메뉴 건너뛰기




Volumn 45, Issue 1, 2010, Pages 23-29

Amyloid β and APP as biomarkers for Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid; Biomarkers; Cerebrospinal fluid; Long term potentiation

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; ISOPROTEIN; OLIGOMER; PRESENILIN; TAU PROTEIN;

EID: 71849099881     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2009.08.002     Document Type: Review
Times cited : (100)

References (109)
  • 1
    • 36248968160 scopus 로고    scopus 로고
    • Reversible synaptic depression in developing rat CA3 CA1 synapses explained by a novel cycle of AMPA silencing-unsilencing
    • Abrahamsson T., Gustafsson B., and Hanse E. Reversible synaptic depression in developing rat CA3 CA1 synapses explained by a novel cycle of AMPA silencing-unsilencing. J. Neurophysiol. 98 (2007) 2604-2611
    • (2007) J. Neurophysiol. , vol.98 , pp. 2604-2611
    • Abrahamsson, T.1    Gustafsson, B.2    Hanse, E.3
  • 4
    • 42049121409 scopus 로고    scopus 로고
    • Amyloid-related biomarkers for Alzheimer's disease
    • Andreasen N., and Zetterberg H. Amyloid-related biomarkers for Alzheimer's disease. Curr. Med. Chem. 15 (2008) 766-771
    • (2008) Curr. Med. Chem. , vol.15 , pp. 766-771
    • Andreasen, N.1    Zetterberg, H.2
  • 6
    • 34548036227 scopus 로고    scopus 로고
    • Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
    • Ballatore C., Lee V.M., and Trojanowski J.Q. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat. Rev. Neurosci. 8 (2007) 663-672
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 663-672
    • Ballatore, C.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 7
    • 33745920161 scopus 로고    scopus 로고
    • Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo
    • Bateman R.J., Munsell L.Y., Morris J.C., Swarm R., Yarasheski K.E., and Holtzman D.M. Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nat. Med. 12 (2006) 856-861
    • (2006) Nat. Med. , vol.12 , pp. 856-861
    • Bateman, R.J.1    Munsell, L.Y.2    Morris, J.C.3    Swarm, R.4    Yarasheski, K.E.5    Holtzman, D.M.6
  • 8
    • 66749084437 scopus 로고    scopus 로고
    • Bateman, R.J., Siemers, E.R., Mawuenyega, K.G., Wen, G., Browning, K.R., Sigurdson, W.C., Yarasheski, K.E., Friedrich, S.W., Demattos, R.B., May, P.C., Paul, S.M., Holtzman, D.M., 2009. A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system. Ann. Neurol. doi:10.1002/ana.21623.
    • Bateman, R.J., Siemers, E.R., Mawuenyega, K.G., Wen, G., Browning, K.R., Sigurdson, W.C., Yarasheski, K.E., Friedrich, S.W., Demattos, R.B., May, P.C., Paul, S.M., Holtzman, D.M., 2009. A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system. Ann. Neurol. doi:10.1002/ana.21623.
  • 10
    • 68949192793 scopus 로고    scopus 로고
    • Buerger, K., Frisoni, G., Uspenskaya, O., Ewers, M., Zetterberg, H., Geroldi, C., Binetti, G., Johannsen, P., Rossini, P.M., Wahlund, L.O., Vellas, B., Blennow, K., Hampel, H., 2009. Validation of Alzheimer's disease CSF and plasma biological markers: the multicentre reliability study of the pilot European Alzheimer's disease neuroimaging initiative (E-ADNI). Exp. Gerontol. doi:10.1016/j.exger.2009.06.003.
    • Buerger, K., Frisoni, G., Uspenskaya, O., Ewers, M., Zetterberg, H., Geroldi, C., Binetti, G., Johannsen, P., Rossini, P.M., Wahlund, L.O., Vellas, B., Blennow, K., Hampel, H., 2009. Validation of Alzheimer's disease CSF and plasma biological markers: the multicentre reliability study of the pilot European Alzheimer's disease neuroimaging initiative (E-ADNI). Exp. Gerontol. doi:10.1016/j.exger.2009.06.003.
  • 11
    • 33645101015 scopus 로고    scopus 로고
    • Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss
    • Campbell W.A., Yang H., Zetterberg H., Baulac S., Sears J.A., Liu T., Wong S.T., Zhong T.P., and Xia W. Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. J. Neurochem. 96 (2006) 1423-1440
    • (2006) J. Neurochem. , vol.96 , pp. 1423-1440
    • Campbell, W.A.1    Yang, H.2    Zetterberg, H.3    Baulac, S.4    Sears, J.A.5    Liu, T.6    Wong, S.T.7    Zhong, T.P.8    Xia, W.9
  • 14
    • 63049085885 scopus 로고    scopus 로고
    • Amyloid beta-protein fragments 25-35 and 31-35 potentiate long-term depression in hippocampal CA1 region of rats in vivo
    • Cheng L., Yin W.J., Zhang J.F., and Qi J.S. Amyloid beta-protein fragments 25-35 and 31-35 potentiate long-term depression in hippocampal CA1 region of rats in vivo. Synapse 63 (2009) 206-214
    • (2009) Synapse , vol.63 , pp. 206-214
    • Cheng, L.1    Yin, W.J.2    Zhang, J.F.3    Qi, J.S.4
  • 15
    • 33751243918 scopus 로고    scopus 로고
    • Spatial and temporal control of age-related APP processing in genomic-based beta-secretase transgenic mice
    • Chiocco M.J., and Lamb B.T. Spatial and temporal control of age-related APP processing in genomic-based beta-secretase transgenic mice. Neurobiol. Aging 28 (2007) 75-84
    • (2007) Neurobiol. Aging , vol.28 , pp. 75-84
    • Chiocco, M.J.1    Lamb, B.T.2
  • 16
    • 0030809128 scopus 로고    scopus 로고
    • Block of LTP in rat hippocampus in vivo by beta-amyloid precursor protein fragments
    • Cullen W.K., Suh Y.H., Anwyl R., and Rowan M.J. Block of LTP in rat hippocampus in vivo by beta-amyloid precursor protein fragments. Neuroreport 8 (1997) 3213-3217
    • (1997) Neuroreport , vol.8 , pp. 3213-3217
    • Cullen, W.K.1    Suh, Y.H.2    Anwyl, R.3    Rowan, M.J.4
  • 17
    • 0031778614 scopus 로고    scopus 로고
    • Neurochemical dissection of synaptic pathology in Alzheimer's disease
    • Davidsson P., and Blennow K. Neurochemical dissection of synaptic pathology in Alzheimer's disease. Int. Psychogeriatr. 10 (1998) 11-23
    • (1998) Int. Psychogeriatr. , vol.10 , pp. 11-23
    • Davidsson, P.1    Blennow, K.2
  • 19
    • 0030700502 scopus 로고    scopus 로고
    • Inhibitory synaptogenesis in mouse somatosensory cortex
    • De Felipe J., Marco P., Fairen A., and Jones E.G. Inhibitory synaptogenesis in mouse somatosensory cortex. Cereb. Cortex 7 (1997) 619-634
    • (1997) Cereb. Cortex , vol.7 , pp. 619-634
    • De Felipe, J.1    Marco, P.2    Fairen, A.3    Jones, E.G.4
  • 20
    • 0037431082 scopus 로고    scopus 로고
    • Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex
    • De Strooper B. Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex. Neuron 38 (2003) 9-12
    • (2003) Neuron , vol.38 , pp. 9-12
    • De Strooper, B.1
  • 23
    • 3242766671 scopus 로고    scopus 로고
    • Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease
    • Fonseca M.I., Zhou J., Botto M., and Tenner A.J. Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease. J. Neurosci. 24 (2004) 6457-6465
    • (2004) J. Neurosci. , vol.24 , pp. 6457-6465
    • Fonseca, M.I.1    Zhou, J.2    Botto, M.3    Tenner, A.J.4
  • 28
    • 0034027642 scopus 로고    scopus 로고
    • Age-dependent change in the levels of Abeta40 and Abeta42 in cerebrospinal fluid from control subjects, and a decrease in the ratio of Abeta42 to Abeta40 level in cerebrospinal fluid from Alzheimer's disease patients
    • Fukuyama R., Mizuno T., Mori S., Nakajima K., Fushiki S., and Yanagisawa K. Age-dependent change in the levels of Abeta40 and Abeta42 in cerebrospinal fluid from control subjects, and a decrease in the ratio of Abeta42 to Abeta40 level in cerebrospinal fluid from Alzheimer's disease patients. Eur. Neurol. 43 (2000) 155-160
    • (2000) Eur. Neurol. , vol.43 , pp. 155-160
    • Fukuyama, R.1    Mizuno, T.2    Mori, S.3    Nakajima, K.4    Fushiki, S.5    Yanagisawa, K.6
  • 30
    • 33748920372 scopus 로고    scopus 로고
    • AMPA and NMDA glutamate receptor trafficking: multiple roads for reaching and leaving the synapse
    • Groc L., and Choquet D. AMPA and NMDA glutamate receptor trafficking: multiple roads for reaching and leaving the synapse. Cell Tissue Res. 326 (2006) 423-438
    • (2006) Cell Tissue Res. , vol.326 , pp. 423-438
    • Groc, L.1    Choquet, D.2
  • 33
    • 32544435900 scopus 로고    scopus 로고
    • Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
    • Hansson O., Zetterberg H., Buchhave P., Londos E., Blennow K., and Minthon L. Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol. 5 (2006) 228-234
    • (2006) Lancet Neurol. , vol.5 , pp. 228-234
    • Hansson, O.1    Zetterberg, H.2    Buchhave, P.3    Londos, E.4    Blennow, K.5    Minthon, L.6
  • 35
    • 16844382811 scopus 로고    scopus 로고
    • CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment
    • Herukka S.K., Hallikainen M., Soininen H., and Pirttila T. CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment. Neurology 64 (2005) 1294-1297
    • (2005) Neurology , vol.64 , pp. 1294-1297
    • Herukka, S.K.1    Hallikainen, M.2    Soininen, H.3    Pirttila, T.4
  • 37
    • 2542604678 scopus 로고    scopus 로고
    • Increased beta-Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects
    • Holsinger R.M., McLean C.A., Collins S.J., Masters C.L., and Evin G. Increased beta-Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects. Ann. Neurol. 55 (2004) 898-899
    • (2004) Ann. Neurol. , vol.55 , pp. 898-899
    • Holsinger, R.M.1    McLean, C.A.2    Collins, S.J.3    Masters, C.L.4    Evin, G.5
  • 38
    • 33747659600 scopus 로고    scopus 로고
    • CSF BACE1 activity is increased in CJD and Alzheimer disease versus [corrected] other dementias
    • Holsinger R.M., Lee J.S., Boyd A., Masters C.L., and Collins S.J. CSF BACE1 activity is increased in CJD and Alzheimer disease versus [corrected] other dementias. Neurology 67 (2006) 710-712
    • (2006) Neurology , vol.67 , pp. 710-712
    • Holsinger, R.M.1    Lee, J.S.2    Boyd, A.3    Masters, C.L.4    Collins, S.J.5
  • 40
  • 42
    • 4344673143 scopus 로고    scopus 로고
    • Biomarkers of Alzheimer disease in plasma
    • Irizarry M.C. Biomarkers of Alzheimer disease in plasma. NeuroRx 1 (2004) 226-234
    • (2004) NeuroRx , vol.1 , pp. 226-234
    • Irizarry, M.C.1
  • 46
    • 59649114125 scopus 로고    scopus 로고
    • Synaptic AMPA receptor plasticity and behavior
    • Kessels H.W., and Malinow R. Synaptic AMPA receptor plasticity and behavior. Neuron 61 (2009) 340-350
    • (2009) Neuron , vol.61 , pp. 340-350
    • Kessels, H.W.1    Malinow, R.2
  • 47
    • 0035034474 scopus 로고    scopus 로고
    • Ontogenetic changes in protein level of amyloid precursor protein (APP) in growth cones and synaptosomes from rat brain and prenatal expression pattern of APP mRNA isoforms in developing rat embryo
    • Kirazov E., Kirazov L., Bigl V., and Schliebs R. Ontogenetic changes in protein level of amyloid precursor protein (APP) in growth cones and synaptosomes from rat brain and prenatal expression pattern of APP mRNA isoforms in developing rat embryo. Int. J. Dev. Neurosci. 19 (2001) 287-296
    • (2001) Int. J. Dev. Neurosci. , vol.19 , pp. 287-296
    • Kirazov, E.1    Kirazov, L.2    Bigl, V.3    Schliebs, R.4
  • 48
    • 0035923502 scopus 로고    scopus 로고
    • Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase
    • Kitazume S., Tachida Y., Oka R., Shirotani K., Saido T.C., and Hashimoto Y. Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase. Proc. Natl. Acad. Sci. USA 98 (2001) 13554-13559
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13554-13559
    • Kitazume, S.1    Tachida, Y.2    Oka, R.3    Shirotani, K.4    Saido, T.C.5    Hashimoto, Y.6
  • 52
    • 33846633336 scopus 로고    scopus 로고
    • Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
    • Lacor P.N., Buniel M.C., Furlow P.W., Clemente A.S., Velasco P.T., Wood M., Viola K.L., and Klein W.L. Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J. Neurosci. 27 (2007) 796-807
    • (2007) J. Neurosci. , vol.27 , pp. 796-807
    • Lacor, P.N.1    Buniel, M.C.2    Furlow, P.W.3    Clemente, A.S.4    Velasco, P.T.5    Wood, M.6    Viola, K.L.7    Klein, W.L.8
  • 55
    • 61349201380 scopus 로고    scopus 로고
    • Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers
    • Lauren J., Gimbel D.A., Nygaard H.B., Gilbert J.W., and Strittmatter S.M. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 457 (2009) 1128-1132
    • (2009) Nature , vol.457 , pp. 1128-1132
    • Lauren, J.1    Gimbel, D.A.2    Nygaard, H.B.3    Gilbert, J.W.4    Strittmatter, S.M.5
  • 56
    • 58549102356 scopus 로고    scopus 로고
    • Insulin rescues amyloid beta-induced impairment of hippocampal long-term potentiation
    • Lee C.C., Kuo Y.M., Huang C.C., and Hsu K.S. Insulin rescues amyloid beta-induced impairment of hippocampal long-term potentiation. Neurobiol. Aging 30 (2009) 377-387
    • (2009) Neurobiol. Aging , vol.30 , pp. 377-387
    • Lee, C.C.1    Kuo, Y.M.2    Huang, C.C.3    Hsu, K.S.4
  • 57
    • 75549090428 scopus 로고    scopus 로고
    • Lewczuk, P., Kamrowski-Kruck, H., Peters, O., Heuser, I., Jessen, F., Popp, J., Burger, K., Hampel, H., Frolich, L., Wolf, S., Prinz, B., Jahn, H., Luckhaus, C., Perneczky, R., Hull, M., Schroder, J., Kessler, H., Pantel, J., Gertz, H.J., Klafki, H.W., Kolsch, H., Reulbach, U., Esselmann, H., Maler, J.M., Bibl, M., Kornhuber, J., Wiltfang, J., 2008. Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study. Mol. Psychiatry doi:10.1038/mp.2008.84.
    • Lewczuk, P., Kamrowski-Kruck, H., Peters, O., Heuser, I., Jessen, F., Popp, J., Burger, K., Hampel, H., Frolich, L., Wolf, S., Prinz, B., Jahn, H., Luckhaus, C., Perneczky, R., Hull, M., Schroder, J., Kessler, H., Pantel, J., Gertz, H.J., Klafki, H.W., Kolsch, H., Reulbach, U., Esselmann, H., Maler, J.M., Bibl, M., Kornhuber, J., Wiltfang, J., 2008. Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study. Mol. Psychiatry doi:10.1038/mp.2008.84.
  • 58
    • 1642345964 scopus 로고    scopus 로고
    • Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1
    • Li Q., and Sudhof T.C. Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. J. Biol. Chem. 279 (2004) 10542-10550
    • (2004) J. Biol. Chem. , vol.279 , pp. 10542-10550
    • Li, Q.1    Sudhof, T.C.2
  • 60
    • 63449105260 scopus 로고    scopus 로고
    • Mattsson, N., Axelsson, M., Haghighi, S., Malmestrom, C., Wu, G., Anckarsater, R., Sankaranarayanan, S., Andreasson, U., Fredrikson, S., Gundersen, A., Johnsen, L., Flaby, T., Tarkowski, A., Trysberg, E., Wallin, A., Anckarsater, H., Lycke, J., Andersen, O., Simon, A., Blennow, K., Zetterberg, H., 2009a. Reduced cerebrospinal fluid BACE1 activity in multiple sclerosis. Mult. Scler. doi:10.1177/1352458508100031.
    • Mattsson, N., Axelsson, M., Haghighi, S., Malmestrom, C., Wu, G., Anckarsater, R., Sankaranarayanan, S., Andreasson, U., Fredrikson, S., Gundersen, A., Johnsen, L., Flaby, T., Tarkowski, A., Trysberg, E., Wallin, A., Anckarsater, H., Lycke, J., Andersen, O., Simon, A., Blennow, K., Zetterberg, H., 2009a. Reduced cerebrospinal fluid BACE1 activity in multiple sclerosis. Mult. Scler. doi:10.1177/1352458508100031.
  • 61
    • 67650149563 scopus 로고    scopus 로고
    • Future screening for incipient Alzheimer's disease - the influence of prevalence on test performance
    • Mattsson N., and Zetterberg H. Future screening for incipient Alzheimer's disease - the influence of prevalence on test performance. Eur. Neurol. 62 (2009) 200-203
    • (2009) Eur. Neurol. , vol.62 , pp. 200-203
    • Mattsson, N.1    Zetterberg, H.2
  • 63
    • 0242412140 scopus 로고    scopus 로고
    • Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and risk
    • Mayeux R., Honig L.S., Tang M.X., Manly J., Stern Y., Schupf N., and Mehta P.D. Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and risk. Neurology 61 (2003) 1185-1190
    • (2003) Neurology , vol.61 , pp. 1185-1190
    • Mayeux, R.1    Honig, L.S.2    Tang, M.X.3    Manly, J.4    Stern, Y.5    Schupf, N.6    Mehta, P.D.7
  • 64
    • 0035808835 scopus 로고    scopus 로고
    • Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells
    • Megias M., Emri Z., Freund T.F., and Gulyas A.I. Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells. Neuroscience 102 (2001) 527-540
    • (2001) Neuroscience , vol.102 , pp. 527-540
    • Megias, M.1    Emri, Z.2    Freund, T.F.3    Gulyas, A.I.4
  • 65
    • 0033975837 scopus 로고    scopus 로고
    • Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease
    • Mehta P.D., Pirttila T., Mehta S.P., Sersen E.A., Aisen P.S., and Wisniewski H.M. Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease. Arch. Neurol. 57 (2000) 100-105
    • (2000) Arch. Neurol. , vol.57 , pp. 100-105
    • Mehta, P.D.1    Pirttila, T.2    Mehta, S.P.3    Sersen, E.A.4    Aisen, P.S.5    Wisniewski, H.M.6
  • 66
    • 0035907123 scopus 로고    scopus 로고
    • Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease
    • Mehta P.D., Pirttila T., Patrick B.A., Barshatzky M., and Mehta S.P. Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease. Neurosci. Lett. 304 (2001) 102-106
    • (2001) Neurosci. Lett. , vol.304 , pp. 102-106
    • Mehta, P.D.1    Pirttila, T.2    Patrick, B.A.3    Barshatzky, M.4    Mehta, S.P.5
  • 67
    • 0033538896 scopus 로고    scopus 로고
    • Expression of presenilin 1 in nervous system during rat development
    • Moreno-Flores M.T., Medina M., and Wandosell F. Expression of presenilin 1 in nervous system during rat development. J. Comp. Neurol. 410 (1999) 556-570
    • (1999) J. Comp. Neurol. , vol.410 , pp. 556-570
    • Moreno-Flores, M.T.1    Medina, M.2    Wandosell, F.3
  • 68
    • 37349016848 scopus 로고    scopus 로고
    • Synaptic plasticity, memory and the hippocampus: a neural network approach to causality
    • Neves G., Cooke S.F., and Bliss T.V. Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nat. Rev. Neurosci. 9 (2008) 65-75
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 65-75
    • Neves, G.1    Cooke, S.F.2    Bliss, T.V.3
  • 69
    • 60549089207 scopus 로고    scopus 로고
    • APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
    • Nikolaev A., McLaughlin T., O'Leary D.D., and Tessier-Lavigne M. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457 (2009) 981-989
    • (2009) Nature , vol.457 , pp. 981-989
    • Nikolaev, A.1    McLaughlin, T.2    O'Leary, D.D.3    Tessier-Lavigne, M.4
  • 71
    • 54249121176 scopus 로고    scopus 로고
    • C1q: the perfect complement for a synaptic feast?
    • Perry V.H., and O'Connor V. C1q: the perfect complement for a synaptic feast?. Nat. Rev. Neurosci. 9 (2008) 807-811
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 807-811
    • Perry, V.H.1    O'Connor, V.2
  • 72
    • 0031871740 scopus 로고    scopus 로고
    • Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy
    • Pitschke M., Prior R., Haupt M., and Riesner D. Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy. Nat. Med. 4 (1998) 832-834
    • (1998) Nat. Med. , vol.4 , pp. 832-834
    • Pitschke, M.1    Prior, R.2    Haupt, M.3    Riesner, D.4
  • 76
    • 2942557310 scopus 로고    scopus 로고
    • APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42
    • Prince J.A., Zetterberg H., Andreasen N., Marcusson J., and Blennow K. APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42. Neurology 62 (2004) 2116-2118
    • (2004) Neurology , vol.62 , pp. 2116-2118
    • Prince, J.A.1    Zetterberg, H.2    Andreasen, N.3    Marcusson, J.4    Blennow, K.5
  • 77
    • 0037432559 scopus 로고    scopus 로고
    • NMDA receptor regulation by amyloid-beta does not account for its inhibition of LTP in rat hippocampus
    • Raymond C.R., Ireland D.R., and Abraham W.C. NMDA receptor regulation by amyloid-beta does not account for its inhibition of LTP in rat hippocampus. Brain Res. 968 (2003) 263-272
    • (2003) Brain Res. , vol.968 , pp. 263-272
    • Raymond, C.R.1    Ireland, D.R.2    Abraham, W.C.3
  • 82
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81 (2001) 741-766
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 88
    • 0037465449 scopus 로고    scopus 로고
    • CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study
    • Strozyk D., Blennow K., White L.R., and Launer L.J. CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study. Neurology 60 (2003) 652-656
    • (2003) Neurology , vol.60 , pp. 652-656
    • Strozyk, D.1    Blennow, K.2    White, L.R.3    Launer, L.J.4
  • 89
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
    • Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., Hansen L.A., and Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30 (1991) 572-580
    • (1991) Ann. Neurol. , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 90
    • 33846068084 scopus 로고    scopus 로고
    • Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms
    • Ting J.T., Kelley B.G., Lambert T.J., Cook D.G., and Sullivan J.M. Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms. Proc. Natl. Acad. Sci. USA 104 (2007) 353-358
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 353-358
    • Ting, J.T.1    Kelley, B.G.2    Lambert, T.J.3    Cook, D.G.4    Sullivan, J.M.5
  • 91
    • 33645505550 scopus 로고    scopus 로고
    • Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers
    • Townsend M., Shankar G.M., Mehta T., Walsh D.M., and Selkoe D.J. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J. Physiol. 572 (2006) 477-492
    • (2006) J. Physiol. , vol.572 , pp. 477-492
    • Townsend, M.1    Shankar, G.M.2    Mehta, T.3    Walsh, D.M.4    Selkoe, D.J.5
  • 92
    • 36348935683 scopus 로고    scopus 로고
    • Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway
    • Townsend M., Mehta T., and Selkoe D.J. Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J. Biol. Chem. 282 (2007) 33305-33312
    • (2007) J. Biol. Chem. , vol.282 , pp. 33305-33312
    • Townsend, M.1    Mehta, T.2    Selkoe, D.J.3
  • 94
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., Rowan M.J., and Selkoe D.J. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416 (2002) 535-539
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 95
    • 14944378094 scopus 로고    scopus 로고
    • Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation
    • Walsh D.M., Townsend M., Podlisny M.B., Shankar G.M., Fadeeva J.V., El Agnaf O., Hartley D.M., and Selkoe D.J. Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. J. Neurosci. 25 (2005) 2455-2462
    • (2005) J. Neurosci. , vol.25 , pp. 2455-2462
    • Walsh, D.M.1    Townsend, M.2    Podlisny, M.B.3    Shankar, G.M.4    Fadeeva, J.V.5    El Agnaf, O.6    Hartley, D.M.7    Selkoe, D.J.8
  • 102
    • 20744454142 scopus 로고    scopus 로고
    • Beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase
    • Wong H.K., Sakurai T., Oyama F., Kaneko K., Wada K., Miyazaki H., Kurosawa M., De Strooper B., Saftig P., and Nukina N. Beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. J. Biol. Chem. 280 (2005) 23009-23017
    • (2005) J. Biol. Chem. , vol.280 , pp. 23009-23017
    • Wong, H.K.1    Sakurai, T.2    Oyama, F.3    Kaneko, K.4    Wada, K.5    Miyazaki, H.6    Kurosawa, M.7    De Strooper, B.8    Saftig, P.9    Nukina, N.10
  • 103
    • 1442348909 scopus 로고    scopus 로고
    • Creation of AMPA-silent synapses in the neonatal hippocampus
    • Xiao M.Y., Wasling P., Hanse E., and Gustafsson B. Creation of AMPA-silent synapses in the neonatal hippocampus. Nat. Neurosci. 7 (2004) 236-243
    • (2004) Nat. Neurosci. , vol.7 , pp. 236-243
    • Xiao, M.Y.1    Wasling, P.2    Hanse, E.3    Gustafsson, B.4
  • 105
    • 0242627597 scopus 로고    scopus 로고
    • Cerebrospinal fluid markers for prediction of Alzheimer's disease
    • Zetterberg H., Wahlund L.O., and Blennow K. Cerebrospinal fluid markers for prediction of Alzheimer's disease. Neurosci. Lett. 352 (2003) 67-69
    • (2003) Neurosci. Lett. , vol.352 , pp. 67-69
    • Zetterberg, H.1    Wahlund, L.O.2    Blennow, K.3
  • 106
    • 33744948515 scopus 로고    scopus 로고
    • The cytosolic loop of the {gamma}-secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis
    • Zetterberg H., Campbell W.A., Yang H.W., and Xia W. The cytosolic loop of the {gamma}-secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis. J. Biol. Chem. 281 (2006) 11933-11939
    • (2006) J. Biol. Chem. , vol.281 , pp. 11933-11939
    • Zetterberg, H.1    Campbell, W.A.2    Yang, H.W.3    Xia, W.4
  • 107
    • 49149095666 scopus 로고    scopus 로고
    • Is plasma amyloid-beta a reliable biomarker for Alzheimer's disease?
    • Zetterberg H. Is plasma amyloid-beta a reliable biomarker for Alzheimer's disease?. Recent Pat. CNS Drug Discov. 3 (2008) 109-111
    • (2008) Recent Pat. CNS Drug Discov. , vol.3 , pp. 109-111
    • Zetterberg, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.