Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: A NAAG-mGluR23-mediated mechanism

Journal of Neurochemistry

Volumn 112, Issue 2, 2010, Pages 564-576

  Xi, Zheng Xiong ^a   Li, Xia ^a   Peng, Xiao Qing ^a   Li, Jie ^a   Chun, Lauren ^a   Gardner, Eliot L ^a   Thomas, Ajit G ^b   Slusher, Barbara S ^b   Ashby Jr , Charles R ^c  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b GUILFORD PHARMACEUTICALS INC   (United States)

^c ST JOHN'S UNIVERSITY   (United States)

Author keywords

2 (phosphonomethyl)pentanedioic acid; Cocaine; Dopamine; Glutamate; N acetyl aspartatylglutamate; Relapse

Indexed keywords

2 (PHOSPHONOMETHYL)PENTANEDIOIC ACID; 2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; COCAINE; GLUTAMATE CARBOXYPEPTIDASE II; GLUTAMATE CARBOXYPEPTIDASE II INHIBITOR; GLUTAMIC ACID; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; N ACETYLASPARTIC ACID; N ACETYLASPARTYLGLUTAMIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCAINE DEPENDENCE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SELF ADMINISTRATION; ENZYME DEGRADATION; ENZYME INHIBITION; HYDROLYSIS; MALE; MICRODIALYSIS; MICROINJECTION; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; RELAPSE; TREATMENT OUTCOME;

AMINO ACIDS; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BICYCLO COMPOUNDS, HETEROCYCLIC; COCAINE; COCAINE-RELATED DISORDERS; CONDITIONING, OPERANT; CORPUS STRIATUM; DIPEPTIDES; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTINCTION, PSYCHOLOGICAL; GLUTAMATE CARBOXYPEPTIDASE II; GLUTAMIC ACID; MALE; MICRODIALYSIS; MICROINJECTIONS; NEUROPROTECTIVE AGENTS; NUCLEUS ACCUMBENS; ORGANOPHOSPHORUS COMPOUNDS; RATS; RATS, LONG-EVANS; RECEPTORS, METABOTROPIC GLUTAMATE; REINFORCEMENT SCHEDULE; SELF ADMINISTRATION; SUCROSE; SWEETENING AGENTS;

RATTUS;

EID: 72849136230     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06478.x     Document Type: Article

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