Chloroquine-mediated radiosensitization is due to the destabilization of the lysosomal membrane and subsequent induction of cell death by necrosis

Radiation Research

Volumn 164, Issue 3, 2005, Pages 250-257

  Zhao, Helen ^a   Cai, Yong ^a,b   Santi, Stacey ^a   Lafrenie, Robert ^a   Lee, Hoyun ^a  

^a Northeastern Ontario Regional Cancer Centre   (Canada)

^b PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CERAMIDE; CHLOROQUINE; DNA; RADIOSENSITIZING AGENT;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA CONTENT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IONIZING RADIATION; LYSOSOME MEMBRANE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; RADIOSENSITIZATION;

APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CHLOROQUINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; INTRACELLULAR MEMBRANES; LYSOSOMES; MEMBRANE FLUIDITY; NECROSIS; RADIATION DOSAGE; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS;

EID: 24144435978     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3436.1     Document Type: Article

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