Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking

Journal of Neuroscience

Volumn 25, Issue 27, 2005, Pages 6389-6393

  Moran, Megan M ^a   McFarland, Krista ^a   Melendez, Roberto I ^a   Kalivas, Peter W ^a   Seamans, Jeremy K ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Accumbens; Cocaine; Cystine glutamate exchange; EPSC; Glutamate; mGluR

Indexed keywords

1 AMINO 1,5 INDANDICARBOXYLIC ACID; 2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 4 CARBOXYPHENYLGLYCINE; ACETYLCYSTEINE; BICUCULLINE; COCAINE; CYSTINE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; METABOTROPIC RECEPTOR; TETRODOTOXIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BRAIN SLICE; COCAINE DEPENDENCE; CONTROLLED STUDY; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

AMINO ACIDS; ANIMALS; BIOLOGICAL TRANSPORT; COCAINE; COCAINE-RELATED DISORDERS; CONSUMMATORY BEHAVIOR; CYSTINE; EXCITATORY AMINO ACID ANTAGONISTS; EXTINCTION, PSYCHOLOGICAL; GLUTAMIC ACID; MALE; NEURAL CONDUCTION; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, PRESYNAPTIC; SELF ADMINISTRATION; XANTHENES;

EID: 21844443565     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1007-05.2005     Document Type: Article

References (25)

1. Alagarsamy S, Sorensen SD, Conn PJ (2001) Coordinate regulation of metabotropic glutamate receptors. Curr Opin Neurobiol 11:357-362.
2. Baker DA, Xi ZX, Shen H, Swanson CJ, Kalivas PW (2002) The origin and neuronal function of in vivo nonsynaptic glutamate. J Neurosci 22:9134-9141.
3. Baker DA, McFarland K, Lake RW, Shen H, Tang XC, Toda S, Kalivas PW (2003) Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci 6:743-749.
4. Bandrowski AE, Huguenard JR, Prince DA (2003) Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol 89:1308-1316.
5. Baptista MA, Martin-Pardon R, Weiss F (2004) Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer. J Neurosci 24:4723-4727.
6. Bossert JM, Liu SY, Lu L, Shaham Y (2004) A role of ventral tegmental area glutamate in contextual cue-induced relapse to heroin seeking. J Neurosci 24:10726-10730.
7. Conn PJ, Pin J-P (1997) Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37:205-237.
8. Dietrich D, Kral T, Clusmann H, Friedl M, Schramm J (2002) Presynaptic group II metabotropic glutamate receptors reduce stimulated and spontaneous transmitter release in human dentate gyrus. Neuropharmacology 42:297-305.
9. Gochenauer GE, Robinson MB (2001) Dibutyryl-cAMP (dbcAMP) upregulates astrocytic chlorinde-dependent L- [3Hjglutamate transport and expression in both system xc- subunits. J Neurochem 78:276-286.
10. Hotsenpiller G, Giorgetti M, Wolf ME (2001) Alterations in behaviour and glutamate transmission following presentation of stimuli previously associated with cocaine exposure. Eur J Neurosci 14:1843-1855.
11. Jabaudon D, Shimamoto K, Yasuda-Kamatani Y, Scanziani M, Gahwiler B, Gerber U (1999) Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin. Proc Natl Acad Sci USA 96:8733-8738.
12. Kalivas PW, Volkow N, Seamans J (2005) Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission. Neuron 45:647-650.
13. Kenny PJ, Markou A (2004) The ups and downs of addiction: role of metabotropic glutamate receptors. Trends in Pharmacol Sci 25:265-272.
14. Manzoni O, Michel J-M, Bockaert J (1997) Metabotropic glutamate receptors in the rat nucleus accumbens. Eur J Neurosci 9:1514-1523.
15. McBean GJ (2002) Cerebral cystine uptake: a tale of two transporters. Trends Pharmacol Sci 23:299-302.
16. McFarland K, Lapish CC, Kalivas PW (2003) Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J Neurosci 23:3531-3537.
17. Otani S, Daniel H, Takita M, Crepel F (2002) Long-term depression induced by postsynaptic group II metabotropic glutamate receptors linked to phospholipase C and intracellular calcium rises in rat prefrontal cortex. J Neurosci 22:3434-3444.
18. -: an obligate exchanger of L-glutamate and L-cystine. Neuropharmacology 46:273-284.
19. Petralia RS, Wang Y-X, Niedzielski AS, Wenthold RJ (1996) The metabotropic glutamate receptors, mGLUR2 and mGLUR3, show unique postsynaptic, presynaptic and glial localizations. Neuroscience 71:949-976.
20. Pierce RC, Bell K, Duffy P, Kalivas PW (1996) Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization. J Neurosci 16:1550-1560.
21. 2+ channels in metabotropic glutamate receptor 2/3 dependent presynaptic long-term depression at nucleus accumbens synapses. J Neurosci 2:4346-4356.
22. Sato H, Tamba M, Okuno S, Sato K, Keino-Masu K, Masu M, Bannai S (2002) Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain. J Neurosci 22:8028-8033.
23. Schoepp DD, Jane DE, Monn JA (1999) Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 38:1431-1476.
24. Thomas MJ, Beurrier C, Bonci A, Malenka RC (2001) Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine. Nat Neurosci 4:1217-1223.
25. Warr O, Takahashi M, Attwell D (1999) Modulation of extracellular glutamate concentration in rat brain slices by cystine-glutamate exchange. J Physiol (Lond) 514:783-793.