • 55
    • 0037024478 scopus 로고    scopus 로고
    • Concordance between local and central laboratory HER2 testing in the breast intergroup trial N9831
    • Roche P.C., Suman V.J., Jenkins R.B., et al. Concordance between local and central laboratory HER2 testing in the breast intergroup trial N9831. J Natl Cancer Inst 94 (2002) 855-857
    • (2002) J Natl Cancer Inst , vol.94 , pp. 855-857
    • Roche, P.C.1    Suman, V.J.2    Jenkins, R.B.3
  • 56
    • 0035873962 scopus 로고    scopus 로고
    • Discrepancies in clinical laboratory testing of eligibility for trastuzumab therapy: apparent immunohistochemical false-positives do not get the message
    • Tubbs R.R., Pettay J.D., Roche P.C., et al. Discrepancies in clinical laboratory testing of eligibility for trastuzumab therapy: apparent immunohistochemical false-positives do not get the message. J Clin Oncol 19 (2001) 2714-2721
    • (2001) J Clin Oncol , vol.19 , pp. 2714-2721
    • Tubbs, R.R.1    Pettay, J.D.2    Roche, P.C.3
  • 57
    • 33645298450 scopus 로고    scopus 로고
    • Chromogenic in-situ hybridization: a viable alternative to fluorescence in-situ hybridization in the HER2 testing algorithm
    • Hanna W.M., and Kwok K. Chromogenic in-situ hybridization: a viable alternative to fluorescence in-situ hybridization in the HER2 testing algorithm. Mod Pathol 19 (2006) 481-487
    • (2006) Mod Pathol , vol.19 , pp. 481-487
    • Hanna, W.M.1    Kwok, K.2
  • 58
    • 33751382730 scopus 로고    scopus 로고
    • Automation of manual components and image quantification of direct dual label fluorescence in situ hybridization (FISH) for HER2 gene amplification: a feasibility study
    • Tubbs R.R., Pettay J.D., Swain E., et al. Automation of manual components and image quantification of direct dual label fluorescence in situ hybridization (FISH) for HER2 gene amplification: a feasibility study. Appl Immunohistochem Mol Morphol 14 (2006) 436-440
    • (2006) Appl Immunohistochem Mol Morphol , vol.14 , pp. 436-440
    • Tubbs, R.R.1    Pettay, J.D.2    Swain, E.3
  • 59
    • 33847147313 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
    • Wolff A.C., Hammond M.E., Schwartz J.N., et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol 25 (2007) 118-145
    • (2007) J Clin Oncol , vol.25 , pp. 118-145
    • Wolff, A.C.1    Hammond, M.E.2    Schwartz, J.N.3
  • 60
    • 33846568336 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer
    • Wolff A.C., Hammond M.E., Schwartz J.N., et al. American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer. Arch Pathol Lab Med 131 (2007) 18
    • (2007) Arch Pathol Lab Med , vol.131 , pp. 18
    • Wolff, A.C.1    Hammond, M.E.2    Schwartz, J.N.3
  • 61
    • 0034788985 scopus 로고    scopus 로고
    • The IGF system and breast cancer
    • Sachdev D., and Yee D. The IGF system and breast cancer. Endocr Relat Cancer 8 (2001) 197-209
    • (2001) Endocr Relat Cancer , vol.8 , pp. 197-209
    • Sachdev, D.1    Yee, D.2
  • 62
    • 0033838566 scopus 로고    scopus 로고
    • Function of the IGF-I receptor in breast cancer
    • Surmacz E. Function of the IGF-I receptor in breast cancer. J Mammary Gland Biol Neoplasia 5 (2000) 95-105
    • (2000) J Mammary Gland Biol Neoplasia , vol.5 , pp. 95-105
    • Surmacz, E.1
  • 63
    • 0035915421 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
    • Lu Y., Zi X., Zhao Y., et al. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 93 (2001) 1852-1857
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1852-1857
    • Lu, Y.1    Zi, X.2    Zhao, Y.3
  • 64
    • 33947246109 scopus 로고    scopus 로고
    • Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer
    • Harris L.N., You F., Schnitt S.J., et al. Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer. Clin Cancer Res 13 (2007) 1198-1207
    • (2007) Clin Cancer Res , vol.13 , pp. 1198-1207
    • Harris, L.N.1    You, F.2    Schnitt, S.J.3
  • 65
    • 0035810044 scopus 로고    scopus 로고
    • Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody
    • Liu B., Fang M., Lu Y., et al. Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody. Oncogene 20 (2001) 1913-1922
    • (2001) Oncogene , vol.20 , pp. 1913-1922
    • Liu, B.1    Fang, M.2    Lu, Y.3
  • 66
    • 0037163646 scopus 로고    scopus 로고
    • The prognostic value of vascular endothelial growth factor in 574 node-negative breast cancer patients who did not receive adjuvant systemic therapy
    • Manders P., Beex L.V., Tjan-Heijnen V.C., et al. The prognostic value of vascular endothelial growth factor in 574 node-negative breast cancer patients who did not receive adjuvant systemic therapy. Br J Cancer 87 (2002) 772-778
    • (2002) Br J Cancer , vol.87 , pp. 772-778
    • Manders, P.1    Beex, L.V.2    Tjan-Heijnen, V.C.3
  • 67
    • 0035266296 scopus 로고    scopus 로고
    • The expression of vascular endothelial growth factor correlates with mutant p53 and poor prognosis in human breast cancer
    • Linderholm B.K., Lindahl T., Holmberg L., et al. The expression of vascular endothelial growth factor correlates with mutant p53 and poor prognosis in human breast cancer. Cancer Res 61 (2001) 2256-2260
    • (2001) Cancer Res , vol.61 , pp. 2256-2260
    • Linderholm, B.K.1    Lindahl, T.2    Holmberg, L.3
  • 68
    • 40149104962 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor (VEGF) levels correlate with tumor VEGF and p53 overexpression in endocrine positive primary breast cancer
    • Iovino F., Ferraraccio F., Orditura M., et al. Serum vascular endothelial growth factor (VEGF) levels correlate with tumor VEGF and p53 overexpression in endocrine positive primary breast cancer. Cancer Invest 26 (2008) 250-255
    • (2008) Cancer Invest , vol.26 , pp. 250-255
    • Iovino, F.1    Ferraraccio, F.2    Orditura, M.3
  • 69
    • 0036546607 scopus 로고    scopus 로고
    • An evaluation of the prognostic significance of vascular endothelial growth factor in node positive primary breast carcinoma
    • MacConmara M., O'Hanlon D.M., Kiely M.J., et al. An evaluation of the prognostic significance of vascular endothelial growth factor in node positive primary breast carcinoma. Int J Oncol 20 (2002) 717-721
    • (2002) Int J Oncol , vol.20 , pp. 717-721
    • MacConmara, M.1    O'Hanlon, D.M.2    Kiely, M.J.3
  • 70
    • 57649172060 scopus 로고    scopus 로고
    • The determination of VEGF and MVD, among patients with primary breast cancer
    • Thielemann A., Kopczynski Z., Filas V., et al. The determination of VEGF and MVD, among patients with primary breast cancer. Pathol Oncol Res 14 (2008) 137-144
    • (2008) Pathol Oncol Res , vol.14 , pp. 137-144
    • Thielemann, A.1    Kopczynski, Z.2    Filas, V.3
  • 71
    • 33847643631 scopus 로고    scopus 로고
    • Drug insight: VEGF as a therapeutic target for breast cancer
    • Schneider B.P., and Sledge Jr. G.W. Drug insight: VEGF as a therapeutic target for breast cancer. Nat Clin Pract Oncol 4 (2007) 181-189
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 181-189
    • Schneider, B.P.1    Sledge Jr., G.W.2
  • 72
    • 35349001189 scopus 로고    scopus 로고
    • MMP-2, MMP-9, VEGF and CA 15.3 in breast cancer
    • Quaranta M., Daniele A., Coviello M., et al. MMP-2, MMP-9, VEGF and CA 15.3 in breast cancer. Anticancer Res 27 (2007) 3593-3600
    • (2007) Anticancer Res , vol.27 , pp. 3593-3600
    • Quaranta, M.1    Daniele, A.2    Coviello, M.3
  • 73
    • 34547726341 scopus 로고    scopus 로고
    • Evaluation of prognostic value of VEGF-C and VEGF-D in breast cancer: 10 years follow-up analysis
    • Gisterek I., Matkowski R., Kozlak J., et al. Evaluation of prognostic value of VEGF-C and VEGF-D in breast cancer: 10 years follow-up analysis. Anticancer Res 27 (2007) 2797-2802
    • (2007) Anticancer Res , vol.27 , pp. 2797-2802
    • Gisterek, I.1    Matkowski, R.2    Kozlak, J.3
  • 74
    • 15244362063 scopus 로고    scopus 로고
    • Association between intratumoral free and total VEGF, soluble VEGFR-1, VEGFR-2 and prognosis in breast cancer
    • Bando H., Weich H.A., Brokelmann M., et al. Association between intratumoral free and total VEGF, soluble VEGFR-1, VEGFR-2 and prognosis in breast cancer. Br J Cancer 92 (2005) 553-561
    • (2005) Br J Cancer , vol.92 , pp. 553-561
    • Bando, H.1    Weich, H.A.2    Brokelmann, M.3
  • 75
    • 33947544435 scopus 로고    scopus 로고
    • Novel approaches to advanced breast cancer: bevacizumab and lapatinib
    • Mayer E.L., Lin N.U., and Burstein H.J. Novel approaches to advanced breast cancer: bevacizumab and lapatinib. J Natl Compr Canc Netw 5 (2007) 314-323
    • (2007) J Natl Compr Canc Netw , vol.5 , pp. 314-323
    • Mayer, E.L.1    Lin, N.U.2    Burstein, H.J.3
  • 77
    • 33644863001 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer
    • Wedam S.B., Low J.A., Yang S.X., et al. Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer. J Clin Oncol 24 (2006) 769-777
    • (2006) J Clin Oncol , vol.24 , pp. 769-777
    • Wedam, S.B.1    Low, J.A.2    Yang, S.X.3
  • 78
    • 33846850223 scopus 로고    scopus 로고
    • Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis
    • Herbst R.S., Heymach J.V., O'Reilly M.S., et al. Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis. Expert Opin Investig Drugs 16 (2007) 239-249
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 239-249
    • Herbst, R.S.1    Heymach, J.V.2    O'Reilly, M.S.3
  • 79
    • 34748881947 scopus 로고    scopus 로고
    • Next generation molecular targeted agents for breast cancer: focus on EGFR and VEGFR pathways
    • Hatake K., Tokudome N., and Ito Y. Next generation molecular targeted agents for breast cancer: focus on EGFR and VEGFR pathways. Breast Cancer 14 (2007) 132-149
    • (2007) Breast Cancer , vol.14 , pp. 132-149
    • Hatake, K.1    Tokudome, N.2    Ito, Y.3
  • 80
    • 0027732538 scopus 로고
    • Proteins regulating Ras and its relatives
    • Boguski M.S., and McCormick F. Proteins regulating Ras and its relatives. Nature 366 (1993) 643-654
    • (1993) Nature , vol.366 , pp. 643-654
    • Boguski, M.S.1    McCormick, F.2
  • 81
    • 34548701082 scopus 로고    scopus 로고
    • Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-negative" breast cancer cell lines growing in vitro
    • Finn R.S., Dering J., Ginther C., et al. Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-negative" breast cancer cell lines growing in vitro. Breast Cancer Res Treat 105 (2007) 319-326
    • (2007) Breast Cancer Res Treat , vol.105 , pp. 319-326
    • Finn, R.S.1    Dering, J.2    Ginther, C.3
  • 82
    • 0038352147 scopus 로고    scopus 로고
    • Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer
    • Johnston S.R., Hickish T., Ellis P., et al. Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer. J Clin Oncol 21 (2003) 2492-2499
    • (2003) J Clin Oncol , vol.21 , pp. 2492-2499
    • Johnston, S.R.1    Hickish, T.2    Ellis, P.3
  • 83
    • 33746015951 scopus 로고    scopus 로고
    • Targeted inhibition of farnesyltransferase in locally advanced breast cancer: a phase I and II trial of tipifarnib plus dose-dense doxorubicin and cyclophosphamide
    • Sparano J.A., Moulder S., Kazi A., et al. Targeted inhibition of farnesyltransferase in locally advanced breast cancer: a phase I and II trial of tipifarnib plus dose-dense doxorubicin and cyclophosphamide. J Clin Oncol 24 (2006) 3013-3018
    • (2006) J Clin Oncol , vol.24 , pp. 3013-3018
    • Sparano, J.A.1    Moulder, S.2    Kazi, A.3
  • 84
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B., Eisen T., Stadler W.M., et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 356 (2007) 125-134
    • (2007) N Engl J Med , vol.356 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 85
    • 34547482919 scopus 로고    scopus 로고
    • Clinical experience of MEK inhibitors in cancer therapy
    • Wang D., Boerner S.A., Winkler J.D., et al. Clinical experience of MEK inhibitors in cancer therapy. Biochim Biophys Acta 1773 (2007) 1248-1255
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 1248-1255
    • Wang, D.1    Boerner, S.A.2    Winkler, J.D.3
  • 86
    • 33646706052 scopus 로고    scopus 로고
    • Oncogenic PI3K and its role in cancer
    • Samuels Y., and Ericson K. Oncogenic PI3K and its role in cancer. Curr Opin Oncol 18 (2006) 77-82
    • (2006) Curr Opin Oncol , vol.18 , pp. 77-82
    • Samuels, Y.1    Ericson, K.2
  • 88
    • 40549113364 scopus 로고    scopus 로고
    • PIK3CA exon 20 mutation is independently associated with a poor prognosis in breast cancer patients
    • Lai Y.L., Mau B.L., Cheng W.H., et al. PIK3CA exon 20 mutation is independently associated with a poor prognosis in breast cancer patients. Ann Surg Oncol 15 (2008) 1064-1069
    • (2008) Ann Surg Oncol , vol.15 , pp. 1064-1069
    • Lai, Y.L.1    Mau, B.L.2    Cheng, W.H.3
  • 89
    • 35148885729 scopus 로고    scopus 로고
    • A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
    • Berns K., Horlings H.M., Hennessy B.T., et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 12 (2007) 395-402
    • (2007) Cancer Cell , vol.12 , pp. 395-402
    • Berns, K.1    Horlings, H.M.2    Hennessy, B.T.3
  • 90
    • 23944439945 scopus 로고    scopus 로고
    • Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
    • Chan S., Scheulen M.E., Johnston S., et al. Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J Clin Oncol 23 (2005) 5314-5322
    • (2005) J Clin Oncol , vol.23 , pp. 5314-5322
    • Chan, S.1    Scheulen, M.E.2    Johnston, S.3
  • 91
    • 33750884079 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibitors in combination with letrozole in breast cancer
    • Chollet P., Abrial C., Tacca O., et al. Mammalian target of rapamycin inhibitors in combination with letrozole in breast cancer. Clin Breast Cancer 7 (2006) 336-338
    • (2006) Clin Breast Cancer , vol.7 , pp. 336-338
    • Chollet, P.1    Abrial, C.2    Tacca, O.3
  • 92
    • 43249131245 scopus 로고    scopus 로고
    • Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors
    • Tabernero J., Rojo F., Calvo E., et al. Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors. J Clin Oncol 26 (2008) 1603-1610
    • (2008) J Clin Oncol , vol.26 , pp. 1603-1610
    • Tabernero, J.1    Rojo, F.2    Calvo, E.3
  • 93
    • 25844519550 scopus 로고    scopus 로고
    • HSP90 and the chaperoning of cancer
    • Whitesell L., and Lindquist S.L. HSP90 and the chaperoning of cancer. Nat Rev Cancer 5 (2005) 761-772
    • (2005) Nat Rev Cancer , vol.5 , pp. 761-772
    • Whitesell, L.1    Lindquist, S.L.2
  • 94
    • 48049112436 scopus 로고    scopus 로고
    • HER-2 positive breast cancer: what else beyond trastuzumab-based therapy?
    • Widakowich C., Dinh P., de Azambuja E., et al. HER-2 positive breast cancer: what else beyond trastuzumab-based therapy?. Anticancer Agents Med Chem 8 (2008) 488-496
    • (2008) Anticancer Agents Med Chem , vol.8 , pp. 488-496
    • Widakowich, C.1    Dinh, P.2    de Azambuja, E.3
  • 95
    • 33644694046 scopus 로고    scopus 로고
    • Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1
    • Zsebik B., Citri A., Isola J., et al. Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1. Immunol Lett 104 (2006) 146-155
    • (2006) Immunol Lett , vol.104 , pp. 146-155
    • Zsebik, B.1    Citri, A.2    Isola, J.3
  • 96
    • 36849055007 scopus 로고    scopus 로고
    • Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study
    • Modi S., Stopeck A.T., Gordon M.S., et al. Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study. J Clin Oncol 25 (2007) 5410-5417
    • (2007) J Clin Oncol , vol.25 , pp. 5410-5417
    • Modi, S.1    Stopeck, A.T.2    Gordon, M.S.3
  • 97
    • 41049113475 scopus 로고    scopus 로고
    • NF-kappa B genes have a major role in inflammatory breast cancer
    • Lerebours F., Vacher S., Andrieu C., et al. NF-kappa B genes have a major role in inflammatory breast cancer. BMC Cancer 8 (2008) 41
    • (2008) BMC Cancer , vol.8 , pp. 41
    • Lerebours, F.1    Vacher, S.2    Andrieu, C.3
  • 98
    • 34447333110 scopus 로고    scopus 로고
    • Nuclear factor-kappaB activation: a molecular therapeutic target for estrogen receptor-negative and epidermal growth factor receptor family receptor-positive human breast cancer
    • Singh S., Shi Q., Bailey S.T., et al. Nuclear factor-kappaB activation: a molecular therapeutic target for estrogen receptor-negative and epidermal growth factor receptor family receptor-positive human breast cancer. Mol Cancer Ther 6 (2007) 1973-1982
    • (2007) Mol Cancer Ther , vol.6 , pp. 1973-1982
    • Singh, S.1    Shi, Q.2    Bailey, S.T.3
  • 99
    • 35148880568 scopus 로고    scopus 로고
    • Inhibition of the canonical IKK/NF kappa B pathway sensitizes human cancer cells to doxorubicin
    • Tapia M.A., Gonzalez-Navarrete I., Dalmases A., et al. Inhibition of the canonical IKK/NF kappa B pathway sensitizes human cancer cells to doxorubicin. Cell Cycle 6 (2007) 2284-2292
    • (2007) Cell Cycle , vol.6 , pp. 2284-2292
    • Tapia, M.A.1    Gonzalez-Navarrete, I.2    Dalmases, A.3
  • 100
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Paik S., Shak S., Tang G., et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 351 (2004) 2817-2826
    • (2004) N Engl J Med , vol.351 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 101
    • 33748693297 scopus 로고    scopus 로고
    • Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer
    • Buyse M., Loi S., van't Veer L., et al. Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer. J Natl Cancer Inst 98 (2006) 1183-1192
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1183-1192
    • Buyse, M.1    Loi, S.2    van't Veer, L.3
  • 102
    • 34147164024 scopus 로고    scopus 로고
    • Is molecular profiling ready for use in clinical decision making?
    • Ioannidis J.P. Is molecular profiling ready for use in clinical decision making?. Oncologist 12 (2007) 301-311
    • (2007) Oncologist , vol.12 , pp. 301-311
    • Ioannidis, J.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.