Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats

Journal of Neuroscience

Volumn 22, Issue 21, 2002, Pages 9595-9603

  Vorel, Stanislav R ^a   Ashby Jr , Charles R ^b   Paul, Mousumi ^c   Liu, Xinhe ^d   Hayes, Robert ^e   Hagan, Jim J ^f   Middlemiss, Derek N ^a,d   Stemp, Geoffrey ^a,e   Gardner, Eliot L ^e  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b Department of Neuroscience ^*  (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d ST JOHN'S UNIVERSITY   (United States)

^e Eon Laboratories   (United States)

^f GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Addiction; Brain stimulation reward; BSR; Cocaine; Conditioned place preference; CPP; D3 antagonist; D3 receptor; Dopamine; ICSS; Mesocorticolimbic; Mesolimbic; Reinstatement; Relapse; Self administration; Self stimulation

Indexed keywords

2 DIPROPYLAMINO 7 HYDROXYTETRALIN; 3,4,4A,10B TETRAHYDRO 4 PROPYL 2H,5H [1]BENZOPYRANO[4,3 B][1,4]OXAZIN 9 OL; 5 METHOXY 1 METHYL 2 PROPYLAMINOTETRALIN; BP 897; COCAINE; DOPAMINE 3 RECEPTOR BLOCKING AGENT; DOPAMINE 3 RECEPTOR STIMULATING AGENT; HALOPERIDOL; N [4 [2 (6 CYANO 1,2,3,4 TETRAHYDROISOQUINOLIN 2 YL)ETHYL]CYCLOHEXYL] 4 QUINOLININECARBOXAMIDE; PRAMIPEXOLE; QUINELORANE; QUINPIROLE; SB 277011 A; UNCLASSIFIED DRUG; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DRD3 PROTEIN, RAT; N [4 [2 (6 CYANO 1,2,3,4 TETRAHYDRO 2 ISOQUINOLINYL)ETHYL]CYCLOHEXYL] 4 QUINOLINECARBOXAMIDE; NITRILE; QUINOLINE DERIVATIVE; TETRAHYDROISOQUINOLINE DERIVATIVE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BRAIN DEPTH STIMULATION; CATALEPSY; COCAINE DEPENDENCE; CONDITIONING; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DOSE RESPONSE; DRUG DEPENDENCE; DRUG POTENCY; DRUG SELECTIVITY; NONHUMAN; PLACE PREFERENCE; PRIORITY JOURNAL; RAT; RELAPSE; ANIMAL; BEHAVIOR; BRAIN; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; DRUG SELF ADMINISTRATION; ELECTRODE; ELECTROSTIMULATION; INSTRUMENTAL CONDITIONING; LONG EVANS RAT; MALE; METABOLISM; PATHOPHYSIOLOGY; RECURRENT DISEASE; REINFORCEMENT; REWARD; SPRAGUE DAWLEY RAT;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CATALEPSY; COCAINE; COCAINE-RELATED DISORDERS; CONDITIONING, OPERANT; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ELECTRODES, IMPLANTED; HALOPERIDOL; MALE; NITRILES; QUINOLINES; RATS; RATS, LONG-EVANS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; RECURRENCE; REINFORCEMENT (PSYCHOLOGY); REWARD; SELF ADMINISTRATION; SPATIAL BEHAVIOR; TETRAHYDROISOQUINOLINES;

EID: 0036827033     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-21-09595.2002     Document Type: Article

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