Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury

Nature Medicine

Volumn 5, Issue 12, 1999, Pages 1396-1402

  Slusher, Barbara S ^a   Vornov, James J ^a,b   Thomas, Ajit G ^a,b   Hurn, Patricia D ^b   Harukuni, Izumi ^b   Bhardwaj, Anish ^b   Traystman, Richard J ^b   Robinson, Michael B ^c   Britton, Paul ^d   Lu, X C May ^a   Tortella, Frank C ^d   Wozniak, Krystyna M ^a   Yudkoff, Marc ^c   Potter, Beth M ^a   Jackson, Paul F ^a  

^a GUILFORD PHARMACEUTICALS INC   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (PHOSPHONOMETHYL)PENTANEDIOIC ACID; DIPEPTIDASE; GLUTAMIC ACID; GLUTARIC ACID DERIVATIVE; N ACETYLASPARTYLGLUTAMIC ACID; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG POTENCY; DRUG TOLERABILITY; ENZYME INHIBITION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN ISCHEMIA; CARBOXYPEPTIDASES; CEREBROVASCULAR ACCIDENT; CULTURE TECHNIQUES; DIPEPTIDES; DISEASE MODELS, ANIMAL; DRUG TOLERANCE; ENZYME INHIBITORS; GLUTAMATE CARBOXYPEPTIDASE II; GLUTAMIC ACID; ISCHEMIC ATTACK, TRANSIENT; MICE; MICE, INBRED ICR; NEUROPROTECTIVE AGENTS; ORGANOPHOSPHORUS COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032710321     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/70971     Document Type: Article

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